The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis

Journal of Nephrology

Volumn 15, Issue SUPPL. 5, 2002, Pages

  Laghmani, Kamel ^a   Preisig, Patricia A ^a   Alpern, Robert J ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

c Src; Endothelin; ETB receptor; Metabolic acidosis; Na+ H+ antiporter; Proximal tubule; Pyk2

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; AMILORIDE; BICARBONATE; CYTOCHALASIN D; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FOCAL ADHESION KINASE 2; HERBIMYCIN A; LATRUNCULIN B; MITOGEN ACTIVATED PROTEIN KINASE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; N ACETYL 10,11 DIHYDRO 5H DIBENZO[A,D]CYCLOHEPTEN 5 YLGLYCYLLEUCYLASPARTYLISOLEUCYLISOLEUCYLTRYPTOPHAN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN TYROSINE KINASE INHIBITOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; S 3226; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; SQUALAMINE; TYRPHOSTIN; TYRPHOSTIN A 47; UNCLASSIFIED DRUG; UNINDEXED DRUG; PROTON;

APICAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; CELL VACUOLE; CHRONIC DISEASE; DOSE RESPONSE; DRUG INHIBITION; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; IMMUNOCYTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; METABOLIC ACIDOSIS; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTON TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; ACIDOSIS; ADAPTATION; ANIMAL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACIDOSIS; ADAPTATION, PHYSIOLOGICAL; ANIMAL; CHRONIC DISEASE; ENDOTHELINS; KIDNEY TUBULES, PROXIMAL; PROTONS; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

