메뉴 건너뛰기




Volumn 22, Issue 6, 2014, Pages 306-312

Circulating levels of proprotein convertase subtilisin kexin type 9 are elevated by fibrate therapy: A systematic review and meta-analysis of clinical trials

Author keywords

Cholesterol; Dyslipidemia; Fibric acid; Peroxisome proliferator activated receptor alpha; Proprotein convertase subtilisin kexin type 9

Indexed keywords

BEZAFIBRATE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KEXIN; PLACEBO; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; UNCLASSIFIED DRUG; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

EID: 84927690991     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0000000000000025     Document Type: Review
Times cited : (20)

References (53)
  • 1
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The scandinavian simvastatin survival study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 2
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators
    • Sacks FM, Pfeffer MA, Moye L.A., et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med. 1996; 335:1001-1009.
    • (1996) N Engl J Med. , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 3
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998; 339:1349-1357.
    • (1998) N Engl J Med. , vol.339 , pp. 1349-1357
  • 4
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002; 360:7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 5
    • 0035804846 scopus 로고    scopus 로고
    • Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial
    • Schwartz GG, Olsson AG, Ezekowitz M.D., et al.; Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA. 2001; 285:1711-1718.
    • (2001) JAMA , vol.285 , pp. 1711-1718
    • Schwartz, G.G.1    Olsson, A.G.2    Ezekowitz, M.D.3
  • 6
    • 71649112327 scopus 로고    scopus 로고
    • Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22) trial
    • Murphy SA, Cannon C P, Wiviott SD, et al. Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial. J Am Coll Cardiol. 2009; 54:2358-2362.
    • (2009) J Am Coll Cardiol. , vol.54 , pp. 2358-2362
    • Murphy, S.A.1    Cannon, C.P.2    Wiviott, S.D.3
  • 7
    • 55949096863 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular mortality and events with statin treatments: A network meta-analysis involving more than 65,000 patients
    • Mills EJ, Rachlis B, Wu P., et al. Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients. J Am Coll Cardiol. 2008; 52:1769-1781.
    • (2008) J Am Coll Cardiol. , vol.52 , pp. 1769-1781
    • Mills, E.J.1    Rachlis, B.2    Wu, P.3
  • 8
    • 84857637931 scopus 로고    scopus 로고
    • Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: The evidence, etiology, and therapeutic challenges
    • Sampson UK, Fazio S, Linton MF. Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges. Curr Atheroscler Rep. 2012; 14:1-10.
    • (2012) Curr Atheroscler Rep. , vol.14 , pp. 1-10
    • Sampson, U.K.1    Fazio, S.2    Linton, M.F.3
  • 9
    • 33746458418 scopus 로고    scopus 로고
    • Contemporary management of dyslipidemia in high-risk patients: Targets still not met
    • Ya n AT, Ya n RT, Tan M, et al. Contemporary management of dyslipidemia in high-risk patients: targets still not met. Am J Med. 2006; 119:676-683.
    • (2006) Am J Med. , vol.119 , pp. 676-683
    • Ya, N.A.T.1    Ya, N.R.T.2    Tan, M.3
  • 10
    • 84861347786 scopus 로고    scopus 로고
    • Novel therapeutic agents for lowering low density lipoprotein cholesterol
    • Joy TR. Novel therapeutic agents for lowering low density lipoprotein cholesterol. Pharmacol Ther. 2012; 135:31-43.
    • (2012) Pharmacol Ther. , vol.135 , pp. 31-43
    • Joy, T.R.1
  • 11
    • 70449578704 scopus 로고    scopus 로고
    • Recent patents on PCSK9: A new target for treating hypercholesterolemia
    • Li H, Li H, Ziegler N., Cui R, Liu J. Recent patents on PCSK9: a new target for treating hypercholesterolemia. Recent Pat DNA Gene Seq. 2009; 3:201-212.
    • (2009) Recent Pat DNA Gene Seq. , vol.3 , pp. 201-212
    • Li, H.1    Li, H.2    Ziegler, N.3    Cui, R.4    Liu, J.5
  • 12
    • 77953535433 scopus 로고    scopus 로고
    • PCSK9 as a therapeutic target in atherosclerosis
    • Marian AJ. PCSK9 as a therapeutic target in atherosclerosis. Curr Atheroscler Rep. 2010; 12:151-154.
    • (2010) Curr Atheroscler Rep. , vol.12 , pp. 151-154
    • Marian, A.J.1
  • 13
    • 13844310887 scopus 로고    scopus 로고
    • Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
