-
1
-
-
84872866038
-
Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries
-
Krall N, Scheuermann J, Neri D. Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries. Angew Chem Int Ed Engl 2013;52:1384-1402.
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, pp. 1384-1402
-
-
Krall, N.1
Scheuermann, J.2
Neri, D.3
-
2
-
-
84879856165
-
Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [(1)(1)C]docetaxel and positron emission tomography
-
van der Veldt AA, et al. Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [(1)(1)C]docetaxel and positron emission tomography. Clin Cancer Res 2013;19:4163-4173.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4163-4173
-
-
van der Veldt, A.A.1
-
3
-
-
79960394764
-
Absolute quantification of [(11)C]docetaxel kinetics in lung cancer patients using positron emission tomography
-
van der Veldt AA, et al. Absolute quantification of [(11)C]docetaxel kinetics in lung cancer patients using positron emission tomography. Clin Cancer Res 2011;17:4814-4824.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4814-4824
-
-
van der Veldt, A.A.1
-
4
-
-
77957361348
-
Development trends for human monoclonal antibody therapeutics
-
Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 2010;9:767-774.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 767-774
-
-
Nelson, A.L.1
Dhimolea, E.2
Reichert, J.M.3
-
5
-
-
84920502297
-
Biopharmaceutical benchmarks 2014
-
Walsh G. Biopharmaceutical benchmarks 2014. Nat Biotechnol 2014;32:992-1000.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 992-1000
-
-
Walsh, G.1
-
6
-
-
84896925253
-
Emerging classes of armed antibody therapeutics against cancer
-
Hess C, Venetz D, Neri D. Emerging classes of armed antibody therapeutics against cancer. Medchemcomm 2014;5:408-431.
-
(2014)
Medchemcomm
, vol.5
, pp. 408-431
-
-
Hess, C.1
Venetz, D.2
Neri, D.3
-
7
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-264.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
8
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
9
-
-
37549063078
-
Cytokines and anti-cytokines as therapeutics-an update
-
Tayal V, Kalra BS. Cytokines and anti-cytokines as therapeutics-an update. Eur J Pharmacol 2008;579:1-12.
-
(2008)
Eur J Pharmacol
, vol.579
, pp. 1-12
-
-
Tayal, V.1
Kalra, B.S.2
-
10
-
-
85047692172
-
Therapeutic vaccines for cancer: an overview of clinical trials
-
Melero I, et al. Therapeutic vaccines for cancer: an overview of clinical trials. Nat Rev Clin Oncol 2014;11:509-524.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 509-524
-
-
Melero, I.1
-
12
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov LB, et al. Signatures of mutational processes in human cancer. Nature 2013;500:415-421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
-
14
-
-
0037137510
-
HLA class I antigen loss, tumor immune escape and immune selection
-
Campoli M, Chang CC, Ferrone S. HLA class I antigen loss, tumor immune escape and immune selection. Vaccine 2002;20(Suppl 4):A40-A45.
-
(2002)
Vaccine
, vol.20
, pp. A40-A45
-
-
Campoli, M.1
Chang, C.C.2
Ferrone, S.3
-
15
-
-
19444382439
-
Classical and nonclassical HLA class I antigen and NK Cell-activating ligand changes in malignant cells: current challenges and future directions
-
Chang CC, Campoli M, Ferrone S. Classical and nonclassical HLA class I antigen and NK Cell-activating ligand changes in malignant cells: current challenges and future directions. Adv Cancer Res 2005;93:189-234.
-
(2005)
Adv Cancer Res
, vol.93
, pp. 189-234
-
-
Chang, C.C.1
Campoli, M.2
Ferrone, S.3
-
16
-
-
33645023639
-
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells
-
Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006;117:433-442.
-
(2006)
Immunology
, vol.117
, pp. 433-442
-
-
Taylor, A.1
Verhagen, J.2
Blaser, K.3
Akdis, M.4
Akdis, C.A.5
-
17
-
-
0042847257
-
Fas ligand on tumor cells mediates inactivation of neutrophils
-
Chen YL, Chen SH, Wang JY, Yang BC. Fas ligand on tumor cells mediates inactivation of neutrophils. J Immunol 2003;171:1183-1191.
-
(2003)
J Immunol
, vol.171
, pp. 1183-1191
-
-
Chen, Y.L.1
Chen, S.H.2
Wang, J.Y.3
Yang, B.C.4
-
18
-
-
79954533158
-
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
-
Quezada SA, Peggs KS, Simpson TR, Allison JP. Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunol Rev 2011;241:104-118.
-
(2011)
Immunol Rev
, vol.241
, pp. 104-118
-
-
Quezada, S.A.1
Peggs, K.S.2
Simpson, T.R.3
Allison, J.P.4
-
19
-
-
27144465484
-
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
-
Vaccaro C, Zhou J, Ober RJ, Ward ES. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol 2005;23:1283-1288.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1283-1288
-
-
Vaccaro, C.1
Zhou, J.2
Ober, R.J.3
Ward, E.S.4
-
20
-
-
0029890827
-
T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy
-
Becker JC, Pancook JD, Gillies SD, Furukawa K, Reisfeld RA. T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy. J Exp Med 1996;183:2361-2366.
-
(1996)
J Exp Med
, vol.183
, pp. 2361-2366
-
-
Becker, J.C.1
Pancook, J.D.2
Gillies, S.D.3
Furukawa, K.4
Reisfeld, R.A.5
-
21
-
-
42549099073
-
A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo
-
Villa A, et al. A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo. Int J Cancer 2008;122:2405-2413.
-
(2008)
Int J Cancer
, vol.122
, pp. 2405-2413
-
-
Villa, A.1
-
22
-
-
0032555478
-
Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
-
Pini A, et al. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem 1998;273:21769-21776.
-
(1998)
J Biol Chem
, vol.273
, pp. 21769-21776
-
-
Pini, A.1
-
23
-
-
84884128485
-
Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia
-
201ra118
-
Gutbrodt KL, et al. Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia. Sci Transl Med 2013;5:201ra118.
-
(2013)
Sci Transl Med
, vol.5
-
-
Gutbrodt, K.L.1
-
24
-
-
84906309157
-
Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis
-
Hemmerle T, Doll F, Neri D. Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis. Proc Natl Acad Sci USA 2014;111:12008-12012.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 12008-12012
-
-
Hemmerle, T.1
Doll, F.2
Neri, D.3
-
25
-
-
84901456581
-
Tumor-targeting properties of novel immunocytokines based on murine IL1beta and IL6
-
Hess C, Neri D. Tumor-targeting properties of novel immunocytokines based on murine IL1beta and IL6. Protein Eng Des Sel 2014;27:207-213.
