Prevalence of Subretinal Drusenoid Deposits in Older Persons with and without Age-Related Macular Degeneration, by Multimodal Imaging

Ophthalmology

Volumn 123, Issue 5, 2016, Pages 1090-1100

  Zarubina, Anna V ^a   Neely, David C ^a   Clark, Mark E ^a   Huisingh, Carrie E ^a,b   Samuels, Brian C ^a   Zhang, Yuhua ^a   McGwin, Gerald ^a,b   Owsley, Cynthia ^a   Curcio, Christine A ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE RELATED MACULAR DEGENERATION; AGED; ARTICLE; COLOR FUNDUS PHOTOGRAPH; CONFOCAL SCANNING LASER OPHTHALMOSCOPE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUSEN; FEMALE; FUNDUS AUTOFLUORESCENCE; FUNDUS CAMERA; GERIATRIC DISORDER; HUMAN; INFRARED REFLECTANCE; MAJOR CLINICAL STUDY; MALE; MULTIMODAL IMAGING; OPTICAL COHERENCE TOMOGRAPHY DEVICE; PREVALENCE; PRIORITY JOURNAL; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; SUBRETINAL DRUSENOID DEPOSIT; VERY ELDERLY; BLOOD; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; OPTIC DISK; OPTICAL COHERENCE TOMOGRAPHY; PROSPECTIVE STUDY; RETINA MACULA LUTEA; RETINAL DRUSEN; WET MACULAR DEGENERATION;

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; C REACTIVE PROTEIN; COMPLEMENT;

AGED; AGED, 80 AND OVER; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; C-REACTIVE PROTEIN; COMPLEMENT SYSTEM PROTEINS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MACULA LUTEA; MALE; MIDDLE AGED; MULTIMODAL IMAGING; OPTIC DISK; PREVALENCE; PROSPECTIVE STUDIES; RETINAL DRUSEN; TOMOGRAPHY, OPTICAL COHERENCE; WET MACULAR DEGENERATION;

EID: 84957927079     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2015.12.034     Document Type: Article

References (82)

