메뉴 건너뛰기




Volumn 36, Issue 1, 2012, Pages 65-84

Renal and cardiac effects of DPP-4 inhibitors - from preclinical development to clinical research

Author keywords

Acute renal failure; Cardiovascular effects; DDP 4 inhibition; Diabetes; Diabetic nephropathy; GLP 1; Kidney; Myocardial infarction

Indexed keywords

ALOGLIPTIN; CAPTOPRIL; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; HYDRALAZINE; ISOLEUCINE THIAZOLIDIDE; LINAGLIPTIN; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN;

EID: 84865576863     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000339028     Document Type: Review
Times cited : (128)

References (112)
  • 2
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH: Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-1431.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 7
    • 0014914649 scopus 로고
    • A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results
    • Meinert CL, Knatterud GL, Prout TE, Klimt CR: A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes 1970;19:S789-830.
    • (1970) Diabetes , vol.19
    • Meinert, C.L.1    Knatterud, G.L.2    Prout, T.E.3    Klimt, C.R.4
  • 8
    • 65549086517 scopus 로고    scopus 로고
    • Therapeutic targets to reduce cardiovascular disease in type 2 diabetes
    • DeSouza C, Fonseca V: Therapeutic targets to reduce cardiovascular disease in type 2 diabetes. Nat Rev Drug Discov 2009;8:361-367.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 361-367
    • Desouza, C.1    Fonseca, V.2
  • 9
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K: Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356:2457-2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 10
    • 33745957332 scopus 로고    scopus 로고
    • Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study
    • Kendall DM, Rubin CJ, Mohideen P, Ledeine J-M, Belder R, Gross J, Norwood P, O'Mahony M, Sall K, Sloan G, Roberts A, Fiedorek FT, DeFronzo RA: Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study. Diabetes Care 2006;29:1016-1023.
    • (2006) Diabetes Care , vol.29 , pp. 1016-1023
    • Kendall, D.M.1    Rubin, C.J.2    Mohideen, P.3    Ledeine, J.-M.4    Belder, R.5    Gross, J.6    Norwood, P.7    O'Mahony, M.8    Sall, K.9    Sloan, G.10    Roberts, A.11    Fiedorek, F.T.12    Defronzo, R.A.13
  • 16
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drugnaïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S: Efficacy and tolerability of vildagliptin monotherapy in drugnaïve patients with type 2 diabetes. Diabetes Res Clin Pract 2007;76:132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 17
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ: Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007;30:890-895.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 18
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley RE, Jauffret-Kamel S, Galbreath E, Holmes D: Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 2006;38:423-428.
    • (2006) Horm Metab Res , vol.38 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3    Holmes, D.4
  • 20
    • 0037777695 scopus 로고    scopus 로고
    • 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    • Villhauer EB, Brinkman JA, Naderi GB, Burkey BF, Dunning BE, Prasad K, Mangold BL, Russell ME, Hughes TE: 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2- cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003;46:2774-2789.
    • (2003) J Med Chem , vol.46 , pp. 2774-2789
    • Villhauer, E.B.1    Brinkman, J.A.2    Naderi, G.B.3    Burkey, B.F.4    Dunning, B.E.5    Prasad, K.6    Mangold, B.L.7    Russell, M.E.8    Hughes, T.E.9
  • 21
    • 20444406121 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2- carbonitrile)
    • Brandt I, Joossens J, Chen X, Maes M-B, Scharpé S, De Meester I, Lambeir A-M: Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2- carbonitrile). Biochem Pharmacol 2005;70:134-143.
