Association between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degeneration

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 12, 2013, Pages 7362-7369

  Marsiglia, Marcela ^a,b,c,d   Boddu, Sucharita ^a   Bearelly, Srilaxmi ^b   Xu, Luna ^e   Breaux Jr , Barry E ^e   Freund, K Bailey ^a,b,c,d   Yannuzzi, Lawrence A ^a,c,d   Smith, R Theodore ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c VITREOUS RETINA MACULA CONSULTANTS OF NEW YORK   (United States)

^d EAR AND THROAT HOSPITAL   (United States)

^e Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Age related macular degeneration; Autofluorescence infrared; Geographic atrophy; Reticular macular disease; Reticular pseudodrusen; Subretinal drusenoid deposits

Indexed keywords

ADULT; AGED; ARTICLE; AUTOFLUORESCENCE IMAGING; DISEASE COURSE; DRUSEN; FEMALE; FOLLOW UP; GEOGRAPHIC ATROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEAR INFRARED REFLECTANCE SPECTROSCOPY; PRIORITY JOURNAL; RETICULAR PSEUDODRUSEN; RETINA MACULA AGE RELATED DEGENERATION; RETROSPECTIVE STUDY; SIGNAL NOISE RATIO;

AGE-RELATED MACULAR DEGENERATION; AUTOFLUORESCENCE; GEOGRAPHIC ATROPHY; INFRARED; RETICULAR MACULAR DISEASE; RETICULAR PSEUDODRUSEN; SUBRETINAL DRUSENOID DEPOSITS;

AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; FEMALE; FLUORESCEIN ANGIOGRAPHY; GEOGRAPHIC ATROPHY; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; RETINAL DRUSEN; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84887371014     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11073     Document Type: Article

References (45)

