Transketolase counteracts oxidative stress to drive cancer development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 6, 2016, Pages E725-E734

  Xu, Iris Ming Jing ^a   Lai, Robin Kit Ho ^a   Lin, Shu Hai ^b   Tse, Aki Pui Wah ^a   Chiu, David Kung Chun ^a   Koh, Hui Yu ^a   Law, Cheuk Ting ^a   Wong, Chun Ming ^a,c   Cai, Zongwei ^b   Wong, Carmen Chak Lui ^a,c   Ng, Irene Oi Lin ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

HCC; Metabolism; PPP; ROS; TKT

Indexed keywords

BACH1 PROTEIN; GLUCOSE; GLUTATHIONE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; TRANSKETOLASE; UNCLASSIFIED DRUG; CARBANILAMIDE DERIVATIVE; MESSENGER RNA; NICOTINAMIDE; PEROXIDE; SORAFENIB; TERT-BUTYL PEROXIDE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE SILENCING; GLUTATHIONE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL DEATH; DRUG EFFECTS; ENZYMOLOGY; GENETICS; LIVER TUMOR; METABOLISM; METABOLOME; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; GLUTATHIONE; GLYCOLYSIS; HUMANS; LIVER NEOPLASMS; MALE; METABOLOME; MICE, NUDE; MOLECULAR SEQUENCE DATA; NIACINAMIDE; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; PEROXIDES; PHENYLUREA COMPOUNDS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSKETOLASE; UP-REGULATION;

EID: 84957810188     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508779113     Document Type: Article

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