1. C.A. Curcio, J.D. Messinger, K.R. Sloan, and et al. Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model Retina 33 2013 265 276
2. S. Schmitz-Valckenberg, F. Alten, J.S. Steinberg, and et al. Reticular drusen associated with geographic atrophy in age-related macular degeneration Invest Ophthalmol Vis Sci 52 2011 5009 5015
3. M. Rudolf, G. Malek, J.D. Messinger, and et al. Sub-retinal drusenoid deposits in human retina: organization and composition Exp Eye Res 87 2008 402 408
4. A.S. Oak, J.D. Messinger, and C.A. Curcio Subretinal drusenoid deposits: further characterization by lipid histochemistry Retina 34 2014 825 826
5. C.A. Curcio, M. Johnson, M. Rudolf, and J.D. Huang The oil spill in ageing Bruch membrane Br J Ophthalmol 95 2011 1638 1645
6. J.J. Arnold, J.P. Sarks, M.C. Killingsworth, and et al. Adult vitelliform macular degeneration: a clinicopathological study Eye (Lond) 17 2003 717 726
7. Y. Zhang, X. Wang, E.B. Rivero, and et al. Photoreceptor perturbation around subretinal drusenoid deposits as revealed by adaptive optics scanning laser ophthalmoscopy Am J Ophthalmol 158 2014 584 596 e1
8. J.S. Steinberg, F.W. Fitzke, R. Fimmers, and et al. Scotopic and photopic microperimetry in patients with reticular drusen and age-related macular degeneration JAMA Ophthalmol 133 2015 690 697
9. J. Flamendorf, E. Agron, W.T. Wong, and et al. Impairments in dark adaptation are associated with age-related macular degeneration severity and reticular pseudodrusen Ophthalmology 122 2015 2053 2062
10. D. Neely, A.V. Zarubina, M.E. Clark, and et al. Association between subretinal drusenoid deposits seen by multimodal imaging and dark adaptation in normal, early, and intermediate age-related macular degeneration eyes Abstract. Invest Ophthalmol Vis Sci 56 2015 2777
11. G. Mimoun, G. Soubrane, and G. Coscas Macular drusen J Fr Ophtalmol 13 1990 511 530
12. J.J. Arnold, S.H. Sarks, M.C. Killingsworth, and J.P. Sarks Reticular pseudodrusen. A risk factor in age-related maculopathy Retina 15 1995 183 191
13. C.A. Curcio, J.B. Presley, G. Malek, and et al. Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy Exp Eye Res 81 2005 731 741
14. S.A. Zweifel, Y. Imamura, T.C. Spaide, and et al. Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration Ophthalmology 117 2010 1775 1781
15. S.A. Zweifel, R.F. Spaide, C.A. Curcio, and et al. Reticular pseudodrusen are subretinal drusenoid deposits Ophthalmology 117 2010 303 312 e1
16. J.L. Prenner, B.J. Rosenblatt, M.J. Tolentino, and et al. Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT Retina 23 2003 307 314
17. W. Einbock, A. Moessner, U.E. Schnurrbusch, and et al. Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study Graefes Arch Clin Exp Ophthalmol 243 2005 300 305
18. R.T. Smith, J.K. Chan, M. Busuoic, and et al. Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration Invest Ophthalmol Vis Sci 47 2006 5495 5504
19. S.Y. Cohen, L. Dubois, R. Tadayoni, and et al. Prevalence of reticular pseudodrusen in age-related macular degeneration with newly diagnosed choroidal neovascularisation Br J Ophthalmol 91 2007 354 359
20. J.J. Wang, E. Rochtchina, A.J. Lee, and et al. Ten-year incidence and progression of age-related maculopathy: the Blue Mountains Eye Study Ophthalmology 114 2007 92 98
21. R. Klein, S.M. Meuer, M.D. Knudtson, and et al. The epidemiology of retinal reticular drusen Am J Ophthalmol 145 2008 317 326
22. R.T. Smith, J.E. Merriam, M.A. Sohrab, and et al. Complement factor H 402H variant and reticular macular disease Arch Ophthalmol 129 2011 1061 1066
23. D. Smailhodzic, M. Fleckenstein, T. Theelen, and et al. Central areolar choroidal dystrophy (CACD) and age-related macular degeneration (AMD): differentiating characteristics in multimodal imaging Invest Ophthalmol Vis Sci 52 2011 8908 8918
24. R. Forte, G. Querques, L. Querques, and et al. Multimodal imaging of dry age-related macular degeneration Acta Ophthalmol 90 2012 e281 e287
25. F. Alten, C.R. Clemens, C. Milojcic, and N. Eter Subretinal drusenoid deposits associated with pigment epithelium detachment in age-related macular degeneration Retina 32 2012 1727 1732
26. N. Ueda-Arakawa, S. Ooto, A. Tsujikawa, and et al. Sensitivity and specificity of detecting reticular pseudodrusen in multimodal imaging in Japanese patients Retina 33 2013 490 497
27. L. Xu, A.M. Blonska, N.M. Pumariega, and et al. Reticular macular disease is associated with multilobular geographic atrophy in age-related macular degeneration Retina 33 2013 1850 1862
