메뉴 건너뛰기




Volumn 29, Issue 6, 2015, Pages 429-436

PCSK9 and triglyceride-rich lipoprotein metabolism

Author keywords

Hypercholesterolemia; Hyperlipidemia; Molecular biology

Indexed keywords

APOLIPOPROTEIN B; CHYLOMICRON; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PRO PROTEIN CONVERTASE SUBTILISIN KEXIN 9; SERINE PROTEINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 84959163895     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.7555/JBR.29.20150052     Document Type: Review
Times cited : (33)

References (75)
  • 1
    • 84881238159 scopus 로고    scopus 로고
    • Thee multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions[J]
    • Seidah NG, Sadr MS, Chrétien M, et al. Thee multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions[J]. J Bio Chem, 2013, 288(30):21473-21481.
    • (2013) J Bio Chem , vol.288 , Issue.30 , pp. 21473-21481
    • Seidah, N.G.1    Sadr, M.S.2    Chrétien, M.3
  • 2
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein covertase neural Liver regeneration and neuronal differentiation[J]
    • Seidah NG, Benjannet S, WIckham L, et al. The secretory proprotein covertase neural Liver regeneration and neuronal differentiation[J]. Proc Natl Acad Sci USA, 2002, 100(3):928-933.
    • (2002) Proc Natl Acad Sci USA , vol.100 , Issue.3 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 3
    • 67651160910 scopus 로고    scopus 로고
    • PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression[J]
    • Labonte P, Begley S, Gúevin C, et al. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression[J]. Hepatology, 2009, 50(1):17-24.
    • (2009) Hepatology , vol.50 , Issue.1 , pp. 17-24
    • Labonte, P.1    Begley, S.2    Gúevin, C.3
  • 4
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia[J]
    • Abifadel M, Varret M, Rabès JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia[J]. Nat Genet, 2003, 34(2):154-156.
    • (2003) Nat Genet , vol.34 , Issue.2 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabès, J.P.3
  • 5
    • 34848861377 scopus 로고    scopus 로고
    • Serum proprotein convertase subtilisin kexin 9 is correlated directly with serum LDL cholesterol[J]
    • Alborn WE, Cao G, Careskey HE, et al. Serum proprotein convertase subtilisin kexin 9 is correlated directly with serum LDL cholesterol[J]. Clin Chem, 2007, 53(10):1814-1819.
    • (2007) Clin Chem , vol.53 , Issue.10 , pp. 1814-1819
    • Alborn, W.E.1    Cao, G.2    Careskey, H.E.3
  • 6
    • 73149094934 scopus 로고    scopus 로고
    • A new method for measurement of total plasma PCSK9: clinical applications[ J]
    • Dubuc G, Tremblay M, ParéG, et al. A new method for measurement of total plasma PCSK9: clinical applications[ J]. J Lipid Res, 2010, 51(1):140-149.
    • (2010) J Lipid Res , vol.51 , Issue.1 , pp. 140-149
    • Dubuc, G.1    Tremblay, M.2    Paré, G.3
  • 7
    • 44849086762 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment[J]
    • Lambert G, Ancellin N, Charlton F, et al. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment[J]. Clin Chem, 2008, 54(6):1038-1045.
    • (2008) Clin Chem , vol.54 , Issue.6 , pp. 1038-1045
    • Lambert, G.1    Ancellin, N.2    Charlton, F.3
  • 8
    • 45549096493 scopus 로고    scopus 로고
    • Plasma PCSK9 levels are significantly modified by statins and fibrates in humans[J]
    • Mayne J, Dewpura T, Raymon A, et al. Plasma PCSK9 levels are significantly modified by statins and fibrates in humans[J]. Lipids Health Dis, 2008, 7(1):22.
    • (2008) Lipids Health Dis , vol.7 , Issue.1 , pp. 22
    • Mayne, J.1    Dewpura, T.2    Raymon, A.3
  • 9
    • 33750597734 scopus 로고    scopus 로고
    • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice[J]
    • Lagace TA, Curtis DE, Garuti R, et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice[J]. J Clin Invest, 2006, 116(11):2995-3005.
