Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Zakaria, Zainul Amiruddin ^a,b   Balan, Tavamani ^a   Mamat, Siti Syariah ^a   Mohtarrudin, Norhafizah ^a   Kek, Teh Lay ^b   Salleh, Mohd Zaki ^b  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Anti inflammatory; Antioxidant; Gastroprotective mechanisms; Melastoma malabathricum; Melastomaceae; Methanol extract; Nitric oxide; Sulfhydryl group

Indexed keywords

CARBENOXOLONE; CATALASE; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPOXYGENASE; MELASTOMA MALABATHRICUM EXTRACT; METHANOL; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PLANT EXTRACT; QUERCITRIN; RANITIDINE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE OXIDASE; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; ETHANOL-INDUCED GASTRIC ULCER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MACROPHAGE; MALE; MEDICINAL PLANT; MELASTOMA MALABATHRICUM; NONHUMAN; PLANT LEAF; PYLORUS LIGATION INDUCED GASTRIC ULCER; RAT; STOMACH MUCUS; STOMACH PH; STOMACH PROTECTION; ANIMAL; CHEMISTRY; DRUG EFFECTS; MELASTOMATACEAE; SPRAGUE DAWLEY RAT; STOMACH; STOMACH JUICE;

ANIMALS; GASTRIC JUICE; MALE; MELASTOMATACEAE; METHANOL; PLANT EXTRACTS; PLANT LEAVES; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH;

EID: 84938968680     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0638-z     Document Type: Article

References (57)

