메뉴 건너뛰기




Volumn 41, Issue 10, 2015, Pages 844-852

Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives

Author keywords

Head and neck cancer; Human papillomavirus 16; Oropharyngeal; Oropharynx; Radiation; Treatment

Indexed keywords

ADVANCED CANCER; ARTICLE; CANCER RADIOTHERAPY; CANCER STAGING; CELL CYCLE REGULATION; DISEASE ASSOCIATION; DNA REPAIR; DOWN REGULATION; HEAD AND NECK CANCER; HUMAN; IN VITRO STUDY; MOLECULAR DYNAMICS; OROPHARYNGEAL SQUAMOUS CELL CARCINOMA; PROCESS OPTIMIZATION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; THERAPY EFFECT; TISSUE OXYGENATION; TREATMENT RESPONSE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; UPREGULATION; VIRUS IDENTIFICATION; WART VIRUS; CARCINOMA, SQUAMOUS CELL; COMPLICATION; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS TYPE 16; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS INFECTION; RADIATION DOSE; VIROLOGY;

EID: 84958913993     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2015.10.001     Document Type: Review
Times cited : (111)

References (82)
  • 1
    • 0035031174 scopus 로고    scopus 로고
    • Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers
    • Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol 2001;13:183-8.
    • (2001) Curr Opin Oncol , vol.13 , pp. 183-188
    • Gillison, M.L.1    Shah, K.V.2
  • 2
    • 77954190940 scopus 로고    scopus 로고
    • Human Papillomavirus and survival of patients with oropharyngeal cancer
    • Ang KK, Harris J, Wheeler R, et al. Human Papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.
    • (2010) N Engl J Med , vol.363 , pp. 24-35
    • Ang, K.K.1    Harris, J.2    Wheeler, R.3
  • 3
    • 39649109915 scopus 로고    scopus 로고
    • Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial
    • Fakhry C, Westra WH, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 2008;100:261-9.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 261-269
    • Fakhry, C.1    Westra, W.H.2    Li, S.3
  • 4
    • 80052981071 scopus 로고    scopus 로고
    • Population-based study of competing mortality in head and neck cancer
    • Rose BS. Population-based study of competing mortality in head and neck cancer. J Clin Oncol 2011;29:3503-9.
    • (2011) J Clin Oncol , vol.29 , pp. 3503-3509
    • Rose, B.S.1
  • 5
    • 49649109914 scopus 로고    scopus 로고
    • Controversies in the management of oropharynx cancer
    • Worden FP, Ha H. Controversies in the management of oropharynx cancer. J Natl Compr Canc Netw 2008;6:707-14.
    • (2008) J Natl Compr Canc Netw , vol.6 , pp. 707-714
    • Worden, F.P.1    Ha, H.2
  • 6
    • 84921000202 scopus 로고    scopus 로고
    • Treatment de-escalation in HPV-positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives
    • Mirghani H, Amen F, Blanchard P, Moreau F, Guigay J, Hartl DM, et al. Treatment de-escalation in HPV-positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives. Int J Cancer 2015;136:1494-503.
    • (2015) Int J Cancer , vol.136 , pp. 1494-1503
    • Mirghani, H.1    Amen, F.2    Blanchard, P.3    Moreau, F.4    Guigay, J.5    Hartl, D.M.6
  • 8
    • 84879014884 scopus 로고    scopus 로고
    • HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity
    • Rieckmann T, Tribius S, Grob TJ, Meyer F, Busch CJ, Petersen C, et al. HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol 2013;107:242-6.
    • (2013) Radiother Oncol , vol.107 , pp. 242-246
    • Rieckmann, T.1    Tribius, S.2    Grob, T.J.3    Meyer, F.4    Busch, C.J.5    Petersen, C.6
  • 9
    • 84906935543 scopus 로고    scopus 로고
    • Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis
    • Arenz A, Ziemann F, Mayer C, Wittig A, Dreffke K, Preising S, et al. Increased radiosensitivity of HPV-positive head and neck cancer cell lines due to cell cycle dysregulation and induction of apoptosis. Strahlenther Onkol 2014;190:839-46.
