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Volumn 59, Issue 5, 2016, Pages 907-917

Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism

Author keywords

Dipeptidyl peptidase 4 inhibitors; GIP; GLP 1; Glucagon; Insulin; Review

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; ANTIDIABETIC AGENT;

EID: 84958777281     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3899-2     Document Type: Review
Times cited : (64)

References (102)
  • 1
    • 84896495719 scopus 로고    scopus 로고
    • Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
    • COI: 1:CAS:528:DC%2BC3sXhvFyqsbbE, PID: 24315620
    • Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 383:1068–1083
    • (2014) Lancet , vol.383 , pp. 1068-1083
    • Kahn, S.E.1    Cooper, M.E.2    Del Prato, S.3
  • 2
    • 0021918189 scopus 로고
    • Pathogenesis of impaired glucose tolerance and type II diabetes mellitus—current status
    • COI: 1:STN:280:DyaL2M3ks1CktA%3D%3D, PID: 3892914
    • Davidson MB (1985) Pathogenesis of impaired glucose tolerance and type II diabetes mellitus—current status. West J Med 142:219–229
    • (1985) West J Med , vol.142 , pp. 219-229
    • Davidson, M.B.1
  • 3
    • 0017099653 scopus 로고
    • Insulin rather than glucose homoeostasis in the pathophysiology of diabetes
    • COI: 1:CAS:528:DyaE28Xks1Sqt74%3D, PID: 73696
    • Turner RC, Holman RR (1976) Insulin rather than glucose homoeostasis in the pathophysiology of diabetes. Lancet 1:1272–1274
    • (1976) Lancet , vol.1 , pp. 1272-1274
    • Turner, R.C.1    Holman, R.R.2
  • 4
    • 77955657267 scopus 로고    scopus 로고
    • Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
    • COI: 1:CAS:528:DC%2BC3cXmsFyrs7w%3D, PID: 20361178
    • DeFronzo RA (2010) Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009. Diabetologia 53:1270–1287
    • (2010) Diabetologia , vol.53 , pp. 1270-1287
    • DeFronzo, R.A.1
  • 5
    • 79960915742 scopus 로고    scopus 로고
    • Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC3MXos1Ogt7o%3D, PID: 21547496
    • Foley JE, Bunck MC, Möller-Goede DL et al (2011) Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial. Diabetologia 54:1985–1991
    • (2011) Diabetologia , vol.54 , pp. 1985-1991
    • Foley, J.E.1    Bunck, M.C.2    Möller-Goede, D.L.3
  • 6
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: influence of glucagon-like peptide-1
    • COI: 1:CAS:528:DC%2BD2MXhtVSqtL3N, PID: 16132964
    • Dunning BE, Foley JE, Ahrén B (2005) Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 48:1700–1713
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahrén, B.3
  • 7
    • 70549113397 scopus 로고    scopus 로고
    • Role of glucotoxicity and lipotoxicity in the pathophysiology of type 2 diabetes mellitus and emerging treatment strategies
    • PID: 20002468
    • Del Prato S (2009) Role of glucotoxicity and lipotoxicity in the pathophysiology of type 2 diabetes mellitus and emerging treatment strategies. Diabet Med 26:1185–1192
    • (2009) Diabet Med , vol.26 , pp. 1185-1192
    • Del Prato, S.1
  • 8
    • 0021263283 scopus 로고
    • Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus
    • COI: 1:CAS:528:DyaL2cXksVyqu7g%3D, PID: 6373827
    • Bolli GB, Tsalikian E, Haymond MW, Cryer P, Gerich JE (1984) Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. J Clin Invest 73:1532–1541
    • (1984) J Clin Invest , vol.73 , pp. 1532-1541
    • Bolli, G.B.1    Tsalikian, E.2    Haymond, M.W.3    Cryer, P.4    Gerich, J.E.5
  • 9
    • 0026596851 scopus 로고
    • Antidiabetic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus
    • Gutnaik M, Ørskov C, Holst JJ, Ahrén B, Efendić S (1992) Antidiabetic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med 326:1316–1322
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutnaik, M.1    Ørskov, C.2    Holst, J.J.3    Ahrén, B.4    Efendić, S.5
  • 10
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-l by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • COI: 1:CAS:528:DyaK2MXktlOnurw%3D, PID: 7883856
    • Deacon CF, Johnsen AH, Holst JJ (1995) Degradation of glucagon-like peptide-l by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80:952–957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 12
    • 33947690115 scopus 로고    scopus 로고
    • Discovery of JANUVIA (sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXlsFersrY%3D, PID: 17352677
    • Thornberry NA, Weber AE (2007) Discovery of JANUVIA (sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem 7:557–568
    • (2007) Curr Top Med Chem , vol.7 , pp. 557-568
    • Thornberry, N.A.1    Weber, A.E.2
  • 13
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • PID: 11978683
    • Ahrén B, Simonsson E, Larsson H et al (2002) Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes. Diabetes Care 25:869–875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1    Simonsson, E.2    Larsson, H.3
  • 14
    • 84917673108 scopus 로고    scopus 로고
    • A review of gliptins for 2014
    • COI: 1:CAS:528:DC%2BC2cXitV2ntr3O
    • Scheen AJ (2015) A review of gliptins for 2014. Exp Opin Pharmacother 16:43–62
    • (2015) Exp Opin Pharmacother , vol.16 , pp. 43-62
    • Scheen, A.J.1
  • 15
    • 84918528393 scopus 로고    scopus 로고
