New perspectives on folate catabolism

Annual Review of Nutrition

Volumn 21, Issue , 2001, Pages 255-282

  Suh, J R ^a   Herbig, A K ^a   Stover, P J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Cancer; Ferritin; Iron; One carbon metabolism; Pregnancy

Indexed keywords

ALCOHOL; ANTICONVULSIVE AGENT; FERRITIN; FOLIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; GAMMA GLUTAMYL HYDROLASE; ORAL CONTRACEPTIVE AGENT; THYROID HORMONE;

CANCER; CATABOLISM; CELL COMPARTMENTALIZATION; CELL LEVEL; CELLULAR DISTRIBUTION; CHILD GROWTH; DRUG USE; MOLECULAR STABILITY; NUTRITIONAL STATUS; ORAL CONTRACEPTION; OXIDATION; PREGNANCY; PRIORITY JOURNAL; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG STABILITY; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FOLIC ACID; HUMANS; INFANT, NEWBORN; NEOPLASMS; NUTRITIONAL STATUS; PREGNANCY;

EID: 0034928775     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.21.1.255     Document Type: Review

References (147)

1. The biological chemistry of folate receptors
2. Megaloblastic anemias
3. Folate receptors
4. Compartmentation of folate-mediated one-carbon metabolism in eukaryotes
5. Mechanism of oxidation of tetrahydropterins
6. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement
7. Affinity labeling of the folate methotrexate transporter from Leishmania-Donovani
8. Folic acid, 5-methyltetrahydrofolate and 5-formyltetrahydrofolate exhibit equivalent intestinal absorption, metabolism and in vivo kinetics in rats
9. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
10. A study of folate absorption and metabolism in man utilizing carbon-14 labeled polyglutamates synthesized by the solid phase method
11. The pteroylglutamate components of American diets as determined by chromatographic fractionation
12. The effect of chronic phenytoin treatment on tissue folate concentrations and the activities of the methyl synthetic enzymes in the rat
13. Folate catabolism in pregnant and nonpregnant women with controlled folate intakes
14. Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice
15. Purification and properties of human cytosolic folylpoly-γ-glutamate synthetase and organization, localization, and differential splicing of its gene
16. Oxidative degradation of dihydrofolate and tetrahydrofolate
17. The role of thymidylate synthase as an RNA binding protein
18. Mammalian folyl-γ-polyglutamate synthetase. 1. Purification and general properties of the hog liver enzyme
19. Tissue distribution and prediction of total body folate of rats
20. Thyrotropin stimulates transcription from the ferritin heavy chain promoter
21. Serum transferrin receptors
22. Urinary excretion of folic acid activity in man
23. Erythropoiesis and erythropoietin in hypothyriodism and hyperthyroidism
24. The metabolic conversion of folic acid and citrovorum factor to a diazotizable amine
25. Folic acid deficiency enhances oral contraceptive-induced platelet activity
26. Plasma and red blood cell folate during normal pregnancies
27. Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region
28. Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice
29. Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia
30. Embryonic folate metabolism and mouse neural tube defects
31. Serum and red cell folate and serum vitamin B-12 levels in hyperthyroidism
32. Para-acetamidobenzoylglutamate is a suitable indicator of folate status in rats
33. Homocysteine and atherosclerosis
34. An account of 335 cases of megaloblastic anemia of pregnancy and the puerpium
35. A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy
36. Plasma ferritin, premature rupture of membranes, and pregnancy outcome
37. Oral contraceptives did not affect biochemical folate indices and homocysteine concentrations in adolescent females
38. 4]folic acid is a functional index of folate nutritional status
39. 2]folic acid: Isotopic labeling of urinary folate and the lite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover pools
40. The folate receptor as a potential therapeutic anticancer target
41. Effects of phenobarbitone and phenytoin on folate catabolism in the rat
42. Cytosol and serum ferritin in breast carcinoma
43. The ferritins: Molecular properties, iron storage function and cellular regulation
44. Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate
45. Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: Evidence for a concentrative role by placental folate receptors in fetal folate delivery
46. The relationship between increased folate catabolism and the increased requirement for folate in pregnancy
47. Effect of nitrous oxide inactivation of vitamin B-12-dependent methionine synthase on the subcellular distribution of folate coenzymes in rat liver
48. Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats
49. Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier, selective effect on carrier-mediated transport of physiological concentrations of reduced folates
50. Receptor-mediated accumulation is regulated by the cellular folate content
51. Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells
52. Integrated saturation model for tissue micronutrient concentrations applied to liver folacin
53. Effect of acute chronic alcohol ingestion on the rate of folate catabolism and hepatic enzyme induction in mice
54. Increased folate catabolism in mice with ascitic tumours
55. Effect of anticonvulsant drugs on the rate of folate catabolism in mice
56. Properties of tetrahydropteroylpen-taglutamate bound to 10-formyltetrahydrofolate dehydrogenase
57. Regulation of one-carbon metabolism in mammalian cells
58. Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazacyclotetrahydrofolate, an antipurine drug
59. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
60. Folate and cancer: A new medical application of folate beyond hyperhomocysteinemia and neural tube defects
61. Ferritin: A tumor marker expressed by renal cell carcinoma
62. Serum ferritin is a clinical marker for renal cell carcinoma: Influence of tumor size and volume
63. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization
64. Urinary excretion of deuterium-labeled folate and the metabolite p-aminobenzoylglutamate in humans
65. 14C folic acid, with observations on the effect of diphenylhydantoin administration
66. Erythropoiesis in pregnancy
67. Oxidative and reductive cleavage of folates - A critical appraisal
68. Regulation of folate and one carbon metabolism in mammalian cells. 3. Role of mitochondrial folylpolyglutamate synthetase
69. Expression of Escherichia coli folylpolyglutamate synthetase in the Chinese hamster ovary cell mitochondrian
70. Oral contraceptive, hormones, folate metabolism and the cervical epithelium
71. Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoabsorbents
72. Folate and folate dependent enzymes associated with rat CNS development
73. The oxidative cleavage of folates
74. Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport
75. Role for cytosolic folate binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyltetrahydrofolate-mediated enhancement of 5-fluoro-2′-deoxyuridine antitumor activity in vitro
76. Evidence for localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells
77. Folate deficiency after anticonvulsant drugs: An effect of hepatic enzyme induction?
78. Folate catabolism is increased during pregnancy in rats
79. Folate catabolism is related to growth rate in weanling rats
80. The quantitative analysis of endogenous folate catabolites in human urine
81. Accelerated folate breakdown in pregnancy
82. The level of folate catabolism in normal populations, suggesting that the current level of RDA for folate is excessive
83. Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa
84. Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol
85. Acetylation of paminobenzoylglutamate, a folate catabolite, by recombinant human arylamine Nacetyltransferase in U937 cells
86. The mechanism of oxidation of 6-methyl-5-carba-5-deazatetrahydropterin. Evidence for the involvement of a 4a-adduct in the oxidation of tetrahydropterins
87. Increased expression of cytokeratin and ferritin H genes in tumorigenic clones of the SW 613-S human colon carcinoma cell line
88. Roles of folylpoly-γ-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: An overview
89. The elucidation of the mechanism of folate catabolism in the rat
90. The turnover/catabolism and excretion of folate administered at physiological concentrations in the rat
91. Mechanism of the antimicrobial drug trimethoprim revisited
92. The occurrence of folate derived pteridines in rat liver
93. Oxidation of tetrahydrofolic acid by air
94. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women
95. Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion
96. Interaction of folylpolyglutamates with enzymes in one-carbon metabolism
97. High third-trimester ferritin concentration: Associations with very preterm delivery, infection and maternal nutritional status
98. Folic acid: Influence on the outcome of pregnancy
99. Pathogenesis of subacute combined degeneration: A result of methyl group deficiency
100. 3H] folic acid in folate adequate rats
101. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
102. Ethanol-induced iron mobilization: Role of acetaldehyde-aldehyde oxidase generated superoxide
103. Cleavage of folates during ethanol metabolism
104. The effect of oral contraceptives on folate metabolism. Part 3: Plasma clearance and urinary folate excretion
105. Oral contraceptives and serum folate level in woman
106. Carrier-mediated membrane transport of folates in mammalian cells
107. Folic acid does not inactivate xanthine oxidase
108. Kinetic modeling of folate metabolism through the use of chronic administration of deuterium-labeled folic acid in men
109. In vitro conversion of formate to serine. Effect of tetrahydropteroylpolyglutamates and serine hydroxymethyltransferase on the rate of 10-formyltetrahydrofolate synthetase
110. Purification and properties of serine hydroxymethyltransferase and Cl-tetrahydrofolate synthase from L1210 cells
111. Purification and properties of a folate catabolizing enzyme
112. Studies on hydroperoxide-dependent folic acid degradation by hemin
113. Serum ferritin: A predictor of early spontaneous preterm delivery
114. Effects of contraceptives on hemoglobin and ferritin
115. Iron-regulatory proteins, iron responsive elements and ferritin mRNA translation
116. Retrovirally mediated complementation of the glyB phenotype: Cloning of a human gene encoding the carrier for entry of folates into mitochondria
117. Folate and iron status of nonanemic women during pregnancy: Effect of routine folate and iron supplementation and relation of erythrocyte folate with iron stores
118. Decreased methylene tetrahydrofolate reductase activity due to the 677C-T mutation in families with spina bifida offspring
119. In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid
120. Relationship between urinary excretion of p-aminobenzoylglutamate and folate status of the growing rat
121. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells
122. Alteration of embryonic folate metabolism by valproic acid during organogenesis: Implications for mechanism of teratogenesis
123. Tissue ferritin concentration and prognosis in carcinoma of the breast
124. Ferritin synthesis in normal and leukemic leukocytes
125. Identification of the folate binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate binding characteristics
126. Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells
127. Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis
128. Increased hepatic ferritin-H messenger RNA levels correlate with thse of c-myc in human hepatocellular carcinoma
129. Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolatepentaglutamate
130. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
131. Evidence for the chemical interaction between 2-mercaptoethanol and tetrahydrofolate
132. Effect of folacin deficiency on folacin binding proteins in the rat
133. Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene
134. Ferritin heavy chain is a progesterone-inducible marker in the uterus during pregnancy