    • (2006) J Clin Invest , vol.116 , Issue.11 , pp. 2995-3005
    • Lagace, T.A.1    Curtis, D.E.2    Garuti, R.3
  • 10
    • 34547108600 scopus 로고    scopus 로고
    • Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation[J]
    • Zhang DW, Lagace TA, Garuti R, et al. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation[J]. J Biol Chem, 2007, 282(25):1802-1812.
    • (2007) J Biol Chem , vol.282 , Issue.25 , pp. 1802-1812
    • Zhang, D.W.1    Lagace, T.A.2    Garuti, R.3
  • 11
    • 34249021762 scopus 로고    scopus 로고
    • The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR[J]
    • Nassoury N, Blasiole DA, Tebon Oler A, et al. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR[J]. Traffic, 2007, 8(6):718-732.
    • (2007) Traffic , vol.8 , Issue.6 , pp. 718-732
    • Nassoury, N.1    Blasiole, D.A.2    Tebon Oler, A.3
  • 12
    • 84897889156 scopus 로고    scopus 로고
    • PCSK9: a key modulator of cardiovascular health[J]
    • Seidah NG, Awan Z, Chrétien M, et al. PCSK9: a key modulator of cardiovascular health[J]. Circ Res, 2014, 114(6):1022-1036.
    • (2014) Circ Res , vol.114 , Issue.6 , pp. 1022-1036
    • Seidah, N.G.1    Awan, Z.2    Chrétien, M.3
  • 13
    • 34548163845 scopus 로고    scopus 로고
    • Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity[J]
    • Li J, Tumanut C, Gavigan JA, et al. Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity[J]. Biochem J, 2007, 406(2):203-207.
    • (2007) Biochem J , vol.406 , Issue.2 , pp. 203-207
    • Li, J.1    Tumanut, C.2    Gavigan, J.A.3
  • 14
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/ PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterl[J]
    • Benjannet S, Rhainds D, Essalmani R, et al. NARC-1/ PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterl[J]. J Biol Chem, 2004, 279(47):48865-48875.
    • (2004) J Biol Chem , vol.279 , Issue.47 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3
  • 15
    • 84903977790 scopus 로고    scopus 로고
    • Isolation and Characterization of the Circulating Truncated Form of PCSK9[J]
    • Han B, Eacho PI, Knierman MD, et al. Isolation and Characterization of the Circulating Truncated Form of PCSK9[J]. J Lipid Res, 2014, 55(7):1505-1514.
    • (2014) J Lipid Res , vol.55 , Issue.7 , pp. 1505-1514
    • Han, B.1    Eacho, P.I.2    Knierman, M.D.3
  • 16
    • 84907075451 scopus 로고    scopus 로고
    • PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification proram[J]
    • Arsenault BJ, Pelletier-Beaumont E, Alméras N, et al. PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification proram[J]. Atherosclerosis, 2014, 236(2):321-326.
    • (2014) Atherosclerosis , vol.236 , Issue.2 , pp. 321-326
    • Arsenault, B.J.1    Pelletier-Beaumont, E.2    Alméras, N.3
  • 17
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents[ J]
    • Baass A, Dubuc G, Tremblay M, et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents[ J]. Clin Chem, 2009, 55(9):1637-1645.
    • (2009) Clin Chem , vol.55 , Issue.9 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3
  • 18
    • 84893950423 scopus 로고    scopus 로고
    • Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein e2[J]
    • Brouwers MCGJ, van Greevenbroek MMJ, Konrad RJ, et al. Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein e2[J]. Clin Sci (Lond), 2014, 126(9):679-684.
    • (2014) Clin Sci (Lond) , vol.126 , Issue.9 , pp. 679-684
    • Brouwers, M.C.G.J.1    van Greevenbroek, M.M.J.2    Konrad, R.J.3
  • 19
    • 84871942788 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets[J]
    • Cariou B, Langhi C, Le Bras M, et al. Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets[J]. Natr Metab (Lond), 2013, 10(1):4.
