Targeted interleukin 2 therapy enhances protective immunity induced by an autologous oral DNA vaccine against murine melanoma

Cancer Research

Volumn 61, Issue 16, 2001, Pages 6178-6184

  Niethammer, A G ^a   Xiang, R ^a   Ruehlmann, J M ^a   Lode, H N ^a   Dolman, C S ^a   Gillies, S D ^a   Reisfeld, R A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; HYBRID PROTEIN; INTERLEUKIN 2;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; FEMALE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD80; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DRUG SYNERGISM; EPITOPES; FEMALE; GANGLIOSIDES; HUMANS; IMMUNOTOXINS; INTERFERON TYPE II; INTERLEUKIN-2; INTRAMOLECULAR OXIDOREDUCTASES; LYMPHOCYTE ACTIVATION; MELANOMA, EXPERIMENTAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, DNA;

EID: 0035882014     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Tumor antigens recognized by T lymphocytes
2. Genes coding for tumor antigens recognized by cytolytic T lymphocytes
3. + T cells
4. Human tumor antigens for cancer vaccine development
5. gp100/pmel 17 is a murine tumor rejection antigen: Induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand
6. Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes
7. Identification of tumor-regression antigens in melanoma
8. Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes
9. Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
10. An autologous oral DNA vaccine protects against murine melanoma
11. Oral somatic transgene vaccination using attenuated S. typhymurium
12. Gene transfer in dendritic cells, induced by oral DNA vaccination with S. typhimurium, results in protective immunity against a murine fibrosarcoma
13. Immunity of intracellular bacteria
14. Tolerance, danger and the extended family
15. T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy
16. T cell memory against colon carcinoma is long-lived in the absence of antigen
17. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration
18. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
19. Intracellular retention of hepatitis B virus surface proteins reduces interleukin-2 augmentation after genetic immunizations
20. In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model
21. Impact of cytokine administration on the generation of antitumor reactivity in patients with metastatic melanoma receiving a peptide vaccine
22. Isolation of GD3 synthase gene by expression cloning of GM3 α-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody
23. Eradication of human hepatic and pulmonary melanoma metastases in SCID mice by antibody-interleukin 2 fusion proteins
24. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction
25. + T cell responses in antitumor immunity