    • DPP-4 inhibitors: focus on safety
    • COI: 1:CAS:528:DC%2BC2cXitFahtLjN
    • Tella SH, Rendell MS (2015) DPP-4 inhibitors: focus on safety. Exp Opin Drug Saf 14:127–140
    • (2015) Exp Opin Drug Saf , vol.14 , pp. 127-140
    • Tella, S.H.1    Rendell, M.S.2
  • 16
    • 84896545458 scopus 로고    scopus 로고
    • DPP-4 inhibitors as therapeutic modulators of immune cell function and associated cardiovascular and renal insulin resistance in obesity and diabetes
    • COI: 1:CAS:528:DC%2BC3sXntV2iurk%3D, PID: 23946724
    • Aroor A, McKarns S, Nistala R et al (2013) DPP-4 inhibitors as therapeutic modulators of immune cell function and associated cardiovascular and renal insulin resistance in obesity and diabetes. Cardiorenal Med 3:48–56
    • (2013) Cardiorenal Med , vol.3 , pp. 48-56
    • Aroor, A.1    McKarns, S.2    Nistala, R.3
  • 17
    • 84884250098 scopus 로고    scopus 로고
    • Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism
    • Ceccarelli E, Guarino EG, Meriotti D et al (2013) Beyond glycemic control in diabetes mellitus: effects of incretin-based therapies on bone metabolism. Front Endocrinol 4:73
    • (2013) Front Endocrinol , vol.4 , pp. 73
    • Ceccarelli, E.1    Guarino, E.G.2    Meriotti, D.3
  • 18
    • 84865576863 scopus 로고    scopus 로고
    • Renal and cardiac effects of DPP4 inhibitors—from preclinical development to clinical research
    • COI: 1:CAS:528:DC%2BC3sXktF2ktbk%3D, PID: 22947920
    • Hocher B, Reichetzeder C, Alter ML (2012) Renal and cardiac effects of DPP4 inhibitors—from preclinical development to clinical research. Kidney Blood Press Res 36:65–84
    • (2012) Kidney Blood Press Res , vol.36 , pp. 65-84
    • Hocher, B.1    Reichetzeder, C.2    Alter, M.L.3
  • 19
    • 23044487247 scopus 로고    scopus 로고
    • Improved meal-related β-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    • PID: 16043735
    • Ahrén B, Pacini G, Foley JE, Schweizer A (2005) Improved meal-related β-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year. Diabetes Care 28:1936–1940
    • (2005) Diabetes Care , vol.28 , pp. 1936-1940
    • Ahrén, B.1    Pacini, G.2    Foley, J.E.3    Schweizer, A.4
  • 20
    • 34147208931 scopus 로고    scopus 로고
    • Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT
    • COI: 1:CAS:528:DC%2BD2sXlsVKktbw%3D, PID: 17442688
    • He YL, Wang Y, Bullock JM et al (2007) Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT. J Clin Pharmacol 47:633–641
    • (2007) J Clin Pharmacol , vol.47 , pp. 633-641
    • He, Y.L.1    Wang, Y.2    Bullock, J.M.3
  • 21
    • 84905019254 scopus 로고    scopus 로고
    • Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin
    • COI: 1:CAS:528:DC%2BC2cXhtlOrs77I, PID: 24647737
    • Wu T, Ma J, Bound MJ et al (2014) Effects of sitagliptin on glycemia, incretin hormones, and antropyloroduodenal motility in response to intraduodenal glucose infusion in healthy lean and obese humans and patients with type 2 diabetes treated with or without metformin. Diabetes 63:2776–2787
    • (2014) Diabetes , vol.63 , pp. 2776-2787
    • Wu, T.1    Ma, J.2    Bound, M.J.3
  • 22
    • 77952083721 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXmslCiu7o%3D, PID: 20415693
    • Williams-Herman D, Johnson J, Teng R et al (2010) Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes. Diabetes Obes Metab 12:442–451
    • (2010) Diabetes Obes Metab , vol.12 , pp. 442-451
    • Williams-Herman, D.1    Johnson, J.2    Teng, R.3
  • 23
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28Xht1WhurnK, PID: 16912128
    • Herman GA, Bergman A, Stevens C et al (2006) Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 91:4612–4619
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 24
    • 70349333861 scopus 로고    scopus 로고
    • Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXhtFCgsLfK, PID: 19650754
    • Rosenstock J, Aguilar-Salinas C, Klein E et al (2009) Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin 25:2401–2411
    • (2009) Curr Med Res Opin , vol.25 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3
  • 25
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • COI: 1:CAS:528:DC%2BD1MXht1agtrzF, PID: 19478198
    • DeFronzo RA, Hissa MN, Garber AJ et al (2009) The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care 32:1649–1655
    • (2009) Diabetes Care , vol.32 , pp. 1649-1655
    • DeFronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3
  • 26
    • 52249090472 scopus 로고    scopus 로고
    • Robust improvements in fasting and prandial measures of β-cell function with vildagliptin in drug-naïve patients: analysis of pooled vildagliptin monotherapy database
    • COI: 1:CAS:528:DC%2BD1cXht1KltbfF, PID: 18093207
    • Pratley RE, Schweizer A, Rosenstock J et al (2008) Robust improvements in fasting and prandial measures of β-cell function with vildagliptin in drug-naïve patients: analysis of pooled vildagliptin monotherapy database. Diabetes Obes Metab 10:931–938
    • (2008) Diabetes Obes Metab , vol.10 , pp. 931-938
    • Pratley, R.E.1    Schweizer, A.2    Rosenstock, J.3
  • 27
    • 84920606469 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice
    • COI: 1:CAS:528:DC%2BC2cXhsFagsLbM, PID: 25195070