    • (2013) Natr Metab (Lond) , vol.10 , Issue.1 , pp. 4
    • Cariou, B.1    Langhi, C.2    Le Bras, M.3
  • 20
    • 84924922779 scopus 로고    scopus 로고
    • Inter-relationships between proprotein convertase subtilisin/kexin type 9, apolipoprotein C-III and plasma apolipoprotein B-48 transport in obese subjects: a stable isotope study in the postprandial state[J]
    • Chan DC, Wong ATY, Pang J, et al. Inter-relationships between proprotein convertase subtilisin/kexin type 9, apolipoprotein C-III and plasma apolipoprotein B-48 transport in obese subjects: a stable isotope study in the postprandial state[J]. Clin Sci (Lond) 2015, 128(6):379-385.
    • (2015) Clin Sci (Lond) , vol.128 , Issue.6 , pp. 379-385
    • Chan, D.C.1    Wong, A.T.Y.2    Pang, J.3
  • 21
    • 84861528559 scopus 로고    scopus 로고
    • Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels[J]
    • Chernogubova E, Strawbridge R, Mahdessian H, et al. Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels[J]. Arterioscler Thromb Vasc Biol, 2012, 32(6):1526-1534.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.6 , pp. 1526-1534
    • Chernogubova, E.1    Strawbridge, R.2    Mahdessian, H.3
  • 22
    • 84900342583 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins[J]
    • Kwakernaak AJ, Lambert G, Dullaart RPF. Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins[J]. Clin Biochem, 2014, 47(7-8):679-682.
    • (2014) Clin Biochem , vol.47 , Issue.7-8 , pp. 679-682
    • Kwakernaak, A.J.1    Lambert, G.2    Dullaart, R.P.F.3
  • 23
    • 67650263873 scopus 로고    scopus 로고
    • Genetic and metabolic determinants of plasma PCSK9 levels[J]
    • Lakoski SG, Lagace TA, Cohen JC, et al. Genetic and metabolic determinants of plasma PCSK9 levels[J]. J Clin Endocrinol Metab, 2009, 94(7):2537-2543.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.7 , pp. 2537-2543
    • Lakoski, S.G.1    Lagace, T.A.2    Cohen, J.C.3
  • 24
    • 84877245019 scopus 로고    scopus 로고
    • Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations[J]
    • Mayne J, Ooi TC, Raymond A, et al. Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations[J]. Lipids Health Dis, 2013, 12(70).
    • (2013) Lipids Health Dis , vol.12 , Issue.70
    • Mayne, J.1    Ooi, T.C.2    Raymond, A.3
  • 25
    • 80054696614 scopus 로고    scopus 로고
    • Lack of relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people[J]
    • Sullivan S, Fabbrini E, Horton JD, et al. Lack of relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people[J]. Trans Res, 2012, 158(5):302-306.
    • (2012) Trans Res , vol.158 , Issue.5 , pp. 302-306
    • Sullivan, S.1    Fabbrini, E.2    Horton, J.D.3
  • 26
    • 84872409052 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin-kexin type 9 is elevated in proteinuric subjects: relationship with lipoprotein response to antiproteinuric treatment[J]
    • Kwakernaak AJ, Lambert G, Slagman MCJ, et al. Proprotein convertase subtilisin-kexin type 9 is elevated in proteinuric subjects: relationship with lipoprotein response to antiproteinuric treatment[J]. Atherosclerosis, 2013, 226(2):459-465.
    • (2013) Atherosclerosis , vol.226 , Issue.2 , pp. 459-465
    • Kwakernaak, A.J.1    Lambert, G.2    Slagman, M.C.J.3
  • 27
    • 84893863331 scopus 로고    scopus 로고
    • Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels[J]
    • Abujrad H, Mayne J, Ruzicka M, et al. Chronic kidney disease on hemodialysis is associated with decreased serum PCSK9 levels[J]. Atherosclerosis, 2014, 233(1):123-129.
    • (2014) Atherosclerosis , vol.233 , Issue.1 , pp. 123-129
    • Abujrad, H.1    Mayne, J.2    Ruzicka, M.3
  • 28
    • 33644807009 scopus 로고    scopus 로고
    • Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response[J]
    • Naoumova RP, Tosi I, Patel D, et al. Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response[J]. Arterioscler Thromb Vasc Biol, 2005, 25(12):2654-2660.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , Issue.12 , pp. 2654-2660
    • Naoumova, R.P.1    Tosi, I.2    Patel, D.3
  • 29
    • 84879315149 scopus 로고    scopus 로고
    • Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy[J]
    • Raal F, Panz V, Immelman A, et al. Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy[J]. J Am Heart Assoc, 2013, 2(2):1-7.
