Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis

Journal of Rheumatology

Volumn 40, Issue 8, 2013, Pages 1379-1387

  Heard, Bryan J ^a   Fritzler, Marvin J ^a   Preston Wiley, J ^b   McAllister, Jenelle ^b   Martin, Liam ^a   El Gabalawy, Hani ^c   Hart, David A ^a   Frank, Cyril B ^a   Krawetz, Roman ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b Faculty of Kinesiology   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cytokines; Inflammation; Luminex; Osteoarthritis; Serum; Synovial fluid

Indexed keywords

ALPHA2 INTERFERON; EOTAXIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FLT3 LIGAND; FRACTALKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; INTERLEUKIN 9; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1;

ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; INFLAMMATION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SYNOVIAL FLUID LEVEL;

CYTOKINES; INFLAMMATION; LUMINEX; OSTEOARTHRITIS; SERUM; SYNOVIAL FLUID;

ADULT; AGED; AGED, 80 AND OVER; ALBERTA; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHEMOKINES; COHORT STUDIES; CYTOKINES; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INFLAMMATION; MIDDLE AGED; OSTEOARTHRITIS; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID;

EID: 84881459326     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.121204     Document Type: Article

References (54)

1. Reginster JY. The prevalence and burden of arthritis. Rheumatology 2002;41 Supp 1:3-6.
2. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ 2003;81:646-56.
3. Funakoshi Y, Hariu M, Tapper JE, Marchuk LL, Shrive NG, Kanaya F, et al. Periarticular ligament changes following ACL/MCL transection in an ovine stifle joint model of osteoarthritis. J Orthop Res 2007;25:997-1006.
4. Panula HE, Helminen HJ, Kiviranta I. Slowly progressive osteoarthritis after tibial valgus osteotomy in young beagle dogs. Clin Orthop Relat Res 1997;343:192-202.
5. Benito MJ, Veale DJ, Fitz Gerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis 2005;64:1263-7.
6. Garvican ER, Vaughan-Thomas A, Innes JF, Clegg PD. Biomarkers of cartilage turnover. Part 1: Markers of collagen degradation and synthesis. Vet J 2010;185:36-42.
7. Burrage PS, Mix KS, Brinckerhoff CE. Matrix metalloproteinases: role in arthritis. Front Biosci 2006;11:529-43.
8. Fan J, Varshney RR, Ren L, Cai D, Wang DA. Synovium-derived mesenchymal stem cells: A new cell source for musculoskeletal regeneration. Tissue Eng Part B Rev 2009;15:75-86.
9. Galois L, Freyria AM, Grossin L, Hubert P, Mainard D, Herbage D, et al. Cartilage repair: Surgical techniques and tissue engineering using polysaccharide-and collagen-based biomaterials. Biorheology 2004;41:433-43.
10. De Rienzo F, Saxena P, Filomia F, Caselli G, Colace F, Stasi L, et al. Progress towards the identification of new aggrecanase inhibitors. Curr Med Chem 2009;16:2395-415.
11. Flynn BP, Bhole AP, Saeidi N, Liles M, Dimarzio CA, Ruberti JW. Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8). PLoS One 2010;5:e12337.
12. Le Graverand MP, Eggerer J, Vignon E, Otterness IG, Barclay L, Hart DA. Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis. J Orthop Res 2002;20:535-44.
13. Fehr JE, Trotter GW, Oxford JT, Hart DA. Comparison of Northern blot hybridization and a reverse transcriptase-polymerase chain reaction technique for measurement of mRNA expression of metalloproteinases and matrix components in articular cartilage and synovial membrane from horses with osteoarthritis. Am J Vet Res 2000;61:900-5.
14. Elsaid KA, Chichester CO. Review: Collagen markers in early arthritic diseases. Clin Chim Acta 2006;365:68-77.
15. Deberg M, Dubuc JE, Labasse A, Sanchez C, Quettier E, Bosseloir A, et al. One-year follow-up of Coll2-1, Coll2-1NO2 and myeloperoxydase serum levels in osteoarthritis patients after hip or knee replacement. Ann Rheum Dis 2008;67:168-74.
16. Andriamanalijaona R, Benateau H, Barre PE, Boumediene K, Labbe D, Compere JF, et al. Effect of interleukin-1-beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables. J Periodontol 2006;77:1156-66.
17. Golightly YM, Marshall SW, Kraus VB, Renner JB, Villaveces A, Casteel C, et al. Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms? Arthritis Rheum 2011;63:2276-83.
18. Chen HC, Shah S, Stabler TV, Li YJ, Kraus VB. Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: The CARRIAGE Family Study. Osteoarthritis Cartilage 2008;16:1054-9.
19. Thampatty BP, Li H, Im HJ, Wang JH. EP4 receptor regulates collagen type-I, MMP-1, and MMP-3 gene expression in human tendon fibroblasts in response to IL-1 beta treatment. Gene 2007;386:154-61.
20. Jimbo K, Park JS, Yokosuka K, Sato K, Nagata K. Positive feedback loop of interleukin-1-beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro. J Neurosurg Spine 2005;2:589-95.
21. Van Den Steen PE, Wuyts A, Husson SJ, Proost P, Van Damme J, Opdenakker G. Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities. Eur J Biochem 2003;270:3739-49.