    • Maxwell KN, Fisher EA, Breslow JL. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A. 2005; 102:2069-2074.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2069-2074
    • Maxwell, K.N.1    Fisher, E.A.2    Breslow, J.L.3
  • 14
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein conver-tase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
    • Seidah NG, Benjannet S, Wickham L., et al. The secretory proprotein conver-tase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A. 2003; 100:928-933.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 15
    • 13844310887 scopus 로고    scopus 로고
    • Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
    • Maxwell KN, Fisher EA, Breslow JL. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A. 2005; 102:2069-2074.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2069-2074
    • Maxwell, K.N.1    Fisher, E.A.2    Breslow, J.L.3
  • 16
    • 17244377696 scopus 로고    scopus 로고
    • Decreased plasma cholesterol and hypersensitivity to statins in mice lacking pcsk9
    • Rashid S, Curtis DE, Garuti R, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A. 2005; 102:5374-5379.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5374-5379
    • Rashid, S.1    Curtis, D.E.2    Garuti, R.3
  • 17
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabès J P, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003; 34:154-156.
    • (2003) Nat Genet. , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabès, J.P.3
  • 18
    • 33847075832 scopus 로고    scopus 로고
    • A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol
    • Fasano T, Cefalù AB, Di Leo E, et al. A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol. 2007; 27:677-681.
    • (2007) Arterioscler Thromb Vasc Biol. , vol.27 , pp. 677-681
    • Fasano, T.1    Cefalù, A.B.2    Di Leo, E.3
  • 20
    • 84882927131 scopus 로고    scopus 로고
    • New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromes
    • Sahebkar A, Watts GF. New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes. Clin Ther. 2013; 35:1082-1098.
    • (2013) Clin Ther. , vol.35 , pp. 1082-1098
    • Sahebkar, A.1    Watts, G.F.2
  • 21
    • 84892369781 scopus 로고    scopus 로고
    • New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: What can the clinician expect?
    • Sahebkar A, Watts GF. New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect? Cardiovasc Drugs Ther. 2013:27:559-67.
    • (2013) Cardiovasc Drugs Ther. , vol.27 , pp. 559-567
    • Sahebkar, A.1    Watts, G.F.2
  • 22
    • 84898597389 scopus 로고    scopus 로고
    • Antihyperlipidemic therapies targeting PCSK9
    • Weinreich M, Frishman WH. Antihyperlipidemic therapies targeting PCSK9. Cardiol Rev. 2014; 22:140-146.
    • (2014) Cardiol Rev. , vol.22 , pp. 140-146
    • Weinreich, M.1    Frishman, W.H.2
  • 23
    • 79952049508 scopus 로고    scopus 로고
    • Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents
    • Konrad RJ, Troutt JS, Cao G. Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents. Lipids Health Dis. 2011; 10:38.
    • (2011) Lipids Health Dis. , vol.10 , pp. 38
    • Konrad, R.J.1    Troutt, J.S.2    Cao, G.3
  • 24
    • 77956230636 scopus 로고    scopus 로고
    • Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients
    • Costet P, Hoffmann MM, Cariou B, et al. Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients. Atherosclerosis. 2010; 212:246-251.
    • (2010) Atherosclerosis. , vol.212 , pp. 246-251
    • Costet, P.1    Hoffmann, M.M.2    Cariou, B.3
  • 25
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • Welder G, Zineh I, Pacanowski M.A., et al. High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res. 2010; 51:2714-2721.
    • (2010) J Lipid Res. , vol.51 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3
  • 26
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey HE, Davis RA, Alborn W.E., et al. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res. 2008; 49:394-398.
    • (2008) J Lipid Res. , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3
  • 27
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated conver-tase-1 implicated in familial hypercholesterolemia
    • Dubuc G, Chamberland A, Wassef H., et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated conver-tase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2004; 24:1454-1459.
    • (2004) Arterioscler Thromb Vasc Biol. , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3
