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Volumn 4, Issue 1, 2015, Pages 965570-

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma

Author keywords

CD8+ T lymphocytes; HNSCC; HPV; PD 1; Tim 3

Indexed keywords

CD123 ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD45 ANTIGEN; CXCL9 CHEMOKINE; CYCLOOXYGENASE 2; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 4; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MESSENGER RNA; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; RANTES; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; T CELL IMMUNOGLOBULIN AND MUCIN PROTEIN 3; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84938717670     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/21624011.2014.965570     Document Type: Article
Times cited : (203)

References (55)
  • 2
    • 77953820020 scopus 로고    scopus 로고
    • The role of human papillomavirus in head and neck cancer
    • 20553531
    • C.B.Lajer, C.von Buchwald. The role of human papillomavirus in head and neck cancer. APMIS 2010; 118:510-9; PMID:20553531; dx.doi.org/10.1111/j.1600-0463.2010.02624.x
    • (2010) APMIS , vol.118 , pp. 510-519
    • Lajer, C.B.1    von Buchwald, C.2
  • 3
    • 34247331367 scopus 로고    scopus 로고
    • High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma
    • 17179101
    • L.Licitra, F.Perrone, P.Bossi, S.Suardi, L.Mariani, R.Artusi, M.Oggionni, C.Rossini, G.Cantu, M.Squadrelli High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 2006; 24:5630-6; PMID:17179101; dx.doi.org/10.1200/JCO.2005.04.6136
    • (2006) J Clin Oncol , vol.24 , pp. 5630-5636
    • Licitra, L.1    Perrone, F.2    Bossi, P.3    Suardi, S.4    Mariani, L.5    Artusi, R.6    Oggionni, M.7    Rossini, C.8    Cantu, G.9    Squadrelli, M.10
  • 4
    • 65349173893 scopus 로고    scopus 로고
    • Effect of HPV-associated p16INK4 A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    • 19289615
    • P.Lassen, J.G.Eriksen, S.Hamilton-Dutoit, T.Tramm, J.Alsner, J.Overgaard. Effect of HPV-associated p16INK4 A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009; 27:1992-8; PMID:19289615; dx.doi.org/10.1200/JCO.2008.20.2853
    • (2009) J Clin Oncol , vol.27 , pp. 1992-1998
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3    Tramm, T.4    Alsner, J.5    Overgaard, J.6
  • 5
    • 73249140737 scopus 로고    scopus 로고
    • Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer
    • 19917928
    • W.C.Spanos, P.Nowicki, D.W.Lee, A.Hoover, B.Hostager, A.Gupta, M.E.Anderson, J.H.Lee. Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer. Arch Otolaryngol Head Neck Surg 2009; 135:1137-46; PMID:19917928; dx.doi.org/10.1001/archoto.2009.159
    • (2009) Arch Otolaryngol Head Neck Surg , vol.135 , pp. 1137-1146
    • Spanos, W.C.1    Nowicki, P.2    Lee, D.W.3    Hoover, A.4    Hostager, B.5    Gupta, A.6    Anderson, M.E.7    Lee, J.H.8
  • 8
    • 0029925375 scopus 로고    scopus 로고
    • Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
    • 8608507
    • C.G.Clemente, M.C.MihmJr, R.Bufalino, S.Zurrida, P.Collini, N.Cascinelli. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996; 77:1303-10; PMID:8608507; dx.doi.org/10.1002/(SICI)1097-0142(19960401)77:7%3c1303::AID-CNCR12%3e3.0.CO;2-5