22. Heard BJ, Martin L, Rattner JB, Frank CB, Hart DA, Krawetz RJ. Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid. BMC Musculoskelet Disord 2012;13:126.
23. Hueber AJ, Asquith DL, McInnes IB, Miller AM. Embracing novel cytokines in RA-complexity grows as does opportunity! Best Pract Res Clin Rheumatol 2010;24:479-87.
24. Atzeni F, Sarzi-Puttini P. Anti-cytokine antibodies for rheumatic diseases. Curr Opin Investig Drugs 2009;10:1204-11.
25. Webb GR, Westacott CI, Elson CJ. Osteoarthritic synovial fluid and synovium supernatants up-regulate tumor necrosis factor receptors on human articular chondrocytes. Osteoarthritis Cartilage 1998;6:167-76.
26. Jacques C, Gosset M, Berenbaum F, Gabay C. The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation. Vitam Horm 2006;74:371-403.
27. Firestein GS, Berger AE, Tracey DE, Chosay JG, Chapman DL, Paine MM, et al. IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. J Immunol 1992;149:1054-62.
28. Danfelter M, Onnerfjord P, Heinegard D. Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain. J Biol Chem 2007;282:36933-41.
29. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002;39:237-46.
30. Chen CW, Tsai YH, Deng WP, Shih SN, Fang CL, Burch JG, et al. Type I and II collagen regulation of chondrogenic differentiation by mesenchymal progenitor cells. J Orthop Res 2005;23:446-53.
31. Vistnes M, Christensen G, Omland T. Multiple cytokine biomarkers in heart failure. Expert Rev Mol Diagn 2010;10:147-57.
32. Huss RS, Huddleston JI, Goodman SB, Butcher EC, Zabel BA. Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation. Arthritis Rheum 2010;62:3799-805.
33. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039-49.
34. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569-81.
35. Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, et al. An evaluation of commercial fluorescent bead-based luminex cytokine assays. PLoS One 2008;3:e2535.
36. Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology 2005;44:7-16.
37. Westacott CI, Sharif M. Cytokines in osteoarthritis: Mediators or markers of joint destruction? Semin Arthritis Rheum 1996; 25:254-72.
38. Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford Study. Arthritis Rheum 2009; 60:2037-45.
39. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008;67 Suppl 3:iii75-82.
40. Shlopov BV, Gumanovskaya ML, Hasty KA. Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis. Arthritis Rheum 2000;43:195-205.
41. Attur M, Wang HY, Kraus VB, Bukowski JF, Aziz N, Krasnokutsky S, et al. Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Ann Rheum Dis 2010;69:856-61.
42. Cuellar JM, Scuderi GJ, Cuellar VG, Golish SR, Yeomans DC. Diagnostic utility of cytokine biomarkers in the evaluation of acute knee pain. J Bone Joint Surg Am 2009;91:2313-20.
43. Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, et al. Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. Arthritis Rheum 2009;60:2019-27.
44. Flytlie HA, Hvid M, Lindgreen E, Kofod-Olsen E, Petersen EL, Jorgensen A, et al. Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Cytokine 2010;49:24-9.
45. Cook AD, Pobjoy J, Steidl S, Durr M, Braine EL, Turner AL, et al. Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development. Arthritis Res Ther 2012;14:R199.
46. Pope RM, Shahrara S. Possible roles of IL-12-family cytokines in rheumatoid arthritis. Nat Rev Rheumatol 2013;9:252-6.
47. Saetan N, Honsawek S, Tanavalee A, Tantavisut S, Yuktanandana P, Parkpian V. Association of plasma and synovial fluid interferon-gamma inducible protein-10 with radiographic severity in knee osteoarthritis. Clin Biochem 2011;44:1218-22.
48. Ceccarelli F, Perricone C, Alessandri C, Modesti M, Iagnocco A, Croia C, et al. Exploratory data analysis on the effects of non pharmacological treatment for knee osteoarthritis. Clin Exp Rheumatol 2010;28:250-3.
49. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci USA 2012;109:20602-7.
50. Makimura C, Arao T, Matsuoka H, Takeda M, Kiyota H, Tsurutani J, et al. Prospective study evaluating the plasma concentrations of twenty-six cytokines and response to morphine treatment in cancer patients. Anticancer Res 2011;31:4561-8.
51. Heitzer E, Sandner-Kiesling A, Schippinger W, Stohscheer I, Osprian I, Bitsche S, et al. IL-7, IL-18, MCP-1, MIP1-beta, and OPG as biomarkers for pain treatment response in patients with cancer. Pain Physician 2012;15:499-510.
52. Orita S, Koshi T, Mitsuka T, Miyagi M, Inoue G, Arai G, et al. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord 2011;12:144.
53. Attur M, Belitskaya-Levy I, Oh C, Krasnokutsky S, Greenberg J, Samuels J, et al. Increased interleukin-1-beta gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum 2011;63:1908-17.
54. Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J, et al. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 2010;18:1441-7.