메뉴 건너뛰기




Volumn 14, Issue 1, 2015, Pages 127-140

DPP-4 inhibitors: Focus on safety

Author keywords

Alogliptin; Dipeptidyl peptidase 4 inhibitors; Glucagon like polypeptide 1; Linagliptin; Saxagliptin; Sitagliptin; Vildagliptin

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALOGLIPTIN; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; ATAZANAVIR; BIGUANIDE DERIVATIVE; CLARITHROMYCIN; DIGOXIN; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCAGON LIKE POLYPEPTIDE 1 AGONIST; HYPERGLYCEMIC AGENT; KETOCONAZOLE; LINAGLIPTIN; METFORMIN; PLACEBO; RIFAMPICIN; RITONAVIR; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN; WARFARIN; ANTIDIABETIC AGENT;

EID: 84918528393     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.977863     Document Type: Review
Times cited : (53)

References (144)
  • 1
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-65
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 2
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: Glp-1 and gip
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 3
    • 21744433419 scopus 로고    scopus 로고
    • Biological actions of the incretins gip and glp-1 and therapeutic perspectives in patients with type 2 diabetes
    • Gautier JF, Fetita S, Sobngwi E, et al. Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes Metab 2005;31(3 Pt 1):233-42
    • (2005) Diabetes Metab , vol.31 , Issue.3 , pp. 233-242
    • Gautier, J.F.1    Fetita, S.2    Sobngwi, E.3
  • 4
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip RG, Wolfe MM. GIP biology and fat metabolism. Life Sci 2000;66:91-103
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.1    Wolfe, M.M.2
  • 5
    • 0036687655 scopus 로고    scopus 로고
    • Mechanisms of mitogenic and antiapoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1) cells
    • Trümper A, Trümper K, Horsch D. Mechanisms of mitogenic and antiapoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1) cells. J Endocrinol 2002;174:233-46
    • (2002) J Endocrinol , vol.174 , pp. 233-246
    • Trümper, A.1    Trümper, K.2    Horsch, D.3
  • 6
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
    • Trümper A, Trümper K, Trusheim H, et al. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol Endocrinol 2001;15:1559-70
    • (2001) Mol Endocrinol , vol.15 , pp. 1559-1570
    • Trümper, A.1    Trümper, K.2    Trusheim, H.3
  • 7
    • 0017377640 scopus 로고
    • Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus
    • Ross SA, Brown JC, Dupré J. Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus. Diabetes 1977;26:525-9
    • (1977) Diabetes , vol.26 , pp. 525-529
    • Ross, S.A.1    Brown, J.C.2    Dupré, J.3
  • 8
    • 84891881674 scopus 로고    scopus 로고
    • Secretion of glucosedependent insulinotropic polypeptide in patients with type 2 diabetes systematic review and meta-analysis of clinical studies
    • Calanna S Christensen M, Holst JJ, Laferriere B, et al. Secretion of glucosedependent insulinotropic polypeptide in patients with type 2 Diabetes. Systematic review and meta-analysis of clinical studies. Diabetes Care 2013;36(10):3346-52
    • (2013) Diabetes Care , vol.36 , Issue.10 , pp. 3346-3352
    • Calanna, S.1    Christensen, M.2    Holst, J.J.3    Laferriere, B.4
  • 9
    • 82255185915 scopus 로고    scopus 로고
    • GIP: A bifunctional glucosedependent regulator of glucagon and insulin secretion in humans
    • Christensen M, Vedtofte L, Holst JJ, et al. GIP: a bifunctional glucosedependent regulator of glucagon and insulin secretion in humans. Diabetes 2011;60:3103-9
    • (2011) Diabetes , vol.60 , pp. 3103-3109
    • Christensen, M.1    Vedtofte, L.2    Holst, J.J.3
  • 10
    • 84918583757 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes
    • Christensen M, Calanna S, Sparre-Ulrich AH, et al. Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes. Diabetes 2014;63:1-7
    • (2014) Diabetes , vol.63 , pp. 1-7
    • Christensen, M.1    Calanna, S.2    Sparre-Ulrich, A.H.3
  • 11
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down?
    • Nauck MA, Verdari I, Deacon CF, et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?. Diabetologia 2011;54(1):10-18
    • (2011) Diabetologia , vol.54 , Issue.1 , pp. 10-18
    • Nauck, M.A.1    Verdari, I.2    Deacon, C.F.3
  • 12
    • 79961191559 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by incretins
    • Holst JJ, Christensen M, Lund A, et al. Regulation of glucagon secretion by incretins. Diabetes Obes Metab 2011;13(Suppl 1):89-94
    • (2011) Diabetes Obes Metab , vol.13 , pp. 89-94
    • Holst, J.J.1    Christensen, M.2    Lund, A.3
  • 13
    • 77953055922 scopus 로고    scopus 로고
    • Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    • Ahrén B, Foley JE, Ferrannini E, et al. Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy. Diabetes Care 2010;33(4):730-2
    • (2010) Diabetes Care , vol.33 , Issue.4 , pp. 730-732
    • Ahrén, B.1    Foley, J.E.2    Ferrannini, E.3
  • 14
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, et al. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993;91(1):301-7
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3
  • 15
    • 84918547602 scopus 로고    scopus 로고
    • Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: Relationships with postprandial glycemic and insulinemic responses
    • Little TJ, Pilichiewicz AN, Russo A, et al. Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: relationships with postprandial glycemic and insulinemic responses. Diabetes Care 2013;36:1396-405
    • (2013) Diabetes Care , vol.36 , pp. 1396-1405
    • Little, T.J.1    Pilichiewicz, A.N.2    Russo, A.3
  • 16
    • 12244275009 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
    • Ahrén B, Schmitz O. GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Horm Metab Res 2004;36:867-76
    • (2004) Horm Metab Res , vol.36 , pp. 867-876
    • Ahrén, B.1    Schmitz, O.2
  • 17
    • 15044357070 scopus 로고    scopus 로고
    • Glycaemic effects of incretins in type 1 diabetes mellitus: A concise review, with emphasis on studies in humans
    • Dupre J. Glycaemic effects of incretins in type 1 diabetes mellitus: a concise review, with emphasis on studies in humans. Regul Pept 2005;128:149-57
    • (2005) Regul Pept , vol.128 , pp. 149-157
    • Dupre, J.1
  • 18
    • 69949083472 scopus 로고    scopus 로고
    • Liraglutide: A once-daily incretin mimetic for the treatment of type 2 diabetes mellitus
    • Neumiller JJ, Campbell RK. Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus. Ann Pharmacother 2009;43:1433-44
    • (2009) Ann Pharmacother , vol.43 , pp. 1433-1444
    • Neumiller, J.J.1    Campbell, R.K.2
  • 19