28. M. Marsiglia, S. Boddu, S. Bearelly, and et al. Association between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degeneration Invest Ophthalmol Vis Sci 54 2013 7362 7369
29. F. Alten, C.R. Clemens, P. Heiduschka, and N. Eter Characterisation of reticular pseudodrusen and their central target aspect in multi-spectral, confocal scanning laser ophthalmoscopy Graefes Arch Clin Exp Ophthalmol 252 2014 715 721
30. M. Suzuki, T. Sato, and R.F. Spaide Pseudodrusen subtypes as delineated by multimodal imaging of the fundus Am J Ophthalmol 157 2014 1005 1012
31. M.Y. Lee, and D.I. Ham Subretinal drusenoid deposits with increased autofluorescence in eyes with reticular pseudodrusen Retina 34 2014 69 76
32. C. Saade, and R.T. Smith Reticular macular lesions: a review of the phenotypic hallmarks and their clinical significance Clin Experiment Ophthalmol 42 2014 865 874
33. R.F. Spaide, and C.A. Curcio Drusen characterization with multimodal imaging Retina 30 2010 1441 1454
34. J.S. Steinberg, A.P. Gobel, M. Fleckenstein, and et al. Reticular drusen in eyes with high-risk characteristics for progression to late-stage age-related macular degeneration Br J Ophthalmol 99 2015 1289 1294
35. N. Ueda-Arakawa, S. Ooto, I. Nakata, and et al. Prevalence and genomic association of reticular pseudodrusen in age-related macular degeneration Am J Ophthalmol 155 2013 260 269 e2
36. J.H. Kim, Y.S. Chang, J.W. Kim, and et al. Prevalence of subtypes of reticular pseudodrusen in newly diagnosed exudative age-related macular degeneration and polypoidal choroidal vasculopathy in Korean patients Retina 35 2015 2604 2612
37. F. De Bats, B. Wolff, M. Mauget-Faysse, and et al. Association of reticular pseudodrusen and early onset drusen ISRN Ophthalmol 2013 2013 273085
38. S.A. Zweifel, I. Maygar, W. Berger, and et al. Multimodal imaging of autosomal dominant drusen Klin Monbl Augenheilkd 229 2012 399 402
39. M. Gliem, D. Hendig, R.P. Finger, and et al. Reticular pseudodrusen associated with a diseased bruch membrane in pseudoxanthoma elasticum JAMA Ophthalmol 133 2015 581 588
40. M. Gliem, P.L. Muller, E. Mangold, and et al. Reticular pseudodrusen in Sorsby fundus dystrophy Ophthalmology 122 2015 1555 1562
41. D.R. Lally, and C. Baumal Subretinal drusenoid deposits associated with complement-mediated IgA nephropathy JAMA Ophthalmol 132 2014 775 777
42. T.S. Aleman, S.T. Garrity, and A.J. Brucker Retinal structure in vitamin A deficiency as explored with multimodal imaging Doc Ophthalmol 127 2013 239 243
43. M.A. Genead, G.A. Fishman, and M. Lindeman Spectral-domain optical coherence tomography and fundus autofluorescence characteristics in patients with fundus albipunctatus and retinitis punctata albescens Ophthalmic Genet 31 2010 66 72
44. N. Joachim, P. Mitchell, E. Rochtchina, and et al. Incidence and progression of reticular drusen in age-related macular degeneration: findings from an older Australian cohort Ophthalmology 121 2014 917 925
45. C. Owsley, C. Huisingh, G.R. Jackson, and et al. Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health Invest Ophthalmol Vis Sci 55 2014 4776 4789
46. C. Owsley, C. Huisingh, M.E. Clark, and et al. Comparison of visual function in older eyes in the earliest stages of age-related macular degeneration to those in normal macular health Curr Eye Res 2015 1 7
47. J. Sarks, J. Arnold, I.V. Ho, and et al. Evolution of reticular pseudodrusen Br J Ophthalmol 95 2011 979 985
48. J.S. Steinberg, J. Auge, G.J. Jaffe, and et al. Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration Invest Ophthalmol Vis Sci 54 2013 4054 4060
49. M.D. Davis, R.E. Gangnon, L.Y. Lee, and et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17 Arch Ophthalmol 123 2005 1484 1498
50. Age-Related Eye Disease Study Research Group The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6 Am J Ophthalmol 132 2001 668 681
51. G. Querques, L. Querques, D. Martinelli, and et al. Pathologic insights from integrated imaging of reticular pseudodrusen in age-related macular degeneration Retina 31 2011 518 526
52. G. Querques, F. Canoui-Poitrine, F. Coscas, and et al. Analysis of progression of reticular pseudodrusen by spectral domain-optical coherence tomography Invest Ophthalmol Vis Sci 53 2012 1264 1270
53. F. De Bats, T. Mathis, M. Mauget-Faysse, and et al. Prevalence of reticular pseudodrusen in age-related macular degeneration using multimodal imaging Retina 36 2016 46 52
54. Z. Wu, L.N. Ayton, G. Makeyeva, and et al. Impact of reticular pseudodrusen on microperimetry and multifocal electroretinography in intermediate age-related macular degeneration Invest Ophthalmol Vis Sci 56 2015 2100 2106