    • (2014) Strahlenther Onkol , vol.190 , pp. 839-846
    • Arenz, A.1    Ziemann, F.2    Mayer, C.3    Wittig, A.4    Dreffke, K.5    Preising, S.6
  • 10
    • 84896515405 scopus 로고    scopus 로고
    • P16INK4a impairs homologous recombination-mediated DNA repair in human papillomavirus-positive head and neck tumors
    • Dok R, Kalev P, Van Limbergen EJ, Asbagh LA, Vázquez I, Hauben E, et al. P16INK4a impairs homologous recombination-mediated DNA repair in human papillomavirus-positive head and neck tumors. Cancer Res 2014;74:1739-51.
    • (2014) Cancer Res , vol.74 , pp. 1739-1751
    • Dok, R.1    Kalev, P.2    Van Limbergen, E.J.3    Asbagh, L.A.4    Vázquez, I.5    Hauben, E.6
  • 12
    • 73249140737 scopus 로고    scopus 로고
    • Immune response during therapy with cisplatin or radiation for human papillomavirusrelated head and neck cancer
    • Spanos WC, Nowicki P, Lee DW, Hoover A, Hostager B, Gupta A, et al. Immune response during therapy with cisplatin or radiation for human papillomavirusrelated head and neck cancer. Arch Otolaryngol Head Neck Surg 2009;135:1137-46.
    • (2009) Arch Otolaryngol Head Neck Surg , vol.135 , pp. 1137-1146
    • Spanos, W.C.1    Nowicki, P.2    Lee, D.W.3    Hoover, A.4    Hostager, B.5    Gupta, A.6
  • 13
    • 67049171135 scopus 로고    scopus 로고
    • Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT
    • Gupta AK, Lee JH, Wilke WW, Quon H, Smith G, Maity A, et al. Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. Int J Radiat Oncol Biol Phys 2009;74:928-33.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 928-933
    • Gupta, A.K.1    Lee, J.H.2    Wilke, W.W.3    Quon, H.4    Smith, G.5    Maity, A.6
  • 17
    • 64249103041 scopus 로고    scopus 로고
    • Smoking modifies the relationship between XRCC1 haplotypes and HPV16- negative head and neck squamous cell carcinoma
    • Applebaum KM, McClean MD, Nelson HH, Marsit CJ, Christensen BC, Kelsey KT. Smoking modifies the relationship between XRCC1 haplotypes and HPV16- negative head and neck squamous cell carcinoma. Int J Cancer 2009;124:2690-6.
    • (2009) Int J Cancer , vol.124 , pp. 2690-2696
    • Applebaum, K.M.1    McClean, M.D.2    Nelson, H.H.3    Marsit, C.J.4    Christensen, B.C.5    Kelsey, K.T.6
  • 18
    • 84915733201 scopus 로고    scopus 로고
    • P16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma
    • Chung CH, Zhang Q, Kong CS, Harris J, Fertig EJ, Harari PM, et al. P16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma. J Clin Oncol 2014;32(35):3930-8.
    • (2014) J Clin Oncol , vol.32 , Issue.35 , pp. 3930-3938
    • Chung, C.H.1    Zhang, Q.2    Kong, C.S.3    Harris, J.4    Fertig, E.J.5    Harari, P.M.6
  • 19
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007;25:2164.
    • (2007) J Clin Oncol , vol.25 , pp. 2164
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3    Jelinek, J.4    Tang, H.5    Liu, D.D.6
  • 20
    • 84897071410 scopus 로고    scopus 로고
    • Oropharyngeal cancers: relationship between epidermal growth factor receptor alterations and human papillomavirus status
    • Mirghani H, Amen F, Moreau F, Guigay J, Hartl DM, Lacau St Guily J. Oropharyngeal cancers: relationship between epidermal growth factor receptor alterations and human papillomavirus status. Eur J Cancer 2014;50:1100-11.
    • (2014) Eur J Cancer , vol.50 , pp. 1100-1111
    • Mirghani, H.1    Amen, F.2    Moreau, F.3    Guigay, J.4    Hartl, D.M.5    Lacau St Guily, J.6
  • 21
    • 84928208245 scopus 로고    scopus 로고
    • Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer
    • Chun SH, Jung CK, Won HS, Kang JH, Kim YS, Kim MS, et al. Divergence of P53, PTEN, PI3K, Akt and mTOR expression in tonsillar cancer. Head Neck 2015;37:636-43.
