메뉴 건너뛰기




Volumn 49, Issue , 2016, Pages 8-26

Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CERAMIDASE; ELONGASE; ENZYME; FILAGGRIN; GAMMA INTERFERON; GLUCOSYLCEREBROSIDASE; HYDROXY FATTY ACID; INTERLEUKIN 4; MESSENGER RNA; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; SERINE PALMITOYL TRANSFERASE; SKIN LIPID; SPHINGOMYELIN; SPHINGOMYELIN DEACYLASE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; CERAMIDE; CHOLESTEROL; FATTY ACID; INTERMEDIATE FILAMENT PROTEIN; LIPID;

EID: 84957623540     PISSN: 14215721     EISSN: 16622944     Source Type: Book Series    
DOI: 10.1159/000441540     Document Type: Article
Times cited : (280)

References (96)
  • 1
    • 33845775154 scopus 로고    scopus 로고
    • Breach delivery: Increased solute uptake points to a defective skin barrier in atopic dermatitis
    • McLean WH, Hull PR: Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis. J Invest Dermatol 2007; 127: 8-10.
    • (2007) J Invest Dermatol , vol.127 , pp. 8-10
    • McLean, W.H.1    Hull, P.R.2
  • 2
    • 0016545625 scopus 로고
    • Drug permeation through human skin-theory and in vitro experimental measurement
    • Michaels AS, Chandrasekaran SK, Shaw JE: Drug permeation through human skin-theory and in vitro experimental measurement. AIChE J 1975; 21: 985-996.
    • (1975) AIChE J , vol.21 , pp. 985-996
    • Michaels, A.S.1    Chandrasekaran, S.K.2    Shaw, J.E.3
  • 5
    • 33745524911 scopus 로고    scopus 로고
    • Breaking the (un)sound barrier: Filaggrin is a major gene for atopic dermatitis
    • Irvine AD, McLean WH: Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol 2006; 126: 1200-1202.
    • (2006) J Invest Dermatol , vol.126 , pp. 1200-1202
    • Irvine, A.D.1    McLean, W.H.2
  • 8
    • 80053517839 scopus 로고    scopus 로고
    • Filaggrin mutations associated with skin and allergic diseases
    • Irvine AD, McLean WHI, Leung DYM: Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011; 365: 1315-1327.
    • (2011) N Engl J Med , vol.365 , pp. 1315-1327
    • Irvine, A.D.1    McLean, W.H.I.2    Leung, D.Y.M.3
  • 12
    • 78651389483 scopus 로고    scopus 로고
    • Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin lossof-function mutations
    • Jakasa I, Koster ES, Calkoen F, McLean WH, Campbell LE, Bos JD, Verberk MM, Kezic S: Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin lossof-function mutations. J Invest Dermatol 2011; 131: 540-542.
    • (2011) J Invest Dermatol , vol.131 , pp. 540-542
    • Jakasa, I.1    Koster, E.S.2    Calkoen, F.3    McLean, W.H.4    Campbell, L.E.5    Bos, J.D.6    Verberk, M.M.7    Kezic, S.8
  • 14
    • 78649639291 scopus 로고    scopus 로고
    • Filaggrin loss-offunction mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age
    • Flohr C, England K, Radulovic S, McLean WH, Campbel LE, Barker J, Perkin M, Lack G: Filaggrin loss-offunction mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 2010; 163: 1333-1336.
    • (2010) Br J Dermatol , vol.163 , pp. 1333-1336
    • Flohr, C.1    England, K.2    Radulovic, S.3    McLean, W.H.4    Campbel, L.E.5    Barker, J.6    Perkin, M.7    Lack, G.8
  • 15
    • 82555170559 scopus 로고    scopus 로고
    • Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris
    • Winge MC, Hoppe T, Berne B, Vahlquist A, Nordenskjold M, Bradley M, Torma H: Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris. PLoS One 2011; 6:e28254.
