Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate

Biochemical Journal

Volumn 365, Issue 3, 2002, Pages 849-856

  Kasahara, Emiko ^a   Sato, Eisuke F ^a   Miyoshi, Mami ^a   Konaka, Ryusei ^a   Hiramoto, Keiichi ^a   Sasaki, Junzo ^a   Tokuda, Masaaki ^a   Nakano, Yoshihisa ^a   Inoue, Masayasu ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ascorbic acid; Glutathione; Phthalate esters; Reactive oxygen species; Testis atrophy

Indexed keywords

BIOLOGICAL ORGANS; ESTERS; HYDROLYSIS; OXYGEN; POLYMERS;

SPERMATOCYTES;

CELLS;

ASCORBIC ACID; CYTOCHROME C; GLUTATHIONE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GERM CELL; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRION; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SERTOLI CELL; SPERMATOCYTE; TESTIS ATROPHY; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BODY WEIGHT; CATALASE; CYTOCHROME C GROUP; GERM CELLS; GLUTATHIONE PEROXIDASE; IN SITU NICK-END LABELING; MALE; ORGAN SIZE; OXIDATIVE STRESS; PHTHALIC ACIDS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TESTIS;

ANIMALIA;

EID: 0036683695     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020254     Document Type: Article

References (46)

1. Single exposure to heat induces stage-specific germ cell apoptosis in rats: Role of intratesticular testosterone on stage specificity
2. Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo
3. Radiation-induced cell death in the mouse testis: Relationship to apoptosis
4. The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology
5. Role of glutathione S-transferases in oxidative stress-induced male germ cell apoptosis
6. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation
7. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm
8. Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs
9. Vitamin E deficiency causes incomplete spermatogenesis and affects the structural differentiation of epithelial cells of the epididymis in the rat
10. Phthalate esters: Occurrence and biological effects
11. Di-2-ethythexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) accumulation in whole blood and red cell concentrates
12. Decrease in the concentration of vitamin E in blood and tissues caused by di(2-ethylhexyl)phthalate, a commonly used plasticizer in blood storage bags and medical tubing
13. Effect of phthalic acid esters on gonadal function in male rats
14. Biological effects of di-(2-ethylhexyl)-phthalate and other phthalic acid esters
15. Testicular atrophy induced by di(2-ethylhexyl)phthalate: Changes in histology, cell specific enzyme activities and zinc concentrations in rat testis
16. Effects of route of administration and repetitive dosing on the disposition kinetics of di(2-ethylhexyl)phthalate and its mono-de-esterified metabolite in rats
17. Aspects of the testicular toxicity of phthalate esters
18. Effect of DEHP [di-(2-ethylhexyl) phthalate] on lipid peroxidation in liver in rats and in primary cultures of rat hepatocytes
19. Monoalkyl phthalates from normal aliphatic alcohols
20. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
21. Tissue sulfhydryl groups
22. Simultaneous determination of uric and ascorbic acids in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection
23. Assays of glutathione peroxidase
24. Catalase in vitro
25. Viability of meiotic prophase spermatocytes of rats is facilitated in primary culture of dispersed testicular cells on collagen gel by supplementing epinephrine or norepinephrine: Evidence that meiotic prophase spermatocytes complete meiotic divisions in vitro
26. Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012
27. Localization of 3-β hydroxysteroid dehydrogenase in the inner membrane subfraction of rat testis mitochondria
28. Metabolism and transport of amphipathic molecules in analbuminemic rats and human subjects
29. Influence of peroxisome proliferator-activated receptor α on ubiquinone biosynthesis
30. Species differences in response to diethylhexylphthalate: Suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor α-mediated gene expression
31. Phthalates rapidly increase production of reactive oxygen species in vivo: Role of Kupffer cells
32. Interorgan metabolism of glutathione as the defence mechanism against oxidative stress
33. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
34. Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes
35. Effects of phthalic acid esters on testicular mitochondrial functions in the rat
36. Effect of administration of diethylhexyl phthalate on the function and turnover of rat hepatic mitochondria
37. Spermatogenic disturbance induced by di-(2-ethylhexyl) phthalate is significantly prevented by treatment with antioxidant vitamins in the rat
38. The Fas system is a key regulator of germ cell apoptosis in the testis
39. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis
40. Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a nonfunctional form of Fas ligand
41. Role of reactive oxygen intermediates in activation-induced CD95 (AP0-1/Fas) ligand expression
42. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB
43. Activation-dependent transcriptional regulation of the human Fas promoter requires NF-κB p50-p65 recruitment
44. Investigation of detoxification capacity of rat testicular germ cells and Sertoli cells
45. Antioxidant system in rat testicular cells
46. Effects of co-administration of di(2-ethylhexyl)phthalate and testosterone on several parameters in the testis and pharmacokinetics of its mono-de-esterified metabolite