Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

Anticancer Research

Volumn 30, Issue 5, 2010, Pages 1653-1659

  Krockenberger, M ^a   Engel, J B ^a   Schmidt, M ^a   Kohrenhagen, N ^a   Hausler S F M ^a   Dombrowski, Y ^a   Kapp, M ^a   Dietl, J ^a   Honig, Arnd ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aerobic glycolysis; Cancer; Endometrial cancer; Glucose metabolism; GLUT1; pAkt; Transketolase like 1 protein (TKTL1)

Indexed keywords

GLUCOSE TRANSPORTER 1; PROTEIN KINASE B; PROTEIN TRANSKETOLASE LIKE 1; TRANSKETOLASE; UNCLASSIFIED DRUG;

ANAEROBIC GLYCOLYSIS; BENIGN TUMOR; CELL LINE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOMETRIUM CANCER; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; CELL LINE, TUMOR; ENDOMETRIAL NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; OXYGEN; RNA, MESSENGER; TRANSKETOLASE;

EID: 77954597050     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (32)

1. Morrow CP and Curtin JP: Synopsis of Gynecologic Oncology, fifth edition. Churchill Livingstone, 2004.
2. Downey RJ, Akhurst T, Gonen M, Vincent A, Bains MS, Larson S and Rusch V: Preoperative F-18 fluorodeoxyglucose positron-emission tomography maximal standardized uptake value predicts survival after lung cancer resection. J Clin Oncol 22: 3255-3260, 2004.
3. Lai CH, Yen TC and Chang TC: Positron-emission tomography imaging for gynecologic malignancy. Curr Opin Obstet Gynecol 19(1): 37-41, 2007.
4. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM and Thompson CB: Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64(11): 3892-3899, 2004. (Pubitemid 38697301)
5. Gillies RJ and Gatenby RA: Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr 39(3): 251-257, 2007.
6. Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick DA: Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292(1): C125-136, 2007 .
7. Shaw RJ: Glucose metabolism and cancer. Curr Opin Cell Biol 18(6): 598-608, 2006.
8. Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer 11: 891-899, 2004.
9. Garber K: Energy boost: the Warburg effect returns in a new theory of cancer. J Natl Cancer Inst 96: 1805-18066, 2004.
10. Warburg O, Posener K and Negelein E: Über den Stoffwechsel der Carcinomzelle. Biochem Z 152: 309-344, 1924.
11. Zhang S, Yang JH, Guo CK and Cai PC: Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett 253(1): 108-114, 2007.
12. Hu LH, Yang JH, Zhang DT, Zhang S, Wang L, Cai PC, Zheng JF and Huang JS: The TKTL1 gene influences total transketolase activity and cell proliferation in human colon cancer LoVo cells. Anticancer Drugs 18(4): 427-433, 2007.
13. Macheda ML, Rogers S and Best JD: Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202(3): 654-662, 2005. (Pubitemid 40175840)
14. Chandler JD, Williams ED, Slavin JL, Best JD and Rogers S: Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Cancer 2003 97(8): 2035-2042, 2003.
15. Boado RJ, Black KL and Pardridge WM: Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors. Brain Res Mol Brain Res 27(1): 51-57, 1994.
16. Goldman NA, Glenn AS, Weldon RH, Jones JG, Lynch U, Fezzari MJ, Runowicz CD, Goldberg GL and Charron MJ: GLUT1 and GLUT8 in endometrium and endometrial adenocarcinoma. Mod Pathol 19(11): 1429-1436, 2006. (Pubitemid 44624161)
17. von Wolff M, Ursel S, Hahn U, Steldinger R and Strowitzki T: Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab 88(8): 3885-3892, 2003. (Pubitemid 37034543)
18. Beckner ME, Gobbel GT, Abounader R, Burovic F, Agostino NR, Laterra J and Pollack IF: Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Lab Invest 85(12): 1457-1470, 2005. (Pubitemid 41662331)
19. Coy JF, Dressier D, Wilde J and Schubert P: Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 51(5-6): 257-273, 2005.
20. Boros LG, Puigjaner J, Cascante M, Lee W-NP, Brandes JL, Bassilian S, Yusuf FI, Williams RD, Muscarella P, Melvin WS and Schirmer WJ: Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res 57: 4242-4248, 1997. (Pubitemid 27413432)
21. Comin-Anduix B, Boren J, Martinez S, Moro C, Centelles JJ, Trebukhina R, Petushok N, Lee W-NP, Boros LG and Cascante M: The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study. Eur J Biochem 268: 4177-4182, 2001. (Pubitemid 32862878)
22. Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899, 2004.
23. 1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett 456: 113-118, 1999. (Pubitemid 29339052)
24. Ramanathan A, Wang C and Schreiber SL: Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA 102(17): 5992-5997, 2005. (Pubitemid 40594243)
25. Bui T and Thompson CB : Cancer's sweet tooth. Cancer Cell 6: 419-420, 2006.
26. Plas DR and Thompson CB: Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24: 7435-7442, 2005.
27. Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH and Dey SK: Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res 68(14): 5619-5627, 2008.
28. Goel A, Mathupala SP and Pedersen PL: Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. J Biol Chem 278(17): 15333-15340, 2003. (Pubitemid 36799872)
29. Ashrafian H: Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis. Lancet 367(9510): 618-621, 2006.
30. Kunkel M, Reichert TE, Benz P, Lehr HA, Jeong JH, Wieand S, Bartenstein P, Wagner W and Whiteside TL: Overexpression of GLUT1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer 97(4): 1015-1024, 2003. (Pubitemid 36173153)
31. 18F]fluoro-D-glucose positron-emission tomography in gastric carcinoma: relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression. Ann Nucl Med 20(9): 597-604, 2006. (Pubitemid 44954052)
32. Ashton-Sager A, Paulino AF and Afify AM: GLUT1 is preferentially expressed in atypical endometrial hyperplasia and endometrial adenocarcinoma. Appl Immunohistochem Mol Morphol 14(2): 187-192, 2006.