    • (2011) PLoS One , vol.6 , pp. e28254
    • Winge, M.C.1    Hoppe, T.2    Berne, B.3    Vahlquist, A.4    Nordenskjold, M.5    Bradley, M.6    Torma, H.7
  • 16
    • 84908140008 scopus 로고    scopus 로고
    • Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis
    • Thyssen JP, Kezic S: Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 2014; 134: 792-799.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 792-799
    • Thyssen, J.P.1    Kezic, S.2
  • 19
    • 0035038540 scopus 로고    scopus 로고
    • Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography
    • Weerheim A, Ponec M: Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography. Arch Dermatol Res 2001; 293: 191-199.
    • (2001) Arch Dermatol Res , vol.293 , pp. 191-199
    • Weerheim, A.1    Ponec, M.2
  • 21
    • 0031672087 scopus 로고    scopus 로고
    • A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction
    • Norlen L, Nicander I, Lundsjo A, Cronholm T, Forslind B: A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction. Arch Dermatol Res 1998; 290: 508-516.
    • (1998) Arch Dermatol Res , vol.290 , pp. 508-516
    • Norlen, L.1    Nicander, I.2    Lundsjo, A.3    Cronholm, T.4    Forslind, B.5
  • 23
    • 0014861491 scopus 로고
    • Fatty acid composition of the living layer and stratum corneum lipids of human sole skin epidermis
    • Ansari MN, Nicolaides N, Fu HC: Fatty acid composition of the living layer and stratum corneum lipids of human sole skin epidermis. Lipids 1970; 5: 838-845.
    • (1970) Lipids , vol.5 , pp. 838-845
    • Ansari, M.N.1    Nicolaides, N.2    Fu, H.C.3
  • 27
    • 84855412135 scopus 로고    scopus 로고
    • Profiling and characterizing skin ceramides using reversed-phase liquid chromatographyquadrupole time-of-flight mass spectrometry
    • t'Kindt R, Jorge L, Dumont E, Couturon P, David F, Sandra P, Sandra K: Profiling and characterizing skin ceramides using reversed-phase liquid chromatographyquadrupole time-of-flight mass spectrometry. Anal Chem 2012; 84: 403-411.
    • (2012) Anal Chem , vol.84 , pp. 403-411
    • T'Kindt, R.1    Jorge, L.2    Dumont, E.3    Couturon, P.4    David, F.5    Sandra, P.6    Sandra, K.7
  • 29
    • 0018191471 scopus 로고
    • Glycosphingolipids and ceramides in human and pig epidermis
    • Gray GM, White RJ: Glycosphingolipids and ceramides in human and pig epidermis. J Invest Dermatol 1978; 70: 336-341.
    • (1978) J Invest Dermatol , vol.70 , pp. 336-341
    • Gray, G.M.1    White, R.J.2
  • 32
    • 0032800021 scopus 로고    scopus 로고
    • A new 6-hydroxy-4-sphingenine-containing ceramide in human skin
    • Stewart ME, Downing DT: A new 6-hydroxy-4-sphingenine-containing ceramide in human skin. J Lipid Res 1999; 40: 1434-1439.
    • (1999) J Lipid Res , vol.40 , pp. 1434-1439
    • Stewart, M.E.1    Downing, D.T.2
  • 34
    • 84898049711 scopus 로고    scopus 로고
    • A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains
    • Shin JH, Shon JC, Lee K, Kim S, Park CS, Choi EH, Lee CH, Lee HS, Liu KH: A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains. Anal Bioanal Chem 2014; 406: 1917-1932.
    • (2014) Anal Bioanal Chem , vol.406 , pp. 1917-1932
    • Shin, J.H.1    Shon, J.C.2    Lee, K.3    Kim, S.4    Park, C.S.5    Choi, E.H.6    Lee, C.H.7    Lee, H.S.8    Liu, K.H.9
  • 35
    • 84930410833 scopus 로고    scopus 로고
    • Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins
    • Joo KM, Hwang JH, Bae S, Nahm DH, Park HS, Ye YM, Lim KM: Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins. J Dermatol Sci 2015; 77: 71-74.
    • (2015) J Dermatol Sci , vol.77 , pp. 71-74
    • Joo, K.M.1    Hwang, J.H.2    Bae, S.3    Nahm, D.H.4    Park, H.S.5    Ye, Y.M.6    Lim, K.M.7
  • 37
    • 0023274940 scopus 로고
    • Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum
    • Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum. J Invest Dermatol 1987; 88: 714-718.
    • (1987) J Invest Dermatol , vol.88 , pp. 714-718
    • Madison, K.C.1    Swartzendruber, D.C.2    Wertz, P.W.3    Downing, D.T.4
  • 38
    • 0025955486 scopus 로고
    • Structural investigations of human stratum corneum by small-angle X-ray scattering
    • Bouwstra JA, Gooris GS, van der Spek JA, Bras W: Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol 1991; 97: 1005-1012.
    • (1991) J Invest Dermatol , vol.97 , pp. 1005-1012
    • Bouwstra, J.A.1    Gooris, G.S.2    Van Der Spek, J.A.3    Bras, W.4
  • 39
    • 0025967516 scopus 로고
    • Oriented structure in human stratum corneum revealed by X-ray diffraction
    • Garson JC, Doucet J, Leveque JL, Tsoucaris G: Oriented structure in human stratum corneum revealed by X-ray diffraction. J Invest Dermatol 1991; 96: 43-49.
    • (1991) J Invest Dermatol , vol.96 , pp. 43-49
    • Garson, J.C.1    Doucet, J.2    Leveque, J.L.3    Tsoucaris, G.4
  • 40
    • 0008653289 scopus 로고    scopus 로고
    • Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging
    • Schreiner V, Gooris GS, Pfeiffer S, Lanzendorfer G, Wenck H, Diembeck W, Proksch E, Bouwstra J: Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging. J Invest Dermatol 2000; 114: 654-660.
    • (2000) J Invest Dermatol , vol.114 , pp. 654-660
    • Schreiner, V.1    Gooris, G.S.2    Pfeiffer, S.3    Lanzendorfer, G.4    Wenck, H.5    Diembeck, W.6    Proksch, E.7    Bouwstra, J.8
  • 44
    • 0025047520 scopus 로고
    • Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy
    • Mak VH, Potts RO, Guy RH: Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res 1990; 7: 835-841.
    • (1990) Pharm Res , vol.7 , pp. 835-841
    • Mak, V.H.1    Potts, R.O.2    Guy, R.H.3
  • 45
    • 0026669010 scopus 로고
    • Structure of human stratum-corneum as a function of temperature and hydration-A wide-angle X-ray-diffraction study
    • Bouwstra JA, Gooris GS, Salomonsdevries MA, Vanderspek JA, Bras W: Structure of human stratum-corneum as a function of temperature and hydration-a wide-angle X-ray-diffraction study. Int J Pharm 1992; 84: 205-216.
    • (1992) Int J Pharm , vol.84 , pp. 205-216
    • Bouwstra, J.A.1    Gooris, G.S.2    Salomonsdevries, M.A.3    Vanderspek, J.A.4    Bras, W.5
  • 46
    • 0032833887 scopus 로고    scopus 로고
    • Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature
    • Pilgram GS, Engelsma-van Pelt AM, Bouwstra JA, Koerten HK: Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature. J Invest Dermatol 1999; 113: 403-409.
    • (1999) J Invest Dermatol , vol.113 , pp. 403-409
    • Pilgram, G.S.1    Engelsma-Van Pelt, A.M.2    Bouwstra, J.A.3    Koerten, H.K.4
  • 47
    • 84912116008 scopus 로고    scopus 로고
    • Micron-scale assessment of molecular lipid organization in human stratum corneum using microprobe X-ray diffraction
    • Doucet J, Potter A, Baltenneck C, Domanov YA: Micron-scale assessment of molecular lipid organization in human stratum corneum using microprobe X-ray diffraction. J Lipid Res 2014; 55: 2380-2388.
    • (2014) J Lipid Res , vol.55 , pp. 2380-2388
    • Doucet, J.1    Potter, A.2    Baltenneck, C.3    Domanov, Y.A.4
  • 48
    • 84902137300 scopus 로고    scopus 로고
    • Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing
    • Mojumdar EH, Helder RW, Gooris GS, Bouwstra JA: Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing. Langmuir 2014; 30: 6534-6543.
    • (2014) Langmuir , vol.30 , pp. 6534-6543
    • Mojumdar, E.H.1    Helder, R.W.2    Gooris, G.S.3    Bouwstra, J.A.4
  • 50
    • 0025819102 scopus 로고
    • Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?
    • Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-526.
    • (1991) J Invest Dermatol , vol.96 , pp. 523-526
    • Imokawa, G.1    Abe, A.2    Jin, K.3    Higaki, Y.4    Kawashima, M.5    Hidano, A.6
  • 51
    • 0025763499 scopus 로고
    • Stratum corneum lipid abnormalities in atopic dermatitis
    • Yamamoto A, Serizawa S, Ito M, Sato Y: Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 1991; 283: 219-223.
    • (1991) Arch Dermatol Res , vol.283 , pp. 219-223
    • Yamamoto, A.1    Serizawa, S.2    Ito, M.3    Sato, Y.4
  • 52
    • 18044396524 scopus 로고    scopus 로고
    • Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin
    • Farwanah H, Raith K, Neubert RH, Wohlrab J: Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res 2005; 296: 514-521.
    • (2005) Arch Dermatol Res , vol.296 , pp. 514-521
    • Farwanah, H.1    Raith, K.2    Neubert, R.H.3    Wohlrab, J.4
  • 54
    • 0031915569 scopus 로고    scopus 로고
    • Ceramide and cholesterol composition of the skin of patients with atopic dermatitis
    • Di Nardo A, Wertz P, Giannetti A, Seidenari S: Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 1998; 78: 27-30.
    • (1998) Acta Derm Venereol , vol.78 , pp. 27-30
    • Di Nardo, A.1    Wertz, P.2    Giannetti, A.3    Seidenari, S.4
  • 55
    • 0033397858 scopus 로고    scopus 로고
    • Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of nonlesional skin of atopic eczema
    • Bleck O, Abeck D, Ring J, Hoppe U, Vietzke JP, Wolber R, Brandt O, Schreiner V: Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of nonlesional skin of atopic eczema. J Invest Dermatol 1999; 113: 894-900.
    • (1999) J Invest Dermatol , vol.113 , pp. 894-900
    • Bleck, O.1    Abeck, D.2    Ring, J.3    Hoppe, U.4    Vietzke, J.P.5    Wolber, R.6    Brandt, O.7    Schreiner, V.8
  • 58
    • 84894030033 scopus 로고    scopus 로고
    • Interferon-gamma decreases ceramides with long-chain fatty acids: Possible involvement in atopic dermatitis and psoriasis
    • Tawada C, Kanoh H, Nakamura M, Mizutani Y, Fujisawa T, Banno Y, Seishima M: Interferon-gamma decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis. J Invest Dermatol 2014; 134: 712-718.
    • (2014) J Invest Dermatol , vol.134 , pp. 712-718
    • Tawada, C.1    Kanoh, H.2    Nakamura, M.3    Mizutani, Y.4    Fujisawa, T.5    Banno, Y.6    Seishima, M.7
  • 59
    • 0036426720 scopus 로고    scopus 로고
    • Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis
    • Macheleidt O, Kaiser HW, Sandhoff K: Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol 2002; 119: 166-173.
    • (2002) J Invest Dermatol , vol.119 , pp. 166-173
    • MacHeleidt, O.1    Kaiser, H.W.2    Sandhoff, K.3
  • 60
    • 0026804703 scopus 로고
    • Disturbed extruDing mechanism of lamellar bodies in dry non-eczematous skin of atopics
    • Fartasch M, Bassukas ID, Diepgen TL: Disturbed extruDing mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol 1992; 127: 221-227.
    • (1992) Br J Dermatol , vol.127 , pp. 221-227
    • Fartasch, M.1    Bassukas, I.D.2    Diepgen, T.L.3
  • 61
    • 69749125763 scopus 로고    scopus 로고
    • Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
    • Elias PM, Schmuth M: Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2009; 9: 437-446.
    • (2009) Curr Opin Allergy Clin Immunol , vol.9 , pp. 437-446
    • Elias, P.M.1    Schmuth, M.2
  • 62
    • 84903161266 scopus 로고    scopus 로고
    • Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema
    • Janssens M, van Smeden J, Puppels GJ, Lavrijsen AP, Caspers PJ, Bouwstra JA: Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema. Br J Dermatol 2014; 170: 1248-1255.
    • (2014) Br J Dermatol , vol.170 , pp. 1248-1255
    • Janssens, M.1    Van Smeden, J.2    Puppels, G.J.3    Lavrijsen, A.P.4    Caspers, P.J.5    Bouwstra, J.A.6
  • 63
    • 84873469301 scopus 로고    scopus 로고
    • Treating atopic dermatitis at the source: Corrective barrier repair therapy based upon new pathogenic insights
    • Elias PM, Sun R, Eder AR, Wakefield JS, Man M-Q: Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights. Exp Rev Dermatol 2013; 8: 27-36.
    • (2013) Exp Rev Dermatol , vol.8 , pp. 27-36
    • Elias, P.M.1    Sun, R.2    Eder, A.R.3    Wakefield, J.S.4    Man, M.-Q.5
  • 65
    • 84903401672 scopus 로고    scopus 로고
    • The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
    • Mojumdar EH, Kariman Z, van Kerckhove L, Gooris GS, Bouwstra JA: The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes. Biochim Biophys Acta 2014; 1838: 2473-2483.
    • (2014) Biochim Biophys Acta , vol.1838 , pp. 2473-2483
    • Mojumdar, E.H.1    Kariman, Z.2    Van Kerckhove, L.3    Gooris, G.S.4    Bouwstra, J.A.5
  • 66
    • 33646878529 scopus 로고    scopus 로고
    • A novel in vitro percutaneous penetration model: Evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives
    • de Jager M, Groenink W, Bielsa i Guivernau R, Andersson E, Angelova N, Ponec M, Bouwstra J: A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives. Pharm Res 2006; 23: 951-960.
    • (2006) Pharm Res , vol.23 , pp. 951-960
    • De Jager, M.1    Groenink, W.2    Bielsa Guivernau, R.3    Andersson, E.4    Angelova, N.5    Ponec, M.6    Bouwstra, J.7
  • 67
    • 84855950624 scopus 로고    scopus 로고
    • Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model
    • Park YH, Jang WH, Seo JA, Park M, Lee TR, Kim DK, Lim KM: Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model. J Invest Dermatol 2012; 132: 476-479.
    • (2012) J Invest Dermatol , vol.132 , pp. 476-479
    • Park, Y.H.1    Jang, W.H.2    Seo, J.A.3    Park, M.4    Lee, T.R.5    Kim, D.K.6    Lim, K.M.7
  • 71
    • 84896710665 scopus 로고    scopus 로고
    • The important role of stratum corneum lipids for the cutaneous barrier function
    • van Smeden J, Janssens M, Gooris GS, Bouwstra JA: The important role of stratum corneum lipids for the cutaneous barrier function. Biochim Biophys Acta 2014; 1841: 295-313.
    • (2014) Biochim Biophys Acta , vol.1841 , pp. 295-313
    • Van Smeden, J.1    Janssens, M.2    Gooris, G.S.3    Bouwstra, J.A.4
  • 72
    • 26444570089 scopus 로고    scopus 로고
    • Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity
    • Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM: Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 2005; 125: 510-520.
    • (2005) J Invest Dermatol , vol.125 , pp. 510-520
    • Hachem, J.P.1    Man, M.Q.2    Crumrine, D.3    Uchida, Y.4    Brown, B.E.5    Rogiers, V.6    Roseeuw, D.7    Feingold, K.R.8    Elias, P.M.9
  • 73
    • 0026670198 scopus 로고
    • Â-Glucocerebrosidase activity in murine epidermis: Characterization and localization in relation to differentiation
    • Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elias PM: â-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation. J Lipid Res 1992; 33: 1201-1209.
    • (1992) J Lipid Res , vol.33 , pp. 1201-1209
    • Holleran, W.M.1    Takagi, Y.2    Imokawa, G.3    Jackson