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Volumn 51, Issue 1, 2010, Pages 140-149

A new method for measurement of total plasma PCSK9: Clinical applications

Author keywords

Cardiovascular disease; ELISA; Hypercholesterolemia; Hypocholesterolemia; LDL cholesterol; Novel natural mutation; Proprotein convertase subtilisin kexin type 9

Indexed keywords

ATORVASTATIN; CHOLESTEROL; EZETIMIBE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLASMA PROTEIN; PRAVASTATIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 PROTEIN; ROSUVASTATIN; SIMVASTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 73149094934     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900273-JLR200     Document Type: Article
Times cited : (199)

References (49)
  • 1
    • 73149121106 scopus 로고    scopus 로고
    • Goldstein, J. L., H. H. Hobbs, and M. S. Brown. Familial hypercholesterolemia. 2001. In The metabolic and molecular bases of inherited disease. Valle D., C. R. Scriver A. L. Beaudet, W. S. Sly, B. Childs, and B. Volgestein, editors. Chapter 120, 8th edition. McGraw Hill, New York. 2863-2913.
    • Goldstein, J. L., H. H. Hobbs, and M. S. Brown. Familial hypercholesterolemia. 2001. In The metabolic and molecular bases of inherited disease. Valle D., C. R. Scriver A. L. Beaudet, W. S. Sly, B. Childs, and B. Volgestein, editors. Chapter 120, 8th edition. McGraw Hill, New York. 2863-2913.
  • 5
    • 34247899771 scopus 로고    scopus 로고
    • The proprotein convertases are potential targets in the treatment of dyslipidemia
    • Seidah, N. G., and A. Prat. 2007. The proprotein convertases are potential targets in the treatment of dyslipidemia. J. Mol. Med. 85: 685-696.
    • (2007) J. Mol. Med , vol.85 , pp. 685-696
    • Seidah, N.G.1    Prat, A.2
  • 7
    • 51349161358 scopus 로고    scopus 로고
    • Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
    • Zhang, D. W., R. Garuti, W. J. Tang, J. C. Cohen, and H. H. Hobbs. 2008. Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor. Proc. Natl. Acad. Sci. USA. 105: 13045-13050.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13045-13050
    • Zhang, D.W.1    Garuti, R.2    Tang, W.J.3    Cohen, J.C.4    Hobbs, H.H.5
  • 9
    • 9644266673 scopus 로고    scopus 로고
    • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    • Park, S. W., Y. A. Moon, and J. D. Horton. 2004. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J. Biol. Chem. 279: 50630-50638.
    • (2004) J. Biol. Chem , vol.279 , pp. 50630-50638
    • Park, S.W.1    Moon, Y.A.2    Horton, J.D.3
  • 10
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/ PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    • Benjannet, S., D. Rhainds, R. Essalmani, J. Mayne, L. Wickham, W. Jin, M. C. Asselin, J. Hamelin, M. Varret, D. Allard, et al. 2004. NARC-1/ PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J. Biol. Chem. 279: 48865-48875.
    • (2004) J. Biol. Chem , vol.279 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3    Mayne, J.4    Wickham, L.5    Jin, W.6    Asselin, M.C.7    Hamelin, J.8    Varret, M.9    Allard, D.10
  • 11
    • 13844310887 scopus 로고    scopus 로고
    • Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
    • Maxwell, K. N., E. A. Fisher, and J. L. Breslow. 2005. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc. Natl. Acad. Sci. USA. 102: 2069-2074.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2069-2074
    • Maxwell, K.N.1    Fisher, E.A.2    Breslow, J.L.3
  • 13
    • 49649128629 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
    • Zaid, A., A. Roubtsova, R. Essalmani, J. Marcinkiewicz, A. Chamberland, J. Hamelin, M. Tremblay, H. Jacques, W. Jin, J. Davignon, et al. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology. 48: 646-654.
    • (2008) Hepatology , vol.48 , pp. 646-654
    • Zaid, A.1    Roubtsova, A.2    Essalmani, R.3    Marcinkiewicz, J.4    Chamberland, A.5    Hamelin, J.6    Tremblay, M.7    Jacques, H.8    Jin, W.9    Davignon, J.10
  • 15
    • 69449094509 scopus 로고    scopus 로고
    • Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice
