Changes of serum sex hormone levels and MT mRNA expression in rats orally exposed to cadmium

Toxicology

Volumn 186, Issue 1-2, 2003, Pages 109-118

  Zeng, Xiangbin ^a   Jin, Taiyi ^a,b   Zhou, Yuanfen ^a   Nordberg, Gunnar F ^b  

^a FUDAN UNIVERSITY   (China)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Cadmium; Metallothionein; Rat prostate; Sex hormone; Zinc

Indexed keywords

CADMIUM; DRINKING WATER; HEAVY METAL; LUTEINIZING HORMONE; MESSENGER RNA; METALLOTHIONEIN; SEX HORMONE; TESTOSTERONE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE VENTRAL LOBE; RAT; TESTOSTERONE BLOOD LEVEL;

RODENTIA;

EID: 0037447589     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00725-4     Document Type: Article

References (39)

1. Achanzar W.E., Diwan B.A., Liu J., Quader S.T., Webber M.M., Waalkes M.P. Cadmium-induced malignant transformation of human prostate epithelial cells. Cancer Res. 61:2001;455-458.
2. Bebianno M.J., Langston W.J. Cadmium and metallothionein turnover in different tissues of the gastropod littorina littorea. Talanta. 46:1998;301-313.
3. Byar D.P., Anderson J.E., Mostofi F.K. The distribution of zinc-65 in the prostate and other organs in control, castrated, and hypophysectomized rats. Invest. Urol. 7:1969;57-65.
4. Clark J.T., Jimenez B., Evans S.L., Barrow R., Winfree M., Mrotek J.J. Cadmium-induced sexual dysfunction does not involve increased hepatic metabolism of testosterone nor increased circulating levels of corticosterone. Physiol. Behav. 56:1994;975-981.
5. Coogan T.P., Shiraishi N., Waalkes M.P. Minimal basal activity and lack of metal-induced activation of the metallothionein gene correlates with lobe-specific sensitivity to the carcinogenic effects of cadmium in the rat prostate. Toxicol. Appl. Pharmacol. 132:1995;164-173.
6. Coogan T.P., Shiraishi N., Waalkes M.P. Metallothionein Gene Expressiion in the Reproductive tissues of the Wistar Rat: Effects of treatment with metals and glucocorticoids. Toxic Subst. Mech. 16:1997;357-370.
7. Cyr D.G., Dufresne J., Pillet S., Alfieri T.J., Hermo L. Expression and regulation of metallothioneins in the rat epididymis. J. Androl. 22:2001;124-135.
8. Gunn S.A., Gould T.C., Anderson W.A.D. Comparison of protein and zinc electrophoretic patterns of lobes of rat prostates. Proc. Soc. Exp. Biol. Med. 110:1962;32-36.
9. Kagi J.H., Schaffer A. Biochemistry of metallothionein. Biochememistry. 27:1988;8509-8515.
10. Kime D.E. The effect of cadmium on steroidogenesis by testes of the rainbow trout, Salmo gairdneri. Toxicol. Lett. 22:1984;83-88.
11. Lafuente A., Marquez N., Piquero S., Esquifino A.I. Cadmium affects the episodic luteinizing hormone secretion in male rats: possible age-dependent effects. Toxicol. Lett. 104:1999;27-33.
12. Lafuente A., Marquez N., Perez-Lorenzo M., Pazo D., Esquifino A.I. Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem. Toxicol. 38:2000;913-923.
13. Laskey J.W., Rehnberg G.L., Laws S.C., Hein J.F. Reproductive effects of low acute doses of cadmium chloride in adult male rats. Toxicol. Appl. Pharmacol. 73:1984;250-255.
14. Lee K.F., Lau K.M., Ho S.M. Effects of cadmium on metallothionein-I and metallothionein-II mRNA expression in rat ventral, lateral, and dorsal prostatic lobes: quantification by competitive RT-PCR. Toxicol. Appl. Pharmacol. 154:1999;20-27.
15. Lu Y., Costello L.C., Franklin R.B. Prolactin and testosterone regulation of mitochondrial zinc in prostate epithelial cells. Prostate. 30:1997;26-32.
16. Misra R.R., Crance K.A., Bare R.M., Waalkes M.P. Lack of correlation between the inducibility of metallothionein mRNA and metallothionein protein in cadmium-exposed rodents. Toxicology. 117:1997;99-109.