    • (2013) J Am Heart Assoc , vol.2 , Issue.2 , pp. 1-7
    • Raal, F.1    Panz, V.2    Immelman, A.3
  • 30
    • 71749110776 scopus 로고    scopus 로고
    • Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9[J]
    • Humphries SE, Neely RDG, Whittall RA, et al. Healthy individuals carrying the PCSK9 p.R46L variant and familial hypercholesterolemia patients carrying PCSK9 p.D374Y exhibit lower plasma concentrations of PCSK9[J]. Clin Chem, 2009, 55(12):2153-2161.
    • (2009) Clin Chem , vol.55 , Issue.12 , pp. 2153-2161
    • Humphries, S.E.1    Neely, R.D.G.2    Whittall, R.A.3
  • 31
    • 33646547336 scopus 로고    scopus 로고
    • Hepatic PCSK9 expression is regulated by nutrtional status via insulin and sterol regulatory-element protein 1c[J]
    • Costet P, Cariou B, Labert G, et al. Hepatic PCSK9 expression is regulated by nutrtional status via insulin and sterol regulatory-element protein 1c[J]. J Biol Chem, 2006, 281(10):6211-6218.
    • (2006) J Biol Chem , vol.281 , Issue.10 , pp. 6211-6218
    • Costet, P.1    Cariou, B.2    Labert, G.3
  • 32
    • 79151473645 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients[J]
    • Kapelle PJWH, Lambert G, Dullaart RPF. Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients[J]. Atherosclerosis, 2011, 214(2):432-435.
    • (2011) Atherosclerosis , vol.214 , Issue.2 , pp. 432-435
    • Kapelle, P.J.W.H.1    Lambert, G.2    Dullaart, R.P.F.3
  • 33
    • 84905752955 scopus 로고    scopus 로고
    • The effect of insulin on circulating PCSK9 in postmenopausal obese women[J]
    • Awan Z, Dubuc G, Faraj M, et al. The effect of insulin on circulating PCSK9 in postmenopausal obese women[J]. Clin Biochem, 2014, 47(12):1033-1039.
    • (2014) Clin Biochem , vol.47 , Issue.12 , pp. 1033-1039
    • Awan, Z.1    Dubuc, G.2    Faraj, M.3
  • 34
    • 79960238532 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus[J]
    • Brouwers MCGJ, Troutt JS, van Greevenbroek MMJ, et al. Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus[J]. Atherosclerosis, 2011, 217(1):263-267.
    • (2011) Atherosclerosis , vol.217 , Issue.1 , pp. 263-267
    • Brouwers, M.C.G.J.1    Troutt, J.S.2    van Greevenbroek, M.M.J.3
  • 35
    • 77649274263 scopus 로고    scopus 로고
    • PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities[J]
    • Mbikay M, Sirois F, Mayne J, et al. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities[J]. FEBS Lett, 2010, 584(4):701-706.
    • (2010) FEBS Lett , vol.584 , Issue.4 , pp. 701-706
    • Mbikay, M.1    Sirois, F.2    Mayne, J.3
  • 36
    • 65549116032 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia[J]
    • Le May C, Kourimate S, Langhi C, et al. Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia[J]. Arterioscler Thromb Vasc Biol, 2009, 29(5):684-690.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.5 , pp. 684-690
    • Le May, C.1    Kourimate, S.2    Langhi, C.3
  • 37
    • 84959138005 scopus 로고    scopus 로고
    • Fibric Acid Derivatives (Fibrates) -Mechanism of Action[J]. In: Katzung BG, Editor
    • 10th edition. New York:McGraw Hill Lange
    • Malloy MJ, Kane JP. Fibric Acid Derivatives (Fibrates) -Mechanism of Action[J]. In: Katzung BG, Editor. Basic and Clinical Pharmacology. 10th edition. New York:McGraw Hill Lange, 2007:569.
