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Volumn 20, Issue 8, 2015, Pages 533-539

Applying computation biology and "big data" to develop multiplex diagnostics for complex chronic diseases such as osteoarthritis

Author keywords

Chronic disease; Computational biology; Diagnostics; Osteoarthritis

Indexed keywords

ARTIFICIAL NEURAL NETWORK; BIOLOGY; CHRONIC DISEASE; CLINICAL PRACTICE; DIAGNOSTIC PROCEDURE; DISCRIMINANT ANALYSIS; DNA METHYLATION; DNA SEQUENCE; EARLY DIAGNOSIS; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HIGH THROUGHPUT SEQUENCING; HUMAN; LIFESTYLE; METABOLOMICS; NON INVASIVE PROCEDURE; NONHUMAN; OSTEOARTHRITIS; PRINCIPAL COMPONENT ANALYSIS; PROTEOMICS; REVIEW; RNA SEQUENCE; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS; SUPPORT VECTOR MACHINE; SYSTEMS BIOLOGY; TRANSCRIPTOMICS; ANIMAL; DATA MINING; FACTUAL DATABASE; GENETIC MARKER; GENETICS; GENOMICS; HIGH THROUGHPUT SCREENING; METABOLISM; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS;

EID: 84958033960     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2015.1105499     Document Type: Review
Times cited : (20)

References (71)
  • 2
    • 77954762633 scopus 로고    scopus 로고
    • Annotating non-coding regions of the genome
    • Alexander RP, Fang G, Rozowsky J, et al. (2010). Annotating non-coding regions of the genome. Nat Rev Genet 11: 559-71
    • (2010) Nat Rev Genet , vol.11 , pp. 559-571
    • Alexander, R.P.1    Fang, G.2    Rozowsky, J.3
  • 3
    • 84903756945 scopus 로고    scopus 로고
    • Proteomic analysis of human osteoarthritis synovial fluid
    • Balakrishnan L, Nirujogi RS, Ahmad S, et al. (2014). Proteomic analysis of human osteoarthritis synovial fluid. Clin Proteomics 11: 6
    • (2014) Clin Proteomics , vol.11 , pp. 6
    • Balakrishnan, L.1    Nirujogi, R.S.2    Ahmad, S.3
  • 4
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabasi AL, Gulbahce N, Loscalzo J. (2011). Network medicine: a network-based approach to human disease. Nat Rev Genet 12: 56-68
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabasi, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 5
    • 79959276553 scopus 로고    scopus 로고
    • Deploying whole genome sequencing in clinical practice and public health: Meeting the challenge one bin at a time
    • Berg JS, Khoury MJ, Evans JP. (2011). Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med 13: 499-504
    • (2011) Genet Med , vol.13 , pp. 499-504
    • Berg, J.S.1    Khoury, M.J.2    Evans, J.P.3
  • 6
    • 84961398422 scopus 로고    scopus 로고
    • THU0455 transcriptomics to identify synovial genes and pathways associated with disease progression in a cohort of early osteoarthritis patients (CHECK)
    • Blom A, van Lent P, van den Bosch M, et al. (2014). THU0455 transcriptomics to identify synovial genes and pathways associated with disease progression in a cohort of early osteoarthritis patients (CHECK). Ann Rheum Dis 73: 340-1
    • (2014) Ann Rheum Dis , vol.73 , pp. 340-341
    • Blom, A.1    Van Lent, P.2    Van Den Bosch, M.3
  • 7
    • 84961409513 scopus 로고    scopus 로고
    • Discovery and analysis of rare coding variants for hipOA by exome-sequencing
    • Boer CG, Rooij JV, Peters M, et al. (2014). Discovery and analysis of rare coding variants for hipOA by exome-sequencing. Osteoarthritis Cartilage 22: S226-7
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. S226-S227
    • Boer, C.G.1    Rooij, J.V.2    Peters, M.3
  • 8
    • 79959937504 scopus 로고    scopus 로고
    • Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing
    • Chen EZ, Chiu RW, Sun H, et al. (2011). Noninvasive prenatal diagnosis of fetal trisomy 18 and trisomy 13 by maternal plasma DNA sequencing. PLoS One 6: e21791