-
(2014)
Protein Eng Des Sel
, vol.27
, pp. 207-213
-
-
Hess, C.1
Neri, D.2
-
26
-
-
84884603722
-
Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse
-
Doll F, Schwager K, Hemmerle T, Neri D. Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse. Arthritis Res Ther 2013;15:R138.
-
(2013)
Arthritis Res Ther
, vol.15
, pp. R138
-
-
Doll, F.1
Schwager, K.2
Hemmerle, T.3
Neri, D.4
-
27
-
-
79953766810
-
Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation
-
Frey K, Zivanovic A, Schwager K, Neri D. Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation. Integr Biol (Camb) 2011;3:468-478.
-
(2011)
Integr Biol (Camb)
, vol.3
, pp. 468-478
-
-
Frey, K.1
Zivanovic, A.2
Schwager, K.3
Neri, D.4
-
28
-
-
84883741949
-
The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity
-
Hemmerle T, Probst P, Giovannoni L, Green AJ, Meyer T, Neri D. The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity. Br J Cancer 2013;109:1206-1213.
-
(2013)
Br J Cancer
, vol.109
, pp. 1206-1213
-
-
Hemmerle, T.1
Probst, P.2
Giovannoni, L.3
Green, A.J.4
Meyer, T.5
Neri, D.6
-
29
-
-
33748866249
-
An engineered antibody-interleukin-12 fusion protein with enhanced tumor vascular targeting properties
-
Gafner V, Trachsel E, Neri D. An engineered antibody-interleukin-12 fusion protein with enhanced tumor vascular targeting properties. Int J Cancer 2006;119:2205-2212.
-
(2006)
Int J Cancer
, vol.119
, pp. 2205-2212
-
-
Gafner, V.1
Trachsel, E.2
Neri, D.3
-
30
-
-
84990001693
-
The dose-dependent tumor targeting of antibody-IFNgamma fusion proteins reveals an unexpected receptor-trapping mechanism in vivo
-
Hemmerle T, Neri D. The dose-dependent tumor targeting of antibody-IFNgamma fusion proteins reveals an unexpected receptor-trapping mechanism in vivo. Cancer Immunol Res 2014;2:559-567.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 559-567
-
-
Hemmerle, T.1
Neri, D.2
-
31
-
-
34250315638
-
The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis
-
Kaspar M, Trachsel E, Neri D. The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis. Cancer Res 2007;67:4940-4948.
-
(2007)
Cancer Res
, vol.67
, pp. 4940-4948
-
-
Kaspar, M.1
Trachsel, E.2
Neri, D.3
-
32
-
-
0037058313
-
Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins
-
Halin C, Niesner U, Villani ME, Zardi L, Neri D. Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins. Int J Cancer 2002;102:109-116.
-
(2002)
Int J Cancer
, vol.102
, pp. 109-116
-
-
Halin, C.1
Niesner, U.2
Villani, M.E.3
Zardi, L.4
Neri, D.5
-
33
-
-
84923197393
-
Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies
-
Venetz D, Hess C, Lin CW, Aebi M, Neri D. Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies. Proc Natl Acad Sci USA 2015;112:2000-2005.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 2000-2005
-
-
Venetz, D.1
Hess, C.2
Lin, C.W.3
Aebi, M.4
Neri, D.5
-
34
-
-
84870232605
-
A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data
-
Hemmerle T, Wulhfard S, Neri D. A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data. Protein Eng Des Sel 2012;25:851-854.
-
(2012)
Protein Eng Des Sel
, vol.25
, pp. 851-854
-
-
Hemmerle, T.1
Wulhfard, S.2
Neri, D.3
-
35
-
-
0036493867
-
Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix
-
Carnemolla B, et al. Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix. Blood 2002;99:1659-1665.
-
(2002)
Blood
, vol.99
, pp. 1659-1665
-
-
Carnemolla, B.1
-
36
-
-
0036194917
-
Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
-
Halin C, et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 2002;20:264-269.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 264-269
-
-
Halin, C.1
-
37
-
-
10744221996
-
Selective targeted delivery of TNFalpha to tumor blood vessels
-
Borsi L, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood 2003;102:4384-4392.
-
(2003)
Blood
, vol.102
, pp. 4384-4392
-
-
Borsi, L.1
-
38
-
-
0037731516
-
Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha
-
Halin C, et al. Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha. Cancer Res 2003;63:3202-3210.
-
(2003)
Cancer Res
, vol.63
, pp. 3202-3210
-
-
Halin, C.1
-
39
-
-
0032926185
-
Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors
-
Hornick JL, Khawli LA, Hu P, Sharifi J, Khanna C, Epstein AL. Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors. Clin Cancer Res 1999;5:51-60.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 51-60
-
-
Hornick, J.L.1
Khawli, L.A.2
Hu, P.3
Sharifi, J.4
Khanna, C.5
Epstein, A.L.6
-
40
-
-
84928013457
-
Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2
-
Zhu EF, et al. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell 2015;27:489-501.
-
(2015)
Cancer Cell
, vol.27
, pp. 489-501
-
-
Zhu, E.F.1
-
41
-
-
84887449396
-
The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer
-
Hemmerle T, Neri D. The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer. Int J Cancer 2014;134:467-477.
-
(2014)
Int J Cancer
, vol.134
, pp. 467-477
-
-
Hemmerle, T.1
Neri, D.2
-
42
-
-
84925424460
-
Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
-
Tzeng A, Kwan BH, Opel CF, Navaratna T, Wittrup KD. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution. Proc Natl Acad Sci USA 2015;112:3320-3325.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 3320-3325
-
-
Tzeng, A.1
Kwan, B.H.2
Opel, C.F.3
Navaratna, T.4
Wittrup, K.D.5
-
43
-
-
84926454355
-
Anti-CD138-targeted interferon is a potent therapeutic against multiple myeloma
-
Yoo EM, et al. Anti-CD138-targeted interferon is a potent therapeutic against multiple myeloma. J Interferon Cytokine Res 2015;35:281-291.
-
(2015)
J Interferon Cytokine Res
, vol.35
, pp. 281-291
-
-
Yoo, E.M.1
-
44
-
-
0036042603
-
Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer
-
Gillies SD, Lan Y, Brunkhorst B, Wong WK, Li Y, Lo KM. Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer. Cancer Immunol Immunother 2002;51:449-460.