    • Wu YJ, Guo X, Li CJ et al (2015) Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism 64:226–235
    • (2015) Metabolism , vol.64 , pp. 226-235
    • Wu, Y.J.1    Guo, X.2    Li, C.J.3
  • 28
    • 78751562877 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and pioglitazone on glycemic control and measures of β-cell function in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXjt1WqtLo%3D, PID: 21235696
    • Yoon KH, Shockey GR, Teng R et al (2011) Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and pioglitazone on glycemic control and measures of β-cell function in patients with type 2 diabetes. Int J Clin Pract 65:154–164
    • (2011) Int J Clin Pract , vol.65 , pp. 154-164
    • Yoon, K.H.1    Shockey, G.R.2    Teng, R.3
  • 29
    • 84906047371 scopus 로고    scopus 로고
    • Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes
    • PID: 24947443
    • Sjöstrand M, Iqbal N, Lu J, Hirshberg B (2014) Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes. Diabetes Res Clin Pract 105:185–191
    • (2014) Diabetes Res Clin Pract , vol.105 , pp. 185-191
    • Sjöstrand, M.1    Iqbal, N.2    Lu, J.3    Hirshberg, B.4
  • 30
    • 38149110484 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor vildagliptin improves β-cell function and insulin sensitivity in subjects with impaired fasting glucose
    • COI: 1:CAS:528:DC%2BD1cXhs1ejt7w%3D, PID: 17909087
    • Utzschneider KM, Tong J, Montgomery B et al (2008) The dipeptidyl peptidase-4 inhibitor vildagliptin improves β-cell function and insulin sensitivity in subjects with impaired fasting glucose. Diabetes Care 31:108–113
    • (2008) Diabetes Care , vol.31 , pp. 108-113
    • Utzschneider, K.M.1    Tong, J.2    Montgomery, B.3
  • 31
    • 77954866977 scopus 로고    scopus 로고
    • The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose
    • COI: 1:CAS:528:DC%2BC3cXhtFSmtb7M
    • Bock G, Dalla Man C, Micheletto F et al (2010) The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose. Clin Endocrinol 73:189–196
    • (2010) Clin Endocrinol , vol.73 , pp. 189-196
    • Bock, G.1    Dalla Man, C.2    Micheletto, F.3
  • 32
    • 58149385790 scopus 로고    scopus 로고
    • Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes
    • PID: 18957505
    • D’Alessio DA, Denney AM, Hermiller LM et al (2009) Treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin improves fasting islet-cell function in subjects with type 2 diabetes. J Clin Endocrinol Metab 94:81–88
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 81-88
    • D’Alessio, D.A.1    Denney, A.M.2    Hermiller, L.M.3
  • 33
    • 79953871128 scopus 로고    scopus 로고
    • Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXltF2qt70%3D, PID: 21239518
    • Vardarli I, Nauck MA, Köthe LD et al (2011) Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes. J Clin Endocrinol Metab 96:945–954
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 945-954
    • Vardarli, I.1    Nauck, M.A.2    Köthe, L.D.3
  • 34
    • 77954380946 scopus 로고    scopus 로고
    • Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC3cXltVahtr8%3D, PID: 20380653
    • Aaboe K, Knop FK, Vilsbøll T et al (2010) Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. Diabetes Obes Metab 12:323–333
    • (2010) Diabetes Obes Metab , vol.12 , pp. 323-333
    • Aaboe, K.1    Knop, F.K.2    Vilsbøll, T.3
  • 35
    • 84893035432 scopus 로고    scopus 로고
    • Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose
    • COI: 1:CAS:528:DC%2BC2cXhvVSrsLY%3D, PID: 24186866
    • Vardarli I, Arndt E, Deacon CF, Holst JJ, Nauck MA (2014) Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and "isoglycemic" intravenous glucose. Diabetes 63:663–674
    • (2014) Diabetes , vol.63 , pp. 663-674
    • Vardarli, I.1    Arndt, E.2    Deacon, C.F.3    Holst, J.J.4    Nauck, M.A.5
  • 36
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
    • COI: 1:CAS:528:DC%2BD1cXhs1ejtrg%3D, PID: 17947341
    • Rosenstock J, Foley JE, Rendell M et al (2008) Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care 31:30–35
    • (2008) Diabetes Care , vol.31 , pp. 30-35
    • Rosenstock, J.1    Foley, J.E.2    Rendell, M.3
  • 37
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BD2sXksVSrsbw%3D, PID: 17244786
    • Balas B, Baig MR, Watson C et al (2007) The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. J Clin Endocrinol Metab 92:1249–1255
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 38
    • 53549129604 scopus 로고    scopus 로고
    • Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia
    • COI: 1:CAS:528:DC%2BD1cXhsVeqsb7M, PID: 18355325
    • Scherbaum WA, Schweizer A, Mari A et al (2008) Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes Metab 10:1114–1124
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1114-1124
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3
  • 39
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • COI: 1:CAS:528:DC%2BD2sXkvVOgu78%3D, PID: 17277036
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ (2007) Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 30:890–895
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 40
    • 54249106294 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    • COI: 1:CAS:528:DC%2BD1cXhsVeqsLfI, PID: 18284434