    • (2007) Basic and Clinical Pharmacology. , pp. 569
    • Malloy, M.J.1    Kane, J.P.2
  • 38
    • 77955046691 scopus 로고    scopus 로고
    • Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/ kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients[J]
    • Chan DC, Hamilton SJ, Rye KA, et al. Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/ kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients[J]. Diabetes Obes Metab, 2010, 12(9):752-756.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.9 , pp. 752-756
    • Chan, D.C.1    Hamilton, S.J.2    Rye, K.A.3
  • 39
    • 77956230636 scopus 로고    scopus 로고
    • Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients[J]
    • Costet P, Hoffmann MM, Cariou B, et al. Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients[J]. Atherosclerosis, 2010, 212(1):246-251.
    • (2010) Atherosclerosis , vol.212 , Issue.1 , pp. 246-251
    • Costet, P.1    Hoffmann, M.M.2    Cariou, B.3
  • 40
    • 79960239872 scopus 로고    scopus 로고
    • Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study[J]
    • Noguchi T, Kobayashi J, Yagi K, et al. Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study[J]. Atherosclerosis, 2011, 217(1):165-170.
    • (2011) Atherosclerosis , vol.217 , Issue.1 , pp. 165-170
    • Noguchi, T.1    Kobayashi, J.2    Yagi, K.3
  • 41
    • 77949525476 scopus 로고    scopus 로고
    • Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels[J]
    • Troutt JS, Alborn WE, Cao G, et al. Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels[J]. J Lipid Res, 2010, 51(2):345-351.
    • (2010) J Lipid Res , vol.51 , Issue.2 , pp. 345-351
    • Troutt, J.S.1    Alborn, W.E.2    Cao, G.3
  • 42
    • 84927690991 scopus 로고    scopus 로고
    • Circulating levels of proprotein convertase subtilisin kexin type 9 are elevated by fibrate therapy: a systematic review and meta-analysis of clinical trials[J]
    • Sahebkar A. Circulating levels of proprotein convertase subtilisin kexin type 9 are elevated by fibrate therapy: a systematic review and meta-analysis of clinical trials[J]. Cardiol Rev. 2014: 22(6):306-312.
    • (2014) Cardiol Rev , vol.22 , Issue.6 , pp. 306-312
    • Sahebkar, A.1
  • 43
    • 44349177547 scopus 로고    scopus 로고
    • Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9[J]
    • Kourimate S, Le May C, Langhi C, et al. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9[J]. J Biol Chem, 2008, 283(15):9666-9673.
    • (2008) J Biol Chem , vol.283 , Issue.15 , pp. 9666-9673
    • Kourimate, S.1    Le May, C.2    Langhi, C.3
  • 44
    • 79953760698 scopus 로고    scopus 로고
    • Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue[J]
    • Roubtsova A, Munkonda MN, Awan Z, et al. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue[J]. Arterioscler Thromb Vasc Bio, 2011, 31(4):785-791.
    • (2011) Arterioscler Thromb Vasc Bio , vol.31 , Issue.4 , pp. 785-791
    • Roubtsova, A.1    Munkonda, M.N.2    Awan, Z.3
  • 45
    • 84920121130 scopus 로고    scopus 로고
    • Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6[J]
    • Mbikay M, Sirois F, Gyamera-Acheampong C, et al. Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice CSK9PC57BL/6[J]. J Diabetes, 2015, 7(1):74-84.
    • (2015) J Diabetes , vol.7 , Issue.1 , pp. 74-84
    • Mbikay, M.1    Sirois, F.2    Gyamera-Acheampong, C.3
  • 46
    • 18144406186 scopus 로고    scopus 로고
    • Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia[J]
    • Sun XM, Eden ER, Tosi I, et al. Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia[J]. Hum Mol Genet, 2005, 14(9):1161-1169.
