Retinal structure in vitamin A deficiency as explored with multimodal imaging

Documenta Ophthalmologica

Volumn 127, Issue 3, 2013, Pages 239-243

  Aleman, Tomas S ^a   Garrity, Sean T ^a   Brucker, Alexander J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Optical coherence tomography; Photoreceptors; Retinoid cycle; Rods; Vitamin A

Indexed keywords

RETINOL;

ADULT; ANTERIOR EYE SEGMENT; ARTICLE; AUTOFLUORESCENCE IMAGING; BLURRED VISION; CASE REPORT; COLOR VISION; DARK ADAPTATION; DISEASE SEVERITY; ELECTRORETINOGRAPHY; EYE EXAMINATION; HUMAN; IMAGING SYSTEM; MALE; MEDICAL DEVICE; NIGHT BLINDNESS; OPTIC NERVE; PHOTORECEPTOR; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PSEUDOPHAKIA; RETINA; RETINA CONE; RETINA MACULA AGE RELATED DEGENERATION; RETINA ROD; RETINOL DEFICIENCY; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VISUAL ACUITY; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ELECTRORETINOGRAPHY; FLUORESCEIN ANGIOGRAPHY; HUMANS; MALE; MIDDLE AGED; MULTIMODAL IMAGING; NIGHT BLINDNESS; PHOTORECEPTOR CELLS, VERTEBRATE; RETINA; RETINAL PIGMENT EPITHELIUM; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 84888377316     PISSN: 00124486     EISSN: 15732622     Source Type: Journal    
DOI: 10.1007/s10633-013-9403-0     Document Type: Article

References (34)