    • (2005) Biochem Pharmacol , vol.70 , pp. 134-143
    • Brandt, I.1    Joossens, J.2    Chen, X.3    Maes, M.-B.4    Scharpé, S.5    De Meester, I.6    Lambeir, A.-M.7
  • 24
    • 34548324787 scopus 로고    scopus 로고
    • The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers
    • He Y-L, Sadler BM, Sabo R, Balez S, Wang Y, Campestrini J, Laurent A, Ligueros-Saylan M, Howard D: The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers. Clin Pharmacokinet 2007;46:787-802.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 787-802
    • He, Y.-L.1    Sadler, B.M.2    Sabo, R.3    Balez, S.4    Wang, Y.5    Campestrini, J.6    Laurent, A.7    Ligueros-Saylan, M.8    Howard, D.9
  • 26
    • 41149118550 scopus 로고    scopus 로고
    • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl- quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M: (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2- ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 2008;325:175-182.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3    Tadayyon, M.4    Himmelsbach, F.5    Mark, M.6
  • 27
    • 67650799130 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
    • Graefe-Mody EU, Padula S, Ring A, Withopf B, Dugi KA: Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects. Curr Med Res Opin 2009;25:1963-1972.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1963-1972
    • Graefe-Mody, E.U.1    Padula, S.2    Ring, A.3    Withopf, B.4    Dugi, K.A.5
  • 28
    • 51849103389 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers
    • Hüttner S, Graefe-Mody EU, Withopf B, Ring A, Dugi KA: Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers. J Clin Pharmacol 2008;48:1171-1178.
    • (2008) J Clin Pharmacol , vol.48 , pp. 1171-1178
    • Hüttner, S.1    Graefe-Mody, E.U.2    Withopf, B.3    Ring, A.4    Dugi, K.A.5
  • 29
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    • Heise T, Graefe-Mody EU, Hüttner S, Ring A, Trommeshauser D, Dugi KA: Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients. Diabetes Obes Metab 2009;11:786-794.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 786-794
    • Heise, T.1    Graefe-Mody, E.U.2    Hüttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 30
    • 77950197593 scopus 로고    scopus 로고
    • The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans
    • Blech S, Ludwig-Schwellinger E, Gräfe-Mody EU, Withopf B, Wagner K: The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. Drug Metab Dispos 2010;38:667-678.
    • (2010) Drug Metab Dispos , vol.38 , pp. 667-678
    • Blech, S.1    Ludwig-Schwellinger, E.2    Gräfe-Mody, E.U.3    Withopf, B.4    Wagner, K.5
  • 31
    • 58149247983 scopus 로고    scopus 로고
    • Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
    • Fuchs H, Tillement J-P, Urien S, Greischel A, Roth W: Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans. J Pharm Pharmacol 2009;61:55-62.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 55-62
    • Fuchs, H.1    Tillement, J.-P.2    Urien, S.3    Greischel, A.4    Roth, W.5
  • 32
    • 70549090031 scopus 로고    scopus 로고
    • Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356)-investigations in DPP-4 deficient and wildtype rats
    • Retlich S, Withopf B, Greischel A, Staab A, Jaehde U, Fuchs H: Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356)-investigations in DPP-4 deficient and wildtype rats. Biopharm Drug Dispos 2009;30:422-436.
    • (2009) Biopharm Drug Dispos , vol.30 , pp. 422-436
    • Retlich, S.1    Withopf, B.2    Greischel, A.3    Staab, A.4    Jaehde, U.5    Fuchs, H.6
  • 35
    • 79956336684 scopus 로고    scopus 로고
    • Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects
    • Patel CG, Kornhauser D, Vachharajani N, Komoroski B, Brenner E, Handschuh del Corral M, Li L, Boulton DW: Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects. Diabetes Obes Metab 2011;13:604-614.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 604-614
    • Patel, C.G.1    Kornhauser, D.2    Vachharajani, N.3    Komoroski, B.4    Brenner, E.5    Handschuh Del-Corral, M.6    Li, L.7    Boulton, D.W.8
  • 36
    • 77951702763 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of once-Daily oral doses of saxagliptin for 2 weeks in type 2 diabetic and healthy subjects
    • Boulton D, Geraldes M: Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Once-Daily Oral Doses of Saxagliptin for 2 Weeks in Type 2 Diabetic and Healthy Subjects. in: 67th Annual Scientific Sessions of the American Diabetes Association. 2007.
    • (2007) 67th Annual Scientific Sessions of the American Diabetes Association.
    • Boulton, D.1    Geraldes, M.2
  • 38
    • 46549083771 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys
    • Lee B, Shi L, Kassel DB, Asakawa T, Takeuchi K, Christopher RJ: Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Eur J Pharmacol 2008;589:306-314.
    • (2008) Eur J Pharmacol , vol.589 , pp. 306-314
    • Lee, B.1    Shi, L.2    Kassel, D.B.3    Asakawa, T.4    Takeuchi, K.5    Christopher, R.J.6
  • 39
    • 41649102998 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
    • Christopher R, Covington P, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A: Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects. Clin Ther 2008;30:513-527.