  • 28
    • 79960239872 scopus 로고    scopus 로고
    • Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: Results from a crossover study
    • Noguchi T, Kobayashi J, Yagi K., et al. Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study. Atherosclerosis. 2011; 217:165-170.
    • (2011) Atherosclerosis. , vol.217 , pp. 165-170
    • Noguchi, T.1    Kobayashi, J.2    Yagi, K.3
  • 29
    • 77949525476 scopus 로고    scopus 로고
    • Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels
    • Troutt JS, Alborn WE, Cao G, Konrad RJ. Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels. J Lipid Res. 2010; 51:345-351.
    • (2010) J Lipid Res. , vol.51 , pp. 345-351
    • Troutt, J.S.1    Alborn, W.E.2    Cao, G.3    Konrad, R.J.4
  • 30
    • 45549096493 scopus 로고    scopus 로고
    • Plasma PCSK9 levels are sig-nificantly modified by statins and fibrates in humans
    • Mayne J, Dewpura T, Raymond A., et al. Plasma PCSK9 levels are sig-nificantly modified by statins and fibrates in humans. Lipids Health Dis. 2008; 7:22.
    • (2008) Lipids Health Dis. , vol.7 , pp. 22
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3
  • 31
    • 77955046691 scopus 로고    scopus 로고
    • Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients
    • Chan DC, Hamilton SJ, Rye K.A., et al. Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients. Diabetes Obes Metab. 2010; 12:752-756.
    • (2010) Diabetes Obes Metab. , vol.12 , pp. 752-756
    • Chan, D.C.1    Hamilton, S.J.2    Rye, K.A.3
  • 32
    • 44849086762 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment
    • Lambert G, Ancellin N, Charlton F., et al. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. Clin Chem. 2008; 54:1038-1045.
    • (2008) Clin Chem. , vol.54 , pp. 1038-1045
    • Lambert, G.1    Ancellin, N.2    Charlton, F.3
  • 35
    • 0034658445 scopus 로고    scopus 로고
    • Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes
    • Hashimoto F, Taira S, Hayashi H. Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. Biochem Pharmacol. 2000; 59:1203-1210.
    • (2000) Biochem Pharmacol. , vol.59 , pp. 1203-1210
    • Hashimoto, F.1    Taira, S.2    Hayashi, H.3
  • 36
    • 0035980764 scopus 로고    scopus 로고
    • Regulation of lipid metabolism and gene expression by fenofibrate in hamsters
    • Guo Q, Wang PR, Milot D P, et al. Regulation of lipid metabolism and gene expression by fenofibrate in hamsters. Biochim Biophys Acta. 2001; 1533:220-232.
    • (2001) Biochim Biophys Acta. , vol.1533 , pp. 220-232
    • Guo, Q.1    Wang, P.R.2    Milot, D.P.3
  • 37
    • 0026631291 scopus 로고
    • Regulation of HMG-coa reductase, apopro-tein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in hep G2, human and rat hepatocytes
    • Qin W, Infante J, Wang S.R., et al. Regulation of HMG-CoA reductase, apopro-tein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. Biochim Biophys Acta. 1992; 1127:57-66.
    • (1992) Biochim Biophys Acta. , vol.1127 , pp. 57-66
    • Qin, W.1    Infante, J.2    Wang, S.R.3
  • 38
    • 33846262603 scopus 로고    scopus 로고
    • Fenofibrate: A review of its use in primary dys-lipidaemia, the metabolic syndrome and type 2 diabetes mellitus
    • Keating GM, Croom KF. Fenofibrate: a review of its use in primary dys-lipidaemia, the metabolic syndrome and type 2 diabetes mellitus. Drugs. 2007; 67:121-153.
    • (2007) Drugs. , vol.67 , pp. 121-153
    • Keating, G.M.1    Croom, K.F.2
  • 39
    • 37249042184 scopus 로고    scopus 로고
    • Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse
    • Valasek MA, Clarke SL, Repa JJ. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res. 2007; 48:2725-2735.
    • (2007) J Lipid Res. , vol.48 , pp. 2725-2735
    • Valasek, M.A.1    Clarke, S.L.2    Repa, J.J.3
  • 40
    • 56049092992 scopus 로고    scopus 로고
    • Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice
    • Martens K, Ver Loren van Themaat E, van Batenburg MF, et al. Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice. Biochim Biophys Acta. 2008; 1781:694-702.
    • (2008) Biochim Biophys Acta. , vol.1781 , pp. 694-702
    • Martens, K.1    Ver Loren Van Themaat, E.2    Van Batenburg, M.F.3
  • 41
    • 0344236142 scopus 로고    scopus 로고
    • Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterolfied mice
    • Maxwell KN, Soccio RE, Duncan E.M., et al. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterolfied mice. J Lipid Res. 2003; 44:2109-2119.