    • 69249195769 scopus 로고    scopus 로고
    • Exenatide efficacy and safety: A systematic review
    • Norris SL, Lee N, Thakurta S, Chan BK. Exenatide efficacy and safety: a systematic review. Diabet Med 2009;26(9):837-46
    • (2009) Diabet Med , vol.26 , Issue.9 , pp. 837-846
    • Norris, S.L.1    Lee, N.2    Thakurta, S.3    Chan, B.K.4
  • 20
    • 84908099303 scopus 로고    scopus 로고
    • Albiglutide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • Trujillo JM, Nuffer W. Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Ann Pharmacother 2014;48(11):1494-501
    • (2014) Ann Pharmacother , vol.48 , Issue.11 , pp. 1494-1501
    • Trujillo, J.M.1    Nuffer, W.2
  • 21
    • 84899709251 scopus 로고    scopus 로고
    • Dulaglutide for the treatment of type 2 diabetes
    • Amblee A. Dulaglutide for the treatment of type 2 diabetes. Drugs Today (Barc) 2014;50(4):277-89
    • (2014) Drugs Today (Barc , vol.50 , Issue.4 , pp. 277-289
    • Amblee, A.1
  • 23
    • 39749169723 scopus 로고    scopus 로고
    • Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: A review of recent clinical trials
    • Karasik A, Aschner P, Katzeff H, et al. Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trials. Curr Med Res Opin 2008;24:489-96
    • (2008) Curr Med Res Opin , vol.24 , pp. 489-496
    • Karasik, A.1    Aschner, P.2    Katzeff, H.3
  • 24
    • 55049090992 scopus 로고    scopus 로고
    • Vildagliptin: A review of its use in the management of type 2 diabetes mellitus
    • Croxtall JD, Keam SJ. Vildagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs 2008;68:2387-409
    • (2008) Drugs , vol.68 , pp. 2387-2409
    • Croxtall, J.D.1    Keam, S.J.2
  • 25
    • 84901047319 scopus 로고    scopus 로고
    • Vildagliptin, a DPP-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin
    • Forst T, Bramlage P. Vildagliptin, a DPP-4 inhibitor for the twice-daily treatment of type 2 diabetes mellitus with or without metformin. Expert Opin Pharmacother 2014;15:1299-313
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 1299-1313
    • Forst, T.1    Bramlage, P.2
  • 26
    • 77952911388 scopus 로고    scopus 로고
    • Saxagliptin: A new dipeptidyl peptidase 4 inhibitor for type 2 diabetes
    • Borja-Hart NL, Whalen KL. Saxagliptin: a new dipeptidyl peptidase 4 inhibitor for type 2 diabetes. Ann Pharmacother 2010;44:1046-53
    • (2010) Ann Pharmacother , vol.44 , pp. 1046-1053
    • Borja-Hart, N.L.1    Whalen, K.L.2
  • 27
    • 77955453343 scopus 로고    scopus 로고
    • Dipeptidylpeptidase-4 inhibitors (gliptins): Focus on drug-drug interactions
    • Scheen AJ. Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet 2010;49(9):573-88
    • (2010) Clin Pharmacokinet , vol.49 , Issue.9 , pp. 573-588
    • Scheen, A.J.1
  • 28
    • 84865661999 scopus 로고    scopus 로고
    • Linagliptin: A review of its use in the management of type 2 diabetes mellitus
    • Deeks ED. Linagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs 2012;72(13):1793-824
    • (2012) Deeks ED.Drugs , vol.72 , Issue.13 , pp. 1793-1824
  • 29
    • 77953181717 scopus 로고    scopus 로고
    • Alogliptin: A new addition to the class of DPP-4 inhibitors
    • Andukuri R, Drincic A, Rendell M. Alogliptin: a new addition to the class of DPP-4 inhibitors. Diabetes Metab Dis Obes 2009;2:117-26
    • (2009) Diabetes Metab Dis Obes , vol.2 , pp. 117-126
    • Andukuri, R.1    Drincic, A.2    Rendell, M.3
  • 30
    • 79961222810 scopus 로고    scopus 로고
    • Pharmacology of dipeptidyl peptidase-4 inhibitors: Similarities and differences
    • Baetta R, Corsini A. Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences. Drugs 2011;71(11):1441-67
    • (2011) Drugs , vol.71 , Issue.11 , pp. 1441-1467
    • Baetta, R.1    Corsini, A.2
  • 31
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebocontrolled studies with single oral doses
    • Herman GA, Stevens C, Van Dyck K, et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebocontrolled studies with single oral doses. Clin Pharmacol Ther 2005;78(6):675-88
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.6 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    Van Dyck, K.3
  • 32
    • 41149118550 scopus 로고    scopus 로고
    • BI 1356- a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas L, Eckhardt M, Langkopf E, et al. BI 1356- a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther 2008;325(1):175-82
    • (2008) J Pharmacol Exp Ther , vol.325 , Issue.1 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3
  • 33
    • 84861683713 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of linagliptin
    • Graefe-Mody U, Retlich S, Friedrich C. Clinical pharmacokinetics and pharmacodynamics of linagliptin. Clin Pharmacokinet 2012;51(7):411-27
    • (2012) Clin Pharmacokinet , vol.51 , Issue.7 , pp. 411-427
    • Graefe-Mody, U.1    Retlich, S.2    Friedrich, C.3
  • 34
    • 84863115894 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of vildagliptin
    • He YL Clinical pharmacokinetics and pharmacodynamics of vildagliptin. Clin Pharmacokinet 2012;51(3):147-62
    • (2012) Clin Pharmacokinet , vol.51 , Issue.3 , pp. 147-162
    • He, Y.L.1
  • 35
    • 34347393269 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus
    • He YL, Serra D, Wang Y, et al. Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus. Clin Pharmacokinet 2007;46(7):577-88
    • (2007) Clin Pharmacokinet , vol.46 , Issue.7 , pp. 577-588
    • He, Y.L.1    Serra, D.2    Wang, Y.3
  • 36
    • 39849094593 scopus 로고    scopus 로고
    • The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers
    • He YL, Sabo R, Campestrini J, et al. The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers. Br J Clin Pharmacol 2008;65(3):338-46
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.3 , pp. 338-346
    • He, Y.L.1    Sabo, R.2    Campestrini, J.3
  • 37
    • 79960831855 scopus 로고    scopus 로고
    • Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans
    • Ahren B, Schweizer A, Dejager S, et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab 2011;13:775-83
    • (2011) Diabetes Obes Metab , vol.13 , pp. 775-783
    • Ahren, B.1    Schweizer, A.2    Dejager, S.3
  • 38
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes. Diabetes Res Clin Pract 2007;76:132-8
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 39
    • 84876384692 scopus 로고    scopus 로고
    • Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment
    • He YL, Kulmatycki K, Zhang Y, et al. Pharmacokinetics of vildagliptin in patients with varying degrees of renal impairment. Int J Clin Pharmacol Ther 2013;51(9):693-703
    • (2013) Int J Clin Pharmacol Ther , vol.51 , Issue.9 , pp. 693-703
