Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: A cross-sectional study

Asian Journal of Andrology

Volumn 15, Issue 1, 2013, Pages 97-104

  Mocevic, Emina ^a   Specht, Ina O ^a   Marott, Jacob L ^a   Giwercman, Aleksander ^b   Jönsson, Bo A G ^c   Toft, Gunnar ^d   Lundh, Thomas ^c   Peter Bonde, Jens ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

blood mercury concentration; environmental mercury exposure; male fertility; reproduction; reproductive hormones; semen characteristics; semen quality

Indexed keywords

ANDROGEN; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; MERCURY; POLYUNSATURATED FATTY ACID; TESTOSTERONE;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GREENLAND; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE GENITAL SYSTEM; POLAND; SEMEN ANALYSIS; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TRACE METAL BLOOD LEVEL; UKRAINE;

ADULT; ANDROGENS; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FOLLICLE STIMULATING HORMONE; GREENLAND; HUMANS; INUITS; LUTEINIZING HORMONE; MALE; MERCURY; POLAND; REPRODUCTION; SEMEN ANALYSIS; SPERM COUNT; TESTOSTERONE; UKRAINE;

EID: 84872189090     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2012.121     Document Type: Article

References (56)

1. Wirth JJ, Mijal RS. Adverse effects of low level heavy metal exposure on male reproductive function. Syst Biol Reprod Med 2010; 56: 147-67.
2. Clarkson TW, Magos L. The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 2006; 36: 609-62. (Pubitemid 44396731)
3. AMAP. AMAP Assessment 2009: Human Health in the Arctic. Oslo: Arctic Monitoring and Assessment Programme (AMAP); 2009.
4. Johansen P, Mulvad G, Pedersen HS, Hansen JC, Riget F. Human accumulation of mercury in Greenland. Sci Total Environ 2007; 377: 173-8. (Pubitemid 46662001)
5. IPCS. Concise International Chemical Assessment Document 50: Elemental mercury and inorganic mercury compounds: Human health aspects. Geneva: World Health Organization; 2003.
6. Johansen P, Pars T, Bjerregaard P. Lead, cadmium, mercury and selenium intake by Greenlanders from local marine food. Sci Total Environ 2000; 245: 187-94. (Pubitemid 30107779)
7. JECFA. Methylmercury. In: JECFA, editor. Safety Evaluation of Certain Food Additives and Contaminants. Report of the 61st Joint FAO/WHO Expert Committee on Food Additives. Geneva: World Health Organization, International Programme on Chemical Safety; 2004.
8. Gibb H, Haver C, Kozlov K, Centeno JA, Jurgenson V et al. Biomarkers of mercury exposure in two eastern Ukraine cities. J Occup Environ Hyg 2011; 8: 187-93.
9. Lech T, Sadlik JK. Total mercury levels in human autopsy materials from a nonexposed Polish population. Arch Environ Health 2004; 59: 50-4. (Pubitemid 41038911)
10. Marzec Z, Schlegel-Zawadzka M. Exposure to cadmium, lead and mercury in the adult population from Eastern Poland, 1990-2002. Food Addit Contam 2004; 21: 963-70. (Pubitemid 39599992)
11. AMAP. AMAP Assessment 2002: Heavy Metals in the Arctic. Oslo: Arctic Monitoring and Assessment Programme (AMAP); 2004.
12. Arabi M, Heydarnejad MS. In vitro mercury exposure on spermatozoa from normospermic individuals. Pak J Biol Sci 2007; 10: 2448-53. (Pubitemid 47121322)
13. Mohamed MK, Lee WI, Mottet NK, Burbacher TM. Laser light-Scattering study of the toxic effects of methylmercury on sperm motility. J Androl 1986; 7: 11-5. (Pubitemid 16132304)
14. Ernst E, Lauritsen JG. Effect of organic and inorganic mercury on human sperm motility. Pharmacol Toxicol 1991; 68: 440-4.
15. Rao MV. Toxic effects of methylmercury on spermatozoa in vitro. Experientia 1989; 45: 985-7. (Pubitemid 19254811)