    • (2015) Head Neck , vol.37 , pp. 636-643
    • Chun, S.H.1    Jung, C.K.2    Won, H.S.3    Kang, J.H.4    Kim, Y.S.5    Kim, M.S.6
  • 22
    • 84938090143 scopus 로고    scopus 로고
    • Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing
    • Chung CH, Guthrie VB, Masica DL, Tokheim C, Kang H, Richmon J, et al. Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing. Ann Oncol 2015;26:1216-23.
    • (2015) Ann Oncol , vol.26 , pp. 1216-1223
    • Chung, C.H.1    Guthrie, V.B.2    Masica, D.L.3    Tokheim, C.4    Kang, H.5    Richmon, J.6
  • 23
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011;333:1154-7.
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3    Bettegowda, C.4    Chang, K.5    Li, R.J.6
  • 24
    • 84961289657 scopus 로고    scopus 로고
    • Integrative and comparative genomic analysis of HPV-positive and HPVnegative head and neck squamous cell carcinomas
    • Seiwert TY, Zuo Z, Keck MK, Khattri A, Pedamallu CS, Stricker T, et al. Integrative and comparative genomic analysis of HPV-positive and HPVnegative head and neck squamous cell carcinomas. Clin Cancer Res 2015;21:632-41.
    • (2015) Clin Cancer Res , vol.21 , pp. 632-641
    • Seiwert, T.Y.1    Zuo, Z.2    Keck, M.K.3    Khattri, A.4    Pedamallu, C.S.5    Stricker, T.6
  • 25
    • 79960999875 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells
    • Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, et al. Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells. Clin Cancer Res 2011;17:5016-25.
    • (2011) Clin Cancer Res , vol.17 , pp. 5016-5025
    • Marshall, M.E.1    Hinz, T.K.2    Kono, S.A.3    Singleton, K.R.4    Bichon, B.5    Ware, K.E.6
  • 26
    • 84899741071 scopus 로고    scopus 로고
    • Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer
    • Sewell A, Brown B, Biktasova A, Mills GB, Lu Y, Tyson DR, et al. Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer. Clin Cancer Res 2014;20:2300-11.
    • (2014) Clin Cancer Res , vol.20 , pp. 2300-2311
    • Sewell, A.1    Brown, B.2    Biktasova, A.3    Mills, G.B.4    Lu, Y.5    Tyson, D.R.6
  • 28
    • 3042661957 scopus 로고    scopus 로고
    • Role of cell cycle in mediating sensitivity to radiotherapy
    • Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004;59:928-42.
    • (2004) Int J Radiat Oncol Biol Phys , vol.59 , pp. 928-942
    • Pawlik, T.M.1    Keyomarsi, K.2
  • 29
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002;2(5):342-50.
    • (2002) Nat Rev Cancer , vol.2 , Issue.5 , pp. 342-350
    • Zur Hausen, H.1
  • 30
    • 2342570379 scopus 로고    scopus 로고
    • Hallmarks of senescence in carcinogenesis and cancer therapy
    • Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004;12(23):2919-33.
    • (2004) Oncogene , vol.12 , Issue.23 , pp. 2919-2933
    • Shay, J.W.1    Roninson, I.B.2
  • 31
    • 84878697058 scopus 로고    scopus 로고
    • Sequential transformation of mesenchymal stem cells is associated with increased radiosensitivity and reduced DNA repair capacity
    • Worku M, Fersht N, Martindale C, Funes JM, Short SC. Sequential transformation of mesenchymal stem cells is associated with increased radiosensitivity and reduced DNA repair capacity. Radiat Res 2013;179:698-706.
    • (2013) Radiat Res , vol.179 , pp. 698-706
    • Worku, M.1    Fersht, N.2    Martindale, C.3    Funes, J.M.4    Short, S.C.5
  • 32
    • 84887017554 scopus 로고    scopus 로고
    • HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1
    • Busch CJ, Kriegs M, Laban S, Tribius S, Knecht R, Petersen C, et al. HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1. Radiother Oncol 2013;108:495-9.
    • (2013) Radiother Oncol , vol.108 , pp. 495-499
    • Busch, C.J.1    Kriegs, M.2    Laban, S.3    Tribius, S.4    Knecht, R.5    Petersen, C.6
  • 33
    • 84875212278 scopus 로고    scopus 로고
    • Targeted radiosensitization by the Chk1 inhibitor SAR-020106
    • [Epub 2012 Sep 14]
    • Borst GR, McLaughlin M, Kyula JN, Neijenhuis S, Khan A, Good J, et al. Targeted radiosensitization by the Chk1 inhibitor SAR-020106. Int J Radiat Oncol Biol Phys 2013;85(4):1110-8. http://dx.doi.org/10.1016/j.ijrobp.2012.08.006 [Epub 2012 Sep 14].