    • He, Y.L.1    Kulmatycki, K.2    Zhang, Y.3
  • 40
    • 84863436536 scopus 로고    scopus 로고
    • Comparative clinical pharmacokinetics of dipeptidyl peptidase- 4 inhibitors
    • Golightly LK, Drayna CC, McDermott MT. Comparative clinical pharmacokinetics of dipeptidyl peptidase- 4 inhibitors. Clin Pharmacokinet 2012;51(8):501-14
    • (2012) Clin Pharmacokinet , vol.51 , Issue.8 , pp. 501-514
    • Golightly, L.K.1    Drayna, C.C.2    McDermott, M.T.3
  • 41
    • 80051653327 scopus 로고    scopus 로고
    • A randomized open-label crossover study evaluating the effect of food on the relative bioavailability of linagliptin in healthy subjects
    • Graefe-Mody U, Giessmann T, Ring A, et al. A randomized, open-label, crossover study evaluating the effect of food on the relative bioavailability of linagliptin in healthy subjects. Clin Ther 2011;33(8):1096-103
    • (2011) Clin Ther , vol.33 , Issue.8 , pp. 1096-1103
    • Graefe-Mody, U.1    Giessmann, T.2    Ring, A.3
  • 42
    • 46449083470 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers
    • He YL, Flannery B, Campestrini J, et al. Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers. Curr Med Res Opin 2008;24(6):1703-9
    • (2008) Curr Med Res Opin , vol.24 , Issue.6 , pp. 1703-1709
    • He, Y.L.1    Flannery, B.2    Campestrini, J.3
  • 43
    • 73649128872 scopus 로고    scopus 로고
    • Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: A two- phase, crossover study in healthy subjects
    • Karim A, Covington P, Christopher R, et al. Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two- phase, crossover study in healthy subjects. Int J Clin Pharmacol Ther 2010;48(1):46-58
    • (2010) Int J Clin Pharmacol Ther , vol.48 , Issue.1 , pp. 46-58
    • Karim, A.1    Covington, P.2    Christopher, R.3
  • 44
    • 77956805536 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin
    • Scheen AJ. Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin. Expert Opin Drug Metab Toxicol 2010;6(10):1265-76
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , Issue.10 , pp. 1265-1276
    • Scheen, A.J.1
  • 45
    • 44949219464 scopus 로고    scopus 로고
    • Sitagliptin, an dipeptidyl peptidase- 4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects
    • Mistry GC, Bergman AJ, Zheng W, et al. Sitagliptin, an dipeptidyl peptidase- 4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects. Br J Clin Pharmacol 2008;66(1):36-42
    • (2008) Br J Clin Pharmacol , vol.66 , Issue.1 , pp. 36-42
    • Mistry, G.C.1    Bergman, A.J.2    Zheng, W.3
  • 46
    • 79956336684 scopus 로고    scopus 로고
    • Saxagliptin a potent selective inhibitor of DPP-4 does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin glyburide or pioglitazone) in healthy subjects
    • Patel CG, Kornhauser D, Vachharajani N, et al. Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects. Diabetes Obes Metab 2011;13(7):604-14
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 604-614
    • Patel, C.G.1    Kornhauser, D.2    Vachharajani, N.3
  • 47
    • 47549105349 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with type 2 diabetes
    • Serra D, He YL, Bullock J, et al. Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with type 2 diabetes. Int J Clin Pharmacol Ther 2008;46(7):349-64
    • (2008) Int J Clin Pharmacol Ther , vol.46 , Issue.7 , pp. 349-364
    • Serra, D.1    He, Y.L.2    Bullock, J.3
  • 48
    • 79955712959 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea glyburide in healthy subjects
    • Graefe-Mody U, Rose P, Ring A, et al. Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide, in healthy subjects. Drug Metab Pharmacokinet 2011;26(2):123-9
    • (2011) Drug Metab Pharmacokinet , vol.26 , Issue.2 , pp. 123-129
    • Graefe-Mody, U.1    Rose, P.2    Ring, A.3
  • 49
    • 67650799130 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
    • Graefe-Mody EU, Padula S, Ring A, et al. Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects. Curr Med Res Opin 2009;25(8):1963-72
    • (2009) Curr Med Res Opin , vol.25 , Issue.8 , pp. 1963-1972
    • Graefe-Mody, E.U.1    Padula, S.2    Ring, A.3
  • 50
    • 77957665412 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers
    • Graefe-Mody EU, Jungnik A, Ring A, et al. Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers. Int J Clin Pharmacol Ther 2010;48(10):652-61
    • (2010) Int J Clin Pharmacol Ther , vol.48 , Issue.10 , pp. 652-661
    • Graefe-Mody, E.U.1    Jungnik, A.2    Ring, A.3
  • 51
    • 79953174825 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: A randomized doubleblind placebo-controlled study
    • Gomis R, Espadero RM, Jones R, et al. Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, doubleblind, placebo-controlled study. Diabetes Obes Metab 2011;13(7):653-61
    • (2011) Diabetes Obes Metab , vol.13 , Issue.7 , pp. 653-661
    • Gomis, R.1    Espadero, R.M.2    Jones, R.3
  • 52
    • 67649320615 scopus 로고    scopus 로고
    • Lack of effect of multiple doses of alogliptin benzoate (syr-322) on the pharmacokinetics of glyburide in healthy subjects [abstract
    • Fleck P, Karim A, Harris S, et al. Lack of effect of multiple doses of alogliptin benzoate (syr-322) on the pharmacokinetics of glyburide in healthy subjects [abstract]. Diabetes 2007;56(Suppl 1):541
    • (2007) Diabetes , vol.56 , pp. 541
    • Fleck, P.1    Karim, A.2    Harris, S.3
  • 53
    • 70349510604 scopus 로고    scopus 로고
    • Coadministration of pioglitazone or glyburide and alogliptin: Pharmacokinetic drug interaction assessment in healthy participants
    • Munsaka M, Wann E, Fleck P, et al. Coadministration of pioglitazone or glyburide and alogliptin: pharmacokinetic drug interaction assessment in healthy participants. J Clin Pharmacol 2009;49(10):1210-19
    • (2009) J Clin Pharmacol , vol.49 , Issue.10 , pp. 1210-1219
    • Munsaka, M.1    Wann, E.2    Fleck, P.3
  • 54
    • 37749015647 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-statepharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects
    • Ayalasomayajula SP, Dole K, He YL, et al. Evaluation of the potential for steady-statepharmacokinetic interaction between vildagliptin and simvastatin in healthy subjects. Curr Med Res Opin 2007;23(12):2913-20
    • (2007) Curr Med Res Opin , vol.23 , Issue.12 , pp. 2913-2920
    • Ayalasomayajula, S.P.1    Dole, K.2    He, Y.L.3
  • 55
    • 84867662710 scopus 로고    scopus 로고
    • The effects of simvastatin on the pharmacokinectics of sitagliptin
    • Cerra M, Luo WL, Li SX, et al. The effects of simvastatin on the pharmacokinectics of sitagliptin. J Popul Ther Clin Pharmacol 2012;19(3):e356-60