    • Garber AJ, Foley JE, Banerji MA et al (2008) Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab 10:1047–1056
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1047-1056
    • Garber, A.J.1    Foley, J.E.2    Banerji, M.A.3
  • 41
    • 83655163721 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin and metformin on β-cell function in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhvFOmsLc%3D, PID: 22050786
    • Williams-Herman D, Xu L, Teng R et al (2012) Effect of initial combination therapy with sitagliptin and metformin on β-cell function in patients with type 2 diabetes. Diabetes Obes Metab 14:67–76
    • (2012) Diabetes Obes Metab , vol.14 , pp. 67-76
    • Williams-Herman, D.1    Xu, L.2    Teng, R.3
  • 42
    • 23844463766 scopus 로고    scopus 로고
    • Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2MXnvVWksL0%3D, PID: 15886245
    • Mari A, Sallas WM, He YL et al (2005) Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes. J Clin Endocrinol Metab 90:4888–4894
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4888-4894
    • Mari, A.1    Sallas, W.M.2    He, Y.L.3
  • 43
    • 38149137991 scopus 로고    scopus 로고
    • Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia
    • COI: 1:CAS:528:DC%2BD1cXnsVyjsQ%3D%3D, PID: 17925336
    • Mari A, Scherbaum WA, Nilsson PM et al (2008) Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia. J Clin Endocrinol Metab 93:103–109
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 103-109
    • Mari, A.1    Scherbaum, W.A.2    Nilsson, P.M.3
  • 44
    • 84908254009 scopus 로고    scopus 로고
    • β-Cell function in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXht1Kqs7rK, PID: 25070616
    • Ferrannini E, Mari A (2014) β-Cell function in type 2 diabetes. Metabolism 63:1217–1227
    • (2014) Metabolism , vol.63 , pp. 1217-1227
    • Ferrannini, E.1    Mari, A.2
  • 45
    • 35948941910 scopus 로고    scopus 로고
    • The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
    • COI: 1:CAS:528:DC%2BD2sXhtlartbzM, PID: 17698900
    • El-Ouaghlidi A, Rehring E, Holst JJ et al (2007) The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion. J Clin Endocrinol Metab 92:4165–4171
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4165-4171
    • El-Ouaghlidi, A.1    Rehring, E.2    Holst, J.J.3
  • 46
    • 84864802728 scopus 로고    scopus 로고
    • Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhtlGnt7fF, PID: 22685234
    • Muscelli E, Casolaro A, Gastaldelli A et al (2012) Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes. J Clin Endocrinol Metab 97:2818–2826
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2818-2826
    • Muscelli, E.1    Casolaro, A.2    Gastaldelli, A.3
  • 47
    • 73349119110 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes
    • PID: 20092585
    • Vilsbøll T, Rosenstock J, Yki-Järvinen H et al (2010) Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 12:167–177
    • (2010) Diabetes Obes Metab , vol.12 , pp. 167-177
    • Vilsbøll, T.1    Rosenstock, J.2    Yki-Järvinen, H.3
  • 48
    • 84899487884 scopus 로고    scopus 로고
    • The effect of alogliptin and pioglitazone combination on various aspects of β-cell function in patients with recent-onset type 2 diabetes
    • PID: 24421302
    • van Raalte DH, van Genugten RE, Eliasson B et al (2014) The effect of alogliptin and pioglitazone combination on various aspects of β-cell function in patients with recent-onset type 2 diabetes. Eur J Endocrinol 170:565–574
    • (2014) Eur J Endocrinol , vol.170 , pp. 565-574
    • van Raalte, D.H.1    van Genugten, R.E.2    Eliasson, B.3
  • 49
    • 53549130683 scopus 로고    scopus 로고
    • An examination of β-cell function measures and their potential use for estimating beta-cell mass
    • Kahn SE, Carr DB, Faulenbach MV, Utzschneider KM (2008) An examination of β-cell function measures and their potential use for estimating beta-cell mass. Diabetes Obes Metab 10(Suppl 4):63–76
    • (2008) Diabetes Obes Metab , vol.10 , pp. 63-76
    • Kahn, S.E.1    Carr, D.B.2    Faulenbach, M.V.3    Utzschneider, K.M.4
  • 50
    • 84879914429 scopus 로고    scopus 로고
    • Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase 4 inhibitor vildagliptin in an advanced age diet induced obesity mouse model
    • COI: 1:CAS:528:DC%2BC3sXhtVyrurzM, PID: 23636640
    • Omar BA, Vikman J, Sörhede Winzell M et al (2013) Enhanced beta cell function and anti-inflammatory effect after chronic treatment with the dipeptidyl peptidase 4 inhibitor vildagliptin in an advanced age diet induced obesity mouse model. Diabetologia 56:1752–1760
    • (2013) Diabetologia , vol.56 , pp. 1752-1760
    • Omar, B.A.1    Vikman, J.2    Sörhede Winzell, M.3
  • 51
    • 77956162063 scopus 로고    scopus 로고
    • Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin
    • COI: 1:CAS:528:DC%2BC3cXht12mtrrO, PID: 20920044
    • Retnakaran R, Qi Y, Opsteen C, Vivero E, Zinman B (2010) Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin. Diabetes Obes Metab 12:909–915
    • (2010) Diabetes Obes Metab , vol.12 , pp. 909-915
    • Retnakaran, R.1    Qi, Y.2    Opsteen, C.3    Vivero, E.4    Zinman, B.5
  • 52
    • 65249095686 scopus 로고    scopus 로고
    • Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    • PID: 19174497
    • Ahrén B, Schweizer A, Dejager S et al (2009) Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes. J Clin Endocrinol Metab 94:1236–1243
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1236-1243
    • Ahrén, B.1    Schweizer, A.2    Dejager, S.3
  • 53
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXjs1SrtL8%3D, PID: 17300594
    • Brazg R, Xu L, Dalla Man C, Cobelli C, Thomas K, Stein PP (2007) Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab 9:186–193
    • (2007) Diabetes Obes Metab , vol.9 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla Man, C.3    Cobelli, C.4    Thomas, K.5    Stein, P.P.6
  • 54
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial
    • PID: 21205122
    • Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle HJ, Dugi KA (2011) Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab 13:258–267
    • (2011) Diabetes Obes Metab , vol.13 , pp. 258-267
    • Del Prato, S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.J.5    Dugi, K.A.6
  • 55
    • 84926501101 scopus 로고    scopus 로고
    • Glucagon—early breakthroughs and recent discoveries
    • PID: 25814364
    • Ahrén B (2015) Glucagon—early breakthroughs and recent discoveries. Peptides 67:74–81
    • (2015) Peptides , vol.67 , pp. 74-81
    • Ahrén, B.1
  • 56
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • PID: 15126524
    • Ahrén B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A (2004) Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 89:2078–2084
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2078-2084
    • Ahrén, B.1    Landin-Olsson, M.2    Jansson, P.A.3    Svensson, M.4    Holmes, D.5    Schweizer, A.6
  • 57
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXltlamsr8%3D, PID: 17303799
    • Vella A, Bock G, Giesler PD et al (2007) Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes. Diabetes 56:1475–1480
    • (2007) Diabetes , vol.56 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3
  • 58
    • 39049141231 scopus 로고    scopus 로고
    • Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXit1SntLo%3D, PID: 18042650
    • Azuma K, Rádiková Z, Mancino J et al (2008) Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. J Clin Endocrinol Metab 93:459–464
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 459-464
    • Azuma, K.1    Rádiková, Z.2    Mancino, J.3
  • 59
    • 64549119188 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes
    • PID: 18931099
    • Man CD, Bock G, Giesler PD et al (2009) Dipeptidyl peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes. Diabetes Care 32:14–18
    • (2009) Diabetes Care , vol.32 , pp. 14-18
    • Man, C.D.1    Bock, G.2    Giesler, P.D.3
  • 60
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study
    • COI: 1:CAS:528:DC%2BD1cXhsVKmt73K, PID: 18786299
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L (2008) Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin 24:2943–2952
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • DeFronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 61
    • 84917742055 scopus 로고    scopus 로고
    • Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy
    • PID: 25370334
    • Hansen L, Jobal N, Ekholm E, Cook W, Hirschberg B (2014) Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy. Endocr Pract 20:1187–1197
    • (2014) Endocr Pract , vol.20 , pp. 1187-1197
    • Hansen, L.1    Jobal, N.2    Ekholm, E.3    Cook, W.4    Hirschberg, B.5
  • 62
    • 77953055922 scopus 로고    scopus 로고
    • Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    • PID: 20067974
    • Ahrén B, Foley JE, Ferrannini E et al (2010) Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Diabetes Care 33:730–732
    • (2010) Diabetes Care , vol.33 , pp. 730-732
    • Ahrén, B.1    Foley, J.E.2    Ferrannini, E.3
  • 63
    • 0038574573 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    • COI: 1:CAS:528:DC%2BD3sXkvFyjtrk%3D, PID: 12764578
    • Meier JJ, Gallwitz B, Siepmann N et al (2003) Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. Diabetologia 46:798–801
    • (2003) Diabetologia , vol.46 , pp. 798-801
    • Meier, J.J.1    Gallwitz, B.2    Siepmann, N.3
  • 64
    • 0038121744 scopus 로고    scopus 로고
    • Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
    • PID: 12832099
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ (2003) Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul Pept 114:115–121
    • (2003) Regul Pept , vol.114 , pp. 115-121
    • Vilsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 65
    • 20044394745 scopus 로고    scopus 로고
    • Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic α-cells
    • COI: 1:CAS:528:DC%2BD2MXltVait7k%3D, PID: 15919801
    • Ravier MA, Rutter GA (2005) Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic α-cells. Diabetes 54:1789–1797
    • (2005) Diabetes , vol.54 , pp. 1789-1797
    • Ravier, M.A.1    Rutter, G.A.2
  • 66
    • 54049099230 scopus 로고    scopus 로고
    • Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtlKhsrvJ, PID: 18597213
    • Foley JE, Ligueros-Saylan M, He YL (2008) Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes. Horm Metab Res 40:727–730