-
(2002)
Cancer Immunol Immunother
, vol.51
, pp. 449-460
-
-
Gillies, S.D.1
Lan, Y.2
Brunkhorst, B.3
Wong, W.K.4
Li, Y.5
Lo, K.M.6
-
45
-
-
0030856116
-
Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy
-
Xiang R, et al. Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy. Cancer Res 1997;57:4948-4955.
-
(1997)
Cancer Res
, vol.57
, pp. 4948-4955
-
-
Xiang, R.1
-
46
-
-
0041335450
-
Chimeric TNT-3 antibody/murine interferon-gamma fusion protein for the immunotherapy of solid malignancies
-
Mizokami MM, Hu P, Khawli LA, Li J, Epstein AL. Chimeric TNT-3 antibody/murine interferon-gamma fusion protein for the immunotherapy of solid malignancies. Hybrid Hybridomics 2003;22:197-207.
-
(2003)
Hybrid Hybridomics
, vol.22
, pp. 197-207
-
-
Mizokami, M.M.1
Hu, P.2
Khawli, L.A.3
Li, J.4
Epstein, A.L.5
-
47
-
-
77951019547
-
Targeted delivery of interferon-alpha via fusion to anti-CD20 results in potent antitumor activity against B-cell lymphoma
-
Xuan C, Steward KK, Timmerman JM, Morrison SL. Targeted delivery of interferon-alpha via fusion to anti-CD20 results in potent antitumor activity against B-cell lymphoma. Blood 2010;115:2864-2871.
-
(2010)
Blood
, vol.115
, pp. 2864-2871
-
-
Xuan, C.1
Steward, K.K.2
Timmerman, J.M.3
Morrison, S.L.4
-
48
-
-
0035882014
-
Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma
-
Niethammer AG, et al. Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma. Cancer Res 2001;61:6178-6184.
-
(2001)
Cancer Res
, vol.61
, pp. 6178-6184
-
-
Niethammer, A.G.1
-
49
-
-
84875249780
-
Current and potential uses of immunocytokines as cancer immunotherapy
-
Sondel PM, Gillies SD. Current and potential uses of immunocytokines as cancer immunotherapy. Antibodies (Basel) 2012;1:149-171.
-
(2012)
Antibodies (Basel)
, vol.1
, pp. 149-171
-
-
Sondel, P.M.1
Gillies, S.D.2
-
50
-
-
84884828581
-
Immunocytokines: a review of molecules in clinical development for cancer therapy
-
List T, Neri D. Immunocytokines: a review of molecules in clinical development for cancer therapy. Clin Pharmacol 2013;5:29-45.
-
(2013)
Clin Pharmacol
, vol.5
, pp. 29-45
-
-
List, T.1
Neri, D.2
-
51
-
-
84909581250
-
Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety
-
Young PA, Morrison SL, Timmerman JM. Antibody-cytokine fusion proteins for treatment of cancer: engineering cytokines for improved efficacy and safety. Semin Oncol 2014;41:623-636.
-
(2014)
Semin Oncol
, vol.41
, pp. 623-636
-
-
Young, P.A.1
Morrison, S.L.2
Timmerman, J.M.3
-
52
-
-
79957917039
-
A low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity
-
Gillies SD, et al. A low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity. Clin Cancer Res 2011;17:3673-3685.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3673-3685
-
-
Gillies, S.D.1
-
53
-
-
0034123555
-
Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction
-
Lode HN, et al. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 2000;105:1623-1630.
-
(2000)
J Clin Invest
, vol.105
, pp. 1623-1630
-
-
Lode, H.N.1
-
54
-
-
84944167446
-
Combination of radiotherapy with the immunocytokine L19-IL2: additive effect in a NK cell dependent tumour model
-
Rekers NH, et al. Combination of radiotherapy with the immunocytokine L19-IL2: additive effect in a NK cell dependent tumour model. Radiother Oncol 2015;116:438-442.
-
(2015)
Radiother Oncol
, vol.116
, pp. 438-442
-
-
Rekers, N.H.1
-
55
-
-
84928804945
-
Radiotherapy combined with the immunocytokine L19-IL2 provides long-lasting antitumor effects
-
Zegers CM, et al. Radiotherapy combined with the immunocytokine L19-IL2 provides long-lasting antitumor effects. Clin Cancer Res 2015;21:1151-1160.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1151-1160
-
-
Zegers, C.M.1
-
56
-
-
84940500691
-
Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
-
Rekers NH, Zegers CM, Germeraad WT, Dubois L, Lambin P. Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2. Oncoimmunology 2015;4:e1021541.
-
(2015)
Oncoimmunology
, vol.4
-
-
Rekers, N.H.1
Zegers, C.M.2
Germeraad, W.T.3
Dubois, L.4
Lambin, P.5
-
57
-
-
84924327807
-
NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
-
van den Heuvel MM, et al. NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy. J Transl Med 2015;13:32.
-
(2015)
J Transl Med
, vol.13
, pp. 32
-
-
van den Heuvel, M.M.1
-
58
-
-
0036837633
-
Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin
-
Borsi L, et al. Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int J Cancer 2002;102:75-85.
-
(2002)
Int J Cancer
, vol.102
, pp. 75-85
-
-
Borsi, L.1
-
59
-
-
84859402603
-
Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts
-
Moschetta M, et al. Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts. Cancer Res 2012;72:1814-1824.
-
(2012)
Cancer Res
, vol.72
, pp. 1814-1824
-
-
Moschetta, M.1
-
60
-
-
84873627355
-
The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF
-
Schwager K, Hemmerle T, Aebischer D, Neri D. The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF. J Invest Dermatol 2013;133:751-758.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 751-758
-
-
Schwager, K.1
Hemmerle, T.2
Aebischer, D.3
Neri, D.4
-
61
-
-
63849274108
-
Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
-
Schliemann C, et al. Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2. Blood 2009;113:2275-2283.
-
(2009)
Blood
, vol.113
, pp. 2275-2283
-
-
Schliemann, C.1
-
62
-
-
77953445215
-
Therapy-induced antitumor vaccination in neuroblastomas by the combined targeting of IL-2 and TNFalpha
-
Balza E, et al. Therapy-induced antitumor vaccination in neuroblastomas by the combined targeting of IL-2 and TNFalpha. Int J Cancer 2010;127:101-110.
-
(2010)
Int J Cancer
, vol.127
, pp. 101-110
-
-
Balza, E.1
-
63
-
-
84876331190
-
Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours
-
Spitaleri G, et al. Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours. J Cancer Res Clin Oncol 2013;139:447-455.
