Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling

Inflammation

Volumn 39, Issue 1, 2016, Pages 483-492

  Chen, Tong ^a   Wang, Ruoning ^a   Jiang, Wenjiao ^a   Wang, Huimin ^a   Xu, Ang ^a   Lu, Guo ^a   Ren, Yi ^a   Xu, Yangmei ^a   Song, Yangyang ^a   Yong, Shoulei ^a   Ji, Hui ^a   Ma, Zhanqiang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

astragaloside IV; lung injury; paraquat; Rho; Txnip Trx

Indexed keywords

ASTRAGALOSIDE IV; CATALASE; DEXAMETHASONE; GLUTATHIONE PEROXIDASE; I KAPPA B ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; PARAQUAT; PROTEIN ROCK1; PROTEIN ROCK2; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; ASTRAGALOSIDE A; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXIDASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SAPONIN; THIOREDOXIN; TRITERPENE; TUMOR NECROSIS FACTOR; TXN1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFICACY; EXPERIMENTAL ACUTE LUNG INJURY; FEMALE; HISTOPATHOLOGY; INFLAMMATORY CELL; LIPID PEROXIDATION; LUNG LAVAGE; LUNG PARENCHYMA; LUNG PROTECTION; LUNG WEIGHT; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARAQUAT INDUCED LUNG INJURY; PROTECTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ACUTE LUNG INJURY; ANIMAL; BAGG ALBINO MOUSE; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; LUNG; METABOLISM; PATHOLOGY; RANDOMIZATION;

ACUTE LUNG INJURY; ANIMALS; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; CATALASE; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; GLUTATHIONE PEROXIDASE; INTERLEUKIN-6; LUNG; MALONDIALDEHYDE; MICE; MICE, INBRED BALB C; NF-KAPPA B; OXIDATIVE STRESS; PARAQUAT; PEROXIDASE; RANDOM ALLOCATION; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SAPONINS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; THIOREDOXINS; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84958035221     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-015-0272-4     Document Type: Article

References (43)