    • (2011) PLoS One , vol.6 , pp. e21791
    • Chen, E.Z.1    Chiu, R.W.2    Sun, H.3
  • 9
    • 84859741480 scopus 로고    scopus 로고
    • Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers
    • Chen L, Liu R, Liu ZP, et al. (2012). Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers. Sci Rep 2: 342
    • (2012) Sci Rep , vol.2 , pp. 342
    • Chen, L.1    Liu, R.2    Liu, Z.P.3
  • 10
    • 84887550824 scopus 로고    scopus 로고
    • Genome-wide expression profiles of subchondral bone in osteoarthritis
    • Chou CH, Wu CC, Song IW, et al. (2013). Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Res Ther 15: R190
    • (2013) Arthritis Res Ther , vol.15 , pp. R190
    • Chou, C.H.1    Wu, C.C.2    Song, I.W.3
  • 11
    • 34547556725 scopus 로고    scopus 로고
    • Introduction to computational proteomics
    • Colinge J, Bennett KL. (2007). Introduction to computational proteomics. PLoS Comput Biol 3: e114
    • (2007) PLoS Comput Biol , vol.3 , pp. e114
    • Colinge, J.1    Bennett, K.L.2
  • 12
    • 79955431733 scopus 로고    scopus 로고
    • Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis
    • Craig-Schapiro R, Kuhn M, Xiong C, et al. (2011). Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis. PLoS One 6: e18850
    • (2011) PLoS One , vol.6 , pp. e18850
    • Craig-Schapiro, R.1    Kuhn, M.2    Xiong, C.3
  • 13
    • 84871770976 scopus 로고    scopus 로고
    • Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
    • Delgado-Calle J, Fernandez AF, Sainz J, et al. (2013). Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum 65: 197-205
    • (2013) Arthritis Rheum , vol.65 , pp. 197-205
    • Delgado-Calle, J.1    Fernandez, A.F.2    Sainz, J.3
  • 14
    • 77958512833 scopus 로고    scopus 로고
    • Urinary proteomic diagnosis of coronary artery disease: Identification and clinical validation in 623 individuals
    • Delles C, Schiffer E, von Zur Muhlen C, et al. (2010). Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. J Hypertension 28: 2316-22
    • (2010) J Hypertension , vol.28 , pp. 2316-2322
    • Delles, C.1    Schiffer, E.2    Von Zur Muhlen, C.3
  • 15
    • 84907067643 scopus 로고    scopus 로고
    • Expanding the computational toolbox for mining cancer genomes
    • Ding L, Wendl MC, Mcmichael JF, Raphael BJ. (2014). Expanding the computational toolbox for mining cancer genomes. Nat Rev Genet 15: 556-70
    • (2014) Nat Rev Genet , vol.15 , pp. 556-570
    • Ding, L.1    Wendl, M.C.2    McMichael, J.F.3    Raphael, B.J.4
  • 16
    • 84877630278 scopus 로고    scopus 로고
    • Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data
    • Elliott KS, Chapman K, Day-Williams A, et al. (2013). Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis 72: 935-41
    • (2013) Ann Rheum Dis , vol.72 , pp. 935-941
    • Elliott, K.S.1    Chapman, K.2    Day-Williams, A.3
  • 17
    • 84895419805 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
    • Fernandez-Tajes J, Soto-Hermida A, Vazquez-Mosquera ME, et al. (2014). Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis 73: 668-77
    • (2014) Ann Rheum Dis , vol.73 , pp. 668-677
    • Fernandez-Tajes, J.1    Soto-Hermida, A.2    Vazquez-Mosquera, M.E.3
  • 18
    • 84857487802 scopus 로고    scopus 로고
    • Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
    • Fu J, Wolfs MG, Deelen P, et al. (2012). Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression. PLoS Genet 8: e1002431
    • (2012) PLoS Genet , vol.8 , pp. e1002431
    • Fu, J.1    Wolfs, M.G.2    Deelen, P.3
  • 19
    • 80051725475 scopus 로고    scopus 로고
    • Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics
    • Gerszten RE, Asnani A, Carr SA. (2011). Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics. Circ Res 109: 463-74
    • (2011) Circ Res , vol.109 , pp. 463-474
    • Gerszten, R.E.1    Asnani, A.2    Carr, S.A.3
  • 20
    • 79958035893 scopus 로고    scopus 로고
    • Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses
    • Gilman SR, Iossifov I, Levy D, et al. (2011). Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70: 898-907
    • (2011) Neuron , vol.70 , pp. 898-907
    • Gilman, S.R.1    Iossifov, I.2    Levy, D.3
  • 21
    • 78149291420 scopus 로고    scopus 로고
    • Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease
    • Good DM, Zurbig P, Argiles A, et al. (2010). Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics 9: 2424-37
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2424-2437
    • Good, D.M.1    Zurbig, P.2    Argiles, A.3
  • 22
    • 68949206409 scopus 로고    scopus 로고
    • Applying mass spectrometry-based proteomics to genetics, genomics and network biology
    • Gstaiger M, Aebersold R. (2009). Applying mass spectrometry-based proteomics to genetics, genomics and network biology. Nat Rev Genet 10: 617-27
    • (2009) Nat Rev Genet , vol.10 , pp. 617-627
    • Gstaiger, M.1    Aebersold, R.2
  • 23
    • 82755161992 scopus 로고    scopus 로고
    • The future of Alzheimer's disease: The next 10 years
    • Hampel H, Prvulovic D, Teipel S, et al. (2011). The future of Alzheimer's disease: the next 10 years. Prog Neurobiol 95: 718-28
    • (2011) Prog Neurobiol , vol.95 , pp. 718-728
    • Hampel, H.1    Prvulovic, D.2    Teipel, S.3
  • 24
    • 84872222387 scopus 로고    scopus 로고
    • Identification of osteoarthritis biomarkers by proteomic analysis of synovial fluid
    • Han MY, Dai JJ, Zhang Y, et al. (2012). Identification of osteoarthritis biomarkers by proteomic analysis of synovial fluid. J Int Med Res 40: 2243-50
    • (2012) J Int Med Res , vol.40 , pp. 2243-2250
    • Han, M.Y.1    Dai, J.J.2    Zhang, Y.3
  • 25
    • 84881459326 scopus 로고    scopus 로고
    • Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis
    • Heard BJ, Fritzler MJ, Wiley JP, et al. (2013). Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis. J Rheumatol 40: 1379-87
    • (2013) J Rheumatol , vol.40 , pp. 1379-1387
    • Heard, B.J.1    Fritzler, M.J.2    Wiley, J.P.3
  • 26
    • 84903641352 scopus 로고    scopus 로고
    • A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers
    • Heard BJ, Rosvold JM, Fritzler MJ, et al. (2014). A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers. J R Soc Interface 11: 20140428
    • (2014) J R Soc Interface , vol.11 , pp. 20140428
    • Heard, B.J.1    Rosvold, J.M.2    Fritzler, M.J.3
  • 27
    • 84862639108 scopus 로고    scopus 로고
    • Principal component analysis of the cytokine and chemokine response to human traumatic brain injury
    • Helmy A, Antoniades CA, Guilfoyle MR, et al. (2012). Principal component analysis of the cytokine and chemokine response to human traumatic brain injury. PLoS One 7: e39677
    • (2012) PLoS One , vol.7 , pp. e39677
    • Helmy, A.1    Antoniades, C.A.2    Guilfoyle, M.R.3
  • 28
    • 84861961870 scopus 로고    scopus 로고
    • Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis
    • Henrotin Y, Gharbi M, Mazzucchelli G, et al. (2012). Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis. Arthritis Rheum 64: 2260-7
    • (2012) Arthritis Rheum , vol.64 , pp. 2260-2267
    • Henrotin, Y.1    Gharbi, M.2    Mazzucchelli, G.3
  • 29
    • 84871511126 scopus 로고    scopus 로고
    • Deaths: Preliminary data for 2011
    • Hoyert DL, Xu J. (2012). Deaths: preliminary data for 2011. Natl Vital Stat Rep 61: 1-51
    • (2012) Natl Vital Stat Rep , vol.61 , pp. 1-51
