A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data

Protein Engineering, Design and Selection

Volumn 25, Issue 12, 2012, Pages 851-854

  Hemmerle, Teresa ^a   Wulhfard, Sarah ^a   Neri, Dario ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

antibody F8; bispecific antibody; co stimulatory molecule B7.2; oncofetal fibronectin; vascular targeting

Indexed keywords

ANIMAL MODEL; ANTI-CANCER THERAPEUTICS; BIFUNCTIONAL; BIODISTRIBUTIONS; CO-STIMULATORY MOLECULE B7.2; CRITICAL EVALUATION; EXTRACELLULAR; IN-VIVO; ONCOFETAL FIBRONECTIN; TUMOR SITE; VASCULAR TARGETING;

MOLECULES; TUMORS;

ANTIBODIES;

ANTIBODY F8; BISPECIFIC ANTIBODY; CD86 ANTIGEN; FIBRONECTIN; GAG PROTEIN; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; DRUG DISTRIBUTION; DRUG SCREENING; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TARGET CELL DESTRUCTION;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; FIBRONECTINS; HEK293 CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; RECOMBINANT FUSION PROTEINS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 84870232605     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs061     Document Type: Article

References (28)

1. Backliwal, G., Hildinger, M., Hasija, V. and Wurm, F.M. (2008) Biotechnol Bioeng, 99, 721-727. First published on 2007/08/08, doi: 10.1002/bit.21596.
2. Brischwein, K., Schlereth, B., Guller, B., Steiger, C., Wolf, A., Lutterbuese, R., Offner, S., Locher, M., Urbig, T., Raum, T., et al. (2006) Mol Immunol, 43, 1129-1143. First published on 2005/09/06, doi: 10.1016/j.molimm. 2005.07.034.
3. Carnemolla, B., Borsi, L., Balza, E., Castellani, P., Meazza, R., Berndt, A., Ferrini, S., Kosmehl, H., Neri, D. and Zardi, L. (2002) Blood, 99, 1659-1665. First published on 2002/02/28.
4. Collins, A.V., Brodie, D.W., Gilbert, R.J., Iaboni, A., Manso-Sancho, R., Walse, B., Stuart, D.I., van der Merwe, P.A. and Davis, S.J. (2002) Immunity, 17, 201-10. First published on 2002/08/28.
5. Dreier, T., Lorenczewski, G., Brandl, C., Hoffmann, P., Syring, U., Hanakam, F., Kufer, P., Riethmuller, G., Bargou, R. and Baeuerle, P.A. (2002) Int J Cancer, 100, 690-697. First published on 2002/09/05, doi: 10.1002/ijc.10557.
6. Eagar, T.N., Karandikar, N.J., Bluestone, J.A. and Miller, S.D. (2002) Eur J Immunol, 32, 972-981. First published on 2002/03/29, doi: 10.1002/1521-4141(200204)32:4 972::AID-IMMU972 3.0.CO;2-M.
7. Ebbinghaus, C., Ronca, R., Kaspar, M., Grabulovski, D., Berndt, A., Kosmehl, H., Zardi, L. and Neri, D. (2005) Int J Cancer, 116, 304-313. First published on 2005/04/01, doi: 10.1002/ijc.20952.
8. Eigentler, T.K., Weide, B., de Braud, F., Spitaleri, G., Romanini, A., Pflugfelder, A., Gonzalez-Iglesias, R., Tasciotti, A., Giovannoni, L., Schwager, K., et al. (2011) Clin Cancer Res, 17, 7732-7742. First published on 2011/10/27, doi: 10.1158/1078-0432.CCR-11-1203.
9. Gafner, V., Trachsel, E. and Neri, D. (2006) Int J Cancer, 119, 2205-2212. First published on 2006/07/11, doi: 10.1002/ijc.22101.
10. Halin, C., Niesner, U., Villani, M.E., Zardi, L. and Neri, D. (2002) Int J Cancer, 102, 109-116. First published on 2002/10/18, doi: 10.1002/ijc.10674.