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.4 , pp. 1110-1118
    • Borst, G.R.1    McLaughlin, M.2    Kyula, J.N.3    Neijenhuis, S.4    Khan, A.5    Good, J.6
  • 34
    • 65949109031 scopus 로고    scopus 로고
    • Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints
    • Tao Y, Leteur C, Yang C, Zhang P, Castedo M, Pierré A, et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle 2009;8(8):1196-205.
    • (2009) Cell Cycle , vol.8 , Issue.8 , pp. 1196-1205
    • Tao, Y.1    Leteur, C.2    Yang, C.3    Zhang, P.4    Castedo, M.5    Pierré, A.6
  • 35
    • 84862818535 scopus 로고    scopus 로고
    • Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
    • Xia Y, Choi HK, Lee K. Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. Eur J Med Chem 2012;49:24-40.
    • (2012) Eur J Med Chem , vol.49 , pp. 24-40
    • Xia, Y.1    Choi, H.K.2    Lee, K.3
  • 36
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004;9:10-7.
    • (2004) Oncologist , vol.9 , pp. 10-17
    • Vaupel, P.1
  • 37
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;14:198-206.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 38
    • 74549123751 scopus 로고    scopus 로고
    • HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer
    • Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J, et al. HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer. Radiother Oncol 2010;94:30-5.
    • (2010) Radiother Oncol , vol.94 , pp. 30-35
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3    Tramm, T.4    Alsner, J.5    Overgaard, J.6
  • 39
    • 84868367617 scopus 로고    scopus 로고
    • FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial
    • Mortensen LS, Johansen J, Kallehauge J, Primdahl H, Busk M, Lassen P, et al. FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: results from the DAHANCA 24 trial. Radiother Oncol 2012;105:14-20.
    • (2012) Radiother Oncol , vol.105 , pp. 14-20
    • Mortensen, L.S.1    Johansen, J.2    Kallehauge, J.3    Primdahl, H.4    Busk, M.5    Lassen, P.6
  • 40
    • 84455209531 scopus 로고    scopus 로고
    • Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck
    • Toustrup K, Sørensen BS, Lassen P, Wiuf C, Alsner J, Overgaard J, et al. Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck. Radiother Oncol 2012;102:122-9.
    • (2012) Radiother Oncol , vol.102 , pp. 122-129
    • Toustrup, K.1    Sørensen, B.S.2    Lassen, P.3    Wiuf, C.4    Alsner, J.5    Overgaard, J.6
  • 41
    • 65449131740 scopus 로고    scopus 로고
    • The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    • Kong CS, Narasimhan B, Cao H, Kwok S, Erickson JP, Koong A, et al. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 2009;74:553-61.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , pp. 553-561
    • Kong, C.S.1    Narasimhan, B.2    Cao, H.3    Kwok, S.4    Erickson, J.P.5    Koong, A.6
  • 43
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007;13(9):1050-9.
    • (2007) Nat Med , vol.13 , Issue.9 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 44
    • 84919464054 scopus 로고    scopus 로고
    • Radiotherapy and immunogenic cell death
    • Golden EB, Apetoh L. Radiotherapy and immunogenic cell death. Semin Radiat Oncol 2015;25(1):11-7.
    • (2015) Semin Radiat Oncol , vol.25 , Issue.1 , pp. 11-17
    • Golden, E.B.1    Apetoh, L.2
  • 45
    • 0035871993 scopus 로고    scopus 로고
    • HPV16 L1E7 chimeric virus-like particles induce specific HLA-restricted T cells in humans after in vitro vaccination
    • Kaufmann AM, Nieland J, Schinz M, Nonn M, Gabelsberger J, Meissner H, et al. HPV16 L1E7 chimeric virus-like particles induce specific HLA-restricted T cells in humans after in vitro vaccination. Int J Cancer 2001;92:285-93.
    • (2001) Int J Cancer , vol.92 , pp. 285-293
    • Kaufmann, A.M.1    Nieland, J.2    Schinz, M.3    Nonn, M.4    Gabelsberger, J.5    Meissner, H.6
  • 46
    • 77949890036 scopus 로고    scopus 로고
    • Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma
    • Jung AC, Briolat J, Millon R, de Reyniès A, Rickman D, Thomas E, et al. Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Int J Cancer 2010;126: 1882-94.