    • (2008) Horm Metab Res , vol.40 , pp. 727-730
    • Foley, J.E.1    Ligueros-Saylan, M.2    He, Y.L.3
  • 67
    • 84867238377 scopus 로고    scopus 로고
    • Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes
    • COI: 1:CAS:528:DC%2BC38XhsFKkurfN, PID: 22855332
    • Farngren J, Persson M, Schweizer A, Foley JE, Ahrén B (2012) Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes. J Clin Endocrinol Metab 97:3799–3806
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3799-3806
    • Farngren, J.1    Persson, M.2    Schweizer, A.3    Foley, J.E.4    Ahrén, B.5
  • 68
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • COI: 1:CAS:528:DC%2BD1cXhtlCjs7zM, PID: 18795252
    • de Heer J, Rasmussen C, Coy DH, Holst JJ (2008) Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51:2263–2270
    • (2008) Diabetologia , vol.51 , pp. 2263-2270
    • de Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 69
    • 84905725690 scopus 로고    scopus 로고
    • Glucagon dynamics during hypoglycemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhtlKjtL%2FE
    • Farngren J, Persson M, Schweizer A, Foley JE, Ahrén B (2014) Glucagon dynamics during hypoglycemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes. Diabet Obes Metab 16:812–818
    • (2014) Diabet Obes Metab , vol.16 , pp. 812-818
    • Farngren, J.1    Persson, M.2    Schweizer, A.3    Foley, J.E.4    Ahrén, B.5
  • 70
    • 82255185915 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans
    • COI: 1:CAS:528:DC%2BC38XpvFOisA%3D%3D, PID: 21984584
    • Christensen M, Vedtofte L, Hot JJ, Vilsbøll T, Knop FK (2011) Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans. Diabetes 60:3103–3109
    • (2011) Diabetes , vol.60 , pp. 3103-3109
    • Christensen, M.1    Vedtofte, L.2    Hot, J.J.3    Vilsbøll, T.4    Knop, F.K.5
  • 71
    • 84939984312 scopus 로고    scopus 로고
    • DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP-glucagon counterregulatory axis in mice
    • COI: 1:CAS:528:DC%2BC2MXislGrsr8%3D, PID: 25660260
    • Malmgren S, Ahrén B (2015) DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP-glucagon counterregulatory axis in mice. Diabetologia 58:1091–1099
    • (2015) Diabetologia , vol.58 , pp. 1091-1099
    • Malmgren, S.1    Ahrén, B.2
  • 72
    • 79960710589 scopus 로고    scopus 로고
    • Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice
    • PID: 21673098
    • Waget A, Cabout C, Masseboeuf M et al (2011) Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology 152:3018–3029
    • (2011) Endocrinology , vol.152 , pp. 3018-3029
    • Waget, A.1    Cabout, C.2    Masseboeuf, M.3
  • 73
    • 0030033930 scopus 로고    scopus 로고
    • Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects
    • COI: 1:CAS:528:DyaK28Xhtlaju70%3D, PID: 8550823
    • Taylor R, Magnusson I, Rothman DL et al (1996) Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest 97:126–132
    • (1996) J Clin Invest , vol.97 , pp. 126-132
    • Taylor, R.1    Magnusson, I.2    Rothman, D.L.3
  • 74
    • 84891784779 scopus 로고    scopus 로고
    • Mechanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes: a double-tracer study
    • COI: 1:CAS:528:DC%2BC2cXhtV2is7nN, PID: 23579178
    • Solis-Herrera C, Triplitt C, Garduno-Garcia Jde J, Adams J, DeFronzo RA, Cersosimo E (2013) Mechanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes: a double-tracer study. Diabetes Care 36:2756–2762
    • (2013) Diabetes Care , vol.36 , pp. 2756-2762
    • Solis-Herrera, C.1    Triplitt, C.2    Garduno-Garcia Jde, J.3    Adams, J.4    DeFronzo, R.A.5    Cersosimo, E.6
  • 75
    • 84927642882 scopus 로고    scopus 로고
    • Effect of vildagliptin on hepatic steatosis
    • COI: 1:CAS:528:DC%2BC2MXmsFaisbc%3D, PID: 25664602
    • Macauley M, Hollingsworth KG, Smith FE et al (2015) Effect of vildagliptin on hepatic steatosis. J Clin Endocrinol Metab 100:1578–1585
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 1578-1585
    • Macauley, M.1    Hollingsworth, K.G.2    Smith, F.E.3
  • 76
    • 84879186130 scopus 로고    scopus 로고
    • Clinical evidence and mechanistic basis for vildagliptin’s effect in combination with insulin
    • COI: 1:CAS:528:DC%2BC3sXjsFShsb0%3D, PID: 23431062
    • Schweizer A, Foley JE, Kothny W, Ahrén B (2013) Clinical evidence and mechanistic basis for vildagliptin’s effect in combination with insulin. Vasc Health Risk Manag 9:57–64
    • (2013) Vasc Health Risk Manag , vol.9 , pp. 57-64
    • Schweizer, A.1    Foley, J.E.2    Kothny, W.3    Ahrén, B.4
  • 77
    • 84918588644 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (DPP-4): localization and activity in human and rodent islets
    • COI: 1:CAS:528:DC%2BC2cXhs1Gqt7rJ
    • Liu L, Omar B, Marchetti P, Ahrén B (2014) Dipeptidyl peptidase-4 (DPP-4): localization and activity in human and rodent islets. Biochem Biophys Res Comun 453:398–404
    • (2014) Biochem Biophys Res Comun , vol.453 , pp. 398-404
    • Liu, L.1    Omar, B.2    Marchetti, P.3    Ahrén, B.4
  • 78
    • 84868193842 scopus 로고    scopus 로고
    • A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
    • COI: 1:CAS:528:DC%2BC38XhsF2qt7zO, PID: 22965295
    • Marchetti P, Lupi R, Bugliani M et al (2012) A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia 55:3262–3272
