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Volumn 12, Issue 9, 2010, Pages 752-756

Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients

Author keywords

Fenofibrate; PCSK9; Type 2 diabetes; VLDL metabolism

Indexed keywords

ANTIDIABETIC AGENT; APOLIPOPROTEIN B100; APOLIPOPROTEIN C3; ATORVASTATIN; CHOLESTEROL; FENOFIBRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KEXIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PLACEBO; PRAVASTATIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; ROSUVASTATIN; SIMVASTATIN; SUBTILISIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 77955046691     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2010.01229.x     Document Type: Article
Times cited : (35)

References (29)
  • 2
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003, 34:154-156.
    • (2003) Nat Genet , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 3
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006, 354:1264-1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 4
    • 48349092091 scopus 로고    scopus 로고
    • Plasma PCSK9 preferentially reduces liver LDL receptors in mice
    • Grefhorst A, McNutt MC, Lagace TA, Horton JD. Plasma PCSK9 preferentially reduces liver LDL receptors in mice. J Lipid Res 2008, 49:1303-1311.
    • (2008) J Lipid Res , vol.49 , pp. 1303-1311
    • Grefhorst, A.1    McNutt, M.C.2    Lagace, T.A.3    Horton, J.D.4
  • 5
    • 66349126280 scopus 로고    scopus 로고
    • PCSK9: a convertase that coordinates LDL catabolism
    • Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res 2009, 50:S172-S177.
    • (2009) J Lipid Res , vol.50
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 6
    • 65549116032 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia
    • Le May C, Kourimate S, Langhi C. Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia. Arterioscler Thromb Vasc Biol 2009, 29:684-690.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 684-690
    • Le May, C.1    Kourimate, S.2    Langhi, C.3
  • 7
    • 33748752232 scopus 로고    scopus 로고
    • Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
    • Lambert G, Jarnoux AL, Pineau T. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology 2006, 147:4985-4995.
    • (2006) Endocrinology , vol.147 , pp. 4985-4995
    • Lambert, G.1    Jarnoux, A.L.2    Pineau, T.3
  • 8
    • 0036894367 scopus 로고    scopus 로고
    • Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients
    • Forcheron F, Cachefo A, Thevenon S, Pinteur C, Beylot M. Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients. Diabetes 2002, 51:3486-3491.
    • (2002) Diabetes , vol.51 , pp. 3486-3491
    • Forcheron, F.1    Cachefo, A.2    Thevenon, S.3    Pinteur, C.4    Beylot, M.5
  • 9
    • 0016162201 scopus 로고
    • The mechanism of action of clofibrate and tetranicotinoylfructose (Bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia
    • Kissebah AH, Adams PW, Harrigan P, Wynn V. The mechanism of action of clofibrate and tetranicotinoylfructose (Bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia. Eur J Clin Invest 1974, 4:163-174.
    • (1974) Eur J Clin Invest , vol.4 , pp. 163-174
    • Kissebah, A.H.1    Adams, P.W.2    Harrigan, P.3    Wynn, V.4
  • 11
    • 0029610832 scopus 로고
    • Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action
    • Haubenwallner S, Essenburg AD, Barnett BC. Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action. J Lipid Res 1995, 36:2541-2551.
    • (1995) J Lipid Res , vol.36 , pp. 2541-2551
    • Haubenwallner, S.1    Essenburg, A.D.2    Barnett, B.C.3
  • 12
    • 53449092689 scopus 로고    scopus 로고
    • Atorvastatin and fenofibrate have comparable effects on VLDL-apolipoprotein C-III kinetics in men with the metabolic syndrome
    • Chan DC, Watts GF, Ooi EMM, Ji J, Johnson AG, Barrett PHR. Atorvastatin and fenofibrate have comparable effects on VLDL-apolipoprotein C-III kinetics in men with the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008, 28:1831-1837.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1831-1837
    • Chan, D.C.1    Watts, G.F.2    Ooi, E.M.M.3    Ji, J.4    Johnson, A.G.5    Barrett, P.H.R.6
  • 13
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey HE, Davis RA, Alborn WE, Troutt JS, Cao G, Konrad RJ. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008, 49:394-398.
