In vitro ischemia promotes glutamate-mediated free radical generation and intracellular calcium accumulation in hippocampal pyramidal neurons

Journal of Neuroscience

Volumn 17, Issue 23, 1997, Pages 9085-9094

  Perez Velazquez, Jose L ^a,b   Frantseva, Marina V ^a   Carlen, Peter L ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Calcium; Free radicals; Glutamate transmission; Ischemia; Organotypic slices; Whole cell recordings

Indexed keywords

GLUTAMIC ACID; RADICAL;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOXIA; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; REOXYGENATION;

EID: 0000236120     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-23-09085.1997     Document Type: Article

References (29)

1. Ankarcrona M, Dybpukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
2. Barzilai A, Rahaminoff H (1987) Stoichiometry of the sodium-calcium exchanger in nerve terminals. Biochemistry 26:6113-6118.
3. Bindokas VP, Miller RJ (1995) Excitotoxic degeneration is initiated at non-random sites in cultured rat cerebellar neurons. J Neurosci 15:6999-7010.
4. Cao W, Carney JM, Duchen A, Floyd RA, Chevion M (1988) Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88:233-238.
5. Choi D (1990) Cerebral hypoxia: some new approaches and unanswered questions. J Neurosci 10:2493-2501.
6. Choi D, Koh J, Peters S (1988) Pharmacology of glutamate neurotoxicity in cortical cell culture. J Neurosci 8:185-196.
7. Cino M, Del Maestro RF (1989) Generation of hydrogen peroxide by brain mitochondria: the effect of reoxygenation following postdecapitative ischemia. Arch Biochem Biophys 269:623-638.
8. Coyle JT, Puttfarcken P (1993) Oxidative stress, glutamate, and neuro-degenerative disorders. Science 262:689-695.
9. Crompton M, Costi A, Hayat L (1987) Evidence for the presence of a reversible calcium-dependent pore activated by oxidative stress in heart mitochondria. Biochem J 245:915-918.
10. Dubinsky JM, Kristal BS, Elizondo-Fournier M (1995) An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death. J Neurosci 15:7071-7078.
11. i in type I cells isolated from the rabbit carotid body. J Physiol (Lond) 450:33-61.
12. Duffy S, MacVicar BA (1996) In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes. J Neurosci 16:71-81.
13. Dugan LL, Sensi SL, Canzoniero LMT, Handran SD, Rothman SM, Lin TS, Goldberg MP, Choi DW (1995) Mitochondrial production of re active oxygen species in cortical neurons following exposure to NMDA. J Neurosci 15:6377-6388.
14. +: implications for neurodegeneration. J Neurochem 63:584-586.
15. Floyd RA (1990) Role of oxygen free radicals in carcinogenesis and rat brain ischemia. FASEB J 4:2587-2597.
16. Folbergrova J, Kiyota Y, Pahlmark K, Memezawa H, Smith ML, Siesjo BK (1993) Does ischemia with reperfusion lead to oxidative damage to proteins in the brain? J Cereb Blood Flow Metab 13:145-152.
17. Hall NC, Carney JM, Cheng MS, Butterfield DA (1995)Ischemiareperfusion induced changes in membrane proteins and lipids of gerbil cortical synaptosomes. Neuroscience 64:81-89.
18. Hamill OP, Marty A, Neher A, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high resolution recording from cells and cell-free membrane patches. Pflügers Arch 391:85-10010.
19. Henderson LM, Chappell JB (1993) Dihydrorhodamine123: a fluorescent probe for Superoxide generation. Eur J Biochem 217:973-908.
20. 2 in vitro. Brain Res 671:181-186.
21. Kiedrowski L, Costa E (1995) Glutamate induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering. Mol Pharmacol 47:140-147.
22. Krnjevic K, Leblond J (1989) Changes in membrane currents of hippocampal neurons evoked by brief anoxia. J Neurophysiol 62:15-30.
23. Lafon-Cazal M, Pletrl S, Culcasi M, Boeckart J (1993) NMDA-dependent Superoxide production and neurotoxicity. Nature 364: 535-537.
24. Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. New Engl J Med 330:613-622.
25. Lundgren J, Zhang H, Agardh CD, Smith Maj-Lis, Evans P, Halliwell B, Siesjo BK (1991) Acidosis-induced ischemic brain damage: are free radicals involved? J Cereb Blood Flow Metab 11:587-596.
26. Martin RL, Lloyd HGE, Cowan AI (1994) The early events of oxygen and glucose deprivation: setting the scene for neuronal death? Trends Neurosci 17:251-257.
27. Michaels RL, Rothman SM (1990) Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J Neurosci 10:283-292.
28. Zimmer J, Gahwiler BH (1984) Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentata. J Comp Neurol 228:432-446.
29. Zini I, Tomasi A, Grimaldi R, Vannini V, Agnati LF (1992) Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neurosci Lett 138:279-282.