-
(2013)
J Cancer Res Clin Oncol
, vol.139
, pp. 447-455
-
-
Spitaleri, G.1
-
64
-
-
78049264752
-
The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma
-
Johannsen M, et al. The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma. Eur J Cancer 2010;46:2926-2935.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2926-2935
-
-
Johannsen, M.1
-
65
-
-
84055176488
-
A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma
-
Eigentler TK, et al. A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma. Clin Cancer Res 2011;17:7732-7742.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7732-7742
-
-
Eigentler, T.K.1
-
66
-
-
84906937730
-
Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses
-
Weide B, et al. Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses. Cancer Immunol Res 2014;2:668-678.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 668-678
-
-
Weide, B.1
-
67
-
-
84937968502
-
Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study
-
Danielli R, et al. Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study. Cancer Immunol Immunother 2015;64:999-1009.
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 999-1009
-
-
Danielli, R.1
-
68
-
-
33744811140
-
Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C
-
Brack SS, Silacci M, Birchler M, Neri D. Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C. Clin Cancer Res 2006;12:3200-3208.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3200-3208
-
-
Brack, S.S.1
Silacci, M.2
Birchler, M.3
Neri, D.4
-
69
-
-
58149189408
-
Antibody-mediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy
-
Marlind J, et al. Antibody-mediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy. Clin Cancer Res 2008;14:6515-6524.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6515-6524
-
-
Marlind, J.1
-
70
-
-
77956450051
-
Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma
-
Pedretti M, et al. Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma. Br J Cancer 2010;103:827-836.
-
(2010)
Br J Cancer
, vol.103
, pp. 827-836
-
-
Pedretti, M.1
-
71
-
-
84939471750
-
The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer
-
Catania C, et al. The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer. Cell Adh Migr 2015;9:14-21.
-
(2015)
Cell Adh Migr
, vol.9
, pp. 14-21
-
-
Catania, C.1
-
72
-
-
84962236885
-
Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation
-
Schliemann C, et al. Targeting interleukin-2 to the bone marrow stroma for therapy of acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplantation. Cancer Immunol Res 2015;3:547-556.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 547-556
-
-
Schliemann, C.1
-
73
-
-
0024791484
-
High-level expression of chimeric antibodies using adapted cDNA variable region cassettes
-
Gillies SD, Lo KM, Wesolowski J. High-level expression of chimeric antibodies using adapted cDNA variable region cassettes. J Immunol Methods 1989;125:191-202.
-
(1989)
J Immunol Methods
, vol.125
, pp. 191-202
-
-
Gillies, S.D.1
Lo, K.M.2
Wesolowski, J.3
-
74
-
-
0032031429
-
Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy
-
Lode HN, Xiang R, Dreier T, Varki NM, Gillies SD, Reisfeld RA. Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy. Blood 1998;91:1706-1715.
-
(1998)
Blood
, vol.91
, pp. 1706-1715
-
-
Lode, H.N.1
Xiang, R.2
Dreier, T.3
Varki, N.M.4
Gillies, S.D.5
Reisfeld, R.A.6
-
75
-
-
0030453784
-
Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy
-
Becker JC, Varki N, Gillies SD, Furukawa K, Reisfeld RA. Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy. J Clin Invest 1996;98:2801-2804.
-
(1996)
J Clin Invest
, vol.98
, pp. 2801-2804
-
-
Becker, J.C.1
Varki, N.2
Gillies, S.D.3
Furukawa, K.4
Reisfeld, R.A.5
-
76
-
-
33645679838
-
A phase I clinical trial of the hu14 18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group
-
Osenga KL, et al. A phase I clinical trial of the hu14 18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group. Clin Cancer Res 2006;12:1750-1759.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1750-1759
-
-
Osenga, K.L.1
-
77
-
-
16544364126
-
Phase I clinical trial of the immunocytokine EMD 273063 in melanoma patients
-
King DM, et al. Phase I clinical trial of the immunocytokine EMD 273063 in melanoma patients. J Clin Oncol 2004;22:4463-4473.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4463-4473
-
-
King, D.M.1
-
78
-
-
79951886003
-
Antitumor activity of hu14 18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study
-
Shusterman S, et al. Antitumor activity of hu14 18-IL2 in patients with relapsed/refractory neuroblastoma: a Children's Oncology Group (COG) phase II study. J Clin Oncol 2010;28:4969-4975.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4969-4975
-
-
Shusterman, S.1
-
79
-
-
68949208645
-
Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma
-
Ribas A, et al. Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma. J Transl Med 2009;7:68.
-
(2009)
J Transl Med
, vol.7
, pp. 68
-
-
Ribas, A.1
-
80
-
-
0023784524
-
A novel method for the detection of necrotic lesions in human cancers
-
Epstein AL, Chen FM, Taylor CR. A novel method for the detection of necrotic lesions in human cancers. Cancer Res 1988;48:5842-5848.
-
(1988)
Cancer Res
, vol.48
, pp. 5842-5848
-
-
Epstein, A.L.1
Chen, F.M.2
Taylor, C.R.3
-
81
-
-
1242317071
-
chTNT-3/hu IL-12 fusion protein for the immunotherapy of experimental solid tumors
-
Li J, Hu P, Khawli LA, Yun A, Epstein AL. chTNT-3/hu IL-12 fusion protein for the immunotherapy of experimental solid tumors. Hybrid Hybridomics 2004;23:1-10.
-
(2004)
Hybrid Hybridomics
, vol.23
, pp. 1-10
-
-
Li, J.1
Hu, P.2
Khawli, L.A.3
Yun, A.4
Epstein, A.L.5
-
82
-
-
84884824690
-
First-in-human phase I trial of NHS-IL12 in advanced solid tumors
-
Kim JW, et al. First-in-human phase I trial of NHS-IL12 in advanced solid tumors. J Clin Oncol 2012;30(Suppl):abstr TPS2617.
-
(2012)
J Clin Oncol
, vol.30
-
-
Kim, J.W.1
-
83
-
-
33846811726
-
huBC1-IL12, an immunocytokine which targets EDB-containing oncofetal fibronectin in tumors and tumor vasculature, shows potent anti-tumor activity in human tumor models
-
Lo KM, et al. huBC1-IL12, an immunocytokine which targets EDB-containing oncofetal fibronectin in tumors and tumor vasculature, shows potent anti-tumor activity in human tumor models. Cancer Immunol Immunother 2007;56:447-457.