    • Hoyert, D.L.1    Xu, J.2
  • 30
    • 84908259216 scopus 로고    scopus 로고
    • Biomarkers and proteomic analysis of osteoarthritis
    • Hsueh MF, Onnerfjord P, Kraus VB. (2014). Biomarkers and proteomic analysis of osteoarthritis. Matrix Biol 39: 56-66
    • (2014) Matrix Biol , vol.39 , pp. 56-66
    • Hsueh, M.F.1    Onnerfjord, P.2    Kraus, V.B.3
  • 31
    • 84906222774 scopus 로고    scopus 로고
    • Big data and large sample size: A cautionary note on the potential for bias
    • Kaplan RM, Chambers DA, Glasgow RE. (2014). Big data and large sample size: a cautionary note on the potential for bias. Clin Transl Sci 7: 342-6
    • (2014) Clin Transl Sci , vol.7 , pp. 342-346
    • Kaplan, R.M.1    Chambers, D.A.2    Glasgow, R.E.3
  • 32
    • 84970928287 scopus 로고    scopus 로고
    • New genetic variants improve personalized breast cancer diagnosis
    • Liu J, Page D, Peissig P, et al. (2014). New genetic variants improve personalized breast cancer diagnosis. AMIA Jt Summits Transl Sci Proc 2014: 83-9
    • (2014) AMIA Jt Summits Transl Sci Proc , vol.2014 , pp. 83-89
    • Liu, J.1    Page, D.2    Peissig, P.3
  • 33
    • 47649096699 scopus 로고    scopus 로고
    • Presymptomatic prediction of sepsis in intensive care unit patients
    • Lukaszewski RA, Yates AM, Jackson MC, et al. (2008). Presymptomatic prediction of sepsis in intensive care unit patients. Clin Vaccine Immunol 15: 1089-94
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 1089-1094
    • Lukaszewski, R.A.1    Yates, A.M.2    Jackson, M.C.3
  • 34
    • 54249156545 scopus 로고    scopus 로고
    • Metabolic syndrome: From epidemiology to systems biology
    • Lusis AJ, Attie AD, Reue K. (2008). Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet 9: 819-30
    • (2008) Nat Rev Genet , vol.9 , pp. 819-830
    • Lusis, A.J.1    Attie, A.D.2    Reue, K.3
  • 35
    • 72549095180 scopus 로고    scopus 로고
    • Chemometrics in metabolomics - A review in human disease diagnosis
    • Madsen R, Lundstedt T, Trygg J. (2010). Chemometrics in metabolomics-a review in human disease diagnosis. Anal Chim Acta 659: 23-33
    • (2010) Anal Chim Acta , vol.659 , pp. 23-33
    • Madsen, R.1    Lundstedt, T.2    Trygg, J.3
  • 36
    • 80052960863 scopus 로고    scopus 로고
    • Next-generation transcriptome assembly
    • Martin JA, Wang Z. (2011). Next-generation transcriptome assembly. Nat Rev Genet 12: 671-82
    • (2011) Nat Rev Genet , vol.12 , pp. 671-682
    • Martin, J.A.1    Wang, Z.2
  • 37
    • 84878979335 scopus 로고    scopus 로고
    • Biology: The big challenges of big data
    • Marx V. (2013). Biology: the big challenges of big data. Nature 498: 255-60
    • (2013) Nature , vol.498 , pp. 255-260
    • Marx, V.1
  • 38
    • 79960654202 scopus 로고    scopus 로고
    • Exciting new advances in oral cancer diagnosis: Avenues to early detection
    • Mehrotra R, Gupta DK. (2011). Exciting new advances in oral cancer diagnosis: avenues to early detection. Head Neck Oncol 3: 1-9
    • (2011) Head Neck Oncol , vol.3 , Issue.1 , pp. 9
    • Mehrotra, R.1    Gupta, D.K.2
  • 39
    • 84892619094 scopus 로고    scopus 로고
    • Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis
    • Nacher JC, Keith B, Schwartz J-M. (2014). Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis. Proc R Soc B: Biol Sci 281: 20132907
    • (2014) Proc R Soc B: Biol Sci , vol.281 , pp. 20132907
    • Nacher, J.C.1    Keith, B.2    Schwartz, J.-M.3
  • 40
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak BJ, Vives L, Girirajan S, et al. (2012). Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485: 246-50
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1    Vives, L.2    Girirajan, S.3
