A novel conditional mouse model for NKX2-5 reveals transcriptional regulation of cardiac ion channels

Differentiation

Volumn 91, Issue 1-3, 2015, Pages 29-41

  Furtado, Milena B ^a,g   Wilmanns, Julia C ^a,b   Chandran, Anjana ^a   Tonta, Mary ^a   Biben, Christine ^c,d   Eichenlaub, Michael ^a   Coleman, Harold A ^a   Berger, Silke ^a   Bouveret, Romaric ^e   Singh, Reena ^e   Harvey, Richard P ^e   Ramialison, Mirana ^a   Pearson, James T ^a   Parkington, Helena C ^a   Rosenthal, Nadia A ^a,f,g   Costa, Mauro W ^a,g  

^a MONASH UNIVERSITY   (Australia)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^f NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^g JACKSON LABORATORY   (United States)

Author keywords

Ion channels; Nkx2 5; Transcriptional regulation

Indexed keywords

TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX5; HOMEOBOX PROTEIN NKX-2.5; ION CHANNEL; KCNH2 PROTEIN, MOUSE; NKX2-5 PROTEIN, MOUSE; POTASSIUM CHANNEL HERG;

3' UNTRANSLATED REGION; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE DELETION; GENE EXPRESSION; HEART DEVELOPMENT; HETEROZYGOSITY; HOMOZYGOSITY; KCNH2 GENE; MOUSE; MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; CONGENITAL HEART MALFORMATION; DISEASE MODEL; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; HUMAN; KNOCKOUT MOUSE; METABOLISM; MUTATION; PATHOPHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; ERG1 POTASSIUM CHANNEL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART DEFECTS, CONGENITAL; HOMEOBOX PROTEIN NKX-2.5; HUMANS; ION CHANNELS; MICE; MICE, KNOCKOUT; MUTATION;

EID: 84958078307     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1016/j.diff.2015.12.003     Document Type: Article

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