17. Muntzing J., Kirdani R., Murphy G.P., Sandberg A.A. Hormonal control of zinc uptake and binding in the rat dorsolateral prostate. Invest. Urol. 14:1977;492-495.
18. Nath R., Kambadur R., Gulati S., Paliwal V.K., Sharma M. Molecular aspects, physiological function, and clinical significance of metallothioneins. Crit. Rev. Food Nutr. 27:1988;41-85.
19. Nordberg G. Cadmium Metabolism and Toxicity. Environ. Physiol. Biochem. 2:1972;7-36.
20. Nordberg G.F. Effects of long-term cadmium exposure on the seminal vesicles of mice. J. Reprod. Fertil. 45:1975;165-167.
21. Nordberg M., Nordberg G.F. Toxicological aspects of metallothionein. Cell. Mol. Biol. 46:2000;451-463.
22. Ross R.K., Shimizu H., Paganini-Hill A., Honda G., Henderson B.E. Case-control studies of prostate cancer in blacks and whites in southern California. J. Natl. Cancer Inst. 78:1987;869-874.
23. Searle P.F., Davison B.L., Stuart G.W., Wilkie T.M., Norstedt G., Palmiter R.D. Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol. Cell. Biol. 4:1984;1221-1230.
24. Shibnath G., Paulo O., Paula K., Shuk-mei H. Expression and regulation of metallothionein mRNA levels in the prostates of Noble rats: lack of expression in the ventral prostate and regulation by sex hormones in the dorsolateral prostate. Prostate. 29:1996;91-100.
25. Suzuki T., Yamanaka H., Tamura Y., Nakajima K., Kanatanni K., Kimura M., Otaki N. Metallothionein of prostatic tissues and fluids in rats and humans. Tohoku J. Exp. Med. 166:1992;251-257.
26. Tohyama C., Suzuki J.S., Homma S., Karasawa M., Kuroki T., Nishimura H., Nishimura N. Testosterone-dependent induction of metallothionein in genital organs of male rats. Biochem. J. 317:1996;97-102.
27. Van der Gulden J.W., Kolk J.J., Berbeek A.L. Work environment and prostate cancer risk. Prostate. 27:1995;250-257.
28. Vallee B.L., Falchuk K.H. The biochemical basis of zinc physiology. Physiol. Rev. 73:1993;79-118.
29. Vallee B.L. The function of metallothionein. Neurochem. Int. 27:1995;23-33.
30. Waalkes M.P., Rehm S., Riggs C.W. Cadmium carcinogenesis in the male Wistar [Crl:(WI)BR] rats: dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res. 48:1988;4656-4663.
31. Waalkes M.P., Perantoni A.O. Apparent deficiency of metallothionein in the Wistar rat prostate. Toxicol. Appl. Pharmacol. 101:1989;83-94.
32. Waalkes M.P., Perantoni A.O., Rehm S. Tissue susceptibility factors in cadmium carcinogenesis. Biol. Trace Elem. Res. 21:1989;483-490.
33. Waalkes M.P., Rehm S., Perantoni A.O., Coogan T.P. Cadmium exposure in rats and tumours of the prostate. IARC Sci. Publ. 118:1992;391-400.
34. Waalkes M.P., Rehm S., Devor D.E. The effects of continuous testosterone exposure on spontaneous and cadmium-induced tumors in the male Fischer (F344/NCr) rat: loss of testicular response. Toxicol. Appl. Pharmacol. 142:1997;40-46.
35. Waalkes M.P., Anver M., Diwan B.A. Carcinogenic effects of cadmium in the noble (NBL/Cr) rat: induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate. Toxicol. Sci. 52:1999;154-161.
36. WHO, 1994. Programme for the provision of matched assay reagents for the immunoassay of hormones. Queen Charlottes's Hospital, Goldhawk Road, London, UK.
37. Zacharewski T. Identification and assessment of endocrine disruptors: limitations of in vivo and invitro assays. Environ. Health Perspect. 106:1998;577-582.
38. Zhou T., Zhou G., Song W., Eguchi N., Lu W., Lundin E., Jin T., Nordberg G. Cadmium-induced apoptosis and changes in expression of p53,c-jun and MT-I genes in testes and ventral prostate of rats. Toxicology. 142:1999;1-13.
39. Zylber-Haran E.A., Gershman H., Rosenmannn E., Spitz I.M. Gonadotrophin, testosterone and prolactin interrelationships in cadmium-treated rats. J. Endocrinol. 92:1982;123-130.