    • (2008) Clin Ther , vol.30 , pp. 513-527
    • Christopher, R.1    Covington, P.2    Davenport, M.3    Fleck, P.4    Mekki, Q.A.5    Wann, E.R.6    Karim, A.7
  • 40
    • 41649083174 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: A randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes
    • Covington P, Christopher R, Davenport M, Fleck P, Mekki QA, Wann ER, Karim A: Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes. Clin Ther 2008;30:499-512.
    • (2008) Clin Ther , vol.30 , pp. 499-512
    • Covington, P.1    Christopher, R.2    Davenport, M.3    Fleck, P.4    Mekki, Q.A.5    Wann, E.R.6    Karim, A.7
  • 41
    • 73649128872 scopus 로고    scopus 로고
    • Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: A two-phase, crossover study in healthy subjects
    • Karim A, Covington P, Christopher R, Davenport M, Fleck P, Li X, Wann E, Mekki Q: Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects. Int J Clin Pharmacol Ther 2010;48:46-58.
    • (2010) Int J Clin Pharmacol Ther , vol.48 , pp. 46-58
    • Karim, A.1    Covington, P.2    Christopher, R.3    Davenport, M.4    Fleck, P.5    Li, X.6    Wann, E.7    Mekki, Q.8
  • 43
    • 70349510604 scopus 로고    scopus 로고
    • Coadministration of pioglitazone or glyburide and alogliptin: Pharmacokinetic drug interaction assessment in healthy participants
    • Karim A, Laurent A, Munsaka M, Wann E, Fleck P, Mekki Q: Coadministration of pioglitazone or glyburide and alogliptin: pharmacokinetic drug interaction assessment in healthy participants. J Clin Pharmacol 2009;49:1210-1219.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1210-1219
    • Karim, A.1    Laurent, A.2    Munsaka, M.3    Wann, E.4    Fleck, P.5    Mekki, Q.6
  • 45
    • 79955480528 scopus 로고    scopus 로고
    • Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis
    • Matsui T, Nishino Y, Takeuchi M, Yamagishi S: Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis. Pharmacol Res 2011;63:383-388.
    • (2011) Pharmacol Res , vol.63 , pp. 383-388
    • Matsui, T.1    Nishino, Y.2    Takeuchi, M.3    Yamagishi, S.4
  • 52
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock BP, Heller RS, Habener JF: Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996;137:2968-2978.
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 53
    • 0030187992 scopus 로고    scopus 로고
    • Distribution of GLP-1 and PACAP receptors in human tissues
    • Wei Y, Mojsov S: Distribution of GLP-1 and PACAP receptors in human tissues. Acta Physiol Scand 1996;157:355-357.
    • (1996) Acta Physiol Scand , vol.157 , pp. 355-357
    • Wei, Y.1    Mojsov, S.2
  • 54
    • 45349103305 scopus 로고    scopus 로고
    • Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia
    • Huisamen B, Genade S, Lochner A: Signalling pathways activated by glucagon-like peptide-1 (7-36) amide in the rat heart and their role in protection against ischaemia. Cardiovasc J Afr 2008;19:77-83.
    • (2008) Cardiovasc J Afr , vol.19 , pp. 77-83
    • Huisamen, B.1    Genade, S.2    Lochner, A.3
  • 55
    • 79959966874 scopus 로고    scopus 로고
    • Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats
    • Huisamen B, Genis A, Marais E, Lochner A: Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats. Cardiovasc Drugs Ther 2011;25:13-20.
    • (2011) Cardiovasc Drugs Ther , vol.25 , pp. 13-20
    • Huisamen, B.1    Genis, A.2    Marais, E.3    Lochner, A.4
  • 56
    • 77955828386 scopus 로고    scopus 로고
    • Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats
    • Gardiner SM, March JE, Kemp PA, Bennett T, Baker DJ: Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats. Br J Pharmacol 2010;161:92-102.
    • (2010) Br J Pharmacol , vol.161 , pp. 92-102
    • Gardiner, S.M.1    March, J.E.2    Kemp, P.A.3    Bennett, T.4    Baker, D.J.5
  • 57
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP: Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 2006;12:694-699.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 59
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, Stolarski C, Shen Y, Shannon RP: Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004;110:955-961.