    • (2010) Int J Cancer , vol.126 , pp. 1882-1894
    • Jung, A.C.1    Briolat, J.2    Millon, R.3    de Reyniès, A.4    Rickman, D.5    Thomas, E.6
  • 47
    • 84928011543 scopus 로고    scopus 로고
    • A predictive transcriptomic signature of oropharyngeal cancer according to HPV16 status exclusively
    • Mirghani H, Ugolin N, Ory C, Lefèvre M, Baulande S, Hofman P, et al. A predictive transcriptomic signature of oropharyngeal cancer according to HPV16 status exclusively. Oral Oncol 2014;50:1025-34.
    • (2014) Oral Oncol , vol.50 , pp. 1025-1034
    • Mirghani, H.1    Ugolin, N.2    Ory, C.3    Lefèvre, M.4    Baulande, S.5    Hofman, P.6
  • 48
    • 84869507183 scopus 로고    scopus 로고
    • CD8- alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis
    • Jung AC, Guihard S, Krugell S, Ledrappier S, Brochot A, Dalstein V, et al. CD8- alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis. Int J Cancer 2013;132(2):E26-36.
    • (2013) Int J Cancer , vol.132 , Issue.2
    • Jung, A.C.1    Guihard, S.2    Krugell, S.3    Ledrappier, S.4    Brochot, A.5    Dalstein, V.6
  • 49
    • 84892948376 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer
    • Ward MJ, Thirdborough SM, Mellows T, Riley C, Harris S, Suchak K, et al. Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer. Br J Cancer 2014;110(2):489-500.
    • (2014) Br J Cancer , vol.110 , Issue.2 , pp. 489-500
    • Ward, M.J.1    Thirdborough, S.M.2    Mellows, T.3    Riley, C.4    Harris, S.5    Suchak, K.6
  • 50
    • 84938717670 scopus 로고    scopus 로고
    • Distinct patterns of intratumoral immune cell infiltrates in patients with HPVassociated compared to non-virally induced head and neck squamous cell carcinoma
    • Partlová S, Bouček J, Kloudová K, Lukešová E, Zábrodský M, Grega M, et al. Distinct patterns of intratumoral immune cell infiltrates in patients with HPVassociated compared to non-virally induced head and neck squamous cell carcinoma. Oncoimmunology 2015;4:e965570.
    • (2015) Oncoimmunology , vol.4
    • Partlová, S.1    Bouček, J.2    Kloudová, K.3    Lukešová, E.4    Zábrodský, M.5    Grega, M.6
  • 51
    • 84861648320 scopus 로고    scopus 로고
    • Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer
    • Heusinkveld M, Goedemans R, Briet RJ, Gelderblom H, Nortier JW, Gorter A, et al. Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer. Int J Cancer 2012;131:E74-85.
    • (2012) Int J Cancer , vol.131
    • Heusinkveld, M.1    Goedemans, R.2    Briet, R.J.3    Gelderblom, H.4    Nortier, J.W.5    Gorter, A.6
  • 52
    • 84897994499 scopus 로고    scopus 로고
    • The interplay between HPV and host immunity in head and neck squamous cell carcinoma
    • Andersen AS, Koldjaer Sølling AS, Ovesen T, Rusan M. The interplay between HPV and host immunity in head and neck squamous cell carcinoma. Int J Cancer 2014;134:2755-63.
    • (2014) Int J Cancer , vol.134 , pp. 2755-2763
    • Andersen, A.S.1    Koldjaer Sølling, A.S.2    Ovesen, T.3    Rusan, M.4
  • 53
    • 49049115379 scopus 로고    scopus 로고
    • Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis
    • Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 2008;26:3582-9.
    • (2008) J Clin Oncol , vol.26 , pp. 3582-3589
    • Machtay, M.1    Moughan, J.2    Trotti, A.3    Garden, A.S.4    Weber, R.S.5    Cooper, J.S.6
  • 54
    • 84900474313 scopus 로고    scopus 로고
    • Is radiation dose reduction the right answer for HPV-positive head and neck cancer?
    • Kimple RJ, Harari PM. Is radiation dose reduction the right answer for HPV-positive head and neck cancer? Oral Oncol 2014;50:560-4.