55. R. Klein, B.E. Klein, and K.L. Linton Prevalence of age-related maculopathy. The Beaver Dam Eye Study Ophthalmology 99 1992 933 943
56. S. Boddu, M.D. Lee, M. Marsiglia, and et al. Risk factors associated with reticular pseudodrusen versus large soft drusen Am J Ophthalmol 157 2014 985 993 e2
57. R.E. Hogg, R. Silva, G. Staurenghi, and et al. Clinical characteristics of reticular pseudodrusen in the fellow eye of patients with unilateral neovascular age-related macular degeneration Ophthalmology 121 2014 1748 1755
58. M.Y. Lee, J. Yoon, and D.I. Ham Clinical characteristics of reticular pseudodrusen in Korean patients Am J Ophthalmol 153 2012 530 535
59. R.F. Spaide Colocalization of pseudodrusen and subretinal drusenoid deposits using high-density en face spectral domain optical coherence tomography Retina 34 2014 2336 2345
60. S. Vongkulsiri, S. Ooto, S. Mrejen, and et al. The lack of concordance between subretinal drusenoid deposits and large choroidal blood vessels Am J Ophthalmol 158 2014 710 715
61. S. Vongkulsiri, M. Suzuki, and R.F. Spaide Colocalization error between the scanning laser ophthalmoscope infrared reflectance and optical coherence tomography images of the Heidelberg Spectralis Retina 35 2015 1211 1215
62. G. Querques, L. Querques, R. Forte, and et al. Choroidal changes associated with reticular pseudodrusen Invest Ophthalmol Vis Sci 53 2012 1258 1263
63. D.S. Grewal, J. Chou, S.D. Rollins, and A.A. Fawzi A pilot quantitative study of topographic correlation between reticular pseudodrusen and the choroidal vasculature using en face optical coherence tomography PLoS One 9 2014 e92841
64. S. Yoneyama, Y. Sakurada, F. Mabuchi, and et al. Genetic and clinical factors associated with reticular pseudodrusen in exudative age-related macular degeneration Graefes Arch Clin Exp Ophthalmol 252 2014 1435 1441
65. K. Eliasieh, L.C. Liets, and L.M. Chalupa Cellular reorganization in the human retina during normal aging Invest Ophthalmol Vis Sci 48 2007 2824 2830
66. C.A. Curcio Photoreceptor topography in ageing and age-related maculopathy Eye (Lond) 15 Pt 3 2001 376 383
67. C.A. Curcio, C.L. Millican, K.A. Allen, and R.E. Kalina Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina Invest Ophthalmol Vis Sci 34 1993 3278 3296
68. T. Ach, E. Tolstik, J.D. Messinger, and et al. Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration Invest Ophthalmol Vis Sci 56 2015 3242 3252
69. T. Ach, C. Huisingh, G. McGwin Jr., and et al. Quantitative autofluorescence and cell density maps of the human retinal pigment epithelium Invest Ophthalmol Vis Sci 55 2014 4832 4841
70. C.A. Curcio, J.D. Messinger, K.R. Sloan, and et al. Human chorioretinal layer thicknesses measured in macula-wide, high-resolution histologic sections Invest Ophthalmol Vis Sci 52 2011 3943 3954
71. R.S. Ramrattan, T.L. van der Schaft, C.M. Mooy, and et al. Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging Invest Ophthalmol Vis Sci 35 1994 2857 2864
72. E.H. Sohn, M.J. Flamme-Wiese, S.S. Whitmore, and et al. Loss of CD34 expression in aging human choriocapillaris endothelial cells PLoS One 9 2014 e86538
73. S. Khandhadia, V. Cipriani, J.R. Yates, and A.J. Lotery Age-related macular degeneration and the complement system Immunobiology 217 2012 127 146
74. J.M. Skeie, J.H. Fingert, S.R. Russell, and et al. Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells Invest Ophthalmol Vis Sci 51 2010 5336 5342
75. I.A. Bhutto, T. Baba, C. Merges, and et al. C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration Br J Ophthalmol 95 2011 1323 1330
76. N. Dashti, G. McGwin, C. Owsley, and C.A. Curcio Plasma apolipoproteins and risk for age related maculopathy Br J Ophthalmol 90 2006 1028 1033
77. N.M. Pumariega, R.T. Smith, M.A. Sohrab, and et al. A prospective study of reticular macular disease Ophthalmology 118 2011 1619 1625
78. N. Tserentsoodol, N.V. Gordiyenko, I. Pascual, and et al. Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors Mol Vis 12 2006 1319 1333
79. C.A. Curcio, K.R. Sloan, R.E. Kalina, and A.E. Hendrickson Human photoreceptor topography J Comp Neurol 292 1990 497 523
80. E.M. Hoffmann, L.M. Zangwill, J.G. Crowston, and R.N. Weinreb Optic disk size and glaucoma Surv Ophthalmol 52 2007 32 49
81. C.A. Curcio, P.L. Saunders, P.W. Younger, and G. Malek Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss Ophthalmology 107 2000 334 343
82. K.B. Schaal, A.D. Legarreta, G. Gregori, and et al. Widefield en face optical coherence tomography imaging of subretinal drusenoid deposits Ophthalmic Surg Lasers Imaging Retina 46 2015 550 559