Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 4, 2016, Pages L377-L386

  Pouwels, Simon D ^a   Zijlstra, G Jan ^a   van der Toorn, Marco ^a   Hesse, Laura ^a   Gras, Renee ^a   Hacken, Nick H T Ten ^a   Krysko, Dmitri V ^b,c   Vandenabeele, Peter ^b,c   De Vries, Maaike ^a   Van Oosterhout, Antoon J M ^a   Heijink, Irene H ^a   Nawijn, Martijn C ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Airway epithelium; Chronic obstructive pulmonary disease; Cigarette smoke; Damage associated molecular patterns; Necroptosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIOLOGICAL FACTOR; CIGARETTE SMOKE; DAMAGE ASSOCIATED MOLECULAR PATTERN; DOUBLE STRANDED DNA; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOCHONDRIAL DNA; MYELOID DIFFERENTIATION FACTOR 88; MYELOPEROXIDASE; NECROSTATIN 1; PATTERN RECOGNITION RECEPTOR; PROTEIN; UNCLASSIFIED DRUG; SMOKE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHUS MUCOSA; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; EPITHELIUM CELL; EXPOSURE; FEMALE; HUMAN; HUMAN CELL; INFLAMMATORY CELL; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MOUSE; NECROPTOSIS; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; ADVERSE EFFECTS; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; LUNG; METABOLISM; NECROSIS; NEUTROPHIL; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; SMOKING; TOBACCO;

ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; INFLAMMATION; LUNG; MICE; NECROSIS; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; SMOKING; TOBACCO;

EID: 84958582284     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00174.2015     Document Type: Article

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