Acid-base homeostasis

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 12, 2015, Pages 2232-2242

  Lee Hamm, L ^a,b   Nakhoul, Nazih ^a,b   Hering Smith, Kathleen S ^a,b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; AMMONIA; BICARBONATE; CARBONATE DEHYDRATASE; PHOSPHORIC ACID; SULFURIC ACID; CARBON DIOXIDE;

ACID BASE BALANCE; ACID BASE HOMEOSTASIS; ACID BASE TRANSPORTATION; ALBERS SCHOENBERG DISEASE; AMMONIA EXCRETION; ARTICLE; CHEMICAL REACTION; CHEMORECEPTOR; DIARRHEA; HOMEOSTASIS; HUMAN; ION TRANSPORT; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE ACIDOSIS; LUNG VENTILATION; MEDULLA OBLONGATA; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; METABOLIC DISORDER; NEPHRON; NONHUMAN; NUTRITION; PH; PHOSPHORYLATION; TITRIMETRY; URINARY EXCRETION; URINE ACIDIFICATION; ANIMAL; BIOLOGICAL MODEL; DISORDERS OF ACID BASE BALANCE; KIDNEY; METABOLISM; PATHOPHYSIOLOGY;

ACID-BASE EQUILIBRIUM; ACID-BASE IMBALANCE; AMMONIA; ANIMALS; BICARBONATES; CARBON DIOXIDE; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; MODELS, BIOLOGICAL; RENAL ELIMINATION; RENAL REABSORPTION;

EID: 84957797837     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.07400715     Document Type: Article

References (84)

