Angiotensin II receptors mediate increased distal nephron acidification caused by acid retention

Kidney International

Volumn 82, Issue 11, 2012, Pages 1184-1194

  Wesson, Donald E ^a,b   Jo, Chan Hee ^b   Simoni, Jan ^c  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

alkali; bosentan; diet; eplerenone; microdialysis; valsartan

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; BICARBONATE; ENDOTHELIN 1; GLUCONATE CALCIUM; MINERALOCORTICOID RECEPTOR;

ACID RETENTION; ACIDIFICATION; ANGIOTENSIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CARBON DIOXIDE BLOOD LEVEL; CONTROLLED STUDY; DISTAL NEPHRON ACIDIFICATION; FEMALE; GLOMERULUS FILTRATION RATE; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY MASS; MALE; MICRODIALYSIS; NEPHRON; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION;

EID: 84869208407     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.267     Document Type: Article

References (51)

1. Hsu CY, Chertow GM. Elevations of serum phosphorous and potassium in mild to moderate chronic renal insufficiency. Neph Dial Transplant 2002; 17: 1419-1425.
2. de Brito-Ashurst I, Varagunam M, Raferty MJ et al. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 2009; 20: 2075-2084.
3. Phisitkul S, Khanna A, Simoni J et al. Amelioration of metabolic acidosis in subjects with low GFR reduces kidney endothelin production, reduces kidney injury, and better preserves GFR. Kidney Int 2010; 77: 617-623.
4. Rapheal KL, Wei G, Baird BC et al. Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes. Kidney Int 2010; 79: 356-362.
5. Mahajan A, Simoni J, Sheather S et al. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 2010; 78: 303-309.
6. Widmer B, Gerhardt RE, Harrington JT et al. The influence of graded degrees of chronic renal failure. Arch Int Med 1979; 139: 1099-1102.
7. MacClean AJ, Hayslett JP. Adaptive change in ammonia excretion in renal insufficiency. Kidney Int 1980; 17: 595-606. (Pubitemid 10121072)
8. Wesson DE, Simoni J, Broglio K et al. Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone. Am J of Physiol Renal Physiol 2011; 300: F830-F837.
9. Goraya N, Simoni J, Jo C-H et al. Dietary acid reduction with fruits and vegetables or sodium bicarbonate reduces kidney injury in subjects with moderately reduced GFR due to hypertensive nephropathy. Kidney Int 2012; 81: 86-93.
10. Levine DZ, Iaocovitti M, Buckman S et al. Ang II-dependent HCO3 reabsorption in surviving rat distal tubules: expression/activation of H+-ATPase. Am J Physiol 1997; 272(Renal Physiol 41): F799-F808.
11. Levine DZ, Iaocovitti M, Luck B et al. Surviving rat distal tubule bicarbonate reabsorption: effects of chronic AT1 blockade. Am J Physiol Renal Physiol 2000; 278(Renal Physiol 47): F476-F483. (Pubitemid 30163247)
12. Wesson DE. Endogenous endothelins mediate augmented acidification in remnant kidneys. J Am Soc Nephrol 2001; 12: 1826-1835. (Pubitemid 32801357)
13. Phisitkul S, Hacker C, Simoni J et al. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney Int 2008; 73: 192-199.
14. Wesson DE, Simoni J. Increased tissue acid mediates progressive GFR decline in animals with reduced nephron mass. Kidney Int 2009; 75: 929-935.
15. Wesson DE, Simoni J. Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int 2010; 78: 1128-1135.
16. Appel LJ, Wright JT, Greene T et al. Long-term effects of reninangiotensin-system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans. Arch Int Med 2008; 168: 832-839. (Pubitemid 351620085)
17. Coresh J, Selvin E, Stevens LA. Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-2047. (Pubitemid 350074801)
18. Anderson S, Meyer TW, Renke HG et al. Control of glomerular hypertension limits progressive glomerular injury in rats with reduced renal mass. J Clin Invest 1985; 76: 612-619. (Pubitemid 15227525)
19. Wesson DE. Dietary acid increases blood and renal cortical acid content in rats. Am J Physiol 1998; 274: F97-F103.
20. Ng H-Y, Chen H-C, Tsai Y-C et al. Activation of intrarenal renin-angiotensin system during metabolic acidosis. Am J Nephrol 2011; 34: 55-63.
21. Sasser J, Pollock JS, Pollock D. Renal endothelin in chronic angiotensin II hypertension. Am J Physiol Regul Integr Comp Physiol 2002; 283: R243-R248. (Pubitemid 34863930)
22. Xue C, Siragy HM. Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin type 1 receptor. Hypertension 2005; 46: 584-590. (Pubitemid 41379384)
23. Khanna A, Simoni J, Wesson DE. Endothelin-induced increased aldosterone activity mediates augmented distal nephron acidification as a result of dietary protein. J Am Soc Nephrol 2005; 16: 1929-1935. (Pubitemid 41716423)
