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Volumn 126, Issue , 2016, Pages 27-30

MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability

Author keywords

DHFR; DNA replication; Folate; Lamin; MTHFD1; Multi enzyme complex; SHMT; Thymidylate; TYMS

Indexed keywords

DIHYDROFOLATE REDUCTASE; ENZYME; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; LAMIN; MTHFD1 ENZYME; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MINOR HISTOCOMPATIBILITY ANTIGEN; MTHFD1 PROTEIN, HUMAN;

EID: 84957717437     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2016.02.001     Document Type: Short Survey
Times cited : (29)

References (27)
  • 1
    • 51849127760 scopus 로고    scopus 로고
    • Folate-mediated one-carbon metabolism
    • J.T. Fox, and P.J. Stover Folate-mediated one-carbon metabolism Vitam. Horm. 79 2008 1 44
    • (2008) Vitam. Horm. , vol.79 , pp. 1-44
    • Fox, J.T.1    Stover, P.J.2
  • 2
    • 77955616558 scopus 로고    scopus 로고
    • Compartmentalization of mammalian folate-mediated one-carbon metabolism
    • A.S. Tibbetts, and D.R. Appling Compartmentalization of mammalian folate-mediated one-carbon metabolism Annu. Rev. Nutr. 30 2010 57 81
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 57-81
    • Tibbetts, A.S.1    Appling, D.R.2
  • 3
    • 80053089625 scopus 로고    scopus 로고
    • Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria
    • D.D. Anderson, C.M. Quintero, and P.J. Stover Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Proc. Natl. Acad. Sci. U. S. A. 108 2011 15163 15168
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 15163-15168
    • Anderson, D.D.1    Quintero, C.M.2    Stover, P.J.3
  • 4
    • 67649225407 scopus 로고    scopus 로고
    • SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
    • D.D. Anderson, and P.J. Stover SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis PLoS One 4 2009 e5839
    • (2009) PLoS One , vol.4 , pp. e5839
    • Anderson, D.D.1    Stover, P.J.2
  • 5
    • 84863421311 scopus 로고    scopus 로고
    • Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
    • D.D. Anderson, C.F. Woeller, E.P. Chiang, B. Shane, and P.J. Stover Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis J. Biol. Chem. 287 2012 7051 7062
    • (2012) J. Biol. Chem. , vol.287 , pp. 7051-7062
    • Anderson, D.D.1    Woeller, C.F.2    Chiang, E.P.3    Shane, B.4    Stover, P.J.5
  • 6
    • 84908191332 scopus 로고    scopus 로고
    • Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency
    • M.S. Field, and et al. Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency J. Biol. Chem. 289 2014 29642 29650
    • (2014) J. Biol. Chem. , vol.289 , pp. 29642-29650
    • Field, M.S.1
  • 7
    • 0037064008 scopus 로고    scopus 로고
    • Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses
    • K. Herbig, and et al. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses J. Biol. Chem. 277 2002 38381 38389
    • (2002) J. Biol. Chem. , vol.277 , pp. 38381-38389
    • Herbig, K.1
  • 8
    • 34547101719 scopus 로고    scopus 로고
    • Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway
    • C.F. Woeller, D.D. Anderson, D.M. Szebenyi, and P.J. Stover Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway J. Biol. Chem. 282 2007 17623 17631
    • (2007) J. Biol. Chem. , vol.282 , pp. 17623-17631
    • Woeller, C.F.1    Anderson, D.D.2    Szebenyi, D.M.3    Stover, P.J.4
  • 9
    • 84863398662 scopus 로고    scopus 로고
    • Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus
    • D.D. Anderson, J.Y. Eom, and P.J. Stover Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus J. Biol. Chem. 287 2012 4790 4799
    • (2012) J. Biol. Chem. , vol.287 , pp. 4790-4799
    • Anderson, D.D.1    Eom, J.Y.2    Stover, P.J.3
  • 10
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • B.C. Blount, and et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage Proc. Natl. Acad. Sci. U. S. A. 94 1997 3290 3295
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 3290-3295
    • Blount, B.C.1
  • 11
    • 83455213193 scopus 로고    scopus 로고
    • Trafficking of intracellular folates
    • P.J. Stover, and M.S. Field Trafficking of intracellular folates Adv. Nutr. 2 2011 325 331
    • (2011) Adv. Nutr. , vol.2 , pp. 325-331
    • Stover, P.J.1    Field, M.S.2
  • 13
    • 0023815995 scopus 로고
    • Substrate flux through methylenetetrahydrofolate dehydrogenase: Predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration
    • J.M. Green, R.E. MacKenzie, and R.G. Matthews Substrate flux through methylenetetrahydrofolate dehydrogenase: predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration Biochemistry 27 1988 8014 8022
