GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury

Molecular Neurobiology

Volumn 53, Issue 2, 2016, Pages 1377-1385

  Li, Ting ^a   You, Hong ^a   Mo, Xiaoye ^a   He, Wenfang ^a   Tang, Xiangqi ^a   Jiang, Zheng ^a   Chen, Shiyu ^a   Chen, Yang ^a   Zhang, Jie ^a   Hu, Zhiping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; ER stress; Golgi stress response; GOLPH3; Ischemia reperfusion; Mitochondria; Oxidative stress; Oxygen glucose deprivation and reoxygenation (OGD R); Reactive oxygen species (ROS)

Indexed keywords

GOLGI PHOSPHOPROTEIN 3; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; OUTER MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; GLUCOSE; GPP34 PROTEIN, MOUSE; OXYGEN; PHOSPHOPROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE REPRESSION; GOLGI COMPLEX; GOLGI MEMBRANE; IN VITRO STUDY; MOUSE; N2A CELL LINE; NEUROBLASTOMA CELL LINE; NONHUMAN; OXIDATIVE STRESS; OXYGEN GLUCOSE DEPRIVATION AND REOXYGENATION INJURY; PERINUCLEAR RIBBON; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; REPERFUSION INJURY; UPREGULATION; ANIMAL; CELL LINE; DEFICIENCY; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; INTRACELLULAR SPACE; METABOLISM; PHYSIOLOGICAL STRESS; TIME FACTOR;

ANIMALS; CELL DEATH; CELL LINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GLUCOSE; GOLGI APPARATUS; INTRACELLULAR SPACE; MICE; OXYGEN; PHOSPHOPROTEINS; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; TIME FACTORS;

EID: 84958108011     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-9083-0     Document Type: Article

References (45)

1. Robbins E, Gonatas NK (1964) The ultrastructure of a mammalian cell during the mitotic cycle. J Cell Biol 21:429–463
2. Nakagomi S et al (2008) A Golgi fragmentation pathway in neurodegeneration. Neurobiol Dis 29(2):221–231
3. Oku M et al (2011) Novel cis-acting element GASE regulates transcriptional induction by the Golgi stress response. Cell Struct Funct 36(1):1–12
4. Wu CC et al (2000) GMx33: a novel family of trans-Golgi proteins identified by proteomics. Traffic 1(12):963–975
5. Bonangelino CJ, Chavez EM, Bonifacino JS (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486–2501
6. Partridge EA et al (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306(5693):120–124
7. Nakashima-Kamimura N et al (2005) MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J Cell Sci 118(Pt 22):5357–5367
8. Snyder CM et al (2006) GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi. Mol Biol Cell 17(1):511–524
9. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124(3):471–484
10. Nagano-Ito M et al (2007) Identification and characterization of a novel alternative splice variant of mouse GMx33alpha/GPP34. Gene 400(1–2):82–88
11. Scott KL et al (2009) GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 459(7250):1085–1090
12. Dippold HC et al (2009) GOLPH3 bridges phosphatidylinositol-4-phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell 139(2):337–351
13. Wood CS et al (2009) PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking. J Cell Biol 187(7):967–975
14. Wong KR, Meyers DD, Cantley LC (1997) Subcellular locations of phosphatidylinositol 4-kinase isoforms. J Biol Chem 272(20):13236–13241
15. D’Angelo G et al (2008) The multiple roles of PtdIns(4)P—not just the precursor of PtdIns(4,5)P2. J Cell Sci 121(Pt 12):1955–1963
16. Godi A et al (2004) FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol 6(5):393–404
17. Shima H et al (1998) Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 17(22):6649–6659
18. Montagne J et al (1999) Drosophila S6 kinase: a regulator of cell size. Science 285(5436):2126–2129
19. Oldham S et al (2000) Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14(21):2689–2694
20. Zhang H et al (2000) Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev 14(21):2712–2724
21. Hashimoto O et al (2011) Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1alpha-dependent manner in pancreatic cancer cells. Pathobiology 78(4):181–192
22. Hu Z et al (2007) Morphological alteration of Golgi apparatus and subcellular compartmentalization of TGF-beta1 in Golgi apparatus in gerbils following transient forebrain ischemia. Neurochem Res 32(11):1927–1931
23. Perez Velazquez JL, Frantseva MV, Carlen PL (1997) In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons. J Neurosci 17(23):9085–9094
24. Ott M et al (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12(5):913–922
25. Shi Y et al (2012) Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS One 7(11):e51076
26. Li L, Ishdorj G, Gibson SB (2012) Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment. Free Radic Biol Med 53(7):1399–1410
27. Shen W et al. 20120 Oxidative stress mediates chemerin-induced autophagy in endothelial cells, in Free Radic Biol Med. p. 73–82
28. Li L, Chen Y, Gibson SB (2013) Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation. Cell Signal 25(1):50–65
29. Hoyer-Hansen M, Jaattela M (2007) Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14(9):1576–1582
30. Lee J, Giordano S, Zhang J (2012) Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 441(2):523–540
31. Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8(7):519–529
32. Hicks SW, Machamer CE (2005) Golgi structure in stress sensing and apoptosis. Biochim Biophys Acta 1744(3):406–414
33. Salvesen GS, Abrams JM (2004) Caspase activation—stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene 23(16):2774–2784
34. Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48(6):749–762
35. Mancini M et al (2000) Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol 149(3):603–612
36. Lowe M et al (2004) Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis. J Cell Sci 117(Pt 7):1139–1150
37. Maag RS et al (2005) Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. Mol Biol Cell 16(6):3019–3027
38. Bell AW et al (2001) Proteomics characterization of abundant Golgi membrane proteins. J Biol Chem 276(7):5152–5165
39. Schmitz KR et al (2008) Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev Cell 14(4):523–534
40. Tu L et al (2008) Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science 321(5887):404–407
41. Cummings RD, Soderquist AM, Carpenter G (1985) The oligosaccharide moieties of the epidermal growth factor receptor in A-431 cells. Presence of complex-type N-linked chains that contain terminal N-acetylgalactosamine residues. J Biol Chem 260(22):11944–11952
42. Soderquist AM, Carpenter G (1984) Glycosylation of the epidermal growth factor receptor in A-431 cells. The contribution of carbohydrate to receptor function. J Biol Chem 259(20):12586–12594
43. Gottlieb RA (2011) Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther 16(3–4):233–238
44. Farinelli SE, Greene LA (1996) Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16(3):1150–1162
45. Olsen A, Vantipalli MC, Lithgow GJ (2006) Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science 312(5778):1381–1385