Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age

Reproductive Toxicology

Volumn 34, Issue 3, 2012, Pages 429-435

  Ferguson, Kelly K ^a   Hauser, Russ ^b,c   Altshul, Larisa ^b,d   Meeker, John D ^a  

^a UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Environmental Health & Engineering Inc   (United States)

Author keywords

Endocrine disruption; Environment; Fertility; Human; Male reproduction; Persistent organic pollutants (POPs); Xenobiotics

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; DIOXIN; ESTRADIOL; FOLLITROPIN; HEXACHLOROBENZENE; INHIBIN B; LIPID; LUTEINIZING HORMONE; POLYCHLORINATED BIPHENYL; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGE; ARTICLE; BLOOD LEVEL; BODY MASS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ESTRADIOL BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; LIPID BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALE GENITAL SYSTEM; REGRESSION ANALYSIS; REPRODUCTIVE HEALTH; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; ADULT; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HEXACHLOROBENZENE; HORMONES; HUMANS; MALE; MIDDLE AGED; POLYCHLORINATED BIPHENYLS; YOUNG ADULT;

EID: 84865544210     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.04.006     Document Type: Article

References (44)

1. ATSDR Toxicological profile for polychlorinated biphenyls (PCBs) 2000, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
2. ATSDR Toxicological profile for DDT, DDE, and DDD 2002, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
3. ATSDR Toxicological profile for hexachlorobenzene 2002, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
4. Patterson D.G., Wong L.Y., Turner W.E., Caudill S.P., Dipietro E.S., McClure P.C., et al. Levels in the U.S. population of those persistent organic pollutants (2003-2003) included in the Stockholm Convention or in other long range transboundary air pollution agreements. Environmental Science and Technology 2009, 43(4):1211-1218.
5. Salay E., Garabrant D. Polychlorinated biphenyls and thyroid hormones in adults: a systematic review appraisal of epidemiological studies. Chemosphere 2009, 74(11):1413-1419.
6. Ahamad S.U., Tariq S., Jalali S., Ahmad M.M. Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male rhesus monkeys (Macaca mulatta). Environmental Research 2003, 93(2):272-278.
7. Andric S.A., Kostic T.S., Stojilkovic S.S., Kovacevic R.Z. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture aroclor 1248. Biology of Reproduction 2000, 62(6):1882-1888.
8. Kovacević R., Vojinović-Miloradov M., Teodorović I., Andrić S. Effects of PCBs on androgen production by suspension of adult rat Leydig cells in vitro. Journal of Steroid Biochemistry and Molecular Biology 1995, 52(6):595-597.
9. Murugesan P., Muthusamy T., Balasubramanian K., Arunakaran J. Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reproductive Toxicology 2008, 25(4):447-454.
10. Kraugerud M., Zimmer K.E., Dahl E., Berg V., Olsaker I., Farstad W., et al. Three structurally different polychlorinated biphenyl congeners (Pcb 118, 153, and 126) affect hormone production and gene expression in the human H295R in vitro model. Journal of Toxicology and Environmental Health Part A 2010, 73(16):1122-1132.
11. Kelce W.R., Stone C.R., Laws S.C., Gray L.E., Kemppainen J.A., Wilson E.M. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature 1995, 375(6532):581-585.
12. Leavens T.L., Sparrow B.R., Devito M.J. Lack of antiandrogenic effects in adult male rats following acute exposure to 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE). Toxicology 2002, 174(2):69-78.
13. Ralph J.L., Orgebin-Crist M.C., Lareyre J.J., Nelson C.C. Disruption of androgen regulation in the prostate by the environmental contaminant hexachlorobenzene. Environmental Health Perspectives 2003, 111(4):461-466.
14. Meeker J.D., Hauser R. Exposure to polychlorinated biphenyls (PCBs) and male reproduction. Systems Biology In Reproductive Medicine 2010, 56(2):122-131.
15. Persky V., Turyk M., Anderson H.A., Hanrahan L.P., Falk C., Steenport D.N., et al. The effects of PCB exposure and fish consumption on endogenous hormones. Environmental Health Perspectives 2001, 109(12):1275-1283.
16. Richtoff J., Rylander L., Jönsson B.A., Akesson H., Hagmar L., Nilsson-Ehle P., et al. Serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environmental Health Perspectives 2003, 111(4):409-413.
17. Turyk M.E., Anderson H.A., Freels S., Chatterton R., Needham L.L., Patterson D.G., et al. Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environmental Research 2006, 102(3):299-307.
18. Goncharov A., Rej R., Negoita S., Schymura M., Santiago-Rivera A., Morse G., et al. Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. Environmental Health Perspectives 2009, 117(9):1454-1460.
19. Asawasinsopon R., Prapamontol T., Prakobvitayakit O., Vaneesorn Y., Mangklabruks A., Hock B. Plasma levels of DDT and their association with reproductive hormones in adult men from northern Thailand. Science of the Total Environment 2006, 355(1-3):98-105.