    • (2012) Diabetologia , vol.55 , pp. 3262-3272
    • Marchetti, P.1    Lupi, R.2    Bugliani, M.3
  • 79
    • 84905576401 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from type 2 diabetic individuals
    • COI: 1:CAS:528:DC%2BC2cXhtVSgsrnK, PID: 24939431
    • Omar BA, Liehua L, Yamada Y, Seino Y, Marchetti P, Ahrén B (2014) Dipeptidyl peptidase-4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from type 2 diabetic individuals. Diabetologia 57:1876–1883
    • (2014) Diabetologia , vol.57 , pp. 1876-1883
    • Omar, B.A.1    Liehua, L.2    Yamada, Y.3    Seino, Y.4    Marchetti, P.5    Ahrén, B.6
  • 80
    • 84879919203 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization
    • COI: 1:CAS:528:DC%2BC3sXhtFChsr%2FL, PID: 23633194
    • Shah P, Ardestani A, Dharmadhikari G et al (2013) The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization. J Clin Endocrinol Metab 98:E1163–E1172
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1163-E1172
    • Shah, P.1    Ardestani, A.2    Dharmadhikari, G.3
  • 81
    • 62349138180 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BD1MXjt1Wmtr4%3D, PID: 19088168
    • Boschmann M, Engeli S, Dobberstein K et al (2009) Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients. J Clin Endocrinol Metab 94:846–852
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 846-852
    • Boschmann, M.1    Engeli, S.2    Dobberstein, K.3
  • 82
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XnslSitbo%3D, PID: 16816950
    • Matikainen N, Mänttäri S, Schweizer A et al (2006) Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia 49:2049–2057
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Mänttäri, S.2    Schweizer, A.3
  • 83
    • 79951933599 scopus 로고    scopus 로고
    • Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXktlylu7s%3D, PID: 21226820
    • Tremblay AJ, Lamarche B, Deacon CF, Weisnagel SJ, Couture P (2011) Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. Diabetes Obes Metab 13:366–373
    • (2011) Diabetes Obes Metab , vol.13 , pp. 366-373
    • Tremblay, A.J.1    Lamarche, B.2    Deacon, C.F.3    Weisnagel, S.J.4    Couture, P.5
  • 84
    • 84859463659 scopus 로고    scopus 로고
    • Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study
    • COI: 1:CAS:528:DC%2BC38Xjs1Sjsrw%3D, PID: 22237690
    • Eliasson B, Möller-Goede D, Eeg-Olofsson K et al (2012) Lowering of postprandial lipids in individuals with type 2 diabetes treated with alogliptin and/or pioglitazone: a randomised double-blind placebo-controlled study. Diabetologia 55:915–925
    • (2012) Diabetologia , vol.55 , pp. 915-925
    • Eliasson, B.1    Möller-Goede, D.2    Eeg-Olofsson, K.3
  • 85
    • 84920063295 scopus 로고    scopus 로고
    • Comparison between sitagliptin and nateglinide on postprandial lipid levels: The STANDARD study
    • PID: 23493856
    • Kojima Y, Kaga H, Hayashi S et al (2013) Comparison between sitagliptin and nateglinide on postprandial lipid levels: The STANDARD study. World J Diabetes 4:8–13
    • (2013) World J Diabetes , vol.4 , pp. 8-13
    • Kojima, Y.1    Kaga, H.2    Hayashi, S.3
  • 86
    • 84903170699 scopus 로고    scopus 로고
    • Sitagliptin, a DPP-4 inhibitor, acutely inhibits intestinal lipoprotein particle secretion in healthy humans
    • PID: 24584549
    • Xiao C, Dash S, Morgantini C, Patterson BW, Lewis GF (2014) Sitagliptin, a DPP-4 inhibitor, acutely inhibits intestinal lipoprotein particle secretion in healthy humans. Diabetes 63:2394–2401
    • (2014) Diabetes , vol.63 , pp. 2394-2401
    • Xiao, C.1    Dash, S.2    Morgantini, C.3    Patterson, B.W.4    Lewis, G.F.5
  • 87
    • 78649713954 scopus 로고    scopus 로고
    • Weight neutrality with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience
    • COI: 1:CAS:528:DC%2BC3cXos12ntbo%3D, PID: 20730070
    • Foley JE, Jordan J (2010) Weight neutrality with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience. Vasc Health Risk Manag 6:541–548
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 541-548
    • Foley, J.E.1    Jordan, J.2
  • 88
    • 77956231970 scopus 로고    scopus 로고
    • One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress
    • COI: 1:CAS:528:DC%2BC3cXhtFams77N, PID: 20494360
    • Bunck MC, Cornér A, Eliasson B et al (2010) One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress. Atherosclerosis 212:223–229
    • (2010) Atherosclerosis , vol.212 , pp. 223-229
    • Bunck, M.C.1    Cornér, A.2    Eliasson, B.3
  • 89
    • 84878047441 scopus 로고    scopus 로고
    • The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhtFWqt77L, PID: 23215876
    • Matikainen N, Taskinen MR (2013) The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with type 2 diabetes. Diabet Med 30:756–757
    • (2013) Diabet Med , vol.30 , pp. 756-757
    • Matikainen, N.1    Taskinen, M.R.2
  • 90
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c
    • Ferre P, Foufelle F (2010) Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 12(Suppl 2):82–93
    • (2010) Diabetes Obes Metab , vol.12 , pp. 82-93
    • Ferre, P.1    Foufelle, F.2
  • 91
    • 54049137296 scopus 로고    scopus 로고
    • The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled crossover study