1. Dowling JE, Wald G (1960) The biological function of vitamin A acid. Proc Natl Acad Sci U S A. 46:587-608
2. Kemp CM, Jacobson SG, Faulkner DJ, Walt RW (1988) Visual function and rhodopsin levels in humans with vitamin A deficiency. Exp Eye Res 46:185-197
3. Newman NJ, Capone A, Leeper HF, O'Day DG, Mandell B, Lambert SR, Thoft RA (1994) Clinical and subclinical ophthalmic findings with retinol deficiency. Ophthalmology 101:1077-1083
4. Jacobson SG, Cideciyan AV, Regunath G, Rodriguez FJ, Vandenburgh K, Sheffield VC, Stone EM (1995) Night blindness in Sorsby's fundus dystrophy reversed by vitamin A. Nat Genet 11:27-32
5. Hayes KC (1974) Retinal degeneration in monkeys induced by deficiencies of vitamin E or A. Invest Ophthalmol 13:499-510
6. Herron WL Jr, Riegel BW (1974) Production rate and removal of rod outer segment material in vitamin A deficiency. Invest Ophthalmol Vis Sci 13:46-53
7. Herron WL Jr, Riegel BW (1974) Vitamin A deficiency-induced "rod thinning" to permanently decrease the production of rod outer segment material. Invest Ophthalmol Vis Sci 13:54-59
8. Carter-Dawson L, Kuwabara T, O'Brien PJ, Bieri JG (1979) Structural and biochemical changes in vitamin A-deficient rat retinas. Invest Ophthalmol Vis Sci 18:437-446
9. Hu Y, Chen Y, Moiseyev G, Takahashi Y, Mott R, Ma JX (2011) Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci 52:5507-5514
10. Fuchs A (1928) Ein fall von weisspunktiertem fundus bei hemeralopie mit xerose. Klin Monatsbl Augenheilkd 81:849-850
11. Elison JR, Friedman AH, Brodie SE (2004) Acquired subretinal flecks secondary to hypovitaminosis A in a patient with hepatitis C. Doc Ophthalmol 109:279-281
12. Apushkin MA, Fishman GA (2005) Improvement in visual function and fundus findings for a patient with vitamin A-deficient retinopathy. Retina 25:650-652
13. Genead MA, Fishman GA, Lindeman M (2009) Fundus white spots and acquired night blindness due to vitamin A deficiency. Doc Ophthalmol 119:229-233
14. Marmor MF (1977) Fundus albipunctatus: a clinical study of the fundus lesions, the physiologic deficit, and the vitamin A metabolism. Doc Ophthalmol 43:277-302
15. De Laey JJ (1993) Flecked retina disorders. Bull Soc Belge Ophtalmol 249:11-22
16. Besch D, Jägle H, Scholl HP, Seeliger MW, Zrenner E (2003) Inherited multifocal RPE-diseases: mechanisms for local dysfunction in global retinoid cycle gene defects. Vision Res 43:3095-3108
17. Lorenz B, Wabbels B, Wegscheider E, Hamel CP, Drexler W, Preising MN (2004) Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65. Ophthalmology 111:1585-1594
18. Schatz P, Preising M, Lorenz B, Sander B, Larsen M, Eckstein C, Rosenberg T (2010) Lack of autofluorescence in fundus albipunctatus associated with mutations in RDH5. Retina 30:1704-1713
19. Schatz P, Preising M, Lorenz B, Sander B, Larsen M, Rosenberg T (2011) Fundus albipunctatus associated with compound heterozygous mutations in RPE65. Ophthalmology 118:888-894
20. Sergouniotis PI, Sohn EH, Li Z, McBain VA, Wright GA, Moore AT, Robson AG, Holder GE, Webster AR (2011) Phenotypic variability in RDH5 retinopathy (Fundus Albipunctatus). Ophthalmology 118:1661-1670
21. Wang NK, Chuang LH, Lai CC, Chou CL, Chu HY, Yeung L, Chen YP, Chen KJ, Wu WC, Chen TL, Chao AN, Hwang YS (2012) Multimodal fundus imaging in fundus albipunctatus with RDH5 mutation: a newly identified compound heterozygous mutation and review of the literature. Doc Ophthalmol 125:51-62
22. Burstedt MS, Golovleva I (2010) Central retinal findings in Bothnia dystrophy caused by RLBP1 sequence variation. Arch Ophthalmol 128:989-995
23. Sergouniotis PI, Davidson AE, Sehmi K, Webster AR, Robson AG, Moore AT (2011) Mizuo-Nakamura phenomenon in Oguchi disease due to a homozygous nonsense mutation in the SAG gene. Eye 25:1098-1101
24. Littink KW, van Genderen MM, van Schooneveld MJ, Visser L, Riemslag FC, Keunen JE, Bakker B, Zonneveld MN, den Hollander AI, Cremers FP, van den Born LI (2012) A homozygous frameshift mutation in LRAT causes retinitis punctata albescens. Ophthalmology 119:1899-1906
25. Zweifel SA, Imamura Y, Spaide TC, Fujiwara T, Spaide RF (2010) Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration. Ophthalmology 117:1775-1781
26. Curcio CA, Messinger JD, Sloan KR, McGwin G, Medeiros NE, Spaide RF (2013) Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina 33:265-276
27. Rodger FC, Grover AD, Fazal A (1961) Experimental hemeralopia uncomplicated by xerophthalmia in Macacus rhesus. Br J Ophthalmol 45:96-108
28. Kemp CM, Jacobson SG, Borruat FX, Chaitin MH (1989) Rhodopsin levels and retinal function in cats during recovery from vitamin A deficiency. Exp Eye Res 49:49-65
29. Katz ML, Eldred GE, Robison WG Jr (1987) Lipofuscin autofluorescence: evidence for vitamin A involvement in the retina. Mech Ageing Dev 39:81-90
30. Katz ML, Kutryb MJ, Norberg M, Gao CL, White RH, Stark WS (1991) Maintenance of opsin density in photoreceptor outer segments of retinoid-deprived rats. Invest Ophthalmol Vis Sci 32:1968-1980
31. Katz ML, Norberg M, Stientjes HJ (1992) Reduced phagosomal content of the retinal pigment epithelium in response to retinoid deprivation. Invest Ophthalmol Vis Sci 33:2612-2618
32. Jacobson SG, Cideciyan AV, Wright E, Wright AF (2001) Phenotypic marker for early disease detection in dominant late-onset retinal degeneration. Invest Ophthalmol Vis Sci 42:1882-1890
33. Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M, Bach M (2009) Standard for clinical electroretinography (2008 update). Doc Ophthalmol 118:69-77
34. Spaide RF, Curcio CA (2011) Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina 31:1609-1619