    • (2008) J Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 14
    • 44349177547 scopus 로고    scopus 로고
    • Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9
    • Kourimate S, Le May C, Langhi C. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9. J Biol Chem 2008, 283:9666-9673.
    • (2008) J Biol Chem , vol.283 , pp. 9666-9673
    • Kourimate, S.1    Le May, C.2    Langhi, C.3
  • 15
    • 44849086762 scopus 로고    scopus 로고
    • Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment
    • Lambert G, Ancellin N, Charlton F. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. Clin Chem 2008, 54:1038-1045.
    • (2008) Clin Chem , vol.54 , pp. 1038-1045
    • Lambert, G.1    Ancellin, N.2    Charlton, F.3
  • 16
    • 0037898380 scopus 로고    scopus 로고
    • Diabetic dyslipidaemia: from basic research to clinical practice
    • Taskinen MR. Diabetic dyslipidaemia: from basic research to clinical practice. Diabetologia 2003, 46:733-749.
    • (2003) Diabetologia , vol.46 , pp. 733-749
    • Taskinen, M.R.1
  • 17
    • 0026644250 scopus 로고
    • Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement
    • Otvos JD, Jeyarajah EJ, Bennett DW, Krauss RM. Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement. Clin Chem 1992, 38:1632-1638.
    • (1992) Clin Chem , vol.38 , pp. 1632-1638
    • Otvos, J.D.1    Jeyarajah, E.J.2    Bennett, D.W.3    Krauss, R.M.4
  • 18
    • 70449732531 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL-apolipoprotein B-100 catabolism?
    • Chan DC, Lambert G, Barrett PHR, Rye KA, Ooi EMM, Watts GF. Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL-apolipoprotein B-100 catabolism? Clin Chem 2009, 55:2049-2052.
    • (2009) Clin Chem , vol.55 , pp. 2049-2052
    • Chan, D.C.1    Lambert, G.2    Barrett, P.H.R.3    Rye, K.A.4    Ooi, E.M.M.5    Watts, G.F.6
  • 19
    • 45549096493 scopus 로고    scopus 로고
    • Plasma PCSK9 levels are significantly modified by statins and fibrates in humans
    • Mayne J, Dewpura T, Raymond A. Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. Lipids Health Dis 2008, 7:22.
    • (2008) Lipids Health Dis , vol.7 , pp. 22
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3
  • 20
    • 77949525476 scopus 로고    scopus 로고
    • Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels
    • Troutt JS, Alborn WE, Cao G, Konrad RJ. Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels. J Lipid Res 2010, 51:345-351.
    • (2010) J Lipid Res , vol.51 , pp. 345-351
    • Troutt, J.S.1    Alborn, W.E.2    Cao, G.3    Konrad, R.J.4
  • 22
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and apoER2
    • Poirier S, Mayer G, Benjannet S. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and apoER2. J Biol Chem 2008, 283:2363-2372.
    • (2008) J Biol Chem , vol.283 , pp. 2363-2372
    • Poirier, S.1    Mayer, G.2    Benjannet, S.3
  • 24
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky M, Grefhorst A, Anderson NN. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci 2008, 105:11915-11920.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1    Grefhorst, A.2    Anderson, N.N.3
  • 25
    • 67649834056 scopus 로고    scopus 로고
    • A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    • Chan JCY, Piper DE, Cao Q. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci 2009, 106:9820-9825.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 9820-9825
    • Chan, J.C.Y.1    Piper, D.E.2    Cao, Q.3
  • 28
    • 0037840242 scopus 로고    scopus 로고
    • Heart Protection Study Collaborative Group. MRC/BHF heart protection study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial
    • Collins R, Armitage J, Parish S, Sleigh P, Peto R. Heart Protection Study Collaborative Group. MRC/BHF heart protection study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003, 361:2005-2016.
    • (2003) Lancet , vol.361 , pp. 2005-2016
    • Collins, R.1    Armitage, J.2    Parish, S.3    Sleigh, P.4    Peto, R.5
  • 29
    • 77951704587 scopus 로고    scopus 로고
    • The ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus
    • (in press).
    • The ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010, (in press).
    • (2010) N Engl J Med


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