    • Luo, Y., L. Warren, D. Xia, H. Jensen, T. Sand, S. Petras, W. Qin, K. S. Miller, and J. Hawkins. 2009. Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. J. Lipid Res. 50: 1581-1588.
    • (2009) J. Lipid Res , vol.50 , pp. 1581-1588
    • Luo, Y.1    Warren, L.2    Xia, D.3    Jensen, H.4    Sand, T.5    Petras, S.6    Qin, W.7    Miller, K.S.8    Hawkins, J.9
  • 17
    • 33750090075 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 is inactivated by furin and/or PC5/ 6A: Functional consequences of natural mutations and post-translational modifications
    • Benjannet, S., D. Rhainds, J. Hamelin, N. Nassoury, and N. G. Seidah. 2006. The proprotein convertase PCSK9 is inactivated by furin and/or PC5/ 6A: Functional consequences of natural mutations and post-translational modifications. J. Biol. Chem. 281: 30561-30572.
    • (2006) J. Biol. Chem , vol.281 , pp. 30561-30572
    • Benjannet, S.1    Rhainds, D.2    Hamelin, J.3    Nassoury, N.4    Seidah, N.G.5
  • 20
    • 34547730366 scopus 로고    scopus 로고
    • After the LDL receptor and apolipoprotein B, autosomal dominant hypercholesterolemia reveals its third protagonist: PCSK9.]
    • Abifadel, M., J. P. Rabes, C. Boileau, and M. Varret. 2007. [After the LDL receptor and apolipoprotein B, autosomal dominant hypercholesterolemia reveals its third protagonist: PCSK9.] Ann. Endocrinol. (Paris). 68: 138-146.
    • (2007) Ann. Endocrinol. (Paris) , vol.68 , pp. 138-146
    • Abifadel, M.1    Rabes, J.P.2    Boileau, C.3    Varret, M.4
  • 23
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen, J. C., E. Boerwinkle, T. H. Mosley, Jr., and H. H. Hobbs. 2006. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354: 1264-1272.
    • (2006) N. Engl. J. Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 24
    • 34447299120 scopus 로고    scopus 로고
    • The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
    • Hooper, A. J., A. D. Marais, D. M. Tanyanyiwa, and J. R. Burnett. 2007. The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis. 193: 445-448.
    • (2007) Atherosclerosis , vol.193 , pp. 445-448
    • Hooper, A.J.1    Marais, A.D.2    Tanyanyiwa, D.M.3    Burnett, J.R.4
  • 25
    • 66349126280 scopus 로고    scopus 로고
    • PCSK9: A convertase that coordinates LDL catabolism
    • Horton, J. D., J. C. Cohen, and H. H. Hobbs. 2009. PCSK9: a convertase that coordinates LDL catabolism. J. Lipid Res. 50: S172-S177.
    • (2009) J. Lipid Res , vol.50
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 26
    • 0344236142 scopus 로고    scopus 로고
    • Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
    • Maxwell, K. N., R. E. Soccio, E. M. Duncan, E. Sehayek, and J. L. Breslow. 2003. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J. Lipid Res. 44: 2109-2119.
    • (2003) J. Lipid Res , vol.44 , pp. 2109-2119
    • Maxwell, K.N.1    Soccio, R.E.2    Duncan, E.M.3    Sehayek, E.4    Breslow, J.L.5
  • 27
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton, J. D., N. A. Shah, J. A. Warrington, N. N. Anderson, S. W. Park, M. S. Brown, and J. L. Goldstein. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA. 100: 12027-12032.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warrington, J.A.3    Anderson, N.N.4    Park, S.W.5    Brown, M.S.6    Goldstein, J.L.7
  • 28
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis- regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc, G., A. Chamberland, H. Wassef, J. Davignon, N. G. Seidah, L. Bernier, and A. Prat. 2004. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis- regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 24: 1454-1459.
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3    Davignon, J.4    Seidah, N.G.5    Bernier, L.6    Prat, A.7
  • 30
    • 44849086762 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment
    • Lambert, G., N. Ancellin, F. Charlton, D. Comas, J. Pilot, A. Keech, S. Patel, D. R. Sullivan, J. S. Cohn, K. A. Rye, et al. 2008. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. Clin. Chem. 54: 1038-1045.
    • (2008) Clin. Chem , vol.54 , pp. 1038-1045
