Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: A multipollutant assessment in Greenlandic, Polish and Ukrainian men

Occupational and Environmental Medicine

Volumn 72, Issue 6, 2015, Pages 385-393

  Lenters, Virissa ^a   Portengen, Lützen ^a   Smit, Lidwien A M ^a   Jönsson, Bo A G ^b   Giwercman, Aleksander ^c   Rylander, Lars ^b   Lindh, Christian H ^b   Spanò, Marcello ^d   Pedersen, Henning S ^e   Ludwicki, Jan K ^f   Chumak, Lyubov ^g   Piersma, Aldert H ^h   Toft, Gunnar ⁱ   Bonde, Jens Peter ^j   Heederik, Dick ^a   Vermeulen, Roel ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d ENEA C R CASACCIA   (Italy)

^e Centre for Arctic Environmental Medicine   (Greenland)

^f NATIONAL MEDICINES INSTITUTE   (Poland)

^g KHARKIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^h NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

ⁱ AARHUS UNIVERSITY HOSPITAL   (Denmark)

^j UNIVERSITY OF COPENHAGEN   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACID; ALPHA GLUCOSIDASE; CADMIUM; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; MERCURY; METAL; ORGANOCHLORINE DERIVATIVE; PERFLUOROALKYL ACID; PHTHALIC ACID; POLYCHLORINATED BIPHENYL DERIVATIVE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; UNCLASSIFIED DRUG; 2,2',4,4',5,5' HEXACHLOROBIPHENYL; PERFLUOROALKANOIC ACID; BIOLOGICAL MARKER; CHLORINATED HYDROCARBON; PHTHALIC ACID DERIVATIVE; POLLUTANT;

ACCESSORY SEX GLAND FUNCTION; ADULT; ARTICLE; BODY MASS; CROSS-SECTIONAL STUDY; DESCRIPTIVE RESEARCH; DNA FRAGMENTATION ASSAY; DNA FRAGMENTATION INDEX; ENVIRONMENTAL EXPOSURE; EPIDIDYMAL SEX GLAND FUNCTION; FOLLITROPIN BLOOD LEVEL; FUNCTIONAL ASSESSMENT; HORMONE BLOOD LEVEL; HUMAN; LIQUID CHROMATOGRAPHY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE GENITAL SYSTEM FUNCTION; MASS FRAGMENTOGRAPHY; OUTCOME ASSESSMENT; POLAND; PRENATAL CARE; PRIORITY JOURNAL; REPRODUCTION; SENSITIVITY ANALYSIS; SEX RATIO; SPERM CHROMATIN INTEGRITY; SPERM QUALITY; SPERMATOZOON MOTILITY; TANDEM MASS SPECTROMETRY; UKRAINE; Y X CHROMOSOME RATIO; CORRELATIONAL STUDY; GREENLAND; ADVERSE EFFECTS; BLOOD; DRUG EFFECTS; POLLUTANT; REGRESSION ANALYSIS; SEMEN ANALYSIS; TOXICITY; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; GONADAL HORMONES; GREENLAND; HUMANS; HYDROCARBONS, CHLORINATED; MALE; METALS; PHTHALIC ACIDS; POLAND; REGRESSION ANALYSIS; REPRODUCTION; SEMEN ANALYSIS; SPERM MOTILITY; UKRAINE; YOUNG ADULT;

EID: 84959048519     PISSN: 13510711     EISSN: 14707926     Source Type: Journal    
DOI: 10.1136/oemed-2014-102264     Document Type: Article

References (50)