-
(2007)
Cancer Immunol Immunother
, vol.56
, pp. 447-457
-
-
Lo, K.M.1
-
84
-
-
79953318400
-
A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma
-
Rudman SM, et al. A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res 2011;17:1998-2005.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1998-2005
-
-
Rudman, S.M.1
-
85
-
-
0029063312
-
Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies
-
Lindhofer H, Mocikat R, Steipe B, Thierfelder S. Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J Immunol 1995;155:219-225.
-
(1995)
J Immunol
, vol.155
, pp. 219-225
-
-
Lindhofer, H.1
Mocikat, R.2
Steipe, B.3
Thierfelder, S.4
-
86
-
-
35948977323
-
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
-
Wu C, et al. Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat Biotechnol 2007;25:1290-1297.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1290-1297
-
-
Wu, C.1
-
87
-
-
84905667525
-
A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action
-
Brack S, et al. A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action. Mol Cancer Ther 2014;13:2030-2039.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 2030-2039
-
-
Brack, S.1
-
88
-
-
84969371820
-
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
-
Silacci M, et al. Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases. MAbs 2015;9:1-9.
-
(2015)
MAbs
, vol.9
, pp. 1-9
-
-
Silacci, M.1
-
89
-
-
0346220285
-
Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors
-
Jendreyko N, et al. Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. J Biol Chem 2003;278:47812-47819.
-
(2003)
J Biol Chem
, vol.278
, pp. 47812-47819
-
-
Jendreyko, N.1
-
90
-
-
0036839077
-
Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma
-
Borchmann P, et al. Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma. Blood 2002;100:3101-3107.
-
(2002)
Blood
, vol.100
, pp. 3101-3107
-
-
Borchmann, P.1
-
91
-
-
79955662260
-
Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab
-
Nagorsen D, Baeuerle PA. Immunomodulatory therapy of cancer with T cell-engaging BiTE antibody blinatumomab. Exp Cell Res 2011;317:1255-1260.
-
(2011)
Exp Cell Res
, vol.317
, pp. 1255-1260
-
-
Nagorsen, D.1
Baeuerle, P.A.2
-
92
-
-
0028945817
-
High-affinity antigen binding by chelating recombinant antibodies (CRAbs)
-
Neri D, Momo M, Prospero T, Winter G. High-affinity antigen binding by chelating recombinant antibodies (CRAbs). J Mol Biol 1995;246:367-373.
-
(1995)
J Mol Biol
, vol.246
, pp. 367-373
-
-
Neri, D.1
Momo, M.2
Prospero, T.3
Winter, G.4
-
93
-
-
77954757304
-
Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion
-
Johnson S, et al. Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion. J Mol Biol 2010;399:436-449.
-
(2010)
J Mol Biol
, vol.399
, pp. 436-449
-
-
Johnson, S.1
-
94
-
-
0033569478
-
Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
-
Kipriyanov SM, et al. Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics. J Mol Biol 1999;293:41-56.
-
(1999)
J Mol Biol
, vol.293
, pp. 41-56
-
-
Kipriyanov, S.M.1
-
95
-
-
35348819390
-
Properties, production, and applications of camelid single-domain antibody fragments
-
Harmsen MM, De Haard HJ. Properties, production, and applications of camelid single-domain antibody fragments. Appl Microbiol Biotechnol 2007;77:13-22.
-
(2007)
Appl Microbiol Biotechnol
, vol.77
, pp. 13-22
-
-
Harmsen, M.M.1
De Haard, H.J.2
-
96
-
-
84878935042
-
Nanobodies: natural single-domain antibodies
-
Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem 2013;82:775-797.
-
(2013)
Annu Rev Biochem
, vol.82
, pp. 775-797
-
-
Muyldermans, S.1
-
97
-
-
84899744468
-
+ tumor cells
-
+ tumor cells. MAbs 2014;6:728-739.
-
(2014)
MAbs
, vol.6
, pp. 728-739
-
-
Reusch, U.1
-
98
-
-
84869798378
-
Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site
-
List T, Neri D. Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site. MAbs 2012;4:775-783.
-
(2012)
MAbs
, vol.4
, pp. 775-783
-
-
List, T.1
Neri, D.2
-
99
-
-
0028882034
-
In vivo studies using bispecific antibodies (anti-CD3 × anti-idiotype) and CD28-induced costimulation in the BCL1 lymphoma
-
Demanet C, Brissinck J, De Jonge J, Thielemans K. In vivo studies using bispecific antibodies (anti-CD3 × anti-idiotype) and CD28-induced costimulation in the BCL1 lymphoma. J Hematother 1995;4:363-368.
-
(1995)
J Hematother
, vol.4
, pp. 363-368
-
-
Demanet, C.1
Brissinck, J.2
De Jonge, J.3
Thielemans, K.4
-
100
-
-
84871360414
-
Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens
-
Friedrich M, et al. Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens. Mol Cancer Ther 2012;11:2664-2673.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2664-2673
-
-
Friedrich, M.1
-
101
-
-
84860515259
-
The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA
-
Peng L, et al. The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA. PLoS ONE 2012;7:e36412.
-
(2012)
PLoS ONE
, vol.7
-
-
Peng, L.1
-
102
-
-
77955433583
-
T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells
-
Lutterbuese R, et al. T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells. Proc Natl Acad Sci USA 2010;107:12605-12610.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12605-12610
-
-
Lutterbuese, R.1
-
103
-
-
84969371816
-
Development of MGD007, a gpA33 × CD3 bi-specific DART for T-cell immunotherapy of metastatic colorectal cancer
-
Moore PA, et al. Development of MGD007, a gpA33 × CD3 bi-specific DART for T-cell immunotherapy of metastatic colorectal cancer. Cancer Res 2014;74:669.
-
(2014)
Cancer Res
, vol.74
, pp. 669
-
-
Moore, P.A.1
-
104
-
-
84927006760
-
Characterization of a bispecific FLT3 × CD3 antibody in an improved, recombinant format for the treatment of leukemia
-
Durben M, et al. Characterization of a bispecific FLT3 × CD3 antibody in an improved, recombinant format for the treatment of leukemia. Mol Ther 2015;23:648-655.
-
(2015)
Mol Ther
, vol.23
, pp. 648-655
-
-
Durben, M.1
-
105
-
-
0028122745
-
Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2
-
Kroesen BJ, et al. Phase I study of intravenously applied bispecific antibody in renal cell cancer patients receiving subcutaneous interleukin 2. Br J Cancer 1994;70:652-661.
-
(1994)
Br J Cancer
, vol.70
, pp. 652-661
-
-
Kroesen, B.J.1
-
106
-
-
0029991804
-
Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab')2 in ovarian carcinoma patients
-
Tibben JG, Boerman OC, Massuger LF, Schijf CP, Claessens RA, Corstens FH. Pharmacokinetics, biodistribution and biological effects of intravenously administered bispecific monoclonal antibody OC/TR F(ab')2 in ovarian carcinoma patients. Int J Cancer 1996;66:477-483.