    • (1996) Cancer , vol.77 , pp. 1303-1310
    • Clemente, C.G.1    Mihm, M.C.2    Bufalino, R.3    Zurrida, S.4    Collini, P.5    Cascinelli, N.6
  • 10
    • 80054092555 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence
    • 21884745
    • P.Kocian, M.Sedivcova, J.Drgac, K.Cerna, J.Hoch, R.Kodet, J.Bartunkova, R.Spisek, A.Fialova. Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence. Hum Immunol 2011; 72:1022-8; PMID:21884745; dx.doi.org/10.1016/j.humimm.2011.07.312
    • (2011) Hum Immunol , vol.72 , pp. 1022-1028
    • Kocian, P.1    Sedivcova, M.2    Drgac, J.3    Cerna, K.4    Hoch, J.5    Kodet, R.6    Bartunkova, J.7    Spisek, R.8    Fialova, A.9
  • 11
    • 53149083361 scopus 로고    scopus 로고
    • Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer
    • 18671239
    • O.Kawai, G.Ishii, K.Kubota, Y.Murata, Y.Naito, T.Mizuno, K.Aokage, N.Saijo, Y.Nishiwaki, A.Gemma Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer. Cancer 2008; 113:1387-95; PMID:18671239; dx.doi.org/10.1002/cncr.23712
    • (2008) Cancer , vol.113 , pp. 1387-1395
    • Kawai, O.1    Ishii, G.2    Kubota, K.3    Murata, Y.4    Naito, Y.5    Mizuno, T.6    Aokage, K.7    Saijo, N.8    Nishiwaki, Y.9    Gemma, A.10
  • 14
    • 84879286045 scopus 로고    scopus 로고
    • CD8(+) and CD4(+) tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma
    • 23571147
    • C.Nordfors, N.Grun, N.Tertipis, A.Ahrlund-Richter, L.Haeggblom, L.Sivars, J.Du, T.Nyberg, L.Marklund, E.Munck-Wikland CD8(+) and CD4(+) tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma. Eur J Cancer 2013; 49:2522-30; PMID:23571147; dx.doi.org/10.1016/j.ejca.2013.03.019
    • (2013) Eur J Cancer , vol.49 , pp. 2522-2530
    • Nordfors, C.1    Grun, N.2    Tertipis, N.3    Ahrlund-Richter, A.4    Haeggblom, L.5    Sivars, L.6    Du, J.7    Nyberg, T.8    Marklund, L.9    Munck-Wikland, E.10
  • 15
    • 84872872011 scopus 로고    scopus 로고
    • Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells
    • 22865582
    • A.Fialova, S.Partlova, L.Sojka, H.Hromadkova, T.Brtnicky, J.Fucikova, P.Kocian, L.Rob, J.Bartunkova, R.Spisek. Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells. Int J Cancer 2013; 132:1070-9; PMID:22865582; dx.doi.org/10.1002/ijc.27759
    • (2013) Int J Cancer , vol.132 , pp. 1070-1079
    • Fialova, A.1    Partlova, S.2    Sojka, L.3    Hromadkova, H.4    Brtnicky, T.5    Fucikova, J.6    Kocian, P.7    Rob, L.8    Bartunkova, J.9    Spisek, R.10
  • 20
    • 38449103549 scopus 로고    scopus 로고
    • Utility of tumour-infiltrating CD25+FOXP3+ regulatory T cell evaluation in predicting local recurrence in vertical growth phase cutaneous melanoma
    • 17914561
    • C.Miracco, V.Mourmouras, M.Biagioli, P.Rubegni, S.Mannucci, I.Monciatti, E.Cosci, P.Tosi, P.Luzi. Utility of tumour-infiltrating CD25+FOXP3+ regulatory T cell evaluation in predicting local recurrence in vertical growth phase cutaneous melanoma. Oncol Rep 2007; 18:1115-22; PMID:17914561; dx.doi.org/10.3892/or.18.5.1115
    • (2007) Oncol Rep , vol.18 , pp. 1115-1122
    • Miracco, C.1    Mourmouras, V.2    Biagioli, M.3    Rubegni, P.4    Mannucci, S.5    Monciatti, I.6    Cosci, E.7    Tosi, P.8    Luzi, P.9