1. Jørgensen N, Asklund C, Carlsen E, et al. Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. Int J Androl 2006;29:54-61.
2. Travison TG, Araujo AB, O'Donnell AB, et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab 2007;92:196-202.
3. Jørgensen N, Joensen UN, Jensen TK, et al. Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men. BMJ Open 2012;2.
4. Carlsen E, Giwercman A, Keiding N, et al. Evidence for decreasing quality of semen during past 50 years. BMJ 1992;305:609-13.
5. Bonde JP, Toft G, Rylander L, et al. Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines. Environ Health Perspect 2008;116:269-77.
6. Toft G, Axmon A, Giwercman A, et al. Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study. Environ Health 2005;4:26.
7. Groshart C, Okkerman PC. Towards the establishment of a priority list of substances for further evaluation of their role in endocrine disruption-preparation of a candidate list of substances as a basis for priority setting. European Commission DG ENV, 2000. http://ec.europa.eu/environment/archives/docum/pdf/bkh-main.pdf (accessed Apr 2014).
8. CDC (Centers for Disease Control and Prevention). Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta, GA. 2009. http://www.cdc.gov/exposurereport/pdf/fourthreport.pdf (accessed Apr 2014).
9. Lindh CH, Rylander L, Toft G, et al. Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations. Chemosphere 2012;88:1269-75.
10. Chun H, Keleş S. Sparse partial least squares regression for simultaneous dimension reduction and variable selection. J R Stat Soc Series B Stat Methodol 2010;72:3-25.
11. Jönsson BAG, Rylander L, Lindh C, et al. Inter-population variations in concentrations, determinants of and correlations between 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations. Environ Health 2005;4:27.
12. Otero R, Santiago-Silva M, Grimalt JO. Hexachlorocyclohexanes in human blood serum. J Chromatogr A 1997;778:87-94.
13. Elzanaty S, Rignell-Hydbom A, Jönsson BAG, et al. Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations. Reprod Toxicol 2006;22:765-73.
14. Stronati A, Manicardi GC, Cecati M, et al. Relationships between sperm DNA fragmentation, sperm apoptotic markers and serum levels of CB-153 and p,p′-DDE in European and Inuit populations. Reproduction 2006;132:949-58.
15. Spanò M, Toft G, Hagmar L, et al. Exposure to PCB and p,p′-DDE in European and Inuit populations: impact on human sperm chromatin integrity. Hum Reprod 2005;20:3488-99.
16. Toft G, Rignell-Hydbom A, Tyrkiel E, et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 2006;17:450-8.
17. Giwercman AH, Rignell-Hydbom A, Toft G, et al. Reproductive hormone levels in men exposed to persistent organohalogen pollutants: a study of inuit and three European cohorts. Environ Health Perspect 2006;114:1348-53.
18. Wold S, Sjöström M, Eriksson L. PLS-regression: a basic tool of chemometrics. Chemom Intell Lab 2001;58:109-30.
19. nd ed. New York, NY: Springer, 2009.
20. Xu Q, Liang Y, Du Y. Monte Carlo cross-validation for selecting a model and estimating the prediction error in multivariate calibration. J Chemom 2004;18:112-20.
21. Lubin JH, Colt JS, Camann D, et al. Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect 2004;112:1691-6.
22. Chadeau-Hyam M, Campanella G, Jombart T, et al. Deciphering the complex: methodological overview of statistical models to derive OMICS-based biomarkers. Environ Mol Mutagen 2013;54:542-57.
23. Van den Berg RA, Hoefsloot HCJ, Westerhuis JA, et al. Centering, scaling, and transformations: improving the biological information content of metabolomics data. BMC Genomics 2006;7:142.
24. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995;57:289-300.
25. Chung D, Chun H, Keles S. spls: Sparse Partial Least Squares (SPLS) Regression and Classification. R Packag version 22-1. 2013. http://cran.r-project.org/package=spls (accessed Jan 2014).
26. Albert O, Jégou B. A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood. Hum Reprod Update 2014;20:231-49.
27. Desdoits-Lethimonier C, Albert O, Le Bizec B, et al. Human testis steroidogenesis is inhibited by phthalates. Hum Reprod 2012;27:1451-9.
28. Pan G, Hanaoka T, Yoshimura M, et al. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ Health Perspect 2006;114:1643-8.
29. Mendiola J, Meeker JD, Jørgensen N, et al. Urinary concentrations of di (2-ethylhexyl) phthalate metabolites and serum reproductive hormones: pooled analysis of fertile and infertile men. J Androl 2012;33:488-98.
30. Jönsson BAG, Richthoff J, Rylander L, et al. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 2005;16:487-93.
31. Joensen UN, Frederiksen H, Jensen MB, et al. Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. Environ Health Perspect 2012;120:1397-403.
32. Meeker JD, Rossano MG, Protas B, et al. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum. Fertil Steril 2010;93:130-40.
33. Menke A, Guallar E, Shiels MS, et al. The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men. BMC Public Health 2008;8:72.
34. Zeng X, Jin T, Zhou Y, et al. Changes of serum sex hormone levels and MT mRNA expression in rats orally exposed to cadmium. Toxicology 2003;186:109-18.
35. Zhou D, Wang H, Zhang J. Di-n-butyl phthalate (DBP) exposure induces oxidative stress in epididymis of adult rats. Toxicol Ind Health 2011;27:65-71.
36. Evenson DP, Larson KL, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002;23:25-43.
37. Kasahara E, Sato EF, Miyoshi M, et al. Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate. Biochem J 2002;365:849-56.
38. Hauser R, Meeker JD, Singh NP, et al. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum Reprod 2007;22:688-95.
39. Specht IO, Toft G, Hougaard KS, et al. Associations between serum phthalates and biomarkers of reproductive function in 589 adult men. Environ Int 2014;66:146-56.
40. Mocevic E, Specht IO, Marott JL, et al. Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: a cross-sectional study. Asian J Androl 2013;15:97-104.
41. Toft G, Jönsson BAG, Lindh CH, et al. Exposure to perfluorinated compounds and human semen quality in arctic and European populations. Hum Reprod 2012;27:2532-40.
42. Richthoff J, Rylander L, Jönsson BAG, et al. Serum levels of 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environ Health Perspect 2003;111:409-13.
43. Hauser R, Chen Z, Pothier L, et al. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p′-DDE. Environ Health Perspect 2003;111:1505-11.
44. Jørgensen N, Liu F, Andersson A-M, et al. Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men. Fertil Steril 2010;94:2128-34.
45. Safarinejad MR. Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia 2011;43:38-47.
46. Ferguson KK, Hauser R, Altshul L, et al. Serum concentrations of p, p′-DDE, HCB, PCBs and reproductive hormones among men of reproductive age. Reprod Toxicol 2012;34:429-35.
47. Wild CP. Complementing the genome with an"exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 2005;14:1847-50.
48. Patel CJ, Bhattacharya J, Butte AJ. An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS ONE 2010;5:e10746.
49. Holmes E, Loo RL, Stamler J, et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008;453:396-400.
50. Xing G, Lin C-Y, Xing C. A comparison of approaches to control for confounding factors by regression models. Hum Hered 2011;72:194-205.