메뉴 건너뛰기




Volumn 63, Issue 7, 2014, Pages 2394-2401

Sitagliptin, a DPP-4 inhibitor, acutely inhibits intestinal lipoprotein particle secretion in healthy humans

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CHOLESTEROL; FATTY ACID; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LIPOPROTEIN; PLACEBO; SITAGLIPTIN; TRIACYLGLYCEROL;

EID: 84903170699     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1654     Document Type: Article
Times cited : (61)

References (46)
  • 1
    • 33644696797 scopus 로고    scopus 로고
    • Type 2 diabetes as a "coronary heart disease equivalent": An 18-year prospective population-based study in Finnish subjects
    • DOI 10.2337/diacare.28.12.2901
    • Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Type 2 diabetes as a "coronary heart disease equivalent": an 18-year prospective population-based study in Finnish subjects. Diabetes Care 2005;28:2901-2907 (Pubitemid 43942922)
    • (2005) Diabetes Care , vol.28 , Issue.12 , pp. 2901-2907
    • Juutilainen, A.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 2
    • 0033860359 scopus 로고    scopus 로고
    • Insulin resistance and cardiovascular disease
    • Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest 2000;106:453-458 (Pubitemid 30666377)
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.4 , pp. 453-458
    • Ginsberg, H.N.1
  • 3
    • 0028298168 scopus 로고
    • Dyslipidemia in non-insulin-dependent diabetes mellitus
    • DOI 10.1210/er.15.3.263
    • Howard BV, Howard WJ. Dyslipidemia in non-insulin-dependent diabetes mellitus. Endocr Rev 1994;15:263-274 (Pubitemid 24180787)
    • (1994) Endocrine Reviews , vol.15 , Issue.3 , pp. 263-274
    • Howard, B.V.1    Howard, W.J.2
  • 4
    • 34447511196 scopus 로고    scopus 로고
    • Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    • DOI 10.1001/jama.298.3.299
    • Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007;298:299-308 (Pubitemid 47080484)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.3 , pp. 299-308
    • Nordestgaard, B.G.1    Benn, M.2    Schnohr, P.3    Tybjaerg-Hansen, A.4
  • 7
    • 43249119219 scopus 로고    scopus 로고
    • Intestinal lipoprotein overproduction in insulin-resistant states
    • DOI 10.1097/MOL.0b013e3282ffaf82, PII 0004143320080600000002
    • Adeli K, Lewis GF. Intestinal lipoprotein overproduction in insulin-resistant states. Curr Opin Lipidol 2008;19:221-228 (Pubitemid 351653558)
    • (2008) Current Opinion in Lipidology , vol.19 , Issue.3 , pp. 221-228
    • Adeli, K.1    Lewis, G.F.2
  • 8
    • 0036595221 scopus 로고    scopus 로고
    • Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the framingham offspring study
    • DOI 10.2337/diacare.25.6.989
    • Schaefer EJ, McNamara JR, Shah PK, et al.; Framingham Offspring Study. Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study. Diabetes Care 2002;25:989-994 (Pubitemid 41110483)
    • (2002) Diabetes Care , vol.25 , Issue.6 , pp. 989-994
    • Schaefer, E.J.1    McNamara, J.R.2    Shah, P.K.3    Nakajima, K.4    Cupples, L.A.5    Ordovas, J.M.6    Wilson, P.W.F.7
  • 9
    • 34548155292 scopus 로고    scopus 로고
    • Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes
    • DOI 10.1194/jlr.M600548-JLR200
    • Hogue JC, Lamarche B, Tremblay AJ, Bergeron J, Gagné C, Couture P. Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes. J Lipid Res 2007;48:1336-1342 (Pubitemid 47312035)
    • (2007) Journal of Lipid Research , vol.48 , Issue.6 , pp. 1336-1342
    • Hogue, J.-C.1    Lamarche, B.2    Tremblay, A.J.3    Bergeron, J.4    Gagne, C.5    Couture, P.6
  • 10
    • 79551586089 scopus 로고    scopus 로고
    • Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans
    • Xiao C, Pavlic M, Szeto L, Patterson BW, Lewis GF. Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans. Diabetes 2011;60:383-390
    • (2011) Diabetes , vol.60 , pp. 383-390
    • Xiao, C.1    Pavlic, M.2    Szeto, L.3    Patterson, B.W.4    Lewis, G.F.5
  • 11
    • 77950363795 scopus 로고    scopus 로고
    • Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids
    • Pavlic M, Xiao C, Szeto L, Patterson BW, Lewis GF. Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids. Diabetes 2010;59:580-587
    • (2010) Diabetes , vol.59 , pp. 580-587
    • Pavlic, M.1    Xiao, C.2    Szeto, L.3    Patterson, B.W.4    Lewis, G.F.5
  • 12
    • 33745024354 scopus 로고    scopus 로고
    • Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans
    • DOI 10.1161/01.ATV.0000222015.76038.14, PII 0004360520060600000029
    • Duez H, Lamarche B, Uffelman KD, Valero R, Cohn JS, Lewis GF. Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans. Arterioscler Thromb Vasc Biol 2006;26:1357-1363 (Pubitemid 44305382)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.6 , pp. 1357-1363
    • Duez, H.1    Lamarche, B.2    Uffelman, K.D.3    Valero, R.4    Cohn, J.S.5    Lewis, G.F.6
  • 13
    • 43249122976 scopus 로고    scopus 로고
    • Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans
    • DOI 10.1161/CIRCULATIONAHA.107.739888
