The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats

Acta Pharmacologica Sinica

Volumn 36, Issue 8, 2015, Pages 917-927

  Hua, Kai ^a   Sheng, Xiao ^a   Li, Ting Ting ^a   Wang, Lin Na ^a   Zhang, Yi Hua ^a   Huang, Zhang Jian ^a   Ji, Hui ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

3 n butylphthalide; cerebral ischemia; edaravone; edaravone and 3 n butylphthalide ringopening derivative; middle cerebral artery occlusion

Indexed keywords

BUTYLPHTHALIDE; CASPASE 3; CASPASE 9; COMPOUND 10B; GLUTATHIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; NEUROPROTECTIVE AGENT; NORPHENAZONE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; SYNAPTOTAGMIN I; THIOREDOXIN INTERACTING PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 3-N-BUTYLPHTHALIDE; ANTIOXIDANT; BENZOFURAN DERIVATIVE; PHENAZONE; PHENYLMETHYLPYRAZOLONE; WATER;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CELL PROTECTION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; HISTOPATHOLOGY; IMMUNOBLOTTING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RING OPENING; UPREGULATION; WATER CONTENT; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BRAIN; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ANTIPYRINE; APOPTOSIS; BENZOFURANS; BRAIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; WATER;

EID: 84938768843     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2015.31     Document Type: Article

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