    • (1988) Biochemistry , vol.27 , pp. 8014-8022
    • Green, J.M.1    MacKenzie, R.E.2    Matthews, R.G.3
  • 15
    • 78649455516 scopus 로고    scopus 로고
    • High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5
    • Y.H. Ching, and et al. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5 BMC Genet. 11 2010 106
    • (2010) BMC Genet. , vol.11 , pp. 106
    • Ching, Y.H.1
  • 16
    • 0025990937 scopus 로고
    • Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
    • E. Chu, and et al. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase Proc. Natl. Acad. Sci. U. S. A. 88 1991 8977 8981
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 8977-8981
    • Chu, E.1
  • 17
    • 54449100192 scopus 로고    scopus 로고
    • Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
    • A.J. MacFarlane, and et al. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice J. Biol. Chem. 283 2008 25846 25853
    • (2008) J. Biol. Chem. , vol.283 , pp. 25846-25853
    • MacFarlane, A.J.1
  • 18
    • 79952743030 scopus 로고    scopus 로고
    • Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk
    • A.J. Macfarlane, C.A. Perry, M.F. McEntee, D.M. Lin, and P.J. Stover Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk Cancer Res. 71 2011 2098 2107
    • (2011) Cancer Res. , vol.71 , pp. 2098-2107
    • MacFarlane, A.J.1    Perry, C.A.2    McEntee, M.F.3    Lin, D.M.4    Stover, P.J.5
  • 19
    • 84455160888 scopus 로고    scopus 로고
    • Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice
    • A.E. Beaudin, and et al. Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice Am. J. Clin. Nutr. 95 2012 109 114
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 109-114
    • Beaudin, A.E.1
  • 20
    • 79953186061 scopus 로고    scopus 로고
    • Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice
    • A.E. Beaudin, and et al. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice Am. J. Clin. Nutr. 93 2011 789 798
    • (2011) Am. J. Clin. Nutr. , vol.93 , pp. 789-798
    • Beaudin, A.E.1
  • 21
    • 84929657813 scopus 로고    scopus 로고
    • Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects
    • PMC4381776
    • L. Martiniova, M.S. Field, J.L. Finkelstein, C.A. Perry, and P.J. Stover Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects Am. J. Clin. Nutr. 101 4 2015 860 869 PMC4381776
    • (2015) Am. J. Clin. Nutr. , vol.101 , Issue.4 , pp. 860-869
    • Martiniova, L.1    Field, M.S.2    Finkelstein, J.L.3    Perry, C.A.4    Stover, P.J.5
  • 22
    • 59449092734 scopus 로고    scopus 로고
    • Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism
    • A.J. MacFarlane, and et al. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism J. Biol. Chem. 284 2009 1533 1539
    • (2009) J. Biol. Chem. , vol.284 , pp. 1533-1539
    • MacFarlane, A.J.1
  • 23
    • 84920973485 scopus 로고    scopus 로고
    • Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis
    • M.S. Field, E. Kamynina, D. Watkins, D.S. Rosenblatt, and P.J. Stover Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis Proc. Natl. Acad. Sci. U. S. A. 112 2015 400 405
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 400-405
    • Field, M.S.1    Kamynina, E.2    Watkins, D.3    Rosenblatt, D.S.4    Stover, P.J.5
  • 24
    • 84872191491 scopus 로고    scopus 로고
    • Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration
    • M.S. Field, and et al. Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration J. Nutr. 143 2013 41 45
    • (2013) J. Nutr. , vol.143 , pp. 41-45
    • Field, M.S.1
  • 25
    • 84859025355 scopus 로고    scopus 로고
    • Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice
    • A.E. Beaudin, C.A. Perry, S.P. Stabler, R.H. Allen, and P.J. Stover Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice Am. J. Clin. Nutr. 95 2012 882 891
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 882-891
    • Beaudin, A.E.1    Perry, C.A.2    Stabler, S.P.3    Allen, R.H.4    Stover, P.J.5
  • 26
    • 80052574435 scopus 로고    scopus 로고
    • Novel inborn error of folate metabolism: Identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband
    • D. Watkins, and et al. Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband J. Med. Genet. 48 2011 590 592
    • (2011) J. Med. Genet. , vol.48 , pp. 590-592
    • Watkins, D.1
  • 27
    • 84873481021 scopus 로고    scopus 로고
    • Severe combined immunodeficiency resulting from mutations in MTHFD1
    • M.D. Keller, and et al. Severe combined immunodeficiency resulting from mutations in MTHFD1 Pediatrics 131 2013 e629 e634
    • (2013) Pediatrics , vol.131 , pp. e629-e634
    • Keller, M.D.1


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