1. Calam J, Baron JH. Pathophysiology of duodenal and gastric ulcer and gastric cancer. Brit Med J. 2001;323:980-3.
2. Gasparetto M, Pescarin M, Guariso G. Helicobacter pylori Eradication Therapy: Current Availabilities. Int Schol Res Network Gastroenterol 2012, 2012: Article ID 186734, 8 pages doi:10.5402/2012/186734
3. Yakoob J, Jafri W, Jafri N, Islam M, Abid S, Hamid S, et al. Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi, Pakistan. World J Gastroenterol. 2005;11:3562-5.
4. Zakaria ZA, Abdul Hisam EE, Mohtarruddin N, Rofiee MS, Othman F, Hasiah AH, et al. Methanol extract of Bauhinia purpurea leaf possesses antiulcer activity. Med Princ Pract. 2012;21:476-82.
5. Mohd. Joffry S, Yob NJ, Rofiee MS, MeorMohd. Affandi MMR, Othman F, Abdah MA et al. Melastoma malabathricum (L.) Smith: a review of its ethnomedicinal, chemical and pharmacological uses. Evid-Bsed Compl Alt 2012, Article ID 258434. doi:10.1155/2012/258434.
6. Hussain F, Abdulla MA, Mohd Noor S, Ismail S, Mohd Ali H. Gastroprotective effects of Melastoma malabathricum aqueous leaf extract against ethanol-induced gastric ulcer in rats. Am J Biochem Biotechnol. 2008;4:438-41.
7. Zakaria ZA, Rofiee MS, Mohamed AM, Teh LK, Salleh MZ. In vitro antiproliferative and antioxidant activities, and total phenolic contents of the extracts of Melastoma malabathricum leaves. J Acupunct Meridian Stud. 2011;4:248-56.
8. Zabidi Z, Wan Zainulddin WN, Mamat SS, Shamsahal Din S, Kamisan FH, Yahya F, et al. Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. Med Princ Pract. 2012;21:501-3.
9. Guay J, Bateman K, Gordon R, Mancini J, Riendeau D. Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. J Biol Chem. 2004;279:24866-72.
10. Tang EHC, Libby P, Vanhoutte PM, Xu A. Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol. 2012;59:116-23.
11. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000;403:103-8.
12. Wiart C, Mogana S, Khalifah S, Mahan M, Ismail S, Buckle M, et al. Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia. Fitoterapia. 2004;75:68-73.
13. Sunilson JAJ, James J, Thomas J, Jayaraj P, Varatharajan R, Muthappan M. Antibacterial and wound healing activities of Melastoma malabathricum Linn. Afr J Infect Dis. 2008;2:68-73.
14. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109-10.
15. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 1945;5:43-61.
16. Srivastava V, Viswanathaswamy AH, Mohan G. Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats. Indian J Pharmacol. 2010;42:185-8.
17. Corne SJ, Morrisey SM, Woods RJ. A method for the quantitative estimation of gastric barrier mucus. J Physiol. 1974;242:116-7.
18. Andreo MA, Ballesteros KVR, Hiruma-Lima CA, Machado da Rocha LR, Souza Brito ARM, Vilegas W. Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J Ethnopharmacol. 2006;107:431-41.
19. Balan T, Sani MHM, Suppaiah V, Mohtarrudin N, Suhaili Z, Ahmad Z, et al. Antiulcer activity of methanol extract of Muntingia calabura leaves involves the modulation of endogenous nitric oxide and non-protein sulfhydryl compounds. Pharm Biol. 2013;Early Online:1-9.
20. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys. 1984;21:130-2.
21. Sinha KA. Colorimetry assay of Catalase. Anal Biochem. 1972;47:389-94.
22. Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206-9.
23. Rotruck JT, Pope AL, Ganther HE, Swanson AB. Selenium: biochemical roles as a component of glutathione peroxidase. Science. 1973;179:588-90.
24. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82:70-7.
25. Okhawa H, Oishi N, Yagi K. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8.
26. Lowry OH, Rosebrough NL, Farr AL, Randall RJ. Protein measurement with Folin Phenol reagent. J Biol Chem. 1951;193:265-75.
27. Lee KH, Padzil AM, Syahida A, Abdullah N, Zuhainis SW, Maziah M, et al. Evaluation of anti-inflammatory, antioxidant and antinociceptive activities of six Malaysian medicinal plants. J Med Plant Res. 2011;5:5555-63.
28. Azhar-Ul-Haq, Malik A, Anis I, Khan SB, Ahmed E, Ahmed Z, et al. Enzymes Inhibiting Lignans from Vitex negundo. Chem Pharmaceut Bull. 2004;52:1269-72.
29. Noro T, Miyase T, Kuroyanagi M. Monoamine oxidase inhibitor from the rhizomes of Kaempferia galanga L. Chem Pharmaceut Bull. 1983;31:2708-11.
30. Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrusdeodara (Roxb.) Loud. In Wistar rats. J Ethnopharmacol. 2011;134:294-7.
31. Goel RK, Bhattacharya SK. Gastroduodenal mucosal defence and mucosal protective agents. Ind J Exp Biol. 1991;29:701-14.
32. Venables CW. Mucus, pepsin and peptic ulcer. Gut. 1986;27:233-8.
33. Brzozowski T, Konturek PC, Sliwowski Z, Kwiecień S, Drozdowicz D, Pawlik M, et al. Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with Helicobacter pylori in the stomach of humans and experimental animals. J Physiol Pharmacol. 2006;57:67-79.
34. Tariq M, Khan HA, Elfaki I, Arshaduddin M, Al Moutaery M, Al Rayes H, et al. Gastric antisecretory and antiulcer effects of simvastatin in rats. J Gastroenterol Hepatol. 2007;22:2316-23.
35. Calatayud S, Barrachina D, Esplugues JV. Nitric oxide: relation to integrity, injury, and healing of the gastric mucosa. Microsc Res Tech. 2001;53:325-35.
36. Szabo S, Vattay P. Experimental gastric and duodenal ulcers. Advances in pathogenesis. Gastroenterol Clin North Am. 1990;19:67-85.
37. Maity S, Vedasiromoni JR, Ganguly DK. Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis). Jpn J Pharmacol. 1998;78:285-92.
38. Salim AS. Sulfhydryl-containing agents: new approach to the problem of refractory peptic ulceration. Pharmacology. 1993;46:281-8.
39. Avila JR, de la Lastra CA, Martin MJ, Motilva V, Luque I, Delgado D, et al. Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm Res. 2005;45:83-8.
40. Goel RK, Sairam K, Rao V. Role of gastric antioxidant and antihelicobacter pyroli activities in antiulcerogenic activities of Plantain banana (Musa spaientum var. paradisiaca). Indian J Exp Biol. 2001;39:719-22.
41. Mates JM, Perez-Gomez C, Nudez de Castro I. Antioxidant enzymes and human diseases. Clin Biochem. 1999;32:595-603.
42. Okado-Matsumoto A, Fridovich I. Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu-, Zn-SOD in mitochondria. J Biol Chem. 2001;276:38388-93.
43. Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP. Comparative effects of curcumin and an analog of curcumin and PUFA induced oxidative stress. J Pharm Pharm Sci. 2004;7:274-83.
44. Schlorff EC, Husain K, Somani SM. Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat. Alcohol. 1999;17:97-105.
45. Recknagel RO, Ghoshal AK. Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning. Exp Mol Pathol. 1996;5:413-26.
46. Brown LA, Harris FL, Ping XD, Gauthier TW. Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability? Alcohol. 2004;33:191-7.
47. Jaya DS, Augstine J, Menon VP. Role of lipid peroxides, glutathione and antiperoxidative enzymes in alcohol and drug toxicity. Indian J Exp Biol. 1993;31:453-9.
48. Halliwell B, Gutteridge JMC, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med. 1992;119(6):598-620.
49. Bayir Y, Odabasoglu F, Cakir A, Aslan A, Suleyman H, Halici M, et al. The inhibition of gastric mucosal lesion, oxidative stress and meutrophil infiltration in rats by the lichen constituent diffractaic acid. Phytomedicine. 2006;13:584-90.
50. Mota KSL, Dias GEN, Pinto MEF, Luiz-Ferreira Â, Monteiro Souza-Brito AR, Hiruma Lima CA, et al. Flavonoids with gastroprotective activity. Molecule. 2009;14:979-1012.
51. Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Indian J Exp Biol. 2001;39:41-6.
52. Fiorucci S, Distrutti E, de Lima OM, Romano M, Mencarelli A, Barbanti M, et al. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J. 2003;17:1171-3.
53. Pelletier JM, Lajeunesse D, Reboul P, Pelletier JP. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and nonselective non-steroidal anti-inflammatory drugs. Ann Rheum Dis. 2003;62:501-9.
54. Camuesco D, Comalada M, Rodriguez-Cabezas ME, Nieto A, Lorente MD, Concha A, et al. The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br J Pharmacol. 2004;143:908-18.
55. Comalada M, Camuesco D, Sierra S, Ballester I, Xaus J, Glvez J, et al. In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-jB pathway. Eur J Immunol. 2005;35:584-92.
56. Bose S, Maji S, Chakraborty P. Research article quercitrin from Ixora coccinea leaves and its anti-oxidant activity. J PharmaSciTech. 2013;2:72-4.
57. Uppugundla N, Engelberth A, Vandhana Ravindranath S, Clausen EC, Lay JO, Gidden J, et al. Switchgrass water extracts: extraction, separation and biological activity of rutin and quercitrin. J Agric Food Chem. 2009;57:7763-70.