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.8    Shannon, R.P.9
  • 60
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, Shannon RP: Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109:962-965.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 61
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM: Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005;54:146-151.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 62
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • Sauvé M, Ban K, Momen MA, Zhou Y-Q, Henkelman RM, Husain M, Drucker DJ: Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice. Diabetes 2010;59:1063-1073.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauvé, M.1    Ban, K.2    Momen, M.A.3    Zhou, Y.-Q.4    Henkelman, R.M.5    Husain, M.6    Drucker, D.J.7
  • 63
    • 78649930490 scopus 로고    scopus 로고
    • GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats
    • Ku H-C, Chen W-P, Su M-J: GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats. Naunyn Schmiedebergs Arch Pharmacol 2010;382:463-474.
    • (2010) Naunyn Schmiedebergs Arch Pharmacol , vol.382 , pp. 463-474
    • Ku, H.-C.1    Chen, W.-P.2    Su, M.-J.3
  • 64
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz S-S, Drucker DJ, Husain M: Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008;117:2340-2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.-S.4    Drucker, D.J.5    Husain, M.6
  • 68
    • 84878587722 scopus 로고    scopus 로고
    • The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats
    • DOI: 10.1016/j.ijcard.2011.12.007
    • Hocher B, Sharkovska Y, Mark M, Klein T, Pfab T: The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Int J Cardiol DOI: 10.1016/j.ijcard.2011.12.007.
    • Int J Cardiol
    • Hocher, B.1    Sharkovska, Y.2    Mark, M.3    Klein, T.4    Pfab, T.5
  • 71
    • 78650023641 scopus 로고    scopus 로고
    • Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial)-rationale, design and first interim analysis
    • Theiss HD, Brenner C, Engelmann MG, Zaruba M-M, Huber B, Henschel V, Mansmann U, Wintersperger B, Reiser M, Steinbeck G, Franz W-M: Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial)-rationale, design and first interim analysis. Int J Cardiol 2010;145:282-284.
    • (2010) Int J Cardiol , vol.145 , pp. 282-284
    • Theiss, H.D.1    Brenner, C.2    Engelmann, M.G.3    Zaruba, M.-M.4    Huber, B.5    Henschel, V.6    Mansmann, U.7    Wintersperger, B.8    Reiser, M.9    Steinbeck, G.10    Franz, W.-M.11
  • 73
    • 36649012372 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure
    • Jackson EK, Dubinion JH, Mi Z: Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure. Clin Exp Pharmacol Physiol 2008;35:29-34.
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 29-34
    • Jackson, E.K.1    Dubinion, J.H.2    Mi, Z.3
  • 74
    • 0027494070 scopus 로고
    • Proteolytic processing of neuropeptide y and peptide YY by dipeptidyl peptidase IV
    • Mentlein R, Dahms P, Grandt D, Krüger R: Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul Pept 1993;49:133-144.
    • (1993) Regul Pept , vol.49 , pp. 133-144
    • Mentlein, R.1    Dahms, P.2    Grandt, D.3    Krüger, R.4
  • 75
    • 0037338622 scopus 로고    scopus 로고
    • Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes
    • Berglund MM, Hipskind PA, Gehlert DR: Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp Biol Med (Maywood) 2003;228:217-244.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 217-244
    • Berglund, M.M.1    Hipskind, P.A.2    Gehlert, D.R.3
  • 76
    • 33644984654 scopus 로고    scopus 로고
    • Pancreatic polypeptide-fold peptide receptors and angiotensin II-induced renal vasoconstriction
    • Dubinion JH, Mi Z, Zhu C, Gao L, Jackson EK: Pancreatic polypeptide-fold peptide receptors and angiotensin II-induced renal vasoconstriction. Hypertension 2006;47:545-551.
    • (2006) Hypertension , vol.47 , pp. 545-551
    • Dubinion, J.H.1    Mi, Z.2    Zhu, C.3    Gao, L.4    Jackson, E.K.5
  • 77
    • 77957231074 scopus 로고    scopus 로고
    • Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans
    • Marney A, Kunchakarra S, Byrne L, Brown NJ: Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 2010;56:728-733.