    • COI: 1:CAS:528:DC%2BD1cXhsVeqsLnN
    • Vella A, Bock G, Giesler PD et al (2008) The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled crossover study. Clin Endocrinol 69:737–744
    • (2008) Clin Endocrinol , vol.69 , pp. 737-744
    • Vella, A.1    Bock, G.2    Giesler, P.D.3
  • 92
    • 84897445343 scopus 로고    scopus 로고
    • Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels
    • COI: 1:CAS:528:DC%2BC2cXhtFSmt7bL, PID: 24389993
    • Aoki K, Kamiyama H, Masuda K et al (2014) Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels. Endocr J 61:249–256
    • (2014) Endocr J , vol.61 , pp. 249-256
    • Aoki, K.1    Kamiyama, H.2    Masuda, K.3
  • 93
    • 84886050803 scopus 로고    scopus 로고
    • Effects of a d-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhtF2jtbvL, PID: 23359361
    • Wu T, Bound MJ, Zhao BR et al (2013) Effects of a d-xylose preload with or without sitagliptin on gastric emptying, glucagon-like peptide-1, and postprandial glycemia in type 2 diabetes. Diabetes Care 36:1913–1918
    • (2013) Diabetes Care , vol.36 , pp. 1913-1918
    • Wu, T.1    Bound, M.J.2    Zhao, B.R.3
  • 94
    • 84863988113 scopus 로고    scopus 로고
    • The effects of sitagliptin on gastric emptying in healthy humans—a randomized, controlled study
    • COI: 1:CAS:528:DC%2BC38XhsVans7zE, PID: 22738299
    • Stevens JE, Horowitz M, Deacon CF, Nauck M, Rayner CK, Jones KL (2012) The effects of sitagliptin on gastric emptying in healthy humans—a randomized, controlled study. Aliment Pharmacol Ther 36:379–390
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 379-390
    • Stevens, J.E.1    Horowitz, M.2    Deacon, C.F.3    Nauck, M.4    Rayner, C.K.5    Jones, K.L.6
  • 95
    • 76049105515 scopus 로고    scopus 로고
    • Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects
    • COI: 1:CAS:528:DC%2BC3cXjtlCqt7o%3D, PID: 20145424
    • Huang CL, Hsu CH, Huang KC, Su HY, Weng SF (2010) Preprandial single oral dose of sitagliptin does not affect circulating ghrelin and gastrin levels in normal subjects. Pharmacology 85:131–135
    • (2010) Pharmacology , vol.85 , pp. 131-135
    • Huang, C.L.1    Hsu, C.H.2    Huang, K.C.3    Su, H.Y.4    Weng, S.F.5
  • 96
    • 84937053742 scopus 로고    scopus 로고
    • Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXhtlKrtbnN, PID: 26052984
    • Green JB, Bethel MA, Armstrong PW et al (2015) Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 373:232–242
    • (2015) N Engl J Med , vol.373 , pp. 232-242
    • Green, J.B.1    Bethel, M.A.2    Armstrong, P.W.3
  • 97
    • 84861857806 scopus 로고    scopus 로고
    • The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
    • Jensen J, Rustad PI, Kolnes AJ, Lai YC (2011) The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol 2:1–11
    • (2011) Front Physiol , vol.2 , pp. 1-11
    • Jensen, J.1    Rustad, P.I.2    Kolnes, A.J.3    Lai, Y.C.4
  • 98
    • 84869798707 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial evaluating sitagliptin action on insulin resistance parameters and β-cell function
    • COI: 1:CAS:528:DC%2BC38Xhs1KmsrvL, PID: 23061989
    • Derosa G, Carbone A, D’Angelo A et al (2012) A randomized, double-blind, placebo-controlled trial evaluating sitagliptin action on insulin resistance parameters and β-cell function. Expert Opin Pharmacother 13:2433–2442
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 2433-2442
    • Derosa, G.1    Carbone, A.2    D’Angelo, A.3
  • 99
    • 84867400778 scopus 로고    scopus 로고
    • Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC38XosFWjur0%3D, PID: 22682949
    • Derosa G, Carbone A, Franzetti I et al (2012) Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients. Diabetes Res Clin Pract 98:51–60
    • (2012) Diabetes Res Clin Pract , vol.98 , pp. 51-60
    • Derosa, G.1    Carbone, A.2    Franzetti, I.3
  • 100
    • 84902546321 scopus 로고    scopus 로고
    • Vildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC2cXoslymtLY%3D, PID: 24874591
    • Derosa G, Bonaventura A, Bianchi L et al (2014) Vildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients. Metabolism 63:957–967
    • (2014) Metabolism , vol.63 , pp. 957-967
    • Derosa, G.1    Bonaventura, A.2    Bianchi, L.3
  • 101
    • 84922981838 scopus 로고    scopus 로고
    • New insights into the pathophysiology of dyslipemia in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXitl2qtrY%3D, PID: 25706066
    • Taskinen MR, Boren J (2015) New insights into the pathophysiology of dyslipemia in type 2 diabetes. Atherosclerosis 239:483–495
    • (2015) Atherosclerosis , vol.239 , pp. 483-495
    • Taskinen, M.R.1    Boren, J.2
  • 102
    • 84927172239 scopus 로고    scopus 로고
    • Changes in body weight after 24 weeks of vildagliptin therapy as a function of fasting glucose levels in patients with type 2 diabetes
    • PID: 25429228
    • Blüher M, Schweizer A, Bader G, Foley JE (2014) Changes in body weight after 24 weeks of vildagliptin therapy as a function of fasting glucose levels in patients with type 2 diabetes. Vasc Health Risk Manag 10:661–664
    • (2014) Vasc Health Risk Manag , vol.10 , pp. 661-664
    • Blüher, M.1    Schweizer, A.2    Bader, G.3    Foley, J.E.4


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