    • (2005) Hum Mol Genet , vol.14 , Issue.9 , pp. 1161-1169
    • Sun, X.M.1    Eden, E.R.2    Tosi, I.3
  • 47
    • 85027929193 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor[J]
    • Sun H, Samarghandi A, Zhang N, et al. Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor[J]. Arterioscler Thromb Vasc Biol, 2012, 32(7):1585-1595.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.7 , pp. 1585-1595
    • Sun, H.1    Samarghandi, A.2    Zhang, N.3
  • 48
    • 17244377696 scopus 로고    scopus 로고
    • Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9[J]
    • Rashid S, Curtis DE, Garuti R, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9[J]. Proc Natl Acad Sci USA, 2005, 102(15):5374-5379.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.15 , pp. 5374-5379
    • Rashid, S.1    Curtis, D.E.2    Garuti, R.3
  • 49
    • 3943090528 scopus 로고    scopus 로고
    • Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9[J]
    • Ouguerram K, Chetiveaux M, Zair Y, et al. Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9[J]. Arterioscler Thromb Vasc Biol, 2004, 24(8):1448-1453.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.8 , pp. 1448-1453
    • Ouguerram, K.1    Chetiveaux, M.2    Zair, Y.3
  • 50
    • 33748752232 scopus 로고    scopus 로고
    • Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the lowdensity lipoprotein receptor[J]
    • Lambert G, Jarnoux AL, Pineau T, et al. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the lowdensity lipoprotein receptor[J]. Endocrinology, 2006, 14(10)7:4985-4995.
    • (2006) Endocrinology , vol.14 , Issue.10
    • Lambert, G.1    Jarnoux, A.L.2    Pineau, T.3
  • 51
    • 84879287631 scopus 로고    scopus 로고
    • Serum proprotein convertase subtilisin/kexin type 9 and cell surface lowdensity lipoprotein receptor: evidence for a reciprocal regulation[J]
    • Tavori H, Fan D, Blakemore JL, et al. Serum proprotein convertase subtilisin/kexin type 9 and cell surface lowdensity lipoprotein receptor: evidence for a reciprocal regulation[J]. Circulation, 2013, 127(24):2403-2413.
    • (2013) Circulation , vol.127 , Issue.24 , pp. 2403-2413
    • Tavori, H.1    Fan, D.2    Blakemore, J.L.3
  • 52
    • 45549096592 scopus 로고    scopus 로고
    • Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB[J]
    • Blasiole DA, Oler AT, Attie AD. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB[J]. J Biol Chem, 2008, 283(17):11374-11381.
    • (2008) J Biol Chem , vol.283 , Issue.17 , pp. 11374-11381
    • Blasiole, D.A.1    Oler, A.T.2    Attie, A.D.3
  • 53
    • 84875055214 scopus 로고    scopus 로고
    • PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells[J]
    • Levy E, Ben Djoudi Ouadda A, Spahis S, et al. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells[J]. Atherosclerosis, 2013, 227(2):297-306.
    • (2013) Atherosclerosis , vol.227 , Issue.2 , pp. 297-306
    • Levy, E.1    Ben Djoudi Ouadda, A.2    Spahis, S.3
  • 54
    • 84905101303 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms[J]
    • Rashid S, Tavori H, Brown PE, et al. Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms[J]. Circulation, 2014, 130(5):431-441.
    • (2014) Circulation , vol.130 , Issue.5 , pp. 431-441
    • Rashid, S.1    Tavori, H.2    Brown, P.E.3
  • 55
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2[J]
    • Poirier S, Mayer G, Benjannet S, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2[J]. J Biol Chem, 2008, 283(4):2363-2372.
    • (2008) J Biol Chem , vol.283 , Issue.4 , pp. 2363-2372
    • Poirier, S.1    Mayer, G.2    Benjannet, S.3
  • 56
    • 84877675332 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)[J]
    • Canuel M, Sun X, Asselin MC, et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)[J]. PLoS One, 2013, 8(5):e64145.
    • (2013) PLoS One , vol.8 , Issue.5 , pp. e64145
    • Canuel, M.1    Sun, X.2    Asselin, M.C.3
  • 57
    • 0029115499 scopus 로고
    • Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor[J]
    • Frykman PK, Brown MS, Yamamoto T, et al. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor[J]. Proc Natl Acad Sci USA, 1995, 92(18):8453-8457.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.18 , pp. 8453-8457
    • Frykman, P.K.1    Brown, M.S.2    Yamamoto, T.3
  • 58
    • 84897847957 scopus 로고    scopus 로고
    • Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Targets the CD36 Receptor for Degradation[J]
    • Demers A, Lauzier B, Des Rosiers C, et al. Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Targets the CD36 Receptor for Degradation[J]. Arterioscler Thromb Vasc Biol. 2013, 33(5):A77.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.5 , pp. A77
    • Demers, A.1    Lauzier, B.2    Des Rosiers, C.3
  • 59
    • 67649381418 scopus 로고    scopus 로고
    • Chylomicron remnants are increased in the postprandial state in CD36 deficiency[J]
    • Masuda D, Hirano K, Oku H, et al. Chylomicron remnants are increased in the postprandial state in CD36 deficiency[J]. J Lipid Res, 2009, 50(5):999-1011.