    • (2010) Hypertension , vol.56 , pp. 728-733
    • Marney, A.1    Kunchakarra, S.2    Byrne, L.3    Brown, N.J.4
  • 80
    • 34447103388 scopus 로고    scopus 로고
    • Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin
    • Yang J, Campitelli J, Hu G, Lin Y, Luo J, Xue C: Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci 2007;81:272-279.
    • (2007) Life Sci , vol.81 , pp. 272-279
    • Yang, J.1    Campitelli, J.2    Hu, G.3    Lin, Y.4    Luo, J.5    Xue, C.6
  • 81
    • 0027497013 scopus 로고
    • Interferon-gamma induces dipeptidylpeptidase IV expression in human glomerular epithelial cells
    • Stefanovic V, Ardaillou N, Vlahovic P, Placier S, Ronco P, Ardaillou R: Interferon-gamma induces dipeptidylpeptidase IV expression in human glomerular epithelial cells. Immunology 1993;80:465-470.
    • (1993) Immunology , vol.80 , pp. 465-470
    • Stefanovic, V.1    Ardaillou, N.2    Vlahovic, P.3    Placier, S.4    Ronco, P.5    Ardaillou, R.6
  • 82
    • 78650175802 scopus 로고    scopus 로고
    • Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
    • Vaghasiya J, Sheth N, Bhalodia Y, Manek R: Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regul Pept 2011;166:48-54.
    • (2011) Regul Pept , vol.166 , pp. 48-54
    • Vaghasiya, J.1    Sheth, N.2    Bhalodia, Y.3    Manek, R.4
  • 83
    • 0035824614 scopus 로고    scopus 로고
    • Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule
    • Girardi AC, Degray BC, Nagy T, Biemesderfer D, Aronson PS: Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule. J Biol Chem 2001;276:46671-46677.
    • (2001) J Biol Chem , vol.276 , pp. 46671-46677
    • Girardi, A.C.1    Degray, B.C.2    Nagy, T.3    Biemesderfer, D.4    Aronson, P.S.5
  • 85
    • 6044261454 scopus 로고    scopus 로고
    • Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells
    • Girardi ACC, Knauf F, Demuth H-U, Aronson PS: Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells. Am J Physiol, Cell Physiol 2004;287:C1238-1245.
    • (2004) Am J Physiol, Cell Physiol , vol.287
    • Girardi, A.C.C.1    Knauf, F.2    Demuth, H.-U.3    Aronson, P.S.4
  • 87
    • 71449111050 scopus 로고    scopus 로고
    • Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells
    • Carraro-Lacroix LR, Malnic G, Girardi ACC: Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. Am J Physiol Renal Physiol 2009;297:F1647-1655.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Carraro-Lacroix, L.R.1    Malnic, G.2    Girardi, A.C.C.3
  • 88
    • 77953846542 scopus 로고    scopus 로고
    • Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome
    • Tofovic DS, Bilan VP, Jackson EK: Sitagliptin augments angiotensin II-induced renal vasoconstriction in kidneys from rats with metabolic syndrome. Clin Exp Pharmacol Physiol 2010;37:689-691.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 689-691
    • Tofovic, D.S.1    Bilan, V.P.2    Jackson, E.K.3
  • 89
    • 45849115827 scopus 로고    scopus 로고
    • Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension
    • Jackson EK, Mi Z: Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension. Hypertension 2008;51:1637-1642.
    • (2008) Hypertension , vol.51 , pp. 1637-1642
    • Jackson, E.K.1    Mi, Z.2
  • 90
    • 35549004526 scopus 로고    scopus 로고
    • Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats
    • Jackson EK, Zhang M, Liu W, Mi Z: Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats. J Pharmacol Exp Ther 2007;323:431-437.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 431-437
    • Jackson, E.K.1    Zhang, M.2    Liu, W.3    Mi, Z.4
  • 91
    • 53349172746 scopus 로고    scopus 로고
    • Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use
    • Kao DP, Kohrt HE, Kugler J: Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use. Diabet Med 2008;25:1229-1230.
    • (2008) Diabet Med , vol.25 , pp. 1229-1230
    • Kao, D.P.1    Kohrt, H.E.2    Kugler, J.3
  • 92
    • 79960633962 scopus 로고    scopus 로고
    • Renal impairment with sitagliptin: Is there a need for active monitoring of potential renal toxicity?