    • (2003) J Lipid Res. , vol.44 , pp. 2109-2119
    • Maxwell, K.N.1    Soccio, R.E.2    Duncan, E.M.3
  • 42
    • 33646547336 scopus 로고    scopus 로고
    • Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
    • Costet P, Cariou B, Lambert G., et al. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem. 2006; 281:6211-6218.
    • (2006) J Biol Chem. , vol.281 , pp. 6211-6218
    • Costet, P.1    Cariou, B.2    Lambert, G.3
  • 43
    • 84860515067 scopus 로고    scopus 로고
    • Fibrates: Old drugs with a new role in type 2 diabetes prevention?
    • Elkeles R. Fibrates: old drugs with a new role in type 2 diabetes prevention? Br J Diabetes Vasc Dis. 2011; 11:4-9.
    • (2011) Br J Diabetes Vasc Dis. , vol.11 , pp. 4-9
    • Elkeles, R.1
  • 44
    • 44349177547 scopus 로고    scopus 로고
    • Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9
    • Kourimate S, Le May C, Langhi C, et al. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. J Biol Chem. 2008; 283:9666-9673.
    • (2008) J Biol Chem. , vol.283 , pp. 9666-9673
    • Kourimate, S.1    Le May, C.2    Langhi, C.3
  • 45
    • 0031952238 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-alpha expression in human liver
    • Palmer CN, Hsu MH, Griffin K.J., et al. Peroxisome proliferator activated receptor-alpha expression in human liver. Mol Pharmacol. 1998; 53: 14-22.
    • (1998) Mol Pharmacol. , vol.53 , pp. 14-22
    • Palmer, C.N.1    Hsu, M.H.2    Griffin, K.J.3
  • 46
    • 79960270412 scopus 로고    scopus 로고
    • Regulation of proprotein convertase subtilisin/kexin type 9: Therapeutical perspectives
    • Chan DC. Regulation of proprotein convertase subtilisin/kexin type 9: therapeutical perspectives. Atherosclerosis. 2011; 217:77-79.
    • (2011) Atherosclerosis. , vol.217 , pp. 77-79
    • Chan, D.C.1
  • 47
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
    • Baass A, Dubuc G, Tremblay M., et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem. 2009; 55:1637-1645.
    • (2009) Clin Chem. , vol.55 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3
  • 48
    • 84881642500 scopus 로고    scopus 로고
    • Fibrate therapy and circulating adiponectin concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials
    • Sahebkar A, Watts GF. Fibrate therapy and circulating adiponectin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. Atherosclerosis. 2013; 230:110-120.
    • (2013) Atherosclerosis. , vol.230 , pp. 110-120
    • Sahebkar, A.1    Watts, G.F.2
  • 49
    • 67650263873 scopus 로고    scopus 로고
    • Genetic and metabolic determinants of plasma PCSK9 levels
    • Lakoski SG, Lagace TA, Cohen J.C., et al. Genetic and metabolic determinants of plasma PCSK9 levels. J Clin Endocrinol Metab. 2009; 94: 2537-2543.
    • (2009) J Clin Endocrinol Metab. , vol.94 , pp. 2537-2543
    • Lakoski, S.G.1    Lagace, T.A.2    Cohen, J.C.3
  • 50
    • 38549113525 scopus 로고    scopus 로고
    • Diabetes alters LDL receptor and PCSK9 expression in rat liver
    • Niesen M, Bedi M, Lopez D. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Arch Biochem Biophys. 2008; 470:111-115.
    • (2008) Arch Biochem Biophys. , vol.470 , pp. 111-115
    • Niesen, M.1    Bedi, M.2    Lopez, D.3
  • 51
    • 80055018021 scopus 로고    scopus 로고
    • Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes
    • Vergès B, Duvillard L, Brindisi M.C., et al. Lack of association between plasma PCSK9 and LDL-apoB100 catabolism in patients with uncontrolled type 2 diabetes. Atherosclerosis. 2011; 219:342-348.
    • (2011) Atherosclerosis. , vol.219 , pp. 342-348
    • Vergès, B.1    Duvillard, L.2    Brindisi, M.C.3
  • 52
    • 79151473645 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients
    • Kappelle PJ, Lambert G, Dullaart R P. Plasma proprotein convertase subtilisin-kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients. Atherosclerosis. 2011; 214:432-435.
    • (2011) Atherosclerosis. , vol.214 , pp. 432-435
    • Kappelle, P.J.1    Lambert, G.2    Dullaart, R.P.3
  • 53
    • 79960238532 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study
    • Brouwers MC, Troutt JS, van Greevenbroek MM, et al. Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study. Atherosclerosis. 2011; 217:263-267.
    • (2011) Atherosclerosis. , vol.217 , pp. 263-267
    • Brouwers, M.C.1    Troutt, J.S.2    Van Greevenbroek, M.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.