    • (2012) J Popul Ther Clin Pharmacol , vol.19 , Issue.3 , pp. e356-e360
    • Cerra, M.1    Luo, W.L.2    Li, S.X.3
  • 56
    • 84862079945 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes
    • Scheen AJ. Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes. Expert Opin Drug Metab Toxicol 2012;8(6):745-58
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , Issue.6 , pp. 745-758
    • Scheen, A.J.1
  • 57
    • 81255189032 scopus 로고    scopus 로고
    • Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: Simvastatin, diltiazem extended-release, and ketoconazole
    • Patel CG, Li L, Girgis S, et al. Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole. Clin Pharmacol 2011;3:13-25
    • (2011) Clin Pharmacol , vol.3 , pp. 13-25
    • Patel, C.G.1    Li, L.2    Girgis, S.3
  • 58
    • 77952770226 scopus 로고    scopus 로고
    • Effect of linagliptin (BI 1356) on the steady-state pharmacokinetics of simvastatin
    • Graefe-Mody U, Huettner S, Stähle H, et al. Effect of linagliptin (BI 1356) on the steady-state pharmacokinetics of simvastatin. Int J Clin Pharmacol Ther 2010;48(6):367-74
    • (2010) Int J Clin Pharmacol Ther , vol.48 , Issue.6 , pp. 367-374
    • Graefe-Mody, U.1    Huettner, S.2    Stähle, H.3
  • 59
    • 70549089727 scopus 로고    scopus 로고
    • Effect of fluconazole, ketoconazole, and gemfibrozil on the pharmacokinetics of alogliptin benzoate (syr-322) in healthy subjects [abstract 105
    • Karim A, Harris S, Fleck P, et al. Effect of fluconazole, ketoconazole, and gemfibrozil on the pharmacokinetics of alogliptin benzoate (SYR-322) in healthy subjects [abstract 105]. J Clin Pharmacol 2007;47(9):1207
    • (2007) J Clin Pharmacol , vol.47 , Issue.9 , pp. 1207
    • Karim, A.1    Harris, S.2    Fleck, P.3
  • 60
    • 70549092750 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between alogliptin, a highly selective dipeptidyl peptidase-4 inhibitor, and atorvastatin in healthy subjects [abstract
    • Karim A, Fleck P, Harris S, et al. Lack of pharmacokinetic interaction between alogliptin, a highly selective dipeptidyl peptidase-4 inhibitor, and atorvastatin in healthy subjects [abstract]. Clin Pharmacol Ther 2008;83(Suppl 1):S14
    • (2008) Clin Pharmacol Ther , vol.83 , pp. S14
    • Karim, A.1    Fleck, P.2    Harris, S.3
  • 61
    • 80051536297 scopus 로고    scopus 로고
    • Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: An open-label two-period fixed-sequence multiple-dose study
    • Friedrich C, Port A, Ring A, et al. Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open-label, two-period, fixed-sequence, multiple-dose study. Clin Drug Investig 2011;31(9):643-53
    • (2011) Clin Drug Investig , vol.31 , Issue.9 , pp. 643-653
    • Friedrich, C.1    Port, A.2    Ring, A.3
  • 62
    • 80051536297 scopus 로고    scopus 로고
    • Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: An open-label two-period fixed-sequence multiple-dose study
    • Friedrich C, Port A, Ring A, et al. Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open-label, two-period, fixed-sequence, multiple-dose study. Clin Drug Investig 2011;31(9):643-53
    • (2011) Clin Drug Investig , vol.31 , Issue.9 , pp. 643-653
    • Friedrich, C.1    Port, A.2    Ring, A.3
  • 63
    • 70549088886 scopus 로고    scopus 로고
    • Effects of alogliptin on the pharmacokinetics and pharmacodynamics of norethindrone and ethinyl estradiol (orthonovum( r) 1/35) in healthy adult female subjects [abstract
    • Suppl
    • Karim A, Copa A, Fleck P, et al. Effects of alogliptin on the pharmacokinetics and pharmacodynamics of norethindrone and ethinyl estradiol (ORTHONOVUM( R) 1/35) in healthy adult female subjects [abstract]. Clin Pharmacol Ther 2008;83(Suppl):S13
    • (2008) Clin Pharmacol Ther , vol.83 , pp. S13
    • Karim, A.1    Copa, A.2    Fleck, P.3
  • 64
    • 70349479419 scopus 로고    scopus 로고
    • Multiple doses of sitagliptin, a selective DPP-4 inhibitor, do not meaningfully alter pharmacokinetics and pharmacodynamics of warfarin
    • Wright DH, Herman GA, Maes A, et al. Multiple doses of sitagliptin, a selective DPP-4 inhibitor, do not meaningfully alter pharmacokinetics and pharmacodynamics of warfarin. J Clin Pharmacol 2009;49(10):1157-67
    • (2009) J Clin Pharmacol , vol.49 , Issue.10 , pp. 1157-1167
    • Wright, D.H.1    Herman, G.A.2    Maes, A.3
  • 65
    • 34249032779 scopus 로고    scopus 로고
    • Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
    • He YL, Sabo R, Riviere GJ, et al. Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Curr Med Res Opin 2007;23(5):1131-8
    • (2007) Curr Med Res Opin , vol.23 , Issue.5 , pp. 1131-1138
    • He, Y.L.1    Sabo, R.2    Riviere, G.J.3
  • 66
    • 79955980589 scopus 로고    scopus 로고
    • Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
    • Graefe-Mody EU, Brand T, Ring A, et al. Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Int J Clin Pharmacol Ther 2011;49(5):300-10
    • (2011) Int J Clin Pharmacol Ther , vol.49 , Issue.5 , pp. 300-310
    • Graefe-Mody, E.U.1    Brand, T.2    Ring, A.3
  • 67
    • 70549089727 scopus 로고    scopus 로고
    • Assessment of drug interaction between alogliptin benzoate (syr-322), a highly selective dipeptidyl peptidase-4 inhibitor, and warfarin at steady state [abstract106
    • Karim A, Harris S, Fleck P, et al. Assessment of drug interaction between alogliptin benzoate (SYR-322), a highly selective dipeptidyl peptidase-4 inhibitor, and warfarin at steady state [abstract106]. J Clin Pharmacol 2007;47(9):1207
    • (2007) J Clin Pharmacol , vol.47 , Issue.9 , pp. 1207
    • Karim, A.1    Harris, S.2    Fleck, P.3
  • 68
    • 34447628472 scopus 로고    scopus 로고
    • Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers
    • He YL, Sabo R, Sunkara G, et al. Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers. J Clin Pharmacol 2007;47(8):998-1004
    • (2007) J Clin Pharmacol , vol.47 , Issue.8 , pp. 998-1004
    • He, Y.L.1    Sabo, R.2    Sunkara, G.3
  • 69
    • 79954427139 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic interaction after multiple oral doses of linagliptin and digoxin in healthy volunteers
    • Friedrich C, Ring A, Brand T, et al. Evaluation of the pharmacokinetic interaction after multiple oral doses of linagliptin and digoxin in healthy volunteers. Eur J Drug Metab Pharmacokinet 2011;36(1):17-24
    • (2011) Eur J Drug Metab Pharmacokinet , vol.36 , Issue.1 , pp. 17-24
    • Friedrich, C.1    Ring, A.2    Brand, T.3
  • 70
    • 70549092751 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between multiple doses of the dipeptidyl peptidase-4 inhibitor alogliptin and digoxin in healthy subjects [abstract