  • 21
    • 56649102194 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target
    • 18820666
    • S.D.Bohling, K.H.Allison. Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target. Mod Pathol 2008; 21:1527-32; PMID:18820666; dx.doi.org/10.1038/modpathol.2008.160
    • (2008) Mod Pathol , vol.21 , pp. 1527-1532
    • Bohling, S.D.1    Allison, K.H.2
  • 22
    • 33749317518 scopus 로고    scopus 로고
    • Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    • 17000676
    • N.Hiraoka, K.Onozato, T.Kosuge, S.Hirohashi. Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006; 12:5423-34; PMID:17000676; dx.doi.org/10.1158/1078-0432.CCR-06-0369
    • (2006) Clin Cancer Res , vol.12 , pp. 5423-5434
    • Hiraoka, N.1    Onozato, K.2    Kosuge, T.3    Hirohashi, S.4
  • 23
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • 19064967
    • P.Salama, M.Phillips, F.Grieu, M.Morris, N.Zeps, D.Joseph, C.Platell, B.Iacopetta. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27:186-92; PMID:19064967; dx.doi.org/10.1200/JCO.2008.18.7229
    • (2009) J Clin Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3    Morris, M.4    Zeps, N.5    Joseph, D.6    Platell, C.7    Iacopetta, B.8
  • 26
    • 84870241436 scopus 로고    scopus 로고
    • Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma
    • 22815199
    • L.Bron, C.Jandus, S.Andrejevic-Blant, D.E.Speiser, P.Monnier, P.Romero, J.P.Rivals. Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma. Int J Cancer 2013; 132:E85-93; PMID:22815199; dx.doi.org/10.1002/ijc.27728
    • (2013) Int J Cancer , vol.132 , pp. 85-93
    • Bron, L.1    Jandus, C.2    Andrejevic-Blant, S.3    Speiser, D.E.4    Monnier, P.5    Romero, P.6    Rivals, J.P.7
  • 27
    • 39749146990 scopus 로고    scopus 로고
    • Prognostic value of CD25 expression on lymphocytes and tumor cells in squamous-cell carcinoma of the head and neck
    • 18298326
    • D.Loose, A.Signore, E.Bonanno, H.Vermeersch, R.Dierckx, P.Deron,C. Van de Wiele. Prognostic value of CD25 expression on lymphocytes and tumor cells in squamous-cell carcinoma of the head and neck. Cancer Biother Radiopharm 2008; 23:25-33; PMID:18298326; dx.doi.org/10.1089/cbr.2007.0373
    • (2008) Cancer Biother Radiopharm , vol.23 , pp. 25-33
    • Loose, D.1    Signore, A.2    Bonanno, E.3    Vermeersch, H.4    Dierckx, R.5    Deron, P.6    Van de Wiele, C.7
  • 33
    • 77956187379 scopus 로고    scopus 로고
    • Squamous carcinoma cells influence monocyte phenotype and suppress lipopolysaccharide-induced TNF-alpha in monocytes
    • 20084448
    • A.Lam-ubol, D.Hopkin, E.M.Letuchy, Z.B.Kurago. Squamous carcinoma cells influence monocyte phenotype and suppress lipopolysaccharide-induced TNF-alpha in monocytes. Inflammation 2010; 33:207-23; PMID:20084448; dx.doi.org/10.1007/s10753-009-9175-6
    • (2010) Inflammation , vol.33 , pp. 207-223
    • Lam-ubol, A.1    Hopkin, D.2    Letuchy, E.M.3    Kurago, Z.B.4
  • 34
    • 33847628325 scopus 로고    scopus 로고
    • Humoral immunity, inflammation and cancer
    • 17276050
    • T.T.Tan, L.M.Coussens. Humoral immunity, inflammation and cancer. Curr Opin Immunol 2007; 19:209-16; PMID:17276050; dx.doi.org/10.1016/j.coi.2007.01.001
    • (2007) Curr Opin Immunol , vol.19 , pp. 209-216
