Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice

Archives of Toxicology

Volumn 90, Issue 2, 2016, Pages 347-357

  Karkampouna, Sofia ^a   Goumans, Marie José ^a   ten Dijke, Peter ^a   Dooley, Steven ^b   Kruithof de Julio, Marianna ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acute hepatotoxicity; ALK5; CCl4; LY364947; Regeneration; Smad; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; CASPASE 3; COLLAGEN TYPE 1; CYTOCHROME P450 2E1; FIBRONECTIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HISTONE H3; LY 364947; PROTEIN INHIBITOR; PROTEIN P21; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; LY-364947; PROTEIN SERINE THREONINE KINASE; PYRAZOLE DERIVATIVE; PYRROLE DERIVATIVE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER HOMOGENATE; LIVER INJURY; LIVER REGENERATION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARBON TETRACHLORIDE POISONING; DRUG EFFECTS; HEPATIC STELLATE CELL; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; BIOMARKERS; CARBON TETRACHLORIDE POISONING; HEPATIC STELLATE CELLS; HEPATOCYTES; LIVER; LIVER REGENERATION; MALE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; PYRROLES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84958113257     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1436-y     Document Type: Article

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