    • (2009) J Lipid Res , vol.50 , Issue.5 , pp. 999-1011
    • Masuda, D.1    Hirano, K.2    Oku, H.3
  • 60
    • 0032409770 scopus 로고    scopus 로고
    • The atherogenic significance of an elevated plasma triglyceride level[J]
    • Ooi TC, Ooi DS. The atherogenic significance of an elevated plasma triglyceride level[J]. Crit Rev Clin Lab Sci, 1998, 35(6):489-516.
    • (1998) Crit Rev Clin Lab Sci , vol.35 , Issue.6 , pp. 489-516
    • Ooi, T.C.1    Ooi, D.S.2
  • 61
    • 84868206496 scopus 로고    scopus 로고
    • Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels[J]
    • Dias CS, Shaywitz AJ, Wasserman SM, et al. Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels[J]. J Am Coll Cardiol, 2012, 60(19):1888-1898.
    • (2012) J Am Coll Cardiol , vol.60 , Issue.19 , pp. 1888-1898
    • Dias, C.S.1    Shaywitz, A.J.2    Wasserman, S.M.3
  • 62
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACETIMI 57): a randomised, placebo-controlled, dose-ranging, phase-2 study[J]
    • Giugliano RP, Desai NR, Kohli P, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACETIMI 57): a randomised, placebo-controlled, dose-ranging, phase-2 study[J]. Lancet, 2007, 380(9858):2007-2017.
    • (2007) Lancet , vol.380 , Issue.9858 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3
  • 63
    • 84899633509 scopus 로고    scopus 로고
    • Effects of Evolocumab (AMG 145), a Monoclonal Antibody to PCSK9, in Hypercholesterolemic, Statin-Treated Japanese Patients at High Cardiovascular Risk[J]
    • Hirayama A, Honarpour N, Yoshida M, et al. Effects of Evolocumab (AMG 145), a Monoclonal Antibody to PCSK9, in Hypercholesterolemic, Statin-Treated Japanese Patients at High Cardiovascular Risk[J]. Circ J, 2014, 78(5):1073-1082.
    • (2014) Circ J , vol.78 , Issue.5 , pp. 1073-1082
    • Hirayama, A.1    Honarpour, N.2    Yoshida, M.3
  • 64
    • 84902142901 scopus 로고    scopus 로고
    • Anti-PCSK9 Monotherapy for Hypercholesterolemia Clinical Trial of Evolocumab[J]
    • Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 Monotherapy for Hypercholesterolemia Clinical Trial of Evolocumab[J]. J Am Coll Cardiol, 2014, 63(23):2531-2540.
    • (2014) J Am Coll Cardiol , vol.63 , Issue.23 , pp. 2531-2540
    • Koren, M.J.1    Lundqvist, P.2    Bolognese, M.3
  • 65
    • 84862219022 scopus 로고    scopus 로고
    • Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy[J]
    • Mckenney JM, Harm PD, Korem MJ, et al. Safety and Efficacy of a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease, SAR236553/REGN727, in Patients With Primary Hypercholesterolemia Receiving Ongoing Stable Atorvastatin Therapy[J]. J Am Coll Cardiol, 2012, 59(25):2344-2353.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.25 , pp. 2344-2353
    • Mckenney, J.M.1    Harm, P.D.2    Korem, M.J.3
  • 66
    • 84900303213 scopus 로고    scopus 로고
    • Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia The LAPLACE-2 Randomized Clinical Trial[J]
    • Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of Evolocumab or Ezetimibe Added to Moderate- or High-Intensity Statin Therapy on LDL-C Lowering in Patients With Hypercholesterolemia The LAPLACE-2 Randomized Clinical Trial[J]. JAMA, 2014, 311(18):1870-1882.