    • Karim A, Fleck P, Harris S, et al. Lack of pharmacokinetic interaction between multiple doses of the dipeptidyl peptidase-4 inhibitor alogliptin and digoxin in healthy subjects [abstract]. Clin Pharmacol Ther 2008;83(Suppl 1):S12-13
    • (2008) Clin Pharmacol Ther , vol.83 , pp. S12-13
    • Karim, A.1    Fleck, P.2    Harris, S.3
  • 71
    • 70349260434 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema
    • Brown NJ, Byiers S, Carr D, et al. Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema. Hypertension 2009;54(3):516-23
    • (2009) Hypertension , vol.54 , Issue.3 , pp. 516-523
    • Brown, N.J.1    Byiers, S.2    Carr, D.3
  • 72
    • 37349024818 scopus 로고    scopus 로고
    • Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects
    • He YL, Ligueros-Saylan M, Sunkara G, et al. Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects. J Clin Pharmacol 2008;48(1):85-95
    • (2008) J Clin Pharmacol , vol.48 , Issue.1 , pp. 85-95
    • He, Y.L.1    Ligueros-Saylan, M.2    Sunkara, G.3
  • 73
    • 34247898818 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 8/9-like activity in human leukocytes
    • Maes MB, Dubois V, Brandt I, et al. Dipeptidyl peptidase 8/9-like activity in human leukocytes. J Leukoc Biol 2007;81(5):1252-7
    • (2007) J Leukoc Biol , vol.81 , Issue.5 , pp. 1252-1257
    • Maes, M.B.1    Dubois, V.2    Brandt, I.3
  • 74
    • 63849095884 scopus 로고    scopus 로고
    • Role of dipeptidyl peptidase iv (dpp iv)-like enzymes in t lymphocyte activation: Investigations in dpp iv/cd26-knockout mice
    • Reinhold D, Goihl A, Wrenger S, et al. Role of dipeptidyl peptidase IV (DPP IV)-like enzymes in T lymphocyte activation: investigations in DPP IV/CD26-knockout mice. Clin Chem Lab Med 2009;2009:47(3):268-74
    • (2009) Clin Chem Lab Med 2009 , vol.47 , Issue.3 , pp. 268-274
    • Reinhold, D.1    Goihl, A.2    Wrenger, S.3
  • 75
    • 48049092062 scopus 로고    scopus 로고
    • Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited
    • Burkey BF, Hoffmann PK, Hassiepen U, et al. Adverse effects of dipeptidyl peptidases 8 and 9 inhibition in rodents revisited. Diabetes Obes Metab 2008;10(11):1057-61
    • (2008) Diabetes Obes Metab , vol.10 , Issue.11 , pp. 1057-1061
    • Burkey, B.F.1    Hoffmann, P.K.2    Hassiepen, U.3
  • 76
    • 81855222104 scopus 로고    scopus 로고
    • Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    • Shah Z, Kampfrath T, Deiuliis JA, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation 2011;124(21):2338-49
    • (2011) Circulation , vol.124 , Issue.21 , pp. 2338-2349
    • Shah, Z.1    Kampfrath, T.2    Deiuliis, J.A.3
  • 77
    • 84899630197 scopus 로고    scopus 로고
    • The dipeptidylpeptidase-IV inhibitors sitagliptin vildagliptin and saxagliptin do not impair innate and adaptiveimmune responses
    • Anz D, Kruger S, Haubner S, et al. The dipeptidylpeptidase-IV inhibitors sitagliptin, vildagliptin and saxagliptin do not impair innate and adaptiveimmune responses. Diabetes Obes Metab 2014;16(6):569-72
    • (2014) Diabetes Obes Metab , vol.16 , Issue.6 , pp. 569-572
    • Anz, D.1    Kruger, S.2    Haubner, S.3
  • 78
    • 84862495415 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice
    • Schürmann C, Linke A, Engelmann-Pilger K, et al. The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice. J Pharmacol Exp Ther 2012;342(1):71-80
    • (2012) J Pharmacol Exp Ther , vol.342 , Issue.1 , pp. 71-80
    • Schürmann, C.1    Linke, A.2    Engelmann-Pilger, K.3
  • 79
    • 84883609473 scopus 로고    scopus 로고
    • Effects of short-term sitagliptin treatment on immune parameters in healthy individuals a randomized placebocontrolled study
    • Price JD, Linder G, Li WP, et al. Effects of short-term sitagliptin treatment on immune parameters in healthy individuals, a randomized placebocontrolled study. Clin Exp Immunol 2013;174(1):120-8
    • (2013) Clin Exp Immunol , vol.174 , Issue.1 , pp. 120-128
    • Price, J.D.1    Linder, G.2    Li, W.P.3
  • 80
    • 79951701438 scopus 로고    scopus 로고
    • Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: A disproportionality analysis in the world health organization vigibase
    • Willemen MJ, Mantel-Teeuwisse AK, Straus SM, et al. Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase. Diabetes Care 2011;34(2):369-74
    • (2011) Diabetes Care , vol.34 , Issue.2 , pp. 369-374
    • Willemen, M.J.1    Mantel-Teeuwisse, A.K.2    Straus, S.M.3
  • 81
    • 84874111992 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor sitagliptin exerts anti-inflammatory effects in type 2 diabetic patients
    • Satoh-Asahara N, Sasaki Y, Wada H, et al. Dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients. Metabolism 2013;62(3):347-51
    • (2013) Metabolism , vol.62 , Issue.3 , pp. 347-351
    • Satoh-Asahara, N.1    Sasaki, Y.2    Wada, H.3
  • 82
    • 0029934961 scopus 로고    scopus 로고
    • Evidence for load-dependent and loadindependent determinants of cardiac natriuretic peptide production
    • Ogawa T, Linz W, Stevenson M, et al. Evidence for load-dependent and loadindependent determinants of cardiac natriuretic peptide production. Circulation 1996;93:2059-67
    • (1996) Circulation , vol.93 , pp. 2059-2067
    • Ogawa, T.1    Linz, W.2    Stevenson, M.3
  • 84
    • 80052808787 scopus 로고    scopus 로고
    • Intramyocardial BNP gene delivery improves cardiac function through distinct context dependent mechanisms
    • Moilanen AM, Rysa J, Mustonen E, et al. Intramyocardial BNP gene delivery improves cardiac function through distinct context dependent mechanisms. Circ Heart Fail 2011;4:483-95
    • (2011) Circ Heart Fail , vol.4 , pp. 483-495
    • Moilanen, A.M.1    Rysa, J.2    Mustonen, E.3
  • 85
    • 79551588582 scopus 로고    scopus 로고
    • Natriuretic peptides in heart failure: Where we are, where we are going
    • Palazzuoli A, Antonelli G, Quatrini I, Nuti R. Natriuretic peptides in heart failure: where we are, where we are going. Intern Emerg Med 2011;6:63-8
    • (2011) Intern Emerg Med , vol.6 , pp. 63-68
    • Palazzuoli, A.1    Antonelli, G.2    Quatrini, I.3    Nuti, R.4
  • 86
    • 29744462729 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-serpro form
    • Brandt I, Lambeir AM, Ketelslegers JM, et al. Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-serpro form. Clin Chem 2006;52:82-7
    • (2006) Clin Chem , vol.52 , pp. 82-87
    • Brandt, I.1    Lambeir, A.M.2    Ketelslegers, J.M.3
  • 87
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 88
    • 84555209178 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing induced heart failure
    • Gomez N, Touihri K, Matheeussen V, et al. Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing induced heart failure. Europ J Heart Fail 2012;14:14-21