-
(1996)
Int J Cancer
, vol.66
, pp. 477-483
-
-
Tibben, J.G.1
Boerman, O.C.2
Massuger, L.F.3
Schijf, C.P.4
Claessens, R.A.5
Corstens, F.H.6
-
107
-
-
84863522243
-
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
-
Klinger M, et al. Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab. Blood 2012;119:6226-6233.
-
(2012)
Blood
, vol.119
, pp. 6226-6233
-
-
Klinger, M.1
-
108
-
-
84957622828
-
-
Amgen. Blinatumomab (AMG103) Background information for the pediatric subcommittee of the oncologic drugs advisory committee meeting
-
Amgen. Blinatumomab (AMG103) Background information for the pediatric subcommittee of the oncologic drugs advisory committee meeting, 2012.
-
(2012)
-
-
-
109
-
-
0343415665
-
A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes
-
Loffler A, et al. A recombinant bispecific single-chain antibody, CD19 × CD3, induces rapid and high lymphoma-directed cytotoxicity by unstimulated T lymphocytes. Blood 2000;95:2098-2103.
-
(2000)
Blood
, vol.95
, pp. 2098-2103
-
-
Loffler, A.1
-
110
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou R, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008;321:974-977.
-
(2008)
Science
, vol.321
, pp. 974-977
-
-
Bargou, R.1
-
112
-
-
84926099033
-
Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study
-
Topp MS, et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. Lancet Oncol 2015;16:57-66.
-
(2015)
Lancet Oncol
, vol.16
, pp. 57-66
-
-
Topp, M.S.1
-
113
-
-
59149100151
-
Intraperitoneal treatment of malignant ascites due to epithelial tumors with catumaxomab: a phase II/III study
-
Parsons S, et al. Intraperitoneal treatment of malignant ascites due to epithelial tumors with catumaxomab: a phase II/III study. J Clin Oncol 2008;26:3000.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3000
-
-
Parsons, S.1
-
114
-
-
0034051390
-
The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
-
Zeidler R, et al. The Fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br J Cancer 2000;83:261-266.
-
(2000)
Br J Cancer
, vol.83
, pp. 261-266
-
-
Zeidler, R.1
-
115
-
-
34447132202
-
Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM × anti-CD3 antibody: a phase I/II study
-
Burges A, et al. Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM × anti-CD3 antibody: a phase I/II study. Clin Cancer Res 2007;13:3899-3905.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3899-3905
-
-
Burges, A.1
-
116
-
-
84969378904
-
Preclinical activity and safety of MGD006, a CD123xCD3 Bispecific DART (R) molecule for the treatment of hematological malignancies
-
Moore P, et al. Preclinical activity and safety of MGD006, a CD123xCD3 Bispecific DART (R) molecule for the treatment of hematological malignancies. Eur J Cancer 2014;50:48.
-
(2014)
Eur J Cancer
, vol.50
, pp. 48
-
-
Moore, P.1
-
117
-
-
84948946365
-
MGD011, Humanized CD19 × CD3 DART (R) protein with enhanced pharmacokinetic properties, demonstrates potent T-cell mediated anti-tumor activity in preclinical models and durable B-cell depletion in cynomolgus monkeys following once-a-week dosing
-
Liu LQ, et al. MGD011, Humanized CD19 × CD3 DART (R) protein with enhanced pharmacokinetic properties, demonstrates potent T-cell mediated anti-tumor activity in preclinical models and durable B-cell depletion in cynomolgus monkeys following once-a-week dosing. Blood 2014;124:21.
-
(2014)
Blood
, vol.124
, pp. 21
-
-
Liu, L.Q.1
-
118
-
-
33846404133
-
Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent
-
Dennis MS, et al. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res 2007;67:254-261.
-
(2007)
Cancer Res
, vol.67
, pp. 254-261
-
-
Dennis, M.S.1
-
119
-
-
78650443580
-
Soluble plasma HLA peptidome as a potential source for cancer biomarkers
-
Bassani-Sternberg M, Barnea E, Beer I, Avivi I, Katz T, Admon A. Soluble plasma HLA peptidome as a potential source for cancer biomarkers. Proc Natl Acad Sci USA 2010;107:18769-18776.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18769-18776
-
-
Bassani-Sternberg, M.1
Barnea, E.2
Beer, I.3
Avivi, I.4
Katz, T.5
Admon, A.6
-
121
-
-
0034327810
-
Recombinant anti-human HER2/neu IgG3-(GM-CSF) fusion protein retains antigen specificity and cytokine function and demonstrates antitumor activity
-
Dela Cruz JS, Trinh KR, Morrison SL, Penichet ML. Recombinant anti-human HER2/neu IgG3-(GM-CSF) fusion protein retains antigen specificity and cytokine function and demonstrates antitumor activity. J Immunol 2000;165:5112-5121.
-
(2000)
J Immunol
, vol.165
, pp. 5112-5121
-
-
Dela Cruz, J.S.1
Trinh, K.R.2
Morrison, S.L.3
Penichet, M.L.4
-
122
-
-
0030974616
-
Chimeric CLL-1 antibody fusion proteins containing granulocyte-macrophage colony-stimulating factor or interleukin-2 with specificity for B-cell malignancies exhibit enhanced effector functions while retaining tumor targeting properties
-
Hornick JL, Khawli LA, Hu P, Lynch M, Anderson PM, Epstein AL. Chimeric CLL-1 antibody fusion proteins containing granulocyte-macrophage colony-stimulating factor or interleukin-2 with specificity for B-cell malignancies exhibit enhanced effector functions while retaining tumor targeting properties. Blood 1997;89:4437-4447.
-
(1997)
Blood
, vol.89
, pp. 4437-4447
-
-
Hornick, J.L.1
Khawli, L.A.2
Hu, P.3
Lynch, M.4
Anderson, P.M.5
Epstein, A.L.6
-
123
-
-
12144288382
-
Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein
-
Bauer S, et al. Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein. J Immunol 2004;172:3930-3939.
-
(2004)
J Immunol
, vol.172
, pp. 3930-3939
-
-
Bauer, S.1
-
124
-
-
66149113671
-
Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNγ
-
Bauer S, et al. Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNγ. Int J Cancer 2009;125:115-123.