20. CDC. Fourth National Report on Human Exposure to Environmental Chemicals, Centers for Disease Control and Prevention, Washington, DC; 2009.
21. Meeker J.D., Altshul L., Hauser R. Serum PCBs, p,p'-DDE and HCB predict thyroid hormone levels in men. Environmental Research 2007, 104(2):296-304.
22. Hauser R., Chen Z., Pothier L., Ryan L., Altshul L. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE. Environmental Health Perspectives 2003, 111(12):1505-1511.
23. Phillips D.L., Pirkle J.L., Burse V.W., Bernert J.T., Henderson L.O., Needham L.L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Archives of Environment Contamination and Toxicology 1989, 18(4):495-500.
24. Korrick S.A., Altshul L.M., Tolbert P.E., Burse V.W., Needham L.L., Monson R.R. Measurement of PCBs, DDE, and hexachlorobenzene in cord blood from infants born in towns adjacent to a PCB-contaminated waste site. Journal of Exposure Analysis and Environmental Epidemiology 2000, 10(6 (Pt 2)):743-754.
25. Wolff M.S., Camann D., Gammon M., Stellman S.D. Proposed PCB congener groupings for epidemiologic studies. Environmental Health Perspectives 1997, 105(1):13-14.
26. Meeker J.D., Calafat A.M., Hauser R. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. Journal of Andrology 1999, 30(3):287-297.
27. Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 1999, 84(10):3666-3667.
28. DeVoto E., Fiore B.J., Millikan R., Anderson H.A., Sheldon L., Sonzogni W.C., Longnecker M.P. Correlations among human blood levels of specific PCB congeners and implications for epidemiologic studies. American Journal of Industrial Medicine 1997, 32(6):606-613.
29. Schisterman E.F., Whitcomb B.W., Louis G.M., Louis T.A. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environmental Health Perspectives 2005, 113(7):853-857.
30. Dhooge W., den Hond E., Koppen G., Bruckers L., Nelen V., van de Mieroop E., et al. Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose-response relationships. Journal of Exposure Analysis and Environmental Epidemiology 2011, 21(1):106-113.
31. Hagmar L., Björk J., Sjödin A., Bergman A., Erfurth E.M. Plasma levels of persistent organohalogens and hormone levels in adult male humans. Archives of Environment Health 2001, 56(2):138-143.
32. Dhooge W., van Larebeke N., Koppen G., Nelen V., Schoeters G., Vlietinck R., et al. Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population. Environmental Health Perspectives 2006, 114(11):1670-1676.
33. Johnson E., Shorter C., Bestervelt L., Patterson D., Needham L., Piper W., et al. Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD. Toxicology and Industrial Health 2001, 17(4):105-112.
34. Blanco-Muñoz J., Lacasaña M., Aguilar-Garduño C., Rodriguez-Barranco M., Bassol S., Cebrián M.E., et al. Effect of exposure to p,p'-DDE on male hormone profile in Mexican flower growers. Occupational and Environmental Medicine 2011, [Epub ahead of print].
35. Rylander L., Wallin E., Jönssson B.A., Stridsberg M., Erfurth E.M., Hagmar L. Associations between CB-153 and p,p'-DDE and hormone levels in serum in middle-aged and elderly men. Chemosphere 2006, 65(3):375-381.
36. Giwercman A.H., Rignell-Hydborn A., Toft G., Rylander L., Hagmar L., Lindh C., et al. Reproductive hormone levels in men exposed to persistent organohalogen pollutants: a study of inuit and three European cohorts. Environmental Health Perspectives 2006, 114(9):1348-1353.
37. Langer P., Kocan A., Drobna B., Susienkova K., Radikova Z., Huckova M., et al. Polychlorinated biphenyls and testosterone: age and congener related correlation approach in heavily exposed males. Endocrine Regulations 2010, 44(3):109-114.
38. Haring R., Baumeister S.E., Völzke H., Dörr M., Felix S.B., Kroemer H.K., et al. Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. European Journal of Cardiovascular Prevention and Rehabilitation 2011, 18(1):86-96.
39. Kalinchenko S.Y., Tishova Y.A., Mskhalaya G.J., Gooren L.J., Giltay E.J., Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clinical Endocrinology 2010, 73(5):602-612.
40. Traish A.M., Abdou R., Kypreos K.E. Androgen deficiency and atherosclerosis: the lipid link. Vascular Pharmacology 2009, 51(5-6):303-313.
41. Bjornerem A., Straume B., Oian P., Berntsen G.K. Seasonal variation of estradiol, follicle stimulating hormone, and dehydroepiandrosterone sulfate in women and men. Journal of Clinical Endocrinology and Metabolism 2006, 91(10):3798-3802.
42. Schrader S.M., Turner T.W., Breitenstein M.J., Simon S.D. Measuring male reproductive hormones for occupational field studies. Journal of Occupational Medicine 1993, 35(6):574-576.
43. Vermeulen A., Verdonck G. Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. Journal of Clinical Endocrinology and Metabolism 1992, 74(4):939-942.
44. Bain J., Langevin R., D'Costa M., Sanders R.M., Hucker S. Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three. Fertility and Sterility 1988, 49(1):123-126.