    • (2012) Europ J Heart Fail , vol.14 , pp. 14-21
    • Gomez, N.1    Touihri, K.2    Matheeussen, V.3
  • 89
    • 62949195390 scopus 로고    scopus 로고
    • 2009 Synergy between cd26/dppiv inhibition and g-csf improves cardiac function after acute myocardial infarction
    • Zaruba MM, Theiss HD, Vallaster M, et al. 2009 Synergy between CD26/DPPIV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009;4:313-23
    • (2009) Cell Stem Cell , vol.4 , pp. 313-323
    • Zaruba, M.M.1    Theiss, H.D.2    Vallaster, M.3
  • 90
    • 79959966874 scopus 로고    scopus 로고
    • Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats
    • Huisamen B, Genis A, Marais E, Lochner A. Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats. Cardiovasc Drugs and Therapy 2011;25:13-20
    • (2011) Cardiovasc Drugs and Therapy , vol.25 , pp. 13-20
    • Huisamen, B.1    Genis, A.2    Marais, E.3    Lochner, A.4
  • 91
    • 84878587722 scopus 로고    scopus 로고
    • The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats
    • Hocher B, Sharkovska Y, Mark M, et al. The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Int J Cardiol 2013;167:87-93
    • (2013) Int J Cardiol , vol.167 , pp. 87-93
    • Hocher, B.1    Sharkovska, Y.2    Mark, M.3
  • 92
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: Possible role of stromal-derived factor-1a
    • Fadini GP, Boscaro E, Albiero M, et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1a. Diabetes Care 2010;33:1607-9
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3
  • 93
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
    • Mistry GC, Maes AL, Lasseter KC, et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. J Clin Pharm 2008;48:592-8
    • (2008) J Clin Pharm , vol.48 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3
  • 94
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (duration-2): A randomised trial
    • Bergenstal RM, Wysham C, Macconell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010;376:431-9
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    MacConell, L.3
  • 95
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (duration-4): A 26- week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M, et al. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26- week double-blind study. Diabetes Care 2012;35:252-8
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 96
    • 77951934948 scopus 로고    scopus 로고
    • DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease
    • Read PA, Khan FZ, Heck PM, et al. DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging 2010;3:195-201
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 195-201
    • Read, P.A.1    Khan, F.Z.2    Heck, P.M.3
  • 97
    • 84898747414 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using dpp-4 inhibitor: The sitagliptin preventive study of intimamedia thickness evaluation (spike
    • Mita T, Katakami N, Shiraiwa T, et al. Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intimamedia thickness Evaluation (SPIKE). Diabetol Metab Syndr 2014;6(1):35
    • (2014) Diabetol Metab Syndr , vol.6 , Issue.1 , pp. 35
    • Mita, T.1    Katakami, N.2    Shiraiwa, T.3
  • 99
    • 84893726667 scopus 로고    scopus 로고
    • All-cause mortality and cardiovascular effects associated with the DPP-IV inhibitor sitagliptin compared with metformin, a retrospective cohort study on the Danish population
    • Scheller NM, Mogensen UM, Andersson C, et al. All-cause mortality and cardiovascular effects associated with the DPP-IV inhibitor sitagliptin compared with metformin, a retrospective cohort study on the Danish population. Diabetes Obes Metab 2014;16(3):231-6
    • (2014) Diabetes Obes Metab , vol.16 , Issue.3 , pp. 231-236
    • Scheller, N.M.1    Mogensen, U.M.2    Andersson, C.3
  • 100
    • 84871713043 scopus 로고    scopus 로고
    • Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus: A pooled analysis
    • Engel S, Golm GT, Shapiro D, et al. Cardiovascular safety of sitagliptin in patients with type 2 diabetes mellitus: a pooled analysis. Cardiovasc Diabetol 2013;12:3
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 3
    • Engel, S.1    Golm, G.T.2    Shapiro, D.3
  • 101
    • 77953182696 scopus 로고    scopus 로고
    • Assessing the cardio-cerebrovascular safety of vildagliptin: Meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    • Schweizer A, Dejager S, Foley JE, et al. Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population. Diabetes Obes Metab 2010;12(6):485-94
    • (2010) Diabetes Obes Metab , vol.12 , Issue.6 , pp. 485-494
    • Schweizer, A.1    Dejager, S.2    Foley, J.E.3
  • 102
    • 84893200919 scopus 로고    scopus 로고
    • Assessment fof the cardiovascular safety of of saxagliptin in patients with type 2 diabetes mellitus: Pooled analysis of 20 clinical trials
    • Iqbal N, Parker A, Frederich R, et al. Assessment fof the cardiovascular safety of of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials. Cardiovasc Diabetol 2014;13:33
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 33
    • Iqbal, N.1    Parker, A.2    Frederich, R.3
  • 103
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated metaanalysis of a phase 3 programme
    • Johansen OE, Neubacher D, von Eynatten M, et al. Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated metaanalysis of a phase 3 programme. Cardiovasc Diabetol 2012;11:3
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 3
    • Johansen, O.E.1    Neubacher, D.2    Von Eynatten, M.3
  • 104
    • 84883745765 scopus 로고    scopus 로고
    • Alogliptin after acute coronary syndrome in patients with type 2 diabetes
    • White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med 2013;369(14):1327-35
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1327-1335
    • White, W.B.1    Cannon, C.P.2    Heller, S.R.3
  • 105
    • 84910601842 scopus 로고    scopus 로고
    • Alogliptin in patients with type 2 diabetes after acute coronary syndromes: Heart failure outcomes and cardiovascular safety in heart failure patients
    • Zannad F, Cannon C, Cushman W, et al. Alogliptin in patients with type 2 diabetes after acute coronary syndromes: heart failure outcomes and cardiovascular safety in heart failure patients. J Am Coll Cardiol 2014;63:12S
    • (2014) J Am Coll Cardiol , vol.63 , pp. 12S
    • Zannad, F.1    Cannon, C.2    Cushman, W.3
  • 106
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369(14):1317-26
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3
  • 107
    • 84918561520 scopus 로고    scopus 로고