    • (2014) Oral Oncol , vol.50 , pp. 560-564
    • Kimple, R.J.1    Harari, P.M.2
  • 55
    • 84863307023 scopus 로고    scopus 로고
    • Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma
    • Sinha P, Lewis Jr JS, Piccirillo JF, Kallogjeri D, Haughey BH. Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer 2012;118:3519-30.
    • (2012) Cancer , vol.118 , pp. 3519-3530
    • Sinha, P.1    Lewis, J.S.2    Piccirillo, J.F.3    Kallogjeri, D.4    Haughey, B.H.5
  • 56
    • 65349173893 scopus 로고    scopus 로고
    • Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    • Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27:1992-8.
    • (2009) J Clin Oncol , vol.27 , pp. 1992-1998
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3    Tramm, T.4    Alsner, J.5    Overgaard, J.6
  • 57
    • 84886432461 scopus 로고    scopus 로고
    • Definitive radiation therapy without chemotherapy for human papillomavirus-positive head and neck cancer
    • Chen AM, Zahra T, Daly ME, Farwell DG, Luu Q, Gandour-Edwards R, et al. Definitive radiation therapy without chemotherapy for human papillomavirus-positive head and neck cancer. Head Neck 2013;35:1652-6.
    • (2013) Head Neck , vol.35 , pp. 1652-1656
    • Chen, A.M.1    Zahra, T.2    Daly, M.E.3    Farwell, D.G.4    Luu, Q.5    Gandour-Edwards, R.6
  • 58
    • 84924262796 scopus 로고    scopus 로고
    • An update on PARP inhibitors for the treatment of cancer
    • Benafif S, Hall M. An update on PARP inhibitors for the treatment of cancer. Onco Targets Ther 2015;26(8):519-28.
    • (2015) Onco Targets Ther , vol.26 , Issue.8 , pp. 519-528
    • Benafif, S.1    Hall, M.2
  • 59
    • 84904978889 scopus 로고    scopus 로고
    • Predictive biomarkers for cancer therapy with PARP inhibitors
    • Michels J, Vitale I, Saparbaev M, Castedo M, Kroemer G. Predictive biomarkers for cancer therapy with PARP inhibitors. Oncogene 2014;33: 3894-907.
    • (2014) Oncogene , vol.33 , pp. 3894-3907
    • Michels, J.1    Vitale, I.2    Saparbaev, M.3    Castedo, M.4    Kroemer, G.5
  • 60
    • 84915737153 scopus 로고    scopus 로고
    • The inhibition of PARP but not EGFR results in the radiosensitization of HPV/ p16-positive HNSCC cell lines
    • Güster JD, Weissleder SV, Busch CJ, Kriegs M, Petersen C, Knecht R, et al. The inhibition of PARP but not EGFR results in the radiosensitization of HPV/ p16-positive HNSCC cell lines. Radiother Oncol 2014;113:345-51.
    • (2014) Radiother Oncol , vol.113 , pp. 345-351
    • Güster, J.D.1    Weissleder, S.V.2    Busch, C.J.3    Kriegs, M.4    Petersen, C.5    Knecht, R.6
  • 61
    • 84871300677 scopus 로고    scopus 로고
    • Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways
    • Raju U, Riesterer O, Wang ZQ, Molkentine DP, Molkentine JM, Johnson FM, et al. Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. Radiother Oncol 2012;105: 241-9.
    • (2012) Radiother Oncol , vol.105 , pp. 241-249
    • Raju, U.1    Riesterer, O.2    Wang, Z.Q.3    Molkentine, D.P.4    Molkentine, J.M.5    Johnson, F.M.6
  • 62
    • 84907200175 scopus 로고    scopus 로고
    • Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522
    • Ang KK, Zhang Q, Rosenthal DI, et al. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 2014;32: 2940-50.
    • (2014) J Clin Oncol , vol.32 , pp. 2940-2950
    • Ang, K.K.1    Zhang, Q.2    Rosenthal, D.I.3
  • 63
    • 84921885267 scopus 로고    scopus 로고
    • Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamouscell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial
    • Giralt J, Trigo J, Nuyts S, et al. Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamouscell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol 2015;16:221-32.