    • (2014) JAMA , vol.311 , Issue.18 , pp. 1870-1882
    • Robinson, J.G.1    Nedergaard, B.S.2    Rogers, W.J.3
  • 67
    • 84906323762 scopus 로고    scopus 로고
    • Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24 week double-blind, randomized Phase 3 trial[J]
    • Roth EM, Taskinen M, Ginsberg HN, et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24 week double-blind, randomized Phase 3 trial[J]. Int J Cardiol, 2014, 176(1):55-61.
    • (2014) Int J Cardiol , vol.176 , Issue.1 , pp. 55-61
    • Roth, E.M.1    Taskinen, M.2    Ginsberg, H.N.3
  • 68
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol[J]
    • Sullivan D, Olsson AG, Scott R, et al. Effect of a Monoclonal Antibody to PCSK9 on Low-Density Lipoprotein Cholesterol[J]. JAMA. 2014: 308(23); 2497-2506.
    • (2014) JAMA , vol.308 , Issue.23 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3
  • 69
    • 84899846576 scopus 로고    scopus 로고
    • A 52-week placebocontrolled trial of evolocumab in hyperlipidemia[J]
    • Blom DJ, Hala T, Bolognese M, et al. A 52-week placebocontrolled trial of evolocumab in hyperlipidemia[J]. N Engl J Med, 2014, 370(19):1809-1819.
    • (2014) N Engl J Med , vol.370 , Issue.19 , pp. 1809-1819
    • Blom, D.J.1    Hala, T.2    Bolognese, M.3
  • 70
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial[J]
    • Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial[J]. Lancet, 2012, 380(9836):29-36.
    • (2012) Lancet , vol.380 , Issue.9836 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3
  • 71
    • 84869220345 scopus 로고    scopus 로고
    • Low-Density Lipoprotein Cholesterol - Lowering Effects of AMG 145, a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients With Heterozygous Familial Hypercholesterolemia[J]
    • Raal F, Scott R, Somaratne R, et al. Low-Density Lipoprotein Cholesterol - Lowering Effects of AMG 145, a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease in Patients With Heterozygous Familial Hypercholesterolemia[J]. Circulation, 2012, 126(20):2408-2417.
    • (2012) Circulation , vol.126 , Issue.20 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3
  • 72
    • 84887164358 scopus 로고    scopus 로고
    • Effect of the Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody, AMG 145, in Homozygous Familial Hypercholesterolemia[J]
    • Stein EA, Honarpour N, Wasserman SM, et al. Effect of the Proprotein Convertase Subtilisin/Kexin 9 Monoclonal Antibody, AMG 145, in Homozygous Familial Hypercholesterolemia[J]. Circulation, 2013, 128(19):2113-2120.
    • (2013) Circulation , vol.128 , Issue.19 , pp. 2113-2120
    • Stein, E.A.1    Honarpour, N.2    Wasserman, S.M.3
  • 73
    • 84921459685 scopus 로고    scopus 로고
    • Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial[J]
    • Raal FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial[J]. Lancet, 2015, 385(9965):341-350.
    • (2015) Lancet , vol.385 , Issue.9965 , pp. 341-350
    • Raal, F.J.1    Honarpour, N.2    Blom, D.J.3
  • 74
    • 84921483643 scopus 로고    scopus 로고
    • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebocontrolled trial[J]
    • Raal FJ, Stein EA, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebocontrolled trial[J]. Lancet, 2015, 385(9965):331-340.
    • (2015) Lancet , vol.385 , Issue.9965 , pp. 331-340
    • Raal, F.J.1    Stein, E.A.2
  • 75
    • 84922670093 scopus 로고    scopus 로고
    • Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies?: pooled analysis of 1359 patients in four phase 2 trials[J]
    • Stein EA, Giugliano RP, Koren MJ, et al. Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies?: pooled analysis of 1359 patients in four phase 2 trials[J]. Eur Heart J, 2014, 35(33):2249-2259.
    • (2014) Eur Heart J , vol.35 , Issue.33 , pp. 2249-2259
    • Stein, E.A.1    Giugliano, R.P.2    Koren, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.