  • 41
    • 84897546311 scopus 로고    scopus 로고
    • Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis
    • Olex AL, Turkett WH, Fetrow JS, Loeser RF. (2014). Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis. Gene 542: 38-45
    • (2014) Gene , vol.542 , pp. 38-45
    • Olex, A.L.1    Turkett, W.H.2    Fetrow, J.S.3    Loeser, R.F.4
  • 42
    • 79954618053 scopus 로고    scopus 로고
    • Lung cancer diagnosis from proteomic analysis of preinvasive lesions
    • Rahman SJ, Gonzalez AL, Li M, et al. (2011). Lung cancer diagnosis from proteomic analysis of preinvasive lesions. Cancer Res 71: 3009-17
    • (2011) Cancer Res , vol.71 , pp. 3009-3017
    • Rahman, S.J.1    Gonzalez, A.L.2    Li, M.3
  • 43
    • 84925232257 scopus 로고    scopus 로고
    • Genes expressed in blood link osteoarthritis with apoptotic pathways
    • Ramos YF, Bos SD, Lakenberg N, et al. (2014). Genes expressed in blood link osteoarthritis with apoptotic pathways. Ann Rheum Dis 73: 1844-53
    • (2014) Ann Rheum Dis , vol.73 , pp. 1844-1853
    • Ramos, Y.F.1    Bos, S.D.2    Lakenberg, N.3
  • 44
    • 84898670941 scopus 로고    scopus 로고
    • Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies
    • Rodriguez-Fontenla C, Calaza M, Evangelou E, et al. (2014). Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol 66: 940-9
    • (2014) Arthritis Rheumatol , vol.66 , pp. 940-949
    • Rodriguez-Fontenla, C.1    Calaza, M.2    Evangelou, E.3
  • 45
    • 77955868506 scopus 로고    scopus 로고
    • Computational solutions to large-scale data management and analysis
    • Schadt EE, Linderman MD, Sorenson J, et al. (2010). Computational solutions to large-scale data management and analysis. Nat Rev Genet 11: 647-57
    • (2010) Nat Rev Genet , vol.11 , pp. 647-657
    • Schadt, E.E.1    Linderman, M.D.2    Sorenson, J.3
  • 46
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok J, Warren HS, Cuenca AG, et al. (2013). Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 110: 3507-12
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3507-3512
    • Seok, J.1    Warren, H.S.2    Cuenca, A.G.3
  • 47
    • 84866999347 scopus 로고    scopus 로고
    • Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies
    • Shaffer LG, Dabell MP, Fisher AJ, et al. (2012). Experience with microarray-based comparative genomic hybridization for prenatal diagnosis in over 5000 pregnancies. Prenat Diagn 32: 976-85
    • (2012) Prenat Diagn , vol.32 , pp. 976-985
    • Shaffer, L.G.1    Dabell, M.P.2    Fisher, A.J.3
  • 48
    • 84891747477 scopus 로고    scopus 로고
    • Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover
    • Siebuhr AS, Petersen KK, Arendt-Nielsen L, et al. (2014). Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover. Osteoarthritis Cartilage 22: 44-50
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 44-50
    • Siebuhr, A.S.1    Petersen, K.K.2    Arendt-Nielsen, L.3
  • 49
    • 84919384253 scopus 로고    scopus 로고
    • Role of hyaluronic acid in early diagnosis of knee osteoarthritis
    • Singh S, Kumar D, Sharma NR. (2014a). Role of hyaluronic acid in early diagnosis of knee osteoarthritis. J Clin Diagn Res 8: LC04-7
    • (2014) J Clin Diagn Res , vol.8 , pp. LC04-7
    • Singh, S.1    Kumar, D.2    Sharma, N.R.3
  • 50
    • 84961403401 scopus 로고    scopus 로고
    • Serum Cartilage Oligomeric Matrix Protein: Tool for early diagnosis and grading of severity of primary knee osteoarthritis
    • Singh S, Shahi U, Kumar D, Shahi NT. (2014b). Serum Cartilage Oligomeric Matrix Protein: tool for early diagnosis and grading of severity of primary knee osteoarthritis. Int J Osteol Orthop 1: 1-7