    • Duez H, Lamarche B, Valéro R, et al. Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans. Circulation 2008;117:2369-2376 (Pubitemid 351653555)
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2369-2376
    • Duez, H.1    Lamarche, B.2    Valero, R.3    Pavlic, M.4    Proctor, S.5    Xiao, C.6    Szeto, L.7    Patterson, B.W.8    Lewis, G.F.9
  • 14
    • 0027299436 scopus 로고
    • Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL ApoB production in normal weight and obese individuals
    • Lewis GF, Uffelman KD, Szeto LW, Steiner G. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 1993;42:833-842 (Pubitemid 23151575)
    • (1993) Diabetes , vol.42 , Issue.6 , pp. 833-842
    • Lewis, G.F.1    Uffelman, K.D.2    Szeto, L.W.3    Steiner, G.4
  • 15
    • 0028839110 scopus 로고
    • Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans
    • Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 1995;95:158-166
    • (1995) J Clin Invest , vol.95 , pp. 158-166
    • Lewis, G.F.1    Uffelman, K.D.2    Szeto, L.W.3    Weller, B.4    Steiner, G.5
  • 16
    • 84876291590 scopus 로고    scopus 로고
    • Novel role of enteral monosaccharides in intestinal lipoprotein production in healthy humans
    • Xiao C, Dash S, Morgantini C, Lewis GF. Novel role of enteral monosaccharides in intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol 2013;33:1056-1062
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1056-1062
    • Xiao, C.1    Dash, S.2    Morgantini, C.3    Lewis, G.F.4
  • 19
    • 34248223285 scopus 로고    scopus 로고
    • Biology of Incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-2157 (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 20
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009;5:262-269
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 21
    • 67049118921 scopus 로고    scopus 로고
    • Incretin therapies: Effects beyond glycemic control
    • Mudaliar S, Henry RR. Incretin therapies: effects beyond glycemic control. Am J Med 2009;122(Suppl.):S25-S36
    • (2009) Am J Med , vol.122 , Issue.SUPPL.
    • Mudaliar, S.1    Henry, R.R.2
  • 22
    • 84870276727 scopus 로고    scopus 로고
    • Mechanisms of incretin effects on plasma lipids and implications for the cardiovascular system
    • Xiao C, Dash S, Lewis GF. Mechanisms of incretin effects on plasma lipids and implications for the cardiovascular system. Cardiovasc Hematol Agents Med Chem 2012;10:289-294
    • (2012) Cardiovasc Hematol Agents Med Chem , vol.10 , pp. 289-294
    • Xiao, C.1    Dash, S.2    Lewis, G.F.3
  • 23
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • DURATION-1 Study Group
    • Buse JB, Drucker DJ, Taylor KL, et al.; DURATION-1 Study Group. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 2010;33:1255-1261
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 24
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • DURATION-1 Study Group
    • Drucker DJ, Buse JB, Taylor K, et al.; DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008;372:1240-1250
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 25
    • 79951933599 scopus 로고    scopus 로고
    • Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes
    • Tremblay AJ, Lamarche B, Deacon CF, Weisnagel SJ, Couture P. Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. Diabetes Obes Metab 2011;13:366-373
    • (2011) Diabetes Obes Metab , vol.13 , pp. 366-373
    • Tremblay, A.J.1    Lamarche, B.2    Deacon, C.F.3    Weisnagel, S.J.4    Couture, P.5
  • 26
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • DOI 10.1007/s00125-006-0340-2
    • Matikainen N, Mänttäri S, Schweizer A, et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia 2006;49:2049-2057 (Pubitemid 44168471)
    • (2006) Diabetologia , vol.49 , Issue.9 , pp. 2049-2057
    • Matikainen, N.1    Manttari, S.2    Schweizer, A.3    Ulvestad, A.4    Mills, D.5    Dunning, B.E.6    Foley, J.E.7    Taskinen, M.-R.8
  • 27
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • DOI 10.1007/s00125-005-0126-y
    • Meier JJ, Gethmann A, Götze O, et al. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia 2006;49:452-458 (Pubitemid 43277867)
    • (2006) Diabetologia , vol.49 , Issue.3 , pp. 452-458
    • Meier, J.J.1    Gethmann, A.2    Gotze, O.3    Gallwitz, B.4    Holst, J.J.5    Schmidt, W.E.6    Nauck, M.A.7
  • 28
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz EA, Koska J, Mullin MP, Syoufi I, Schwenke DC, Reaven PD. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis 2010;212:217-222
    • (2010) Atherosclerosis , vol.212 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3    Syoufi, I.4    Schwenke, D.C.5    Reaven, P.D.6
  • 29
    • 84861528676 scopus 로고    scopus 로고
    • Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans
    • Xiao C, Bandsma RH, Dash S, Szeto L, Lewis GF. Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans. Arterioscler Thromb Vasc Biol 2012;32:1513-1519
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1513-1519