1. Banerjee T, Crews DC, Wesson DE, Tilea A, Saran R, Rios Burrows N, Williams DE, Powe NR; Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team: Dietary acid load and chronic kidney disease among adults in the United States. BMC Nephrol 15: 137, 2014.
2. Moe OW, Huang CL: Hypercalciuria from acid load: Renal mechanisms. J Nephrol 19 [Suppl 9]: S53-S61, 2006.
3. Wang XH, Mitch WE: Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol 10: 504-516, 2014.
4. Ruffin VA, Salameh AI, Boron WF, Parker MD: Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol 5: 43, 2014.
5. Remer T, Manz F: Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 95:791-797, 1995.
6. Goraya N, Wesson DE: Dietary interventions to improve outcomes in chronic kidney disease. CurrOpin Nephrol Hypertens 24: 505-510, 2015.
7. Hood VL, Tannen RL: Protection of acid-base balance by pH regulation of acid production. N Engl J Med 339: 819-826, 1998.
8. Haussinger D: Liver regulation of acid-base balance. Miner Electrolyte Metab 23: 249-252, 1997.
9. Adrogue HJ, Madias NE: Tools for clinical assessment. In: Acid-Base Disorders and Their Treatment, edited by Gennari FJ, Adrogue HJ, Galla JH, Madias NE, Boca Baton, FL, Taylor and Francis Group, 2005, pp 801-816.
10. Adrogue HJ, Madias NE: Secondary responses to altered acid-base status: The rules of engagement. J Am Soc Nephrol 21: 920-923, 2010.
11. Albert MS, Dell RB, Winters RW: Quantitative displacement of acid-base equilibrium in metabolic acidosis. Ann Intern Med66: 312-322, 1967.
12. Javaheri S: Determinants of carbon dioxide tension. In: Acid-Base Disorders and Their Treatment, edited by Gennari FJ, Adrogue HJ, Galla JH, Madias NE, Boca Raton, FL, Taylor and Francis Group, 2005, pp 47-77.
13. Hamm LL, Simon EE: Roles and mechanisms of urinary buffer excretion. Am J Physiol 253: F595-F605, 1987.
14. Elkinton JR, Huth EJ, Webster GD Jr., McCance RA: The renal excretion of hydrogen ion in renal tubular acidosis. I. Quantitative assessment of the response to ammonium chloride as an acid load. Am J Med 29: 554-575, 1960.
15. Lemann J Jr., Bushinsky DA, Hamm LL: Bonebufferingofacidand base in humans. Am J Physiol Renal Physiol 285: F811-F832,2003.
16. Brant SR, Yun CH, Donowitz M, Tse CM: Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. Am J Physiol 269: C198-C206, 1995.
17. Baum M, Twombley K, Gattineni J, Joseph C, Wang L, Zhang Q, Dwarakanath V, Moe OW: Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-NHE3-/-, and NHE3-/-/NHE8-/-mice. Am J Physiol Renal Physiol 303: F1495-F1502, 2012.
18. Curthoys NP, MoeOW: Proximal tubule function and response to acidosis. Clin J Am Soc Nephrol 9: 1627-1638, 2014.
19. Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M: Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: Effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl) 91: 951-963, 2013.
20. Purkerson JM, Schwartz GJ: The role of carbonic anhydrases in renal physiology. Kidney Int 71: 103-115, 2007.
21. Schwartz GJ: Physiology and molecular biology of renal carbonic anhydrase. J Nephrol 15[Suppl 5]: S61-S74, 2002.
22. Alper SL: Genetic diseases of acid-base transporters. Annu Rev Physiol 64: 899-923, 2002.
23. Parker MD, Boron WF: The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev 93: 803-959, 2013.
24. Igarashi T, Inatomi J, Sekine T, Cha SH, Kanai Y, Kunimi M, Tsukamoto K, Satoh H, Shimadzu M, Tozawa F, Mori T, Shiobara M, Seki G, Endou H: Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet23: 264-266, 1999.
25. Brown D, Wagner CA: Molecular mechanisms of acid-base sensing by the kidney. J Am Soc Nephrol 23: 774-780, 2012.
26. Laghmani K, Preisig PA, Alpern RJ: The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. J Nephrol 15[Suppl 5]: S75-S87, 2002.
27. Wesson DE: Endothelins and kidney acidification. Contrib Nephrol 172: 84-93, 2011.
28. Skelton LA, Boron WF: Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-g1 and Erk1/2 in the renal proximal tubule. Physiol Rep 3: e12280, 2015.
29. Aronson PS, Nee J, Suhm MA: Modifier role of internal H+ in activating the Na+-H+ exchanger in renal microvillus membrane vesicles. Nature 299: 161-163, 1982.
30. Kwon TH, Fulton C, Wang W, Kurtz I, Frokiaer J, Aalkjaer C, Nielsen S: Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1. Am J Physiol Renal Physiol 282: F341-F351, 2002.