    • (2014) Int J Osteol Orthop , vol.1 , pp. 1-7
    • Singh, S.1    Shahi, U.2    Kumar, D.3    Shahi, N.T.4
  • 51
    • 77954526823 scopus 로고    scopus 로고
    • The case for cloud computing in genome informatics
    • Stein LD. (2010). The case for cloud computing in genome informatics. Genome Biol 11: 207
    • (2010) Genome Biol , vol.11 , pp. 207
    • Stein, L.D.1
  • 52
    • 84889971850 scopus 로고    scopus 로고
    • Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning
    • Swan AL, Hillier KL, Smith JR, et al. (2013). Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning. BMC Musculoskelet Disord 14: 349
    • (2013) BMC Musculoskelet Disord , vol.14 , pp. 349
    • Swan, A.L.1    Hillier, K.L.2    Smith, J.R.3
  • 53
    • 84881042313 scopus 로고    scopus 로고
    • Identification of potential prognostic markers for knee osteoarthritis by serum proteomic analysis
    • Takinami Y, Yoshimatsu S, Uchiumi T, et al. (2013). Identification of potential prognostic markers for knee osteoarthritis by serum proteomic analysis. Biomark Insights 8: 85-95
    • (2013) Biomark Insights , vol.8 , pp. 85-95
    • Takinami, Y.1    Yoshimatsu, S.2    Uchiumi, T.3
  • 54
    • 84902813290 scopus 로고    scopus 로고
    • Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis: The Matsudai knee osteoarthritis survey
    • Tanishi N, Yamagiwa H, Hayami T, et al. (2014). Usefulness of urinary CTX-II and NTX-I in evaluating radiological knee osteoarthritis: the Matsudai knee osteoarthritis survey. J Orthop Sci 19: 429-36
    • (2014) J Orthop Sci , vol.19 , pp. 429-436
    • Tanishi, N.1    Yamagiwa, H.2    Hayami, T.3
  • 55
    • 84927631951 scopus 로고    scopus 로고
    • Osteoarthritis year in review 2014: Genetics and genomics. Osteoarthritis
    • Tsezou A. (2014). Osteoarthritis year in review 2014: genetics and genomics. Osteoarthritis Cartilage 22: 2017-24
    • (2014) Cartilage , vol.22 , pp. 2017-2024
    • Tsezou, A.1
  • 56
    • 84862278781 scopus 로고    scopus 로고
    • Pseudogenes
    • Tutar Y. (2012). Pseudogenes. Comp Funct Genomics 2012: 424526
    • (2012) Comp Funct Genomics , vol.2012 , pp. 424526
    • Tutar, Y.1
  • 57
    • 79952389826 scopus 로고    scopus 로고
    • Algorithms for detecting significantly mutated pathways in cancer
    • Vandin F, Upfal E, Raphael BJ. (2011). Algorithms for detecting significantly mutated pathways in cancer. J Comput Biol 18: 507-22
    • (2011) J Comput Biol , vol.18 , pp. 507-522
    • Vandin, F.1    Upfal, E.2    Raphael, B.J.3
  • 58
    • 79952674000 scopus 로고    scopus 로고
    • Interactome networks and human disease
    • Vidal M, Cusick ME, Barabasi A-L. (2011). Interactome networks and human disease. Cell 144: 986-98
    • (2011) Cell , vol.144 , pp. 986-998
    • Vidal, M.1    Cusick, M.E.2    Barabasi, A.-L.3
  • 60
    • 67649407372 scopus 로고    scopus 로고
    • A neural network-based biomarker association information extraction approach for cancer classification
    • Wang HQ, Wong HS, Zhu H, Yip TT. (2009). A neural network-based biomarker association information extraction approach for cancer classification. J Biomed Inform 42: 654-66
    • (2009) J Biomed Inform , vol.42 , pp. 654-666
    • Wang, H.Q.1    Wong, H.S.2    Zhu, H.3    Yip, T.T.4
  • 61
    • 84940163308 scopus 로고    scopus 로고
    • Bioinformatics analysis of gene expression profiles of osteoarthritis
    • Wang Q, Li Y, Zhang Z, et al. (2014). Bioinformatics analysis of gene expression profiles of osteoarthritis. Acta Histochem 117: 40-6
    • (2014) Acta Histochem , vol.117 , pp. 40-46
    • Wang, Q.1    Li, Y.2    Zhang, Z.3
  • 62
    • 84870549609 scopus 로고    scopus 로고
    • Chromosomal microarray versus karyotyping for prenatal diagnosis