    • Lambert, G.1    Ancellin, N.2    Charlton, F.3    Comas, D.4    Pilot, J.5    Keech, A.6    Patel, S.7    Sullivan, D.R.8    Cohn, J.S.9    Rye, K.A.10
  • 31
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey, H. E., R. A. Davis, W. E. Alborn, J. S. Troutt, G. Cao, and R. J. Konrad. 2008. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J. Lipid Res. 49: 394-398.
    • (2008) J. Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 32
    • 0034515791 scopus 로고    scopus 로고
    • Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: A study in familial combined hyperlipidemia
    • Demacker, P. N., M. J. Veerkamp, S. J. Bredie, S. M. Marcovina, J. de Graaf, and A. F. Stalenhoef. 2000. Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: a study in familial combined hyperlipidemia. Atherosclerosis. 153: 483-490.
    • (2000) Atherosclerosis , vol.153 , pp. 483-490
    • Demacker, P.N.1    Veerkamp, M.J.2    Bredie, S.J.3    Marcovina, S.M.4    de Graaf, J.5    Stalenhoef, A.F.6
  • 33
    • 57649129016 scopus 로고    scopus 로고
    • Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
    • Mayer, G., S. Poirier, and N. G. Seidah. 2008. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J. Biol. Chem. 283: 31791-31801.
    • (2008) J. Biol. Chem , vol.283 , pp. 31791-31801
    • Mayer, G.1    Poirier, S.2    Seidah, N.G.3
  • 34
    • 33646382116 scopus 로고    scopus 로고
    • The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population
    • Yue, P., M. Averna, X. Lin, and G. Schonfeld. 2006. The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. Hum. Mutat. 27: 460-466.
    • (2006) Hum. Mutat , vol.27 , pp. 460-466
    • Yue, P.1    Averna, M.2    Lin, X.3    Schonfeld, G.4
  • 36
    • 34248366942 scopus 로고    scopus 로고
    • Unravelling the functional significance of PCSK9
    • Lambert, G. 2007. Unravelling the functional significance of PCSK9. Curr. Opin. Lipidol. 18: 304-309.
    • (2007) Curr. Opin. Lipidol , vol.18 , pp. 304-309
    • Lambert, G.1
  • 41
    • 0030775556 scopus 로고    scopus 로고
    • Risk factors for cardiovascular disease during the period 1985-1995 in Goteborg, Sweden. The GOT-MONICA Project
    • Wilhelmsen, L., S. Johansson, A. Rosengren, I. Wallin, A. Dotevall, and G. Lappas. 1997. Risk factors for cardiovascular disease during the period 1985-1995 in Goteborg, Sweden. The GOT-MONICA Project. J. Intern. Med. 242: 199-211.
    • (1997) J. Intern. Med , vol.242 , pp. 199-211
    • Wilhelmsen, L.1    Johansson, S.2    Rosengren, A.3    Wallin, I.4    Dotevall, A.5    Lappas, G.6
  • 45
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge, K. E., L. Ose, and T. P. Leren. 2006. Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Arterioscler. Thromb. Vasc. Biol. 26: 1094-1100.
    • (2006) Arterioscler. Thromb. Vasc. Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 46
    • 40949129205 scopus 로고    scopus 로고
    • Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: A randomized trial in healthy men
    • Gouni-Berthold, I., H. K. Berthold, H. Gylling, M. Hallikainen, E. Giannakidou, S. Stier, Y. Ko, D. Patel, A. K. Soutar, U. Seedorf, et al. 2008. Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men. Atherosclerosis. 198: 198-207.
    • (2008) Atherosclerosis , vol.198 , pp. 198-207
    • Gouni-Berthold, I.1    Berthold, H.K.2    Gylling, H.3    Hallikainen, M.4    Giannakidou, E.5    Stier, S.6    Ko, Y.7    Patel, D.8    Soutar, A.K.9    Seedorf, U.10
  • 49
    • 67649834056 scopus 로고    scopus 로고
    • From the cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    • Chan, J. C., D. E. Piper, Q. Cao, D. Liu, C. King, W. Wang, J. Tang, Q. Liu, J. Higbee, Z. Xia, et al. 2009. From the cover: a proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc. Natl. Acad. Sci. USA. 106: 9820-9825.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9820-9825
    • Chan, J.C.1    Piper, D.E.2    Cao, Q.3    Liu, D.4    King, C.5    Wang, W.6    Tang, J.7    Liu, Q.8    Higbee, J.9    Xia, Z.10


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