-
(2009)
Int J Cancer
, vol.125
, pp. 115-123
-
-
Bauer, S.1
-
125
-
-
70449729725
-
CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas
-
Rossi EA, Goldenberg DM, Cardillo TM, Stein R, Chang CH. CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas. Blood 2009;114:3864-3871.
-
(2009)
Blood
, vol.114
, pp. 3864-3871
-
-
Rossi, E.A.1
Goldenberg, D.M.2
Cardillo, T.M.3
Stein, R.4
Chang, C.H.5
-
126
-
-
0036369434
-
In vivo tumor delivery of a recombinant single chain Fv:tumor necrosis factor-alpha fusion [correction of factor: a fusion] protein
-
Cooke SP, Pedley RB, Boden R, Begent RH, Chester KA. In vivo tumor delivery of a recombinant single chain Fv:tumor necrosis factor-alpha fusion [correction of factor: a fusion] protein. Bioconjug Chem 2002;13:7-15.
-
(2002)
Bioconjug Chem
, vol.13
, pp. 7-15
-
-
Cooke, S.P.1
Pedley, R.B.2
Boden, R.3
Begent, R.H.4
Chester, K.A.5
-
127
-
-
38449120108
-
Targeting IFN-alpha to B cell lymphoma by a tumor-specific antibody elicits potent antitumor activities
-
Huang TH, Chintalacharuvu KR, Morrison SL. Targeting IFN-alpha to B cell lymphoma by a tumor-specific antibody elicits potent antitumor activities. J Immunol 2007;179:6881-6888.
-
(2007)
J Immunol
, vol.179
, pp. 6881-6888
-
-
Huang, T.H.1
Chintalacharuvu, K.R.2
Morrison, S.L.3
-
128
-
-
0346156081
-
Recombinant single-chain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor
-
Liu Y, Cheung LH, Marks JW, Rosenblum MG. Recombinant single-chain antibody fusion construct targeting human melanoma cells and containing tumor necrosis factor. Int J Cancer 2004;108:549-557.
-
(2004)
Int J Cancer
, vol.108
, pp. 549-557
-
-
Liu, Y.1
Cheung, L.H.2
Marks, J.W.3
Rosenblum, M.G.4
-
129
-
-
80051867145
-
Preclinical studies on targeted delivery of multiple IFNalpha2b to HLA-DR in diverse hematologic cancers
-
Rossi EA, Rossi DL, Cardillo TM, Stein R, Goldenberg DM, Chang CH. Preclinical studies on targeted delivery of multiple IFNalpha2b to HLA-DR in diverse hematologic cancers. Blood 2011;118:1877-1884.
-
(2011)
Blood
, vol.118
, pp. 1877-1884
-
-
Rossi, E.A.1
Rossi, D.L.2
Cardillo, T.M.3
Stein, R.4
Goldenberg, D.M.5
Chang, C.H.6
-
130
-
-
0030223024
-
Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells
-
Scherf U, Benhar I, Webber KO, Pastan I, Brinkmann U. Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells. Clin Cancer Res 1996;2:1523-1531.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1523-1531
-
-
Scherf, U.1
Benhar, I.2
Webber, K.O.3
Pastan, I.4
Brinkmann, U.5
-
131
-
-
0034896595
-
Efficacy of local versus systemic application of antibody-cytokine fusion proteins in tumor therapy
-
Christ O, Seiter S, Matzku S, Burger C, Zoller M. Efficacy of local versus systemic application of antibody-cytokine fusion proteins in tumor therapy. Clin Cancer Res 2001;7:985-998.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 985-998
-
-
Christ, O.1
Seiter, S.2
Matzku, S.3
Burger, C.4
Zoller, M.5
-
132
-
-
0038706226
-
Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins
-
Sharifi J, Khawli LA, Hu P, Li J, Epstein AL. Generation of human interferon gamma and tumor Necrosis factor alpha chimeric TNT-3 fusion proteins. Hybrid Hybridomics 2002;21:421-432.
-
(2002)
Hybrid Hybridomics
, vol.21
, pp. 421-432
-
-
Sharifi, J.1
Khawli, L.A.2
Hu, P.3
Li, J.4
Epstein, A.L.5
-
133
-
-
22044456976
-
Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy
-
Ebbinghaus C, et al. Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy. Int J Cancer 2005;116:304-313.
-
(2005)
Int J Cancer
, vol.116
, pp. 304-313
-
-
Ebbinghaus, C.1
-
134
-
-
0029038828
-
An antimelanoma immunotoxin containing recombinant human tumor necrosis factor: tissue disposition, pharmacokinetic, and therapeutic studies in xenograft models
-
Rosenblum MG, Cheung L, Mujoo K, Murray JL. An antimelanoma immunotoxin containing recombinant human tumor necrosis factor: tissue disposition, pharmacokinetic, and therapeutic studies in xenograft models. Cancer Immunol Immunother 1995;40:322-328.
-
(1995)
Cancer Immunol Immunother
, vol.40
, pp. 322-328
-
-
Rosenblum, M.G.1
Cheung, L.2
Mujoo, K.3
Murray, J.L.4
-
135
-
-
79960646478
-
Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine
-
Huang X, Ye D, Thorpe PE. Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine. Vaccine 2011;29:4785-4793.
-
(2011)
Vaccine
, vol.29
, pp. 4785-4793
-
-
Huang, X.1
Ye, D.2
Thorpe, P.E.3
-
136
-
-
84904876346
-
Evaluation of antibody-chemokine fusion proteins for tumor-targeting applications
-
Hess C, Neri D. Evaluation of antibody-chemokine fusion proteins for tumor-targeting applications. Exp Biol Med (Maywood) 2014;239:842-852.
-
(2014)
Exp Biol Med (Maywood)
, vol.239
, pp. 842-852
-
-
Hess, C.1
Neri, D.2
-
137
-
-
0034662638
-
Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein
-
Xu X, et al. Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein. Cancer Res 2000;60:4475-4484.
-
(2000)
Cancer Res
, vol.60
, pp. 4475-4484
-
-
Xu, X.1
-
138
-
-
18544371520
-
An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma
-
Gillies SD, et al. An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma. Blood 2005;105:3972-3978.
-
(2005)
Blood
, vol.105
, pp. 3972-3978
-
-
Gillies, S.D.1
-
139
-
-
0035059013
-
A recombinant IgG3-(IL-2) fusion protein for the treatment of human HER2/neu expressing tumors
-
Penichet ML, Dela Cruz JS, Shin SU, Morrison SL. A recombinant IgG3-(IL-2) fusion protein for the treatment of human HER2/neu expressing tumors. Hum Antibodies 2001;10:43-49.