31. Adam WR, Koretsky AP, Weiner MW: 31P-NMR in vivo measurement of renal intracellular pH: Effects of acidosis and K+ depletion in rats. Am J Physiol 251: F904-F910, 1986.
32. Hamm LL, Nakhoul NL: Renal acidification mechanisms. In: The Kidney, edited by Brenner B, Philadelphia, W.B. Saunders, 2008, pp 248-279.
33. Weiner ID, Verlander JW: Renal acidification mechanisms. In: Brenner and Rector’s The Kidney, 9th Ed., edited by Brenner B, Philadelphia, W.B. Saunders, 2011, pp 293-325.
34. Bobulescu IA, Dwarakanath V, Zou L, Zhang J, Baum M, Moe OW: Glucocorticoids acutely increase cell surface Na+/H + exchanger-3 (NHE3) by activation of NHE3 exocytosis. Am J Physiol Renal Physiol 289: F685-F691, 2005.
35. Capasso G, Unwin R, Rizzo M, Pica A, Giebisch G: Bicarbonate transport along the loop of Henle: Molecular mechanisms and regulation. J Nephrol 15[Suppl 5]: S88-S96, 2002.
36. Good DW, George T, Watts BA: High sodium intake increases HCO(3)- absorption in medullary thick ascending limb through adaptations in basolateral and apical Na+/H+ exchangers. Am J Physiol Renal Physiol 301: F334-F343, 2011.
37. Watts BA III, George T, Good DW: Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb. Am J Physiol Renal Physiol 291: F1005-F1013, 2006.
38. Watts BA, III, George T, Good DW: Lumen LPS inhibits HCO3(-) absorption in the medullary thick ascending limb through TLR4-PI3K-Akt-mTOR-dependent inhibition of basolateral Na+/H + exchange. Am J Physiol Renal Physiol 305: F451-F462, 2013.
39. Roy A, Al-bataineh MM, Pastor-Soler NM: Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol 10: 305-324, 2015.
40. Batlle D, Haque SK: Genetic causes and mechanismsofdistal renal tubular acidosis. Nephrol Dial Transplant 27: 3691-3704, 2012.
41. Breton S, Brown D: Regulation of luminal acidification by the V-ATPase. Physiology (Bethesda) 28: 318-329, 2013.
42. Gumz ML, Lynch IJ, Greenlee MM, Cain BD, WingoCS: The renal H+-K+-ATPases: Physiology, regulation, and structure. Am J Physiol Renal Physiol 298: F12-F21, 2010.
43. Buffin-Meyer B, Younes-Ibrahim M, Barlet-Bas C, Cheval L, Marsy S, Doucet A: Kdepletion modifies the properties of Sch-28080-sensitive K-ATPase in rat collecting duct. Am J Physiol 272: F124-F131, 1997.
44. Greenlee MM, Lynch IJ, Gumz ML, Cain BD, Wingo CS: The renal H,K-ATPases. Curr Opin Nephrol Hypertens 19: 478-482, 2010.
45. Alper SL: Molecular physiology of SLC4 anion exchangers. Exp Physiol 91: 153-161, 2006.
46. Alper SL: Familial renal tubular acidosis. J Nephrol 23[Suppl 16]: S57-S76, 2010.
47. Alper SL, Sharma AK: The SLC26 gene family of anion transporters and channels. Mol Aspects Med 34: 494-515, 2013.
48. Melo Z, Cruz-Rangel S, Bautista R, Vaquez N, Castaneda-Bueno M, Mount DB, Pasantes-Morales H, Mercado A, Gamga G: Molecular evidence for a role for K(+)-C1(-) cotransporters in the kidney. AM J Physiol Renal Physiol 305: F1402-F1411, 2013.
49. Soleimani M: SLC26 C1 2/HCO32 exchangers in the kidney: Roles in health and disease. Kidney Int 84: 657-666, 2013.
50. Hamm LL, Hering-Smith KS, Vehaskari VM: Control of bicarbonate transport in collecting tubules from normal and remnant kidneys. Am J Physiol 256: F680-F687, 1989.
51. Weiner ID, Hamm LL: Regulation of intracellular pH in the rabbit cortical collecting tubule. J Clin Invest 85: 274-281, 1990.
52. Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED: Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci USA 98: 4221-4226, 2001.
53. Wall SM, Lazo-Fernandez Y: The role of pendrin in renal physiology. Annu Rev Physiol 77: 363-378, 2015.
54. Chambrey R, Kurth I, Peti-Peterdi J, Houillier P, Purkerson JM, Leviel F, Hentschke M, Zdebik AA, Schwartz GJ, Hubner CA, Eladari D: Renal intercalated cells are rather energized by a proton than a sodium pump. Proc Natl Acad Sci USA 110: 7928-7933, 2013.
55. Eladari D, Chambrey R, Picard N, Hadchouel J: Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: Implication for normal electrolytes homeostasis and blood pressure regulation. Cell Mol Life Sci 71: 2879-2895, 2014.
56. Leviel F, Hubner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hassan H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D: The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electro-neutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest 120: 1627-1635, 2010.