    • (2015) Lancet Oncol , vol.16 , pp. 221-232
    • Giralt, J.1    Trigo, J.2    Nuyts, S.3
  • 64
    • 84939871526 scopus 로고    scopus 로고
    • Cellular senescence checkpoint function determines differential Notch1- dependent oncogenic and tumor-suppressor activities
    • Kagawa S, Natsuizaka M, Whelan KA, Facompre N, Naganuma S, Ohashi S, et al. Cellular senescence checkpoint function determines differential Notch1- dependent oncogenic and tumor-suppressor activities. Oncogene 2015;34:2347-59.
    • (2015) Oncogene , vol.34 , pp. 2347-2359
    • Kagawa, S.1    Natsuizaka, M.2    Whelan, K.A.3    Facompre, N.4    Naganuma, S.5    Ohashi, S.6
  • 65
    • 84925543362 scopus 로고    scopus 로고
    • Inhibition of the NOTCH pathway using c-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors
    • Dantas-Barbosa C, Bergthold G, Daudigeos-Dubus E, Blockus H, Boylan JF, Ferreira C, et al. Inhibition of the NOTCH pathway using c-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors. Anticancer Drugs 2015;26(3):272-83.
    • (2015) Anticancer Drugs , vol.26 , Issue.3 , pp. 272-283
    • Dantas-Barbosa, C.1    Bergthold, G.2    Daudigeos-Dubus, E.3    Blockus, H.4    Boylan, J.F.5    Ferreira, C.6
  • 66
    • 84887019478 scopus 로고    scopus 로고
    • Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells
    • Saki M, Toulany M, Rodemann HP. Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells. Radiother Oncol 2013;108 (3):473-8.
    • (2013) Radiother Oncol , vol.108 , Issue.3 , pp. 473-478
    • Saki, M.1    Toulany, M.2    Rodemann, H.P.3
  • 67
    • 84884885139 scopus 로고    scopus 로고
    • A phase 1 study of everolimus + weekly cisplatin + intensity modulated radiation therapy in head-and-neck cancer
    • Fury MG, Lee NY, Sherman E, Ho AL, Rao S, Heguy A, et al. A phase 1 study of everolimus + weekly cisplatin + intensity modulated radiation therapy in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2013;87:479-86.
    • (2013) Int J Radiat Oncol Biol Phys , vol.87 , pp. 479-486
    • Fury, M.G.1    Lee, N.Y.2    Sherman, E.3    Ho, A.L.4    Rao, S.5    Heguy, A.6
  • 68
    • 84938079441 scopus 로고    scopus 로고
    • Phase I trial of everolimus in combination with thoracic radiotherapy in non-small-cell lung cancer
    • Deutsch E, Le Péchoux C, Faivre L, Rivera S, Tao Y, Pignon JP, et al. Phase I trial of everolimus in combination with thoracic radiotherapy in non-small-cell lung cancer. Ann Oncol 2015;26:1223-9.
    • (2015) Ann Oncol , vol.26 , pp. 1223-1229
    • Deutsch, E.1    Le Péchoux, C.2    Faivre, L.3    Rivera, S.4    Tao, Y.5    Pignon, J.P.6
  • 69
    • 84927782533 scopus 로고    scopus 로고
    • A Phase I study of CUDC-101, a multitarget inhibitor of HDACs, EGFR, and HER2, in combination with chemoradiation in patients with head and neck squamous cell carcinoma
    • Galloway TJ, Wirth LJ, Colevas AD, Gilbert J, Bauman JE, Saba NF, et al. A Phase I study of CUDC-101, a multitarget inhibitor of HDACs, EGFR, and HER2, in combination with chemoradiation in patients with head and neck squamous cell carcinoma. Clin Cancer Res 2015;21:1566-73.
    • (2015) Clin Cancer Res , vol.21 , pp. 1566-1573
    • Galloway, T.J.1    Wirth, L.J.2    Colevas, A.D.3    Gilbert, J.4    Bauman, J.E.5    Saba, N.F.6
  • 70
    • 0842329851 scopus 로고    scopus 로고
    • E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells
    • Al Moustafa AE, Foulkes WD, Benlimame N, Wong A, Yen L, Bergeron J, et al. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. Oncogene 2004;23:350-8.