16. Lee IP, Dixon RL. Effects of mercury on spermatogenesis studied by velocity sedimentation cell separation and serial mating. J Pharmacol Exp Ther 1975; 194: 171-81.
17. Mohamed MK, Burbacher TM, Mottet NK. Effects of methyl mercury on testicular functions in Macaca fascicularis monkeys. Pharmacol Toxicol 1987; 60: 29-36. (Pubitemid 17042682)
18. Orisakwe OE, Afonne OJ, Nwobodo E, Asomugha L, Dioka CE. Low-Dose mercury induces testicular damage protected by zinc in mice. Eur J Obstet Gynecol Reprod Biol 2001; 95: 92-6. (Pubitemid 32208676)
19. Boujbiha MA, Hamden K, Guermazi F, Bouslama A, Omezzine A et al. Testicular toxicity in mercuric chloride treated rats: Association with oxidative stress. Reprod Toxicol 2009; 28: 81-9.
20. Homma-Takeda S, Kugenuma Y, Iwamuro T, Kumagai Y, Shimojo N. Impairment of spermatogenesis in rats by methylmercury: Involvement of stage- And cell-Specific germ cell apoptosis. Toxicology 2001; 169: 25-35. (Pubitemid 33033315)
21. Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP et al. Infertility, blood mercury concentrations and dietary seafood consumption: A case-control study. BJOG 2002; 109: 1121-5. (Pubitemid 35287081)
22. Dickman MD, Leung KM. Mercury and organochlorine exposure from fish consumption in Hong Kong. Chemosphere 1998; 37: 991-1015. (Pubitemid 28362504)
23. Keck C, Bergmann M, Ernst E, Muller C, Kliesch S et al. Autometallographic detection of mercury in testicular tissue of an infertile man exposed to mercury vapor. Reprod Toxicol 1993; 7: 469-75.
24. Chia SE, Ong CN, Lee ST, Tsakok FH. Blood concentrations of lead, cadmium, mercury, zinc, and copper and human semen parameters. Arch Androl 1992; 29: 177-83.
25. Leung TY, Choy CM, Yim SF, Lam CW, Haines CJ. Whole blood mercury concentrations in sub-fertile men in Hong Kong. Aust N Z J Obstet Gynaecol 2001; 41: 75-7. (Pubitemid 32201298)
26. Rignell-Hydbom A, Axmon A, Lundh T, Jonsson BA, Tiido T et al. Dietary exposure to methyl mercury and PCB and the associations with semen parameters among Swedish fishermen. Environ Health 2007; 6: 14.
27. Meeker JD, Rossano MG, Protas B, Padmanahban V, DiamondMPet al. Environmental exposure to metals and male reproductive hormones: Circulating testosterone is inversely associated with blood molybdenum. Fertil Steril 2010; 93: 130-40.
28. McGregor AJ, Mason HJ. Occupational mercury vapour exposure and testicular, pituitary and thyroid endocrine function. Hum Exp Toxicol 1991; 10: 199-203.
29. Choy CM, Yeung QS, Briton-Jones CM, Cheung CK, Lam CW et al. Relationship between semen parameters and mercury concentrations in blood and in seminal fluid from subfertile males in Hong Kong. Fertil Steril 2002; 78: 426-8. (Pubitemid 34831751)
30. Rachootin P, Olsen J. The risk of infertility and delayed conception associated with exposures in the Danish workplace. J Occup Med 1983; 25: 394-402. (Pubitemid 13058045)
31. Cordier S, Deplan F, Mandereau L, Hemon D. Paternal exposure to mercury and spontaneous abortions. Br J Ind Med 1991; 48: 375-81.
32. Cole DC, Wainman B, Sanin LH, Weber JP, Muggah H et al. Environmental contaminant levels and fecundability among non-Smoking couples. Reprod Toxicol 2006; 22: 13-9. (Pubitemid 43963320)
33. Alcser KH, Brix KA, Fine LJ, Kallenbach LR, Wolfe RA. Occupational mercury exposure and male reproductive health. Am J Ind Med 1989; 15: 517-29. (Pubitemid 19146516)
34. Lauwerys R, Roels H, Genet P, Toussaint G, Bouckaert A et al. Fertility of male workers exposed to mercury vapor or to manganese dust: A questionnaire study. Am J Ind Med 1985; 7: 171-6. (Pubitemid 15171895)
35. Toft G, Axmon A, Giwercman A, Thulstrup AM, Rignell-Hydbom A et al. Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-Sectional study. Environ Health 2005; 4: 26.
