Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein

International Journal of Molecular Sciences

Volumn 14, Issue 12, 2013, Pages 23700-23710

  Jeong, Da Hee ^a   Hwang, Meeyul ^a   Park, Jin Kyu ^a   Goo, Moon Jung ^a   Hong, Il Hwa ^a   Ki, Mi Ran ^a   Ishigami, Akihito ^b   Kim, Ah Young ^a   Lee, Eun Mi ^a   Lee, Eun Joo ^a   Jeong, Kyu Shik ^a  

^a Kyungpook National University   (South Korea)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Antioxidant; Liver fibrosis; Smad3; SMP 30

Indexed keywords

CARBON TETRACHLORIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; OROSOMUCOID; PEROXIREDOXIN 6; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REGUCALCIN; SELENIUM BINDING PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CALCIUM BINDING PROTEIN; CELL SURFACE RECEPTOR; RGN PROTEIN, MOUSE; SIGNAL PEPTIDE; SP56 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROGENESIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFORMATION PROCESSING; LIVER FIBROSIS; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; LIVER CIRRHOSIS; MASS SPECTROMETRY; METABOLISM; PATHOLOGY; SEVERITY OF ILLNESS INDEX; TOXICITY; UPREGULATION;

ANIMALS; CALCIUM-BINDING PROTEINS; CARBON TETRACHLORIDE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GLUTATHIONE TRANSFERASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; MALE; MICE; MICE, KNOCKOUT; PROTEOMICS; RECEPTORS, CELL SURFACE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84889571398     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141223700     Document Type: Article

References (20)

1. Biernacka, A.; Dobaczewski, M.; Frangogiannis, N.G. TGF-β signaling in fibrosis. Growth Factors 2011, 29, 196-202.
2. Dooley, S.; Ten Dijke, P. TGF-β in progression of liver disease. Cell Tissue Res. 2012, 347, 245-256.
3. Han, G.; Wang, X.J. Roles of TGFβ signaling Smads in squamous cell carcinoma. Cell Biosci. 2011, 28, 1-41.
4. Matsuzaki, K. Smad phosphoisoform signals in acute and chronic liver injury: Similarities and differences between epithelial and mesenchymal cells. Cell Tissue Res. 2012, 347, 225-243.
5. Stramer, B.M.; Austin, J.S.; Roberts, A.B.; Fini, M.E. Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J. Cell Physiol. 2005, 203, 226-232.
6. Megiorni, F.; Cialfi, S.; Cimino, G.; de Biase, R.V.; Dominici, C.; Quattrucci, S.; Pizzuti, A. Elevated levels of miR-145 correlate with Smad3 down-regulation in Cystic Fibrosis patients. J. Cyst. Fibros. 2013, doi:10.1016/j.jcf.2013.03.007.
7. Hu, B.; Wu, Z.; Phan, S.H. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am. J. Resp. Cell Mol. Biol. 2003, 29, 397-404.
8. Flanders, K.C.; Major, C.D.; Arabshahi, A.; Aburime, E.E.; Okada, M.H.; Fujii, M.; Blalock, T.D.; Schultz, G.S.; Sowers, A.; Anzano, M.A.; et al. Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am. J. Pathol. 2003, 163, 2247-2257.
9. Liu, Z.; Huang, X.R.; Lan, H.Y. Smad3 mediates ANG II-induced hypertensive kidney disease in mice. Am. J. Physiol. Renal Physiol. 2012, 302, F986.
10. Low, T.Y.; Leow, C.K.; Salto-Tellez, M.; Chung, M.C. A proteomic analysis of thioacetamide-induced hepatotoxicity and cirrhosis in rat livers. Proteomics 2004, 4, 3960-3974.
11. Mendler, M.H.; Kanel, G.; Govindarajan, S. Proposal for a histological scoring and grading system for non-alcoholic fatty liver disease. Liver Int. 2005, 25, 294-304.
12. Haschek, W.M.; Rousseaux, C.G. Handbook of Toxicologic Pathology, 2nd ed.; Academic Press: San Francisco, CA, USA, 2002; pp. 72-75.
13. Fujita, T.; Uchida, K.; Maruyama, N. Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver. Biochim. Biophys. Acta 1992, 1116, 122-128.
14. Kondo, Y.; Inai, Y.; Sato, Y.; Handa, S.; Kubo, S.; Shimokado, K.; Goto, S.; Nishikimi, M.; Maruyama, N.; Ishigami, A. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc. Natl. Acad. Sci. USA 2006, 103, 5723-5728.
15. Son, T.G.; Zou, Y.; Jung, K.J.; Yu, B.P.; Ishigami, A.; Maruyama, N.; Lee, J. SMP30 deficiency causes increased oxidative stress in brain. Mech. Ageing Dev. 2006, 127, 451-457.
16. Andreyev, A.Y.; Kushnareva, Y.E.; Starkov, A.A. Mitochondrial metabolism of reactive oxygen species. Biochemistry 2005, 70, 200-214.
17. Yang, X.; Letterio, J.J.; Lechleider, R.J.; Chen, L.; Hayman, R.; Gu, H.; Roberts, A.B.; Deng, C. Targeted disruption of Smad3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO J. 1999, 18, 1280-1291.
18. Ishigami, A.; Fujita, T.; Handa, S.; Shirasawa, T.; Koseki, H.; Kitamura, T.; Enomoto, N.; Sato, N.; Shimosawa, T.; Maruyama, N. Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis. Am. J. Pathol. 2002, 161, 1273-1281.
19. Fountoulakis, M.; de Vera, M.C.; Crameri, F.; Boess, F.; Gasser, R.; Albertini, S.; Suter, L. Modulation of gene and protein expression by carbon tetrachloride in the rat liver. Toxicol. Appl. Pharmacol. 2002, 183, 71-80.
20. Gorg, A.; Obermaier, C.; Boguth, G.; Harder, A.; Scheibe, B.; Wildgruber, R.; Weiss, W. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 2000, 21, 1037-1053.