    • Xiao, C.1    Bandsma, R.H.2    Dash, S.3    Szeto, L.4    Lewis, G.F.5
  • 30
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh J, Longuet C, Baker CL, et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 2010;53:552-561
    • (2010) Diabetologia , vol.53 , pp. 552-561
    • Hsieh, J.1    Longuet, C.2    Baker, C.L.3
  • 31
    • 84878047441 scopus 로고    scopus 로고
    • The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with type 2 diabetes
    • Matikainen N, Taskinen MR. The effect of vildagliptin therapy on atherogenic postprandial remnant particles and LDL particle size in subjects with type 2 diabetes. Diabet Med 2013;30:756-757
    • (2013) Diabet Med , vol.30 , pp. 756-757
    • Matikainen, N.1    Taskinen, M.R.2
  • 33
    • 0347360186 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4): A potential therapeutic for improved glycemic control of type 2 diabetes
    • DOI 10.1016/j.regpep.2003.10.028
    • Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept 2004;117:77-88 (Pubitemid 38045329)
    • (2004) Regulatory Peptides , vol.117 , Issue.2 , pp. 77-88
    • Nielsen, L.L.1    Young, A.A.2    Parkes, D.G.3
  • 34
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, crossover study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, crossover study. Curr Med Res Opin 2008;24:2943-2952
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • DeFronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 35
    • 0017227895 scopus 로고
    • Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin
    • Gerich JE, Lorenzi M, Bier DM, et al. Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin. J Clin Invest 1976;57:875-884
    • (1976) J Clin Invest , vol.57 , pp. 875-884
    • Gerich, J.E.1    Lorenzi, M.2    Bier, D.M.3
  • 36
    • 0020030089 scopus 로고
    • Somatostatin and the intestinal transport of glucose and other nutrients in the anaesthetised rat
    • Daumerie C, Henquin JC. Somatostatin and the intestinal transport of glucose and other nutrients in the anaesthetised rat. Gut 1982;23:140-145 (Pubitemid 12171871)
    • (1982) Gut , vol.23 , Issue.2 , pp. 140-145
    • Daumerie, C.1    Henquin, J.C.2
  • 38
    • 0842346386 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum
    • DOI 10.1016/j.regpep.2003.10.021
    • Hansen L, Hartmann B, Mineo H, Holst JJ. Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum. Regul Pept 2004;118:11-18 (Pubitemid 38167361)
    • (2004) Regulatory Peptides , vol.118 , Issue.1-2 , pp. 11-18
    • Hansen, L.1    Hartmann, B.2    Mineo, H.3    Holst, J.J.4
  • 40
    • 17644373076 scopus 로고    scopus 로고
    • GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats
    • Qin X, Shen H, Liu M, et al. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol 2005;288:G943- G949
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Qin, X.1    Shen, H.2    Liu, M.3
  • 41
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher JR, Drucker DJ. Cardiovascular biology of the incretin system. Endocr Rev 2012;33:187-215
    • (2012) Endocr Rev , vol.33 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 42
    • 0019407932 scopus 로고
    • Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs
    • Wasada T, McCorkle K, Harris V, Kawai K, Howard B, Unger RH. Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. J Clin Invest 1981;68:1106-1107 (Pubitemid 11023541)
    • (1981) Journal of Clinical Investigation , vol.68 , Issue.4 , pp. 1106-1107
    • Wasada, T.1    McCorkle, K.2    Harris, V.3
  • 43
    • 84896281396 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 acutely stimulates chylomicron release in healthy humans
    • Dash S, Xiao C, Morgantini C, Szeto L, Patterson BW, Lewis GF. Glucagon-like peptide-2 acutely stimulates chylomicron release in healthy humans. Diabetes 2013;62(Suppl. 1):A76
    • (2013) Diabetes , vol.62 , Issue.SUPPL. 1
    • Dash, S.1    Xiao, C.2    Morgantini, C.3    Szeto, L.4    Patterson, B.W.5    Lewis, G.F.6
  • 44
    • 84873023759 scopus 로고    scopus 로고
    • GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: Evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states
    • Hein GJ, Baker C, Hsieh J, Farr S, Adeli K. GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states. Diabetes 2013;62:373-381
    • (2013) Diabetes , vol.62 , pp. 373-381
    • Hein, G.J.1    Baker, C.2    Hsieh, J.3    Farr, S.4    Adeli, K.5
  • 45
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • EXAMINE Investigators
    • White WB, Cannon CP, Heller SR, et al.; EXAMINE Investigators. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 2013;369:1327-1335
    • (2013) N Engl J Med , vol.369 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 46
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • SAVOR-TIMI 53 Steering Committee and Investigators
    • Scirica BM, Bhatt DL, Braunwald E, et al.; SAVOR-TIMI 53 Steering Committee and Investigators. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369:1317-1326
    • (2013) N Engl J Med , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.