36. Giwercman A, Richthoff J, Hjollund H, Bonde JP, Jepson K et al. Correlation between sperm motility and sperm chromatin structure assay parameters. Fertil Steril 2003; 80: 1404-12. (Pubitemid 37532456)
37. Groome NP, Illingworth PJ, O'Brien M, Pai R, Rodger FE et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996; 81: 1401-5. (Pubitemid 26119665)
38. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology 2006; 17: 450-8. (Pubitemid 44305519)
39. World Health Organization. Laboratory Manual for the Examination of Human Semen and Sperm - Cervical Mucus Interaction. Cambridge/New York: Cambridge University Press; 1999.
40. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A. Quality control workshops in standardization of sperm concentration and motility assessment in multicentre studies. Int J Androl 2005; 28: 144-9. (Pubitemid 40780340)
41. Giwercman AH, Rignell-Hydbom A, Toft G, Rylander L, Hagmar L et al. Reproductive hormone levels in men exposed to persistent organohalogen pollutants: A study of inuit and three European cohorts. Environ Health Perspect 2006; 114: 1348-53. (Pubitemid 44314756)
42. Bonde JP, Toft G, Rylander L, Rignell-Hydbom A, Giwercman A et al. Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines. Environ Health Perspect 2008; 116: 269-77. (Pubitemid 351395591)
43. Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004; 82: 863-70. (Pubitemid 39346431)
44. Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS, ToftGet al. Is smoking a risk factor for decreased semen quality? A cross-Sectional analysis. Hum Reprod 2007; 22: 188-96. (Pubitemid 44942684)
45. Hassan MA, Killick SR. Effect of male age on fertility: Evidence for the decline in male fertility with increasing age. Fertil Steril 2003; 79: 1520-7. (Pubitemid 36687928)
46. Mamsen LS, Lutterodt MC, Andersen EW, Skouby SO, Sorensen KP et al. Cigarette smoking during early pregnancy reduces the number of embryonic germ and somatic cells. Hum Reprod 2010; 25: 2755-61.
47. Gaur DS, Talekar MS, Pathak VP. Alcohol intake and cigarette smoking: Impact of two major lifestyle factors on male fertility. Indian J Pathol Microbiol 2010; 53: 35-40.
48. Monsees TK, Franz M, Gebhardt S, Winterstein U, Schill WB et al. Sertoli cells as a target for reproductive hazards. Andrologia 2000; 32: 239-46.
49. Attaman JA, Toth TL, Furtado J, Campos H, Hauser R et al. Dietary fat and semen quality among men attending a fertility clinic. Hum Reprod 2012; 27: 1466-74.
50. Aksoy Y, Aksoy H, Altinkaynak K, Aydin HR, Ozkan A. Sperm fatty acid composition in subfertile men. Prostaglandins Leukot Essent Fatty Acids 2006; 75: 75-9. (Pubitemid 44287467)
51. Safarinejad MR. Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: A double-Blind, placebo-controlled, randomised study. Andrologia 2011; 43: 38-47.
52. Olsen J, Ramlau-Hansen CH. Dietary fats may impact semen quantity and quality. Asian J Androl 2012; 14: 511-2.
53. Bonde JP, Joffe M, Sallmen M, Kristensen P, Olsen J et al. Validity issues relating to time-To-Pregnancy studies of fertility. Epidemiology 2006; 17: 347-9. (Pubitemid 44305505)
54. Moussa H, Hachfi L, Trimeche M, Najjar MF, Sakly R. Accumulation of mercury and its effects on testicular functions in rats intoxicated orally by methylmercury. Andrologia 2011; 43: 23-7.
55. Bakir F, Damluji SF, Amin-Zaki L, Murtadha M, Khalidi A et al. Methylmercury poisoning in Iraq. Science 1973; 181: 230-41.
56. Grandjean P, Weihe P, White RF, Debes F, Araki S et al. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997; 19: 417-28. (Pubitemid 27489345)