    • Wapner RJ, Martin CL, Levy B, et al. (2012). Chromosomal microarray versus karyotyping for prenatal diagnosis. N Engl J Med 367: 2175-84
    • (2012) N Engl J Med , vol.367 , pp. 2175-2184
    • Wapner, R.J.1    Martin, C.L.2    Levy, B.3
  • 63
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control, C. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-78
    • (2007) Nature , vol.447 , pp. 661-678
  • 64
    • 84888217689 scopus 로고    scopus 로고
    • Molecular diagnosis of eosinophilic esophagitis by gene expression profiling
    • Wen T, Stucke EM, Grotjan TM, et al. (2013). Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology 145: 1289-99
    • (2013) Gastroenterology , vol.145 , pp. 1289-1299
    • Wen, T.1    Stucke, E.M.2    Grotjan, T.M.3
  • 65
    • 84885226405 scopus 로고    scopus 로고
    • Whole-transcriptome profiling of thyroid nodules identifies expression-based signatures for accurate thyroid cancer diagnosis
    • Wiseman SM, Haddad Z, Walker B, et al. (2013). Whole-transcriptome profiling of thyroid nodules identifies expression-based signatures for accurate thyroid cancer diagnosis. J Clin Endocrinol Metab 98: 4072-9
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4072-4079
    • Wiseman, S.M.1    Haddad, Z.2    Walker, B.3
  • 66
    • 84893804427 scopus 로고    scopus 로고
    • TSG-6 activity as a novel biomarker of progression in knee osteoarthritis
    • Wisniewski HG, Colon E, Liublinska V, et al. (2014). TSG-6 activity as a novel biomarker of progression in knee osteoarthritis. Osteoarthritis Cartilage 22: 235-41
    • (2014) Osteoarthritis Cartilage , vol.22 , pp. 235-241
    • Wisniewski, H.G.1    Colon, E.2    Liublinska, V.3
  • 67
    • 84870328390 scopus 로고    scopus 로고
    • Urinary proteomics for early diagnosis in diabetic nephropathy
    • Zurbig P, Jerums G, Hovind P, et al. (2012). Urinary proteomics for early diagnosis in diabetic nephropathy. Diabetes 61: 3304-13
    • (2012) Diabetes , vol.61 , pp. 3304-3313
    • Zurbig, P.1    Jerums, G.2    Hovind, P.3
  • 68
    • 84871784703 scopus 로고    scopus 로고
    • Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment
    • Zhang A, Sun H, Wang X. (2012). Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment. Appl Biochem Biotechnol 168: 1718-27
    • (2012) Appl Biochem Biotechnol , vol.168 , pp. 1718-1727
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 69
    • 85018192922 scopus 로고    scopus 로고
    • A neural network approach to multi-biomarker panel discovery by high-throughput plasma proteomics profiling of breast cancer
    • Zhang F, Chen J, Wang M, Drabier R. (2013). A neural network approach to multi-biomarker panel discovery by high-throughput plasma proteomics profiling of breast cancer. BMC Proc 7: S10
    • (2013) BMC Proc , vol.7 , pp. S10
    • Zhang, F.1    Chen, J.2    Wang, M.3    Drabier, R.4
  • 70
    • 84911886343 scopus 로고    scopus 로고
    • Classification of osteoarthritis phenotypes by metabolomics analysis
    • Zhang W, Likhodii S, Zhang Y, et al. (2014). Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open 4: e006286
    • (2014) BMJ Open , vol.4 , pp. e006286
    • Zhang, W.1    Likhodii, S.2    Zhang, Y.3
  • 71
    • 79952161655 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein-inflammation biomarker in knee osteoarthritis
    • Zivanovic S, Rackov LP, Zivanovic A, et al. (2011). Cartilage oligomeric matrix protein-inflammation biomarker in knee osteoarthritis. Bosn J Basic Med Sci 11: 27-32
    • (2011) Bosn J Basic Med Sci , vol.11 , pp. 27-32
    • Zivanovic, S.1    Rackov, L.P.2    Zivanovic, A.3


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