57. Koeppen BM: Electrophysiological identification of principal and intercalated cells in the rabbit outer medullary collecting duct. Pflugers Arch 409: 138-141, 1987.
58. Koeppen BM: Electrophysiology of collecting duct H+ secretion: Effect of inhibitors. Am J Physiol 256: F79-F84, 1989.
59. Greenlee MM, Lynch IJ, Gumz ML, Cain BD, Wingo CS: Miner-alocorticoids stimulate the activity and expression of renal H +,K+-ATPases. JAmSoc Nephrol 22: 49-58, 2011.
60. Stone DK, Seldin DW, Kokko JP, Jacobson HR: Mineralocorticoid modulation of rabbit medullary collecting duct acidification. A sodium-independent effect. J Clin Invest 72: 77-83, 1983.
61. Wagner CA, Devuyst O, Bourgeois S, Mohebbi N: Regulated acid-base transport in the collecting duct. Pflugers Arch 458: 137-156, 2009.
62. Wesson DE, Jo CH, Simoni J: Angiotensin II receptors mediate increased distal nephron acidification caused by acid retention. Kidney Int 82: 1184-1194, 2012.
63. Wesson DE, Simoni J, Broglio K, Sheather S: Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone. Am J Physiol Renal Physiol 300: F830-F837, 2011.
64. Al-Awqati Q: Terminal differentiation of intercalated cells: The role of hensin. Annu Rev Physiol 65: 567-583, 2003.
65. Gao X, Eladari D, Leviel F, Tew BY, Miro-Julia C, Cheema FH, Miller L, Nelson R, Paunescu TG, McKee M, Brown D, Al-Awqati Q: Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis. Proc Natl Acad Sci U SA 107:21872-21877, 2010.
66. Weiner ID, Hamm LL: Molecular mechanisms of renal ammonia transport. Annu Rev Physiol 69: 317-340, 2007.
67. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Bruzzone M, Passerone GC: Renal ammoniagenesis during the adaptation to metabolic acidosis in man. Contrib Nephrol31: 40-46, 1982.
68. Hamm LL, Simon EE: Ammonia transport in the proximal tubule. Miner Electrolyte Metab 16: 283-290, 1990.
69. Kinsella JL, Aronson PS: Interaction of NH4+ and Li+ with the renal microvillus membrane Na+-H+ exchanger. Am J Physiol 241: C220-C226, 1981.
70. Nagami GT: Ammonia production and secretion by isolated perfused proximal tubule segments. Miner Electrolyte Metab 16: 259-263, 1990.
71. Nagami GT: Enhanced ammonia secretion by proximal tubules from mice receiving NH(4)Cl: Role of angiotensin II. Am J Physiol Renal Physiol 282: F472-F477, 2002.
72. Houillier P, Bourgeois S: More actors in ammonia absorption by the thick ascending limb. Am J Physiol Renal Physiol 302: F293-F297, 2012.
73. Weiner ID, Verlander JW: Renal ammonia metabolism and transport. Compr Physiol 3: 201-220, 2013.
74. Kikeri D, Sun A, Zeidel ML, Hebert SC: Cell membranes impermeable to NH3. Nature 339: 478-480, 1989.
75. Heitman J, Agre P: A new face of the Rhesus antigen. Nat Genet 26: 258-259, 2000.
76. Marini AM, Matassi G, Raynal V, André B, Cartron JP, Cheerif-Zahar B: The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet 26: 341-344, 2000.
77. Nakhoul NL, Abdulnour-Nakhoul SM, Boulpaep EL, Rabon E, Schmidt E, Hamm LL: Substrate specificity of Rhbg: Ammonium and methyl ammonium transport. Am J Physiol Cell Physiol 299: C695-C705, 2010.
78. Nakhoul NL, Lee Hamm L: Characteristics of mammalian Rh glycoproteins (SLC42 transporters) and their role in acid-base transport. Mol Aspects Med 34: 629-637, 2013.
79. Seldin DW, Rector FC Jr.: Symposium on acid-base homeostasis. The generation and maintenance of metabolic alkalosis. Kidney Int 1: 306-321, 1972.
80. Schrier RW: Decreased effective blood volume in edematous disorders: What does this mean? J Am Soc Nephrol 18: 2028-2031, 2007.
81. Gledhill N, Beirne GJ, Dempsey JA: Renal response to short-term hypocapnia in man. Kidney Int 8: 376-384, 1975.
82. Madias NE, Adrogue HJ: Cross-talk between two organs: How the kidney responds to disruption of acid-base balance by the lung. Nephron, Physiol 93: 61-66, 2003.
83. Polak A, Haynie GD, Hays RM, Schwartz WB: Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. I. Adaptation. J Clin Invest 40: 1223-1237, 1961.
84. Madias NE, Schwartz WB, Cohen JJ: The maladaptive renal response to secondary hypocapnia during chronic HCl acidosis in the dog. J Clin Invest 60: 1393-1401, 1977.