    • (2004) Oncogene , vol.23 , pp. 350-358
    • Al Moustafa, A.E.1    Foulkes, W.D.2    Benlimame, N.3    Wong, A.4    Yen, L.5    Bergeron, J.6
  • 71
    • 84878939724 scopus 로고    scopus 로고
    • The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines' in-vitro and in-vivo xenografts
    • Deberne M, Levy A, Mondini M, Dessen P, Vivet S, Supiramaniam A, et al. The combination of the antiviral agent cidofovir and anti-EGFR antibody cetuximab exerts an antiproliferative effect on HPV-positive cervical cancer cell lines' in-vitro and in-vivo xenografts. Anticancer Drugs 2013;24:599-608.
    • (2013) Anticancer Drugs , vol.24 , pp. 599-608
    • Deberne, M.1    Levy, A.2    Mondini, M.3    Dessen, P.4    Vivet, S.5    Supiramaniam, A.6
  • 72
    • 15244363807 scopus 로고    scopus 로고
    • Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck(SCCHN) cell line improves radiation sensitivity
    • Sirianni N, Wang J, Ferris RL. Antiviral activity of Cidofovir on a naturally human papillomavirus-16 infected squamous cell carcinoma of the head and neck(SCCHN) cell line improves radiation sensitivity. Oral Oncol 2005;41:423-8.
    • (2005) Oral Oncol , vol.41 , pp. 423-428
    • Sirianni, N.1    Wang, J.2    Ferris, R.L.3
  • 73
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • Demaria S, Ng B, Devitt ML, Babb JS, Kawashima N, Liebes L, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004;58(3):862-70.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , Issue.3 , pp. 862-870
    • Demaria, S.1    Ng, B.2    Devitt, M.L.3    Babb, J.S.4    Kawashima, N.5    Liebes, L.6
  • 74
    • 84871694504 scopus 로고    scopus 로고
    • A systemic complete response of metastatic melanoma to local radiation and immunotherapy
    • Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, et al. A systemic complete response of metastatic melanoma to local radiation and immunotherapy. Transl Oncol 2012;5:404-7.
    • (2012) Transl Oncol , vol.5 , pp. 404-407
    • Hiniker, S.M.1    Chen, D.S.2    Reddy, S.3    Chang, D.T.4    Jones, J.C.5    Mollick, J.A.6
  • 75
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1:365-72.
    • (2013) Cancer Immunol Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 76
    • 84942108093 scopus 로고    scopus 로고
    • Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer
    • Epub ahead of print
    • Mondini M, Nizard M, Tran T, Mauge L, Loi M, Clémenson C, et al. Synergy of radiotherapy and a cancer vaccine for the treatment of HPV-associated head and neck cancer. Mol Cancer Ther 2015 [Epub ahead of print].
    • (2015) Mol Cancer Ther
    • Mondini, M.1    Nizard, M.2    Tran, T.3    Mauge, L.4    Loi, M.5    Clémenson, C.6
  • 77
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 78
    • 84875475811 scopus 로고    scopus 로고
    • Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma
    • Lyford-Pike S, Peng S, Young GD, et al. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res 2013;73:1733-41.
    • (2013) Cancer Res , vol.73 , pp. 1733-1741
    • Lyford-Pike, S.1    Peng, S.2    Young, G.D.3
  • 79
    • 84877061277 scopus 로고    scopus 로고
    • B7-H1 expression model for immune evasion in human papillomavirus-related oropharyngeal squamous cell carcinoma
    • Ukpo OC, Thorstad WL, Lewis Jr JS. B7-H1 expression model for immune evasion in human papillomavirus-related oropharyngeal squamous cell carcinoma. Head Neck Pathol 2013;7:113-21.
    • (2013) Head Neck Pathol , vol.7 , pp. 113-121
    • Ukpo, O.C.1    Thorstad, W.L.2    Lewis, J.S.3
  • 80
    • 84880062401 scopus 로고    scopus 로고
    • Mission impossible: how HPV-associated head and neck cancers escape a primed immune response
    • Pai SI. Mission impossible: how HPV-associated head and neck cancers escape a primed immune response. Oral Oncol 2013;49:723-5.
    • (2013) Oral Oncol , vol.49 , pp. 723-725
    • Pai, S.I.1
  • 81
    • 84958869074 scopus 로고    scopus 로고
    • NCT01693562
    • NCT01693562 ().
  • 82
    • 84907521155 scopus 로고    scopus 로고
    • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer
    • abstr 6011]
    • Seiwer TY, Burtness B, Weiss J, et al. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer. J Clin Oncol 2014;32:5s [suppl; abstr 6011].
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Seiwer, T.Y.1    Burtness, B.2    Weiss, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.