1. Silva, R., H. Carmo, V. Vilas-Boas, D.J. Barbosa, M. Monteiro, P.G. de Pinho, et al. 2014. Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects. Toxicology Letters 232: 271–283.
2. Choi, J.S., S.S. Jou, M.H. Oh, Y.H. Kim, M.J. Park, H.W. Gil, et al. 2013. The dose of cyclophosphamide for treating paraquat-induced rat lung injury. The Korean Journal of Internal Medicine 28: 420–427.
3. Brennan, F.M., D. Chantry, A. Jackson, R. Maini, and M. Feldmann. 1989. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 2: 244–247.
4. Jing, W., M. Chunhua, and W. Shumin. 2015. Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-kappaB pathway in vivo and in vitro. Toxicology and Applied Pharmacology 285: 128–135.
5. Hua, K., X. Sheng, T.T. Li, L.N. Wang, Y.H. Zhang, Z.J. Huang, et al. 2015. The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats. Acta Pharmacologica Sinica 36: 917–927.
6. Gao, J., H. He, W. Jiang, X. Chang, L. Zhu, F. Luo, et al. 2015. Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer's disease. Behavioural Brain Research 293: 27–33.
7. Kim, S.J., and S.M. Lee. 2013. NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1. Free Radical Biology & Medicine 65: 997–1004.
8. Segain, J.P., D. Raingeard de la Bletiere, V. Sauzeau, A. Bourreille, G. Hilaret, C. Cario-Toumaniantz, et al. 2003. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. Gastroenterology 124: 1180–1187.
9. Santos, L.A., E.L. Ribeiro, K.P. Barbosa, I.T. Fragoso, F.O. Gomes, M.A. Donato, et al. 2014. Diethylcarbamazine inhibits NF-kappaB activation in acute lung injury induced by carrageenan in mice. International Immunopharmacology 23: 153–162.
10. Chen, T., J. Gao, P. Xiang, Y. Chen, J. Ji, P. Xie, et al. 2015. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. International Immunopharmacology 26: 338–348.
11. Chen, T., L. Xiao, L. Zhu, S. Ma, T. Yan, and H. Ji. 2015. Anti-asthmatic effects of ginsenoside rb1 in a mouse model of allergic asthma through relegating Th1/Th2. Inflammation 38(5): 1814–1822.
12. Ko, J.K., F.Y. Lam, and A.P. Cheung. 2005. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World Journal of Gastroenterology 11: 5787–5794.
13. Zhang, W.J., P. Hufnagl, B.R. Binder, and J. Wojta. 2003. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thrombosis and Haemostasis 90: 904–914.
14. Luo, Y., Z. Qin, Z. Hong, X. Zhang, D. Ding, J.H. Fu, et al. 2004. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neuroscience Letters 363: 218–223.
15. Zhang, W.D., C. Zhang, X.H. Wang, P.J. Gao, D.L. Zhu, H. Chen, et al. 2006. Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways. Planta Medica 72: 621–626.
16. Li, Z.P., and Q. Cao. 2002. Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats. Acta Pharmacologica Sinica 23: 898–904.
17. Nguyen, V., D.S. Malik, and M.A. Howland. 2014. Methylene blue protects against paraquat-induced acute lung injury in rats. International Immunopharmacology 20: 358.
18. Wang, J., Y.T. Liu, L. Xiao, L. Zhu, Q. Wang, and T. Yan. 2014. Anti-inflammatory effects of apigenin in lipopolysaccharide-induced inflammatory in acute lung injury by suppressing COX-2 and NF-kB pathway. Inflammation 37: 2085–2090.
19. Chen, T., Y. Mou, J. Tan, L. Wei, Y. Qiao, T. Wei, et al. 2015. The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice. International Immunopharmacology 25: 55–64.
20. Li, W., Y.N. Sun, X.T. Yan, S.Y. Yang, S.B. Song, Y.M. Lee, et al. 2013. NF-kappaB inhibitory activity of sucrose fatty acid esters and related constituents from Astragalus membranaceus. Journal of Agricultural and Food Chemistry 61: 7081–7088.
21. Jin, H., Q. Luo, Y. Zheng, M. Nurahmat, J. Wu, B. Li, et al. 2013. CD4 + CD25 + Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma. International Immunopharmacology 15: 42–49.
22. Tao, W., Q. Su, H. Wang, S. Guo, Y. Chen, J. Duan, et al. 2015. Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro. International Immunopharmacology 27: 138–147.
23. Lee, C.Y., J.J. Yang, S.S. Lee, C.J. Chen, Y.C. Huang, K.H. Huang, et al. 2014. Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via a JNK- and Akt-dependent NFkappaB pathway. Journal of Agricultural and Food Chemistry 62: 6337–6344.
24. Qian, J., Y. Ye, L. Lv, C. Zhu, and S. Ye. 2014. FTY720 attenuates paraquat-induced lung injury in mice. International Immunopharmacology 21: 426–431.
25. Huang, G.J., J.S. Deng, C.C. Chen, C.J. Huang, P.J. Sung, S.S. Huang, et al. 2014. Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-kappaB and MAPK pathways in mice. Journal of Agricultural and Food Chemistry 62: 5321–5329.
26. Lou, T., W. Jiang, D. Xu, T. Chen, and Y. Fu. 2015. Inhibitory effects of polydatin on lipopolysaccharide-stimulated RAW 264.7 cells. Inflammation 38: 1213–1220.
27. Tianzhu, Z., Y. Shihai, and D. Juan. 2014. The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3 inflammasome. Inflammation 37: 1976–1983.
28. Su, Z.Q., Z.Z. Mo, J.B. Liao, X.X. Feng, Y.Z. Liang, X. Zhang, et al. 2014. Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress. International Immunopharmacology 22: 371–378.
29. Chen, L., L. Zhao, C. Zhang, and Z. Lan. 2014. Protective effect of p-cymene on lipopolysaccharide-induced acute lung injury in mice. Inflammation 37: 358–364.
30. Wang, Y.Z., Y.C. Zhang, J.S. Cheng, Q. Ni, P.W. Li, W. Han, et al. 2014. Protective effects of BML-111 on cerulein-induced acute pancreatitis-associated lung injury via activation of Nrf2/ARE signaling pathway. Inflammation 37: 1120–1133.
31. Xu, L., Y. Li, S. Wan, Y. Wang, and P. Yu. 2014. Protective effects of apocynin nitrone on acute lung injury induced by lipopolysaccharide in rats. International Immunopharmacology 20: 377–382.
32. Chen, Y., Y.C. Nie, Y.L. Luo, F. Lin, Y.F. Zheng, G.H. Cheng, et al. 2013. Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. Food and Chemical Toxicology 58: 133–140.
33. Huang, X., Y. Liu, Y. Lu, and C. Ma. 2015. Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status. International Immunopharmacology 26: 265–271.
34. Li, Y., J. Li, S. Li, Y. Li, X. Wang, B. Liu, et al. 2015. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicology and Applied Pharmacology 286: 53–63.
35. Spindel, O.N., C. World, and B.C. Berk. 2012. Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms. Antioxidants & Redox Signaling 16: 587–596.
36. Kelleher, Z.T., Y. Sha, M.W. Foster, W.M. Foster, M.T. Forrester, and H.E. Marshall. 2014. Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor kappaB (NF-kappaB) activation. The Journal of Biological Chemistry 289: 3066–3072.
37. Wong, C.M., L. Wei, S.L. Au, D.N. Fan, Y. Zhou, F.H. Tsang, et al. 2015. MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. Oncotarget 6(15): 13658–13670.
38. Perey, A.C., I.M. Weishaar, and D.W. McGee. 2015. The effect of ROCK on TNF-alpha-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling. Cellular Immunology 293: 80–86.
39. Shi, J., X. Wu, M. Surma, S. Vemula, L. Zhang, Y. Yang, et al. 2013. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell death & Disease 4: e483.
40. Kanno, S., S. Hirano, S. Chiba, H. Takeshita, T. Nagai, M. Takada, et al. 2015. The role of Rho-kinases in IL-1beta release through phagocytosis of fibrous particles in human monocytes. Archives of Toxicology 89: 73–85.
41. Yu, W.W., Z. Lu, H. Zhang, Y.H. Kang, Y. Mao, H.H. Wang, et al. 2014. Anti-inflammatory and protective properties of daphnetin in endotoxin-induced lung injury. Journal of Agricultural and Food Chemistry 62: 12315–12325.
42. Chen T, Guo Q, Wang H, Zhang H, Wang C, Zhang P, et al. 2015 Effects of esculetin on lipopolysaccharide(LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-кB pathways in vivo and in vitro. Free Radical Research:1-21.
43. Yeh, Y.H., Y.L. Hsieh, and Y.T. Lee. 2013. Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. Journal of Agricultural and Food Chemistry 61: 7387–7396.