    • Lestner JM, Baburaj R, Edwards CMB: Renal impairment with sitagliptin: is there a need for active monitoring of potential renal toxicity? Br J Hosp Med (Lond) 2011;72:412-413.
    • (2011) Br J Hosp Med (Lond) , vol.72 , pp. 412-413
    • Lestner, J.M.1    Baburaj, R.2    Edwards, C.M.B.3
  • 94
    • 30944468979 scopus 로고    scopus 로고
    • Hypertension and "microalbuminuria": The bell tolls for thee
    • Forman JP, Brenner BM: "Hypertension" and " microalbuminuria": the bell tolls for thee. Kidney Int 2006;69:22-28.
    • (2006) Kidney Int , vol.69 , pp. 22-28
    • Forman, J.P.1    Brenner, B.M.2
  • 95
    • 33645462551 scopus 로고    scopus 로고
    • Prevention and treatment of diabetic renal disease in type 2 diabetes: The BENEDICT study
    • Remuzzi G, Macia M, Ruggenenti P: Prevention and treatment of diabetic renal disease in type 2 diabetes: the BENEDICT study. J Am Soc Nephrol 2006;17:S90-97.
    • (2006) J Am Soc Nephrol , vol.17
    • Remuzzi, G.1    MacIa, M.2    Ruggenenti, P.3
  • 96
    • 70449382515 scopus 로고    scopus 로고
    • Pathogenesis and treatment of microalbuminuria in patients with diabetes: The road ahead
    • Kalaitzidis R, Bakris G: Pathogenesis and treatment of microalbuminuria in patients with diabetes: the road ahead. J Clin Hypertens (Greenwich) 2009;11:636-643.
    • (2009) J Clin Hypertens (Greenwich) , vol.11 , pp. 636-643
    • Kalaitzidis, R.1    Bakris, G.2
  • 97
    • 79953836889 scopus 로고    scopus 로고
    • Current strategies to achieve further cardiac and renal protection through enhanced renin-angiotensin-aldosterone system inhibition
    • Alfie J, Aparicio LS, Waisman GD: Current strategies to achieve further cardiac and renal protection through enhanced renin-angiotensin-aldosterone system inhibition. Rev Recent Clin Trials 2011;6:134-146.
    • (2011) Rev Recent Clin Trials , vol.6 , pp. 134-146
    • Alfie, J.1    Aparicio, L.S.2    Waisman, G.D.3
  • 99
    • 79251604529 scopus 로고    scopus 로고
    • Sitagliptin reduces albuminuria in patients with type 2 diabetes
    • Hattori S: Sitagliptin reduces albuminuria in patients with type 2 diabetes. Endocr J 2011;58:69-73.
    • (2011) Endocr J , vol.58 , pp. 69-73
    • Hattori, S.1
  • 101
    • 77950561809 scopus 로고    scopus 로고
    • Rationale and design of the trial evaluating cardiovascular outcomes with sitagliptin (TECOS)
    • Bethel M, Green J, Califf R, Holman R: Rationale and design of the trial evaluating cardiovascular outcomes with sitagliptin (TECOS). Diabetes 2009;58:2152.
    • (2009) Diabetes , vol.58 , pp. 2152
    • Bethel, M.1    Green, J.2    Califf, R.3    Holman, R.4
  • 102
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, Couturier A, Ligueros-Saylan M, Kothny W: Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes Metab 2010;12:485-494.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3    Couturier, A.4    Ligueros-Saylan, M.5    Kothny, W.6
  • 107
    • 80051775077 scopus 로고    scopus 로고
    • Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy
    • Chaykovska L, Tsuprykov O, Hocher B: Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy. Clin Lab 2011;57:455-467.
    • (2011) Clin Lab , vol.57 , pp. 455-467
    • Chaykovska, L.1    Tsuprykov, O.2    Hocher, B.3
  • 109
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme
    • Johansen OE, Neubacher D, von Eynatten M, Patel S, Woerle H-J: Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a phase 3 programme. Cardiovasc Diabetol 2012;11:3.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 3
    • Johansen, O.E.1    Neubacher, D.2    Von Eynatten, M.3    Patel, S.4    Woerle, H.-J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.