24. Goodman AD, Lemann Jr J, Lennon EJ et al. Production, excretion, and net balance of fixed acid in patients with renal failure. J Clin Invest 1980; 17: 595-606.
25. Remer T. Influence of nutrition on acid-base balance-metabolic aspects. Eur J Nutr 2001; 40: 214-220. (Pubitemid 34093227)
26. Nagami G. Role of angiotensin II in the enhancement of ammonia production and secretion by the proximal tubule in metabolic acidosis. Am J Physiol Renal Physiol 2008; 294: F874-F880.
27. Wesson DE. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats. J Clin Invest 1997; 99: 2203-2211. (Pubitemid 27203776)
28. Hood VL, Tannen RL. Protection of acid-base balance by pH regulation of acid production. N Engl J Med 1998; 339: 819-826. (Pubitemid 28447457)
29. Lemann Jr J, Lennon EJ, Goodman AD et al. The net balance of acid in subjects given large loads of acid or alkali. J Clin Invest 1965; 44: 507-517.
30. Wesson DE, Simoni J, Green DF. Reduced extracellular pH increases endothelin-1 secretion by human renal microvascular cells. J Clin Invest 1998; 101: 578-583. (Pubitemid 28084240)
31. Kohan DE. Endothelin synthesis by rabbit renal tubule cells. Am J Physiol 1991; 261(Renal Fluid Electrolyte Physiol 30): F221-F226.
32. Radke KJ, Taylor Jr RE, Schneider EG. Effect of hydrogen ion concentration on aldosterone secretion by isolated perfused canine adrenal glands. J Endocrinol 1986; 110: 293-301. (Pubitemid 16035802)
33. Seney F, Marver D. Protein intake and cation transport in the loop of Henle. J Lab Clin Med 1989; 114: 587-594. (Pubitemid 19285580)
34. Schambelan M, Sebastian A, Katuna A et al. Adrenocortical hormone secretory response to chronic NH4Cl-induced metabolic acidosis. Am J Physiol (Endocrin Metab 15) 1987; 252: E454-E460.
35. Andreis PG, Tortorella C, Malendowicz LK et al. Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting ETB receptors coupled with the phospholipase C-dependent signaling pathway. Peptides 2000; 22: 117-122. (Pubitemid 32146690)
36. Liu FY, Cogan MG. Angiotensin II stimulates early proximal bicarbonate reabsorption in the rat by decreasing cyclic adenosine monophosphate. J Clin Invest 1989; 84: 83-91. (Pubitemid 19170098)
37. Schuster VL. Cyclic adenosine monophosphate-stimulated anion transport in rabbit cortical collecting duct. J Clin Invest 1986; 78: 1621-1630.
38. Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest 1996; 98: 1063-1068. (Pubitemid 26293326)
39. Henger A, Tutt P, Riesen WF et al. Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients. J Lab Clin Med 2000; 136: 379-389.
40. Lariviere R, Lebel M, Kingma I et al. Effects of lorsartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass. Am J Hypertens 1998; 11: 989-997. (Pubitemid 28378414)
41. Siragy HM, El-Kersh MA, de Gasparo M et al. Differences in AT2-receptor stimulation between AT1-receptor blockers valsartan and losartan quantified by renal interstitial fluid cGMP. J Hypertens 2002; 20: 1157-1163. (Pubitemid 34913635)
42. Xue C, Siragy HM. Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor. Hypertension 2005; 46: 584-590. (Pubitemid 41379384)
43. Clozel M, Breu V, Gray G et al. Pharmacological characterization of Bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 1994; 270: 228-235. (Pubitemid 24229632)
44. Lam EY, Funder JW, Nikolic-Paterson DJ et al. Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats. Endocrinology 2006; 147: 3623-3629. (Pubitemid 43901155)
45. Wesson DE. Dietary bicarbonate reduces rat distal nephron acidification evaluated in situ. Am J Physiol 1990; 258(Renal Fluid Electrolyte Physiol 27): F870-F876. (Pubitemid 20155498)
46. Blaufox MD, Aurell M, Bubeck B et al. Report of the Radionuclides in Nephrourology Committee on renal clearance. J Nucl Med 1999; 37: 1883-1890. (Pubitemid 26378383)
47. Wesson DE, Dolson GM. Augmented bidirectional HCO3 transport by rat distal tubules in chronic alkalosis. Am J Physiol 1991; 261(Renal Fluid Electrolyte Physiol 30): F308-F317.
48. Levine DZ, Iacovitti M, Nash L et al. Secretion of bicarbonate by rat distal tubules in vivo. Modulation by overnight fasting. J Clin Invest 1988; 81: 1873-1878.
49. Wesson DE. Depressed distal tubule acidification corrects chloridedeplete alkalosis in rats. Am J Physiol 1990; 259(Renal Fluid Electrolyte Physiol 28): F636-F644.
50. Wesson DE. Dietary HCO3 reduces distal tubule acidification by increasing cellular HCO3 secretion. Am J Physiol 1996; 271(Renal Fluid Electrolyte Physiol 40): F132-F142.
51. Abdel-Rahman EM, Abadir PM, Siragy HM. Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiontensin AT1 and AT2 receptors. Am J Physiol Regul Integr Comp Physiol 2008; 295: R1473-R1478.