Subretinal drusenoid deposits associated with pigment epithelium detachment in age-related macular degeneration

Retina

Volumn 32, Issue 9, 2012, Pages 1727-1732

  Alten, Florian ^a   Clemens, Christoph R ^a   Milojcic, Carolin ^b   Eter, Nicole ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

age related macular degeneration; near infrared reflectance; pigment epithelium detachment; reticular drusen; reticular pseudodrusen; scanning laser ophthalmoscopy; spectral domain optical coherence tomography; subretinal drusenoid deposits

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CONFOCAL SCANNING LASER OPHTHALMOSCOPY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEAR INFRARED REFLECTANCE SPECTROSCOPY; PHENOTYPE; PREDICTIVE VALUE; RETINA DETACHMENT; RETINA DISEASE; RETINA MACULA AGE RELATED DEGENERATION; RETROSPECTIVE STUDY; SCANNING LASER OPHTHALMOSCOPY; SEX DIFFERENCE; SUBRETINAL DRUSENOID DEPOSIT;

AGED; AGED, 80 AND OVER; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; LASERS; MACULAR DEGENERATION; MALE; MIDDLE AGED; OPHTHALMOSCOPY; RETINAL DETACHMENT; RETINAL DRUSEN; RETINAL PIGMENT EPITHELIUM; RETROSPECTIVE STUDIES; RISK FACTORS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84866942742     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e3182475b03     Document Type: Article

References (29)

1. Klein R, Klein BE, Knudtson MD, et al. Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 2007;114:253-262.
2. Wang JJ, Rochtchina E, Lee AJ, et al. Ten-year incidence and progression of age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 2007;114:92-98.
3. Tomany SC, Wang JJ, Van LR, et al. Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology 2004;111:1280-1287.
4. Augood CA, Vingerling JR, de Jong PT, et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol 2006;124:529-535.
5. Fritsche LG, Loenhardt T, Janssen A, et al. Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet 2008;40:892-896.
6. Edwards AO, Ritter R, 3rd, Abel KJ, et al. Complement factor H polymorphism and age-related macular degeneration. Science 2005;308:421-424.
7. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005;308:419-421.
8. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005;308:385-389.
9. Scholl HP, Fleckenstein M, Fritsche LG, et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PloS One 2009;4: e7418.
10. Scholl HP, Fleckenstein M, Charbel Issa P, et al. An update on the genetics of age-related macular degeneration. Mol Vis 2007;13:196-205.
11. Mimoun G, Soubrane G, Coscas G. [Macular drusen]. J Fr Ophtalmol 1990;13:511-530.
12. Klein R, Davis MD, Magli YL, et al. The Wisconsin agerelated maculopathy grading system. Ophthalmology 1991;98: 1128-1134.
13. Klein R, Meuer SM, Knudtson MD, et al. The epidemiology of retinal reticular drusen. Am J Ophthalmol 2008;145:317-326.
14. Knudtson MD, Klein R, Klein BE, et al. Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 2004; 45:2135-2142.
15. Zweifel SA, Spaide RF, Curcio CA, et al. Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology 2010; 117:303-312.e1.
16. Zweifel SA, Imamura Y, Spaide TC, et al. Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration. Ophthalmology 2010;117:1775-1781.
17. Spaide RF, Curcio CA. Drusen characterization with multimodal imaging. Retina 2010;30:1441-1454.
18. Schmitz-Valckenberg S, Alten F, Steinberg JS, et al. Reticular drusen associated with geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 2011;24:52: 5009-5015.
19. Pauleikoff D, Löffert D, Spital G, et al. Pigment epithelial detachment in the elderly. Clinical differentiation, natural course and pathogenetic implications. Graefes Arch Clin Exp Ophthalmol 2002;240:533-538.
20. Smith RT, Sohrab MA, Busuioc M, Barile G. Reticular macular disease. Am J Ophthalmol 2009;148:733-743.e2.
21. Cohen SY, Dubois L, Tadayoni R, et al. Prevalence of reticular pseudodrusen in age-related macular degeneration with newly diagnosed choroidal neovascularisation. Br J Ophthalmol 2007;91:354-359.
22. Arnold JJ, Sarks SH, Killingsworth MC, Sarks JP. Reticular pseudodrusen: a risk factor in age-related maculopathy. Retina 1995;15:183-191.
23. Sarks J, Arnold J, Ho I-V, et al. Evolution of reticular pseudodrusen. Br J Ophthalmol 2011;95:979-985.
24. Fleckenstein M, Charbel Issa P, Helb HM, et al. Highresolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2008;49:4137-4144.
25. Schmitz-Valckenberg S, Steinberg JS, Fleckenstein M, et al. Combined confocal scanning laser ophthalmoscopy and spectral- domain optical coherence tomography imaging of reticular drusen associated with age-related macular degeneration. Ophthalmology 2010;117:1169-1176.
26. Rudolf M, Malek G, Messinger JD, et al. Subretinal drusenoid deposits in human retina: organization and composition. Exp Eye Res 2008;87:402-408.
27. Curcio CA, Johnson M, Rudolf M. Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins [review]. Prog Retin Eye Res 2009; 28:393-422.
28. Querques G, Querques L, Martinelli D, et al. Pathologic insights from integrated imaging of reticular pseudodrusen in age-related macular degeneration. Retina 2011;31:518-526.
29. Pumariega NM, Smith RT, Sohrab MA, et al. A prospective study of reticular macular disease. Ophthalmology 2011;118: 1619-1625.