    • Tan, T.T.1    Coussens, L.M.2
  • 35
    • 33847789122 scopus 로고    scopus 로고
    • + CD16+ blood monocytes: their role in infection and inflammation
    • 17135573
    • + CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 2007; 81:584-92; PMID:17135573; dx.doi.org/10.1189/jlb.0806510
    • (2007) J Leukoc Biol , vol.81 , pp. 584-592
    • Ziegler-Heitbrock, L.1
  • 36
    • 84875266788 scopus 로고    scopus 로고
    • Dendritic Cells (DC) facilitate detachment of squamous carcinoma cells (SCC), while SCC promote an immature CD16(+) DC phenotype and control DC migration
    • 21809059
    • L.V.Ramanathapuram, D.Hopkin, Z.B.Kurago. Dendritic Cells (DC) facilitate detachment of squamous carcinoma cells (SCC), while SCC promote an immature CD16(+) DC phenotype and control DC migration. Cancer Microenviron 2013; 6:41-55; PMID:21809059; dx.doi.org/10.1007/s12307-011-0077-4
    • (2013) Cancer Microenviron , vol.6 , pp. 41-55
    • Ramanathapuram, L.V.1    Hopkin, D.2    Kurago, Z.B.3
  • 39
    • 0037416171 scopus 로고    scopus 로고
    • Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen
    • 12615900
    • J.Alferink, I.Lieberam, W.Reindl, A.Behrens, S.Weiss, N.Huser, K.Gerauer, R.Ross, A.B.Reske-Kunz, P.Ahmad-Nejad Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med 2003; 197:585-99; PMID:12615900; dx.doi.org/10.1084/jem.20021859
    • (2003) J Exp Med , vol.197 , pp. 585-599
    • Alferink, J.1    Lieberam, I.2    Reindl, W.3    Behrens, A.4    Weiss, S.5    Huser, N.6    Gerauer, K.7    Ross, R.8    Reske-Kunz, A.B.9    Ahmad-Nejad, P.10
  • 40
    • 0035496616 scopus 로고    scopus 로고
    • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    • 11900248
    • R.A.Gupta, R.N.Dubois. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001; 1:11-21; PMID:11900248; dx.doi.org/10.1038/35094017
    • (2001) Nat Rev Cancer , vol.1 , pp. 11-21
    • Gupta, R.A.1    Dubois, R.N.2
  • 41
    • 0034947506 scopus 로고    scopus 로고
    • Cyclooxygenase-2: a target for the prevention and treatment of breast cancer
    • 11397667
    • L.R.Howe, K.Subbaramaiah, A.M.Brown, A.J.Dannenberg. Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. Endocr Relat Cancer 2001; 8:97-114; PMID:11397667; dx.doi.org/10.1677/erc.0.0080097
    • (2001) Endocr Relat Cancer , vol.8 , pp. 97-114
    • Howe, L.R.1    Subbaramaiah, K.2    Brown, A.M.3    Dannenberg, A.J.4
  • 43
    • 33846465547 scopus 로고    scopus 로고
    • Immunostimulatory monoclonal antibodies for cancer therapy
    • 17251916
    • I.Melero, S.Hervas-Stubbs, M.Glennie, D.M.Pardoll, L.Chen. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 2007; 7:95-106; PMID:17251916; dx.doi.org/10.1038/nrc2051
    • (2007) Nat Rev Cancer , vol.7 , pp. 95-106
    • Melero, I.1    Hervas-Stubbs, S.2    Glennie, M.3    Pardoll, D.M.4    Chen, L.5
  • 44
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • 19433785
    • S.N.Mueller, R.Ahmed. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci USA 2009; 106:8623-8; PMID:19433785; dx.doi.org/10.1073/pnas.0809818106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 45
    • 77949357362 scopus 로고    scopus 로고
    • T-cell exhaustion: characteristics, causes and conversion