1. Hyman L. Epidemiology of eye disease in the elderly. Eye (Lond). 1987;1:330-341.
2. Friedman DS, O'Colmain BJ, Munoz, B, et al. Prevalence of agerelated macular degeneration in the United States. Arch Ophthalmol. 2004;122:564-572.
3. Kumar N, Mrejen S, Fung AT, Marsiglia M, Loh BK, Spaide RF. Retinal pigment epithelial cell loss assessed by fundus autofluorescence imaging in neovascular age-related macular degeneration. Ophthalmology. 2013;120;334-341.
4. Zarbin MA. Current concepts in the pathogenesis of agerelated macular degeneration. Arch Ophthalmol. 2004;122: 598-614.
5. Scholl HP, Fleckenstein M, Charbel Issa P, Keilhauer C, Holz FG, Weber BH. An update on the genetics of age-related macular degeneration. Mol Vis. 2007;13:196-205.
6. Kaneko H, Dridi S, Tarallo V, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325-330.
7. Chew EY, Clemons TE, Agrón E, et al. Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report No. 35. Ophthalmology. 2013; 120:1604-1611.
8. Sarks JP, Sarks SH, Killingworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond). 1988;2: 552-577.
9. Sunness JS, Bressler NM, Tian Y, Alexander J, Applegate CA. Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:1761-1769.
10. Göbel AP, Fleckenstein M, Schmitz-Valckenberg S, Brinkmann CK, Holz FG. Imaging geographic atrophy in age-related macular degeneration. Ophthalmologica. 2011;226:182-190.
11. Spaide RF. Fundus autofluorescence and age-related macular degeneration. Ophthalmology. 2003;110:392-399.
12. Sunness JS, Ziegler MD, Applegate CA. Issues in quantifying atrophic macular disease using retinal autofluorescence. Retina. 2006;26:666-672.
13. Schmitz-Valckenberg S, Holz FG, Bird AC, Spaide RF. Fundus autofluorescence imaging: review and perspectives. Retina. 2008;28:385-409.
14. Khanifar AA, Lederer DE, Ghodasra JH, et al. Comparison of color fundus photographs and fundus autofluorescence images in measuring geographic atrophy area. Retina. 2012; 32:1884-1891.
15. Arnold JJ, Sarks SH, Killingsworth MC, Sarks JP. Reticular pseudodrusen: a risk factor in age-related maculopathy. Retina. 1995;15:183-191.
16. Mimoun G, Soubrane G, Coscas G. Macular drusen [in French]. J Fr Ophtalmol. 1990;13:511-530.
17. Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991;98:1128-1134.
18. Arnold JJ, Quaranta M, Soubrane G, Sarks SH, Coscas G. Indocyanine green angiography of drusen. Am J Ophthalmol. 1997;124:344-356.
19. Lois N, Owens SL, Coco R, Hopkins J, Fitzke FW, Bird AC. Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol. 2002;133:341-349.
20. Smith RT, Sohrab MA, Busuioc M, Barile G. Reticular macular disease. Am J Ophthalmol. 2009;148:733-743.
21. Martillo MA, Marsiglia M, Lee MD, Pumariega N, Bearelly S, Smith T. Is reticular macular disease a choriocapillaris perfusion problem? Med Hypothesis Discov Innovation Ophthalmol J. 2012;1:37-41.
22. Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y. Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology. 2010;117:303-312, e1.
23. Querques G, Querques L, Forte R, Massamba N, Coscas F, Soured EH. Choroidal changes associated with reticular pseudodrusen. Invest Ophthalmol Vis Sci. 2012;53:1258-1263.
24. Klein R, Meuer SM, Knudtson MD, Iyengar SK, Klein BE. The epidemiology of retinal reticular drusen. Am J Ophthalmol. 2008;145:317-326.
25. Schmitz-Valckenberg S, Alten F, Steinberg JS, et al. Reticular drusen associated with geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52: 5009-5015.
26. Smith RT, Chan JK, Busuoic M, Sivagnanavel V, Bird AC, Chong NV. Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2006;47:5495-5504.
27. Chen J, Smith R, Tian J, Laine AF. A novel registration method for retinal images based on local features. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:2242-2245.
28. Lee N, Laine AF, Smith RT. Bayesian transductive Markov random fields for interactive segmentation in retinal disorders. IFMBE Proc. 2009;25:227-230.
29. Lee N, Smith RT, Laine AF. Interactive segmentation for geographic atrophy in retinal fundus images. Conf Rec Asilomar Conf Signals Syst Comput. 2008;2008:655-658.
30. Schmitz-Valckenberg S, Steinberg JS, Fleckenstein M, Visvalingam S, Brinkmann CK, Holz FG. Combined confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography imaging of reticular drusen associated with agerelated macular degeneration. Ophthalmology. 2010;117: 1169-1176.
31. Klein R, Meuer SM, Knudtson MD, Klein BE. The epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye Study. Am J Ophthalmol. 2008;146:692-699.
32. Hayreh SS. Posterior ciliary artery circulation in health and disease: the Weisenfeld lecture. Invest Ophthalmol Vis Sci. 2004;45:749-757; 748.
33. Hayreh SS. Macular lesions secondary to choroidal vascular disorders. Int Ophthalmol. 1983;6:161-170.
34. Hayreh SS. Controversies on submacular choroidal circulation. Ophthalmologica. 1981;183:11-19.
35. Foos RY, Trese MT. Chorioretinal juncture. Vascularization of Bruch's membrane in peripheral fundus. Arch Ophthalmol. 1982;100:1492-1503.
36. Anderson DH, Radeke MJ, Gallo NB, et al. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res. 2010; 29:95-112.
37. Curcio CA, Messinger JD, Sloan KR, McGwin G, Medeiros NE, Spaide RF. Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model. Retina. 2013;33:265-276.
38. Pumariega NM, Smith RT, Sohrab MA, LeTien V, Souied EH. A prospective study of reticular macular disease. Ophthalmology. 2011;118:1619-1625.
39. Spaide RF, Armstrong D, Browne R. Continuing medical education review: choroidal neovascularization in age-related macular degeneration-what is the cause? Retina. 2003;23: 595-614.
40. Sohrab MA, Smith RT, Salehi-Had H, Sadda SR, Fawzi AA. Image registration and multimodal imaging of reticular pseudodrusen. Invest Ophthalmol Vis Sci. 2011;52:5743-5748.
41. Hayreh SS. Segmental nature of the choroidal vasculature. Br J Ophthalmol. 1975;59:631-648.
42. Yehoshua Z, Rosenfeld PJ, Gregori G, et al. Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography. Ophthalmology. 2011;118:679-686.
43. Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463-472.
44. Bearelly S, Khanifar AA, Lederer DE, et al. Use of fundus autofluorescence images to predict geographic atrophy progression. Retina. 2011;31:81-86.
45. Lindblad AS, Lloyd PC, Clemons TE, et al. Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26. Arch Ophthalmol. 2009;127:1168-1174.