EID: 0036262846     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (128)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Endothelin system: The double-edged sword in health and disease
3. Endothelins: Multifunctional renal peptides
4. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression
5. Endothelin-1 mRNA expression in the rat kidney
6. Immunoreactive endothelin in rat kidney inner medulla: Marked decrease in spontaneously hypertensive rats
7. Localization of endothelin-like immunoreactivity in rat kidneys
8. Localization of endothelin receptors in rat kidney
9. Autoradiographic localisation of endothelin binding sites in kidney
10. Endothelin-1 mRNA in glomerular and epithelial cells of kidney
11. Expression of endothelin-3 mRNA along rat nephron segments using polymerase chain reaction
12. Expression of endothelins 1 and 3 in the rat kidney
13. An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration
14. Endothelins in the kidney: Physiology and pathophysiology
15. Renal endothelin in hypertension
16. Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade
17. Endothelin inhibits thick ascending limb chloride flux via ET (B) receptor-mediated NO release
18. Effects of ET-1 on water and chloride transport in cortical collecting ducts of the rat
19. Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct
20. The role of bicarbonate and other buffers on isotonic fluid absorption in the proximal convolutions of the rat kidney
21. Sodium/proton antiport in brush-border membrane vesicles isolated from rat small intestine and kidney
22. Molecular cloning, primary structure, and expression of the human growth factor-activatable Na/H antiporter
23. + exchanger subtypes in the renal tubule: Function and regulation in physiology and disease
24. + exchanger isoforms
25. + exchanger isoform 5 (NHE5) from human brain
26. + exchanger
27. + exchanger localized to the trans-Golgi network
28. 3 transport
29. 3 to SRC
30. 2 in the rat renal cortex
31. 3 symporter activities in chronic hyperfiltration
32. - cotransport in rat renal cortex
33. Role of the Na/H antiporter in rat proximal tubule bicarbonate absorption
34. Bicarbonate and fluid absorption by renal proximal straight tubules
35. Relationship between sodium and bicarbonate transport in the rat proximal convoluted tubule
36. Bicarbonate transport by isolated perfused rabbit proximal convoluted tubules
37. Amiloride inhibition of the Na-H exchanger in renal microfillus membrane vesicles
38. Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1)
39. Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger
40. Functional characteristics of a cloned epithelial Na/H exchanger (NHE3): Resistance to amiloride and inhibition by protein kinase C
41. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti ischemic properties
42. + exchanger isoform NHE3
43. + exchanger subtype 3 in various cell types
44. Immunocytochemical characterization of Na-H exchanger isoform NHE-1 in rabbit kidney
45. + exchanger in rat renal cortical tubules
46. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity
47. + exchanger isoform NHE2 in rat kidney
48. + exchange. Adaptation to metabolic acidosis
49. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule
50. NHE3: A Na/H exchanger isoform of the renal brush border
51. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb
52. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts
53. + exchanger 3 (NHE3)
54. + exchanger NHE3 in nephron function: Micropuncture studies with S3226, an inhibitor of NHE3
55. Polarity and kinetics of Na-H exchange in cultured opossum kidney cells
56. Acid incubation increases NHE-3 mRNA abundance in OKP cells
57. Effect of high osmolality on Na/H exchange in renal proximal tubule cells
58. Rheogenic sodium-bicarbonate cotransport in the peritubular cell membrane of rat renal proximal tubule
59. 3 transport in the rat proximal convoluted tubule
60. Localization of a proton-pumping ATPase in rat kidney
61. Presence of a bicarbonate stimulated ATPase in the brush border microvillus membranes of the proximal tubule
62. An ATP-driven proton pump in brush-border membranes from rat renal cortex
63. Bicarbonate-stimulated ATPase in the renal proximal tubule luminal (brush border) membrane
64. + pump in membrane vesicles from rat kidney cortex
65. Characteristics of the proton pump in rat renal cortical endocytotic vesicles
66. Effect of bafilomycin on proximal bicarbonate absorption in the rat
67. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice
68. Ouabain-sensitive and -insensitive K-ATPases in rat nephron: Effect of K depletion
69. - transporters in rabbit renal cortex
70. + exchange
71. + exchange activity by endothelin in opossum kidney cells
72. 2+-dependent pathway in OKP cells
73. Cloning and expression of a cDNA encoding an endothelin receptor
74. Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor
75. Cloning and functional expression of human cDNA for the ETB endothelin receptor
76. Endothelin-1 and -3 binding to ETB receptors in rat renal tubules
77. Distribution of endothelin-B receptor-like immunoreactivity in rat brain, kidney, and pancreas
78. [125I]endothelin-1 binding to renal brush border and basolateral membranes
79. Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis
80. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
81. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschprung disease
82. Role of tyrosine kinase pathways in ETB receptor activation of NHE3
83. Growth factors induce phosphorylation of the Na/H antiporter, a glycoprotein of 110 kD
84. Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3
85. (+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor
86. + exchanger by protein phosphorylation
87. B receptor activation leads to activation and phosphorylation of NHE3
88. Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA
89. Adaptation of NHE-3 in the rat thick ascending limb: Effects of high sodium intake and metabolic alkalosis
90. Isolation and characterization of luminal and basolateral plasma membrane vesicles from the medullary thick ascending loop of Henle
91. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney
92. ETB receptor activation causes exocytic insertion of NHE3 in OKP cells
93. A) receptor required for regulation of proximal tubule Na/H antiproter 3 (NHE3) activity by endothelin-1 (ET-1)
94. B) receptor second intracellular loop defines NHE3 activation by endothelin-1 (ET-1)
95. 2 absorption
96. 3 symporter in the rat proximal convoluted tubule
97. An autocrine role for endothelin-1 (ET-1) in acid regulation of the proximal tubule
98. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
99. Media acidification stimulates endothelin-1 (ET-1) synthesis and receptor binding in OKP cells
100. B) receptor contribute to hypokalemic nephropathy
101. B) receptor
102. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats
103. Acid activation of immediate early genes in renal epithelial cells
104. Acid incubation causes exocytic insertion of NHE3 in OKP cells
105. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney
106. Regulation of endothelin-1 gene expression by Fos and Jun
107. Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity
108. Overexpression of Csk inhibits acid-induced activation of NHE-3
109. Transcriptional regulation of the endothelin-1 (ET-1) gene by metabolic acidosis: Role of AP-1
110. The when and how of Src regulation
111. Role of c-Src and ERK in acid-induced activation of NHE3
112. Intracellular acidosis activates c-Src
113. c-src
114. CSK: A protein-tyrosine kinase involved in regulation of Src family kinases
115. RAFTK/Pyk2-mediated cellular signalling
116. FAK and PYK2/CAKβ in the nervous system: A link between neuronal activity, plasticity, and survival?
117. Incubation of OKP cells in acid media induces Pyk2 phosphorylation
118. Pyk2 is a pH sensor signaling acid activation of NHE3 in OKP cells
119. + gradient-dependent phosphate-uptake systems in renal brush border membrane vesicles
120. Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism
121. Acidosis activation of the pituitary-adrenal-renal glutaminase I axis
122. + exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: The role of glucocorticoids
123. Glucocorticoids induce endothelin release from vascular smooth muscle cells but not endothelial cells
124. Expression of endothelin-1 in human broncho-epithelial and monocytic cell lines: Influence of tumor necrosis factor-alpha and dexamethasone
125. Dexamethasone and phosphoramidon inhibit endothelin release by cultured nonciliated bronchiolar epithelial (Clara) cells
126. Transcriptional regulation of pre-pro-endothelin-1 gene by glucocortoids in vascular smooth muscle cells
127. Modulation of endothelin-1 production by a pulmonary epithelial cell line. I. Regulation by glucocorticoids
128. Glucocorticoids decrease endothelin-A- and -B-receptor expression in the kidney