    • Sitagliptin use in patients with diabetes and heart failure: A population based retrospective cohort study
    • Weir DL, McAlister FA, Senthiselvan A, et al. Sitagliptin use in patients with diabetes and heart failure: a population based retrospective cohort study. JCHF 2014;2:573-82
    • (2014) JCHF , vol.2 , pp. 573-582
    • Weir, D.L.1    McAlister, F.A.2    Senthiselvan, A.3
  • 108
    • 84904007147 scopus 로고    scopus 로고
    • Dipeptidylpeptidase-4 inhibitors and cardiovascular outcomes: Meta-analysis of randomized clinical trials with 55141 participants
    • Wu S, Hopper I, Skiba M, Krum H. Dipeptidylpeptidase-4 inhibitors and cardiovascular outcomes: Meta-analysis of randomized clinical trials with 55,141 participants. Cardiovasc Ther 2014;32(4):147-58
    • (2014) Cardiovasc Ther , vol.32 , Issue.4 , pp. 147-158
    • Wu, S.1    Hopper, I.2    Skiba, M.3    Krum, H.4
  • 109
    • 77952118055 scopus 로고    scopus 로고
    • Emea.europa.edu [homepage on the internet Available from Last accessed 5 Dec 2014
    • Emea.europa.edu [homepage on the internet]. Summary of product characteristics of vildagliptin 2007. Available from: http://www.ema. europa.eu/docs/en-GB/document-library/EPAR-Product-Information/human/000771/WC500020327.pdf. [Last accessed 5 Dec 2014
    • (2007) Summary of Product Characteristics of Vildagliptin
  • 110
    • 84879324855 scopus 로고    scopus 로고
    • Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: Rationale for the activecomparator carolina trial
    • Rosenstock J, Marx N, Kahn S, et al. Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the activecomparator CAROLINA trial. Diab Vasc Dis Res 2013;10:289-301
    • (2013) Diab Vasc Dis Res , vol.10 , pp. 289-301
    • Rosenstock, J.1    Marx, N.2    Kahn, S.3
  • 112
    • 84888644874 scopus 로고    scopus 로고
    • Rationale, design, and organization of a randomized, controlled trial evaluating cardiovascular outcomes with sitagliptin (tecos) in patients with type 2 diabetes and established cardiovascular disease
    • Green JB, Bethel MA, Paul SK, et al. Rationale, design, and organization of a randomized, controlled trial evaluating cardiovascular outcomes with sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease. Am Heart J 2013;166(6):983-9
    • (2013) Am Heart J , vol.166 , Issue.6 , pp. 983-989
    • Green, J.B.1    Bethel, M.A.2    Paul, S.K.3
  • 113
    • 84890118673 scopus 로고    scopus 로고
    • Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells
    • Lee YS, Jun HS. Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells. Metabolism 2014;63(1):9-19
    • (2014) Metabolism , vol.63 , Issue.1 , pp. 9-19
    • Lee, Y.S.1    Jun, H.S.2
  • 114
    • 84883527081 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: Modulator of beta-cell dysfunction and death
    • Rondas D, DHertog W, Overbergh L, Mathieu C. Glucagon-like peptide-1: modulator of beta-cell dysfunction and death. Diabetes Obes Metab 2013;15(Suppl 3):185-92
    • (2013) Diabetes Obes Metab , vol.15 , Issue.SUPPL3 , pp. 185-192
    • Rondas, D.1    Dhertog, W.2    Overbergh, L.3    Mathieu, C.4
  • 115
    • 77952692112 scopus 로고    scopus 로고
    • Sitagliptin: Review of preclinical and clinical data regarding incidence of pancreatitis
    • Engel SS, Williams-Herman DE, Golm GT, et al. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis. Int J Clin Pract 2010;64:984-90
    • (2010) Int J Clin Pract , vol.64 , pp. 984-990
    • Engel, S.S.1    Williams-Herman, D.E.2    Golm, G.T.3
  • 116
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011;141:150-6
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3
  • 117
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Butler AE, Campbell-Thompson M, Gurlo T, et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62(7):2595-604
    • (2013) Diabetes , vol.62 , Issue.7 , pp. 2595-2604
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3
  • 118
    • 84878185729 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: Are the GLP-1 therapies safe?
    • Butler PC, Elashoff M, Elashoff R, Gale EA. A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?. Diabetes Care 2013;36(7):2118-25
    • (2013) Diabetes Care , vol.36 , Issue.7 , pp. 2118-2125
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.4
  • 119
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: The benefits by far outweigh the potential risks
    • Nauck MA. A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks. Diabetes Care 2013;36:2126-32
    • (2013) Diabetes Care , vol.36 , pp. 2126-2132
    • Nauck, M.A.1
  • 120
    • 84883560410 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and pancreatitis risk: A meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Mannucci E. Dipeptidyl peptidase-4 inhibitors and pancreatitis risk: a meta-analysis of randomized clinical trials. Diabetes Metab Res Rev 2013;29(8):624-30
    • (2013) Diabetes Metab Res Rev , vol.29 , Issue.8 , pp. 624-630
    • Monami, M.1    Dicembrini, I.2    Mannucci, E.3
  • 121
    • 84896731936 scopus 로고    scopus 로고
    • Pancreatic safety of incretin-based drugs - FDA and EMA assessment
    • Egan AG, Blind E, Dunder K, et al. Pancreatic safety of incretin-based drugs - FDA and EMA assessment. N Engl J Med 2014;370:794-7
    • (2014) N Engl J Med , vol.370 , pp. 794-797
    • Egan, A.G.1    Blind, E.2    Dunder, K.3
  • 122
    • 84918593846 scopus 로고    scopus 로고
    • Saxagliptin (BMS-477118 Advisory committee briefing document for April Meeting NDA 22-350; 2 March 2009; Silver Spring, Maryland
    • Saxagliptin (BMS-477118) FDAs endocrinologic and metabolic drugs. Advisory committee briefing document for April 2009 Meeting NDA 22-350; 2 March 2009; Silver Spring, Maryland
    • (2009) FDAs Endocrinologic and Metabolic Drugs
  • 123
    • 84918532038 scopus 로고    scopus 로고
    • Emea.europa.edu [homepage on the internet Available from Last accessed 5 Dec 2014
    • Emea.europa.edu [homepage on the internet]. Scientific discussion on vlidagliptin: pharmacodynamics, pharmacokinetics, efficacy and safety 2007. Available from: http://www.ema. europa.eu/docs/en-GB/document-library/EPAR-Scientific-Discussion/human/000771/WC500020330.pdf. [Last accessed 5 Dec 2014
    • (2007) Scientific Discussion on Vlidagliptin: Pharmacodynamics, Pharmacokinetics, Efficacy and Safety
  • 125
    • 84918494250 scopus 로고    scopus 로고
    • Fda.gov/medwatch[homepage on the internet Available from Last accessed 5 Dec 2014
    • Fda.gov/medwatch[homepage on the internet]. Patient information Januvia. 2007. Available from: http://www.fda. gov/Safety/MedWatch/SafetyInformation/ucm196611.htm. [Last accessed 5 Dec 2014
    • (2007) Patient Information Januvia