    • 20201977
    • J.S.Yi, M.A.Cox, A.J.Zajac. T-cell exhaustion: characteristics, causes and conversion. Immunology 2010; 129:474-81; PMID:20201977; dx.doi.org/10.1111/j.1365-2567.2010.03255.x
    • (2010) Immunology , vol.129 , pp. 474-481
    • Yi, J.S.1    Cox, M.A.2    Zajac, A.J.3
  • 46
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • 21739672
    • E.J.Wherry. T cell exhaustion. Nat Immunol 2011; 12:492-9; PMID:21739672; dx.doi.org/10.1038/ni.2035
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 47
    • 84857159981 scopus 로고    scopus 로고
    • TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
    • 22363469
    • X.Gao, Y.Zhu, G.Li, H.Huang, G.Zhang, F.Wang, J.Sun, Q.Yang, X.Zhang, B.Lu. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One 2012; 7:e30676; PMID:22363469; dx.doi.org/10.1371/journal.pone.0030676
    • (2012) PLoS One , vol.7 , pp. 30676
    • Gao, X.1    Zhu, Y.2    Li, G.3    Huang, H.4    Zhang, G.5    Wang, F.6    Sun, J.7    Yang, Q.8    Zhang, X.9    Lu, B.10
  • 48
    • 84859701005 scopus 로고    scopus 로고
    • IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
    • 22426209
    • Z.Z.Yang, D.M.Grote, S.C.Ziesmer, T.Niki, M.Hirashima, A.J.Novak, T.E.Witzig, S.M.Ansell. IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J Clin Invest 2012; 122:1271-82; PMID:22426209; dx.doi.org/10.1172/JCI59806
    • (2012) J Clin Invest , vol.122 , pp. 1271-1282
    • Yang, Z.Z.1    Grote, D.M.2    Ziesmer, S.C.3    Niki, T.4    Hirashima, M.5    Novak, A.J.6    Witzig, T.E.7    Ansell, S.M.8
  • 52
    • 20144374287 scopus 로고    scopus 로고
    • HPV and other risk factors of oral cavityoropharyngeal cancer in the Czech Republic
    • 15888110
    • R.Tachezy, J.Klozar, M.Salakova, E.Smith, L.Turek, J.Betka, R.Kodet, E.Hamsikova. HPV and other risk factors of oral cavityoropharyngeal cancer in the Czech Republic. Oral Dis 2005; 11:181-5; PMID:15888110; dx.doi.org/10.1111/j.1601-0825.2005.01112.x
    • (2005) Oral Dis , vol.11 , pp. 181-185
    • Tachezy, R.1    Klozar, J.2    Salakova, M.3    Smith, E.4    Turek, L.5    Betka, J.6    Kodet, R.7    Hamsikova, E.8
  • 53
    • 0036197930 scopus 로고    scopus 로고
    • GP5+6 +PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes
    • 11880393
    • A.J.van den Brule, R.Pol, N.Fransen-Daalmeijer, L.M.Schouls, C.J.Meijer, P.J.Snijders. GP5+6 +PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes. J Clin Microbiol 2002; 40:779-87; PMID:11880393; dx.doi.org/10.1128/JCM.40.3.779-787.2002
    • (2002) J Clin Microbiol , vol.40 , pp. 779-787
    • van den Brule, A.J.1    Pol, R.2    Fransen-Daalmeijer, N.3    Schouls, L.M.4    Meijer, C.J.5    Snijders, P.J.6
  • 54
    • 0242348847 scopus 로고    scopus 로고
    • Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays
    • 12951209
    • P.E.Gravitt, C.Peyton, C.Wheeler, R.Apple, R.Higuchi, K.V.Shah. Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays. J Virol Methods 2003; 112:23-33; PMID:12951209; dx.doi.org/10.1016/S0166-0934(03)00186-1
    • (2003) J Virol Methods , vol.112 , pp. 23-33
    • Gravitt, P.E.1    Peyton, C.2    Wheeler, C.3    Apple, R.4    Higuchi, R.5    Shah, K.V.6


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