11. Halin, C., Rondini, S., Nilsson, F., Berndt, A., Kosmehl, H., Zardi, L. and Neri, D. (2002) Nat Biotechnol, 20, 264-269. First published on 2002/03/05, doi: 10.1038/nbt0302-264.
12. Hammond, S.A., Lutterbuese, R., Roff, S., Lutterbuese, P., Schlereth, B., Bruckheimer, E., Kinch, M.S., Coats, S., Baeuerle, P.A., Kufer, P., et al. (2007) Cancer Res, 67, 3927-3935. First published on 2007/04/19, doi: 10.1158/0008-5472.CAN-06-2760.
13. Kipriyanov, S.M., Moldenhauer, G., Schuhmacher, J., Cochlovius, B., Von der Lieth, C.W., Matys, E.R. and Little, M. (1999) J Mol Biol, 293, 41-56. First published on 1999/10/08, doi: 10.1006/jmbi.1999.3156.
14. Kontermann, R.E. (2012) Arch Biochem Biophys, 526, 194-205. First published on 2012/03/27, doi: 10.1016/j.abb.2012.03.001.
15. Kontermann, R.E. (2005) Acta Pharmacol Sin, 26, 1-9. First published on 2005/01/22, doi: 10.1111/j.1745-7254.2005.00008.x.
16. Little, M. and Kipriyanov, S. (2007) Mol Immunol, 44, p3083; author reply 3084. First published on 2007/03/07, doi: 10.1016/j.molimm.2007.01.006.
17. Melkko, S., Halin, C., Borsi, L., Zardi, L. and Neri, D. (2002) Int J Radiat Oncol Biol Phys, 54, 1485-1490. First published on 2002/12/03.
18. Molhoj, M., Crommer, S., Brischwein, K., Rau, D., Sriskandarajah, M., Hoffmann, P., Kufer, P., Hofmeister, R. and Baeuerle, P.A. (2007) Mol Immunol, 44, 1935-1943. First published on 2006/11/07, doi: 10.1016/j.molimm.2006.09.032.
19. Nagorsen, D. and Baeuerle, P.A. (2011) Exp Cell Res, 317, 1255-1260. First published on 2011/03/23, doi: 10.1016/j.yexcr.2011.03.010.
20. Niesner, U., Halin, C., Lozzi, L., Gunthert, M., Neri, P., Wunderli-Allenspach, H., Zardi, L. and Neri, D. (2002) Bioconjug Chem, 13, 729-736. First published on 2002/07/18.
21. Pasche, N. and Neri, D. (2012) Drug Discov Today, 17, 583-590. First published on 2012/02/01, doi: 10.1016/j.drudis.2012.01.007.
22. Pasche, N., Woytschak, J., Wulhfard, S., Villa, A., Frey, K. and Neri, D. (2011) J Biotechnol, 154, 84-92. First published on 2011/04/30, doi: 10.1016/j.jbiotec.2011.04.003.
23. Rybak, J.N., Roesli, C., Kaspar, M., Villa, A. and Neri, D. (2007) Cancer Res, 67, 948-10957. First published on 2007/11/17, doi: 10.1158/0008-5472.CAN- 07-1436.
24. Sharpe, A.H. and Freeman, G.J. (2002) Nat Rev Immunol, 2, 6-126. First published on 2002/03/26, doi: 10.1038/nri727.
25. Stork, R., Campigna, E., Robert, B., Muller, D. and Kontermann, R.E. (2009) J Biol Chem, 284, 612-25619. First published on 2009/07/25, doi: 10.1074/jbc.M109.027078.
26. Topp, M.S., Kufer, P., Gokbuget, N., Goebeler, M., Klinger, M., Neumann, S., Horst, H.A., Raff, T., Viardot, A., Schmid, M., et al. (2011) J Clin Oncol, 29, 93-2498. First published on 2011/05/18, doi: 10.1200/JCO.2010.32.7270.
27. Villa, A., Trachsel, E., Kaspar, M., Schliemann, C., Sommavilla, R., Rybak, J.N., Rosli, C., Borsi, L. and Neri, D. (2008) Int J Cancer, 122, 05-2413. First published on 2008/02/14, doi: 10.1002/ijc.23408.
28. Wagner, K., Schulz, P., Scholz, A., Wiedenmann, B. and Menrad, A. (2008) Clin Cancer Res, 14, 51-4960. First published on 2008/08/05, doi: 10.1158/1078-0432.CCR-08-0157.