-
(2001)
Hum Antibodies
, vol.10
, pp. 43-49
-
-
Penichet, M.L.1
Dela Cruz, J.S.2
Shin, S.U.3
Morrison, S.L.4
-
140
-
-
84907792121
-
Novel CEA-targeted IL2 variant immunocytokine for immunotherapy of cancer
-
Klein C. Novel CEA-targeted IL2 variant immunocytokine for immunotherapy of cancer. J Immunother Cancer 2014;2:I8.
-
(2014)
J Immunother Cancer
, vol.2
, pp. I8
-
-
Klein, C.1
-
141
-
-
77956434470
-
The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma
-
Frey K, Schliemann C, Schwager K, Giavazzi R, Johannsen M, Neri D. The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma. J Urol 2010;184:2540-2548.
-
(2010)
J Urol
, vol.184
, pp. 2540-2548
-
-
Frey, K.1
Schliemann, C.2
Schwager, K.3
Giavazzi, R.4
Johannsen, M.5
Neri, D.6
-
142
-
-
0036339224
-
Targeting of interleukin-2 to human MK-1-expressing carcinoma by fusion with a single-chain Fv of anti-MK-1 antibody
-
Matsumoto H, et al. Targeting of interleukin-2 to human MK-1-expressing carcinoma by fusion with a single-chain Fv of anti-MK-1 antibody. Anticancer Res 2002;22:2001-2007.
-
(2002)
Anticancer Res
, vol.22
, pp. 2001-2007
-
-
Matsumoto, H.1
-
143
-
-
84892654619
-
Tumor targeting properties of antibody fusion proteins based on different members of the murine tumor necrosis superfamily
-
Hemmerle T, Hess C, Venetz D, Neri D. Tumor targeting properties of antibody fusion proteins based on different members of the murine tumor necrosis superfamily. J Biotechnol 2014;172:73-76.
-
(2014)
J Biotechnol
, vol.172
, pp. 73-76
-
-
Hemmerle, T.1
Hess, C.2
Venetz, D.3
Neri, D.4
-
144
-
-
0032530237
-
Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody
-
Melani C, et al. Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody. Cancer Res 1998;58:4146-4154.
-
(1998)
Cancer Res
, vol.58
, pp. 4146-4154
-
-
Melani, C.1
-
145
-
-
79957437540
-
Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7
-
Pasche N, Woytschak J, Wulhfard S, Villa A, Frey K, Neri D. Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7. J Biotechnol 2011;154:84-92.
-
(2011)
J Biotechnol
, vol.154
, pp. 84-92
-
-
Pasche, N.1
Woytschak, J.2
Wulhfard, S.3
Villa, A.4
Frey, K.5
Neri, D.6
-
146
-
-
75649113035
-
Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis
-
Schwager K, et al. Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis Res Ther 2009;11:R142.
-
(2009)
Arthritis Res Ther
, vol.11
, pp. R142
-
-
Schwager, K.1
-
147
-
-
33847286913
-
Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis
-
Trachsel E, Bootz F, Silacci M, Kaspar M, Kosmehl H, Neri D. Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis. Arthritis Res Ther 2007;9:R9.
-
(2007)
Arthritis Res Ther
, vol.9
, pp. R9
-
-
Trachsel, E.1
Bootz, F.2
Silacci, M.3
Kaspar, M.4
Kosmehl, H.5
Neri, D.6
-
148
-
-
77954981781
-
Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12
-
Sommavilla R, et al. Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12. Protein Eng Des Sel 2010;23:653-661.
-
(2010)
Protein Eng Des Sel
, vol.23
, pp. 653-661
-
-
Sommavilla, R.1
-
149
-
-
0035863566
-
Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
-
Nilsson F, Kosmehl H, Zardi L, Neri D. Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res 2001;61:711-716.
-
(2001)
Cancer Res
, vol.61
, pp. 711-716
-
-
Nilsson, F.1
Kosmehl, H.2
Zardi, L.3
Neri, D.4
-
150
-
-
84894100387
-
Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice
-
Kim H, Gao W, Ho M. Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice. PLoS ONE 2013;8:e81919.
-
(2013)
PLoS ONE
, vol.8
-
-
Kim, H.1
Gao, W.2
Ho, M.3
-
151
-
-
0032526895
-
Antibody-IL-12 fusion proteins are effective in SCID mouse models of prostate and colon carcinoma metastases
-
Gillies SD, et al. Antibody-IL-12 fusion proteins are effective in SCID mouse models of prostate and colon carcinoma metastases. J Immunol 1998;160:6195-6203.
-
(1998)
J Immunol
, vol.160
, pp. 6195-6203
-
-
Gillies, S.D.1
-
152
-
-
0033168121
-
A single-chain IL-12 IgG3 antibody fusion protein retains antibody specificity and IL-12 bioactivity and demonstrates antitumor activity
-
Peng LS, Penichet ML, Morrison SL. A single-chain IL-12 IgG3 antibody fusion protein retains antibody specificity and IL-12 bioactivity and demonstrates antitumor activity. J Immunol 1999;163:250-258.
-
(1999)
J Immunol
, vol.163
, pp. 250-258
-
-
Peng, L.S.1
Penichet, M.L.2
Morrison, S.L.3
-
153
-
-
84938418857
-
The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity
-
Hess C, Neri D. The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity. Cancer Immunol Immunother 2015;64:635-644.
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 635-644
-
-
Hess, C.1
Neri, D.2
-
154
-
-
84877964989
-
Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency
-
Vincent M, et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int J Cancer 2013;133:757-765.
-
(2013)
Int J Cancer
, vol.133
, pp. 757-765
-
-
Vincent, M.1
-
155
-
-
84861538603
-
The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate
-
Pasche N, Frey K, Neri D. The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate. Angiogenesis 2012;15:165-169.
-
(2012)
Angiogenesis
, vol.15
, pp. 165-169
-
-
Pasche, N.1
Frey, K.2
Neri, D.3
-
156
-
-
84909644287
-
Targeting B-cell malignancies with anti-CD20-interleukin-21 fusokine
-
Bhatt SZ, Jiang X, Shin S, Timmermann JM, Rosenblatt JD, Lossos IS. Targeting B-cell malignancies with anti-CD20-interleukin-21 fusokine. Blood 2013;122:21.
-
(2013)
Blood
, vol.122
, pp. 21
-
-
Bhatt, S.Z.1
Jiang, X.2
Shin, S.3
Timmermann, J.M.4
Rosenblatt, J.D.5
Lossos, I.S.6
|