Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone

American Journal of Physiology - Renal Physiology

Volumn 300, Issue 4, 2011, Pages 830-837

  Wesson, Donald E ^a,b   Simoni, Jan ^c   Broglio, Kristine ^b,d   Sheather, Simon ^d  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Acidosis; Bicarbonate; Chronic kidney disease; Diet

Indexed keywords

ALDOSTERONE; BICARBONATE; ENDOTHELIN 1; PLACEBO; SODIUM CHLORIDE;

ACIDURIA; ADULT; ALBUMINURIA; ALDOSTERONE BLOOD LEVEL; ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; CONTROLLED STUDY; ENDOTHELIN BLOOD LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TREATMENT DURATION;

EID: 79954490055     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00587.2010     Document Type: Article

References (38)

1. Abboud H, Henrich W. Stage IV chronic kidney disease. N Engl J Med 362: 56-65, 2010.
2. Adrogue HJ, Brensilver J, Cohen Madias NE JJ. Influence of steady-state alterations in acid-base equilibrium on the fate of administered bicarbonate in the dog. J Clin Invest 71: 687-883, 1983.
3. Aldigier JC, Kanjanbuch T, Ma LJ, Brown NJ, Fogo AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol 16: 3306-3314, 2005.
4. Appel LJ, Wright JT, Greene T, Kusek JW, Lewis JB, Wang X, Lipkowitz MS, Norris KC, Bakris GL, Rahman M, Contreras G, Rostand SG, Kopple JD, Gabbai FB, Schulman GI, Gassman JJ, Charleston Agodoa JLY. Long-term effects of renin-angiotensin-system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans. Arch Int Med 168: 832-839, 2008.
5. Bailey JL, England BK, Long RC Jr, Weissman J, Mitch WE. Experimental acidemia and muscle cell pH in chronic acidosis and renal failure. Am J Physiol Cell Physiol 269: C706-C712, 1995.
6. Chobanion AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BM, Oparil S, Wright, JT Jr, Roccella EJ. The seventh report of the Joint National Commission on Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 289: 2560-2572, 2003.
7. Coresh J, Selvin E, Stevens LA. Prevalence of chronic kidney disease in the United States. JAMA 298: 2038-2047, 2007.
8. Cunarro JA, Weiner MW. A comparison of methods for measuring urinary ammonium. Kidney Int 5:303-305, 1974.
9. de Brito-Ashurst I, Varagunam M, Raferty MJ, Yaqoob M. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 20: 2075-2084, 2009.
10. Goodman AD, Lemann J, Lennon EJ, Relman AS. Production, excretion, and net balance of fixed acid in patients with renal acidosis. J Clin Invest 44: 495-506, 1965.
11. Greene EL, Kren S, Hostetter TH. Role of aldosterone in the remnant kidney model in the rat. J Clin Invest 98: 1063-1068, 1996.
12. Hostetter TH, Meyer TW, Rennke HG, Brenner BM. Chronic effects of dietary protein in the rat with intact and reduced renal mass. Kidney Int 30: 509-517, 1986.
13. Klahr S, Levey AS, Beck GJ, Caggiula AW, Hunsicker L, Kusek JW, Striker G. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med 330: 877-884, 1994.
14. Lemann J, Lennon EJ, Goodman AD, Litzow JR, Relman AS. The net balance of acid in subjects given large loads of acid or alkali. J Clin Invest 44: 507-517, 1965.
15. Lemann J, Litzow JR, Lennon EJ. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J Clin Invest 45: 1608-1614, 1966.
16. Mahajan A, Simoni J, Sheather S, Broglio K, Rajab MH, Wesson DE. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 78: 303-309, 2010.
17. Mann JFE, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G. Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21: 527-535, 2010.
18. Maurer M, Riesen W, Muser J, Hulter HN, Krapf R. Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol Renal Physiol 284: F32-F40, 2003.
19. Mehdi U, Adams-Huet B, Raskin P, Vega GL, Toto RD. Addition of angiotensin receptor blockade of mineralocorticoid antagonism to maximal angiotensin converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 20: 2641-2650, 2009.
20. National Kidney Foundation. K/DOQI Clinical Practice Guidelines for Nutrition in Chronic Renal Failure. Am J Kidney Dis 35: S1-S140, 2000.
21. Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab H, Wesson DE. Amelioration of metabolic acidosis in subjects with low GFR reduces kidney endothelin production, reduces kidney injury, and better preserves GFR. Kidney Int 77: 617-623, 2010.
22. Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney Int 73: 192-199, 2008.
23. Radke KJ, Taylor RE Jr, Schneider EG. Effect of hydrogen ion concentration on aldosterone secretion by isolated perfused canine adrenal glands. J Endocrinol 110: 293-301, 1986.
24. Regalado M, Yang S, Wesson DE. Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension. Am J Kidney Dis 35: 687-694, 2000.
25. Remer T, Manz F. Potential renal acid load of foods and its influence on urine pH. J Am Dietetic Assn 95: 791-797, 1995.
26. Remer T. Influence of nutrition on acid-base balance-metabolic aspects. Eur J Nutr 40: 214-220, 2001.
27. Sheather SJ. Mixed models. In: A Modern Approach to Regression with R, edited by Sheather SJ. New York: Springer, 2009, p. 331-368.
28. Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB, Petrovic S. Deletion of the pH sensor GPR4 decreases renal acid excretion. J Am Soc Neprol 21: 1745-1755, 2010.
29. Swan RC, Pitts RF. Neutralization of infused acid by nephrectomized dogs. J Clin Invest 34: 205-230, 1955.
30. Wesson DE. Dietary HCO3 reduces distal tubule acidification by increasing cellular HCO3 secretion. Am J Physiol Renal Fluid Electrolyte Physiol 271: F132-F140, 1996.
31. Wesson DE. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats. J Clin Invest 99: 2203-2211, 1997.
32. Wesson DE. Dietary acid increases blood and renal cortical acid content in rats. Am J Physiol Renal Physiol 274: F97-F103, 1998.
33. Wesson DE, Simoni J, Green DF. Reduced extracellular pH increases endothelin-1 secretion by human renal microvascular cells. J Clin Invest 101: 578-583, 1998.
34. Wesson DE. Endogenous endothelins mediate augmented acidification in remnant kidneys. J Am Soc Nephrol 12: 1826-1835. 2001.
35. Wesson DE, Nathan T, Rose T, Simoni J, Tran RM. Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. Kidney Int 71: 210-217, 2007.
36. Wesson DE, Simoni J. Increased tissue acid mediates progressive GFR decline in animals with reduced nephron mass. Kidney Int 75: 929-935, 2009.
37. Wesson DE, Simoni J. Acid retention during renal failure induces endothelin and aldosterone production which lead to progressive decline of the GFR, a situation ameliorated by alkali diet. Kidney Int 78: 1128-1135, 2010.
38. Widmer B, Gerhardt RE, Harrington JT, Cohen JJ. The influence of graded degrees of chronic renal failure. Arch Int Med 139: 1099-1102, 1979.