  • 126
    • 84857343528 scopus 로고    scopus 로고
    • Alogliptin benzoate for the treatment of type 2 diabetes
    • Rendell M, Drincic A, Andukuri R. Alogliptin benzoate for the treatment of type 2 diabetes. Expert Opin Pharmacother 2012;13(4):553-63
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.4 , pp. 553-563
    • Rendell, M.1    Drincic, A.2    Andukuri, R.3
  • 127
    • 84863039515 scopus 로고    scopus 로고
    • Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism
    • Miyazaki M, Kato M, Tanaka K, et al. Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Mol Med Rep 2012;5:729-33
    • (2012) Mol Med Rep , vol.5 , pp. 729-733
    • Miyazaki, M.1    Kato, M.2    Tanaka, K.3
  • 128
    • 37549001305 scopus 로고    scopus 로고
    • Dipeptidyl peptidase iv (ddp iv) in nash patients
    • Balaban YH, Korkusuz P, Simsek H, et al. Dipeptidyl peptidase IV (DDP IV) in NASH patients. Ann Hepatol 2007;6:242-50
    • (2007) Ann Hepatol , vol.6 , pp. 242-250
    • Balaban, Y.H.1    Korkusuz, P.2    Simsek, H.3
  • 129
    • 34250307638 scopus 로고    scopus 로고
    • The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin
    • He YL, Sabo R, Campestrini J, et al. The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin. Eur J Clin Pharmacol 2007;63(7):677-86
    • (2007) Eur J Clin Pharmacol , vol.63 , Issue.7 , pp. 677-686
    • He, Y.L.1    Sabo, R.2    Campestrini, J.3
  • 130
    • 84918535791 scopus 로고    scopus 로고
    • Accessed May
    • Merck Sharp & Dohme Corp. Januvia PI 2010. http://www.merck.com/product/usa/pi-circulars/j/januvia/januvia-pi.pdf [Accessed May 2010
    • (2010) Merck Sharp Dohme Corp Januvia PI 2010
  • 131
    • 84918590472 scopus 로고    scopus 로고
    • Accessed Dec
    • Bristol-Myers Squibb. Onglyza PI. http://packageinserts.bms.com/pi/pi-onglyza.pdf [Accessed Dec 2014
    • (2014) Bristol-Myers Squibb Onglyza PI
  • 132
    • 84918511898 scopus 로고    scopus 로고
    • Available from Accessed June
    • Takeda, Inc. Nesina package insert 2013. Available from: http://www. accessdata.fda.gov/drugsatfda-docs/label/2013/022271s000lbl.pdf [Accessed June 2014
    • (2014) Takeda Inc Nesina Package Insert 2013
  • 133
    • 84918582213 scopus 로고    scopus 로고
    • Available from Accessed June
    • Galvus product information 2013. Available from: http://www.ema. europa.eu/docs/en-GB/document-library/EPAR-Product-Information/human/000771/WC500020327.pdf [Accessed June 2014
    • (2014) Galvus Product Information 2013
  • 134
    • 84918510650 scopus 로고    scopus 로고
    • Trajenta SPC 2014. Available from Accessed May
    • Boehringer Ingelheim Pharmaceuticals, Inc. Trajenta SPC 2014. Available from: http://www.ema. europa.eu/docs/en-GB/document-library/EPAR-Product-Information/human/002110/WC500115745.pdf [Accessed May 2013
    • (2013) Boehringer Ingelheim Pharmaceuticals Inc
  • 135
    • 79952273819 scopus 로고    scopus 로고
    • Long-term effects of intensive glucose lowering on cardiovascular outcomes
    • ACCORD Study Group
    • ACCORD Study Group. Gerstein HC, Miller ME, Genuth S, et al. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med 2011;364(9):818-28
    • (2011) N Engl J Med , vol.364 , Issue.9 , pp. 818-828
    • Gerstein, H.C.1    Miller, M.E.2    Genuth, S.3
  • 136
    • 74949117631 scopus 로고    scopus 로고
    • The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: Retrospective epidemiological analysis of the accord study
    • Bonds DE, Miller ME, Bergenstal RM, et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 2010;340:b4909
    • (2010) BMJ , vol.340 , pp. b4909
    • Bonds, D.E.1    Miller, M.E.2    Bergenstal, R.M.3
  • 137
    • 65349096195 scopus 로고    scopus 로고
    • Intensive insulin therapy and mortality among critically ill patients: A meta-analysis including nice-sugar study data
    • Griesdale DE, de Souza RJ, van Dam RM, et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 2009;180(8):821-7
    • (2009) CMAJ , vol.180 , Issue.8 , pp. 821-827
    • Griesdale, D.E.1    De Souza, R.J.2    Van Dam, R.M.3
  • 138
    • 84867238377 scopus 로고    scopus 로고
    • Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes
    • Farngren J, Persson M, Schweizer A, et al. Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes. Clin Endocrinol Metab 2012;97(10):3799-806
    • (2012) Clin Endocrinol Metab , vol.97 , Issue.10 , pp. 3799-3806
    • Farngren, J.1    Persson, M.2    Schweizer, A.3
  • 139
    • 84905725690 scopus 로고    scopus 로고
    • Glucagon dynamics during hypoglycaemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes
    • Farngren J, Persson M, Schweizer A, et al. Glucagon dynamics during hypoglycaemia and food-re-challenge following treatment with vildagliptin in insulin-treated patients with type 2 diabetes. Diabetes Obes Metab 2014;16(9):812-18
    • (2014) Diabetes Obes Metab , vol.16 , Issue.9 , pp. 812-818
    • Farngren, J.1    Persson, M.2    Schweizer, A.3
  • 140
    • 58149330590 scopus 로고    scopus 로고
    • Fifty-two-week efficacy and safety of vildagliptin vs. Glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    • Ferrannini E, Fonseca V, Zinman B, et al. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab 2009;11(2):157-66
    • (2009) Diabetes Obes Metab , vol.11 , Issue.2 , pp. 157-166
    • Ferrannini, E.1    Fonseca, V.2    Zinman, B.3
  • 141
    • 78650656671 scopus 로고    scopus 로고
    • Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: A randomized double-blind noninferiority trial
    • Arechavaleta R, Seck T, Chen Y, et al. Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, noninferiority trial. Diabetes Obes Metab 2011;13(2):160-8
    • (2011) Diabetes Obes Metab , vol.13 , Issue.2 , pp. 160-168
    • Arechavaleta, R.1    Seck, T.2    Chen, Y.3
  • 142
    • 78349292168 scopus 로고    scopus 로고
    • Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: A 52-week randomised controlled trial
    • D1680C00001 Investigators
    • Goke B, Gallwitz B, Eriksson J, D1680C00001 Investigators. Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomised controlled trial. Int J Clin Pract 2010;64(12):1619-31
    • (2010) Int J Clin Pract , vol.64 , Issue.12 , pp. 1619-1631
    • Goke, B.1    Gallwitz, B.2    Eriksson, J.3
  • 143
    • 84864757433 scopus 로고    scopus 로고
    • 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: A randomised double-blind non-inferiority trial
    • Gallwitz B, Rosenstock J, Rauch T, et al. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet 2012;380(9840):475-83
    • (2012) Lancet , vol.380 , Issue.9840 , pp. 475-483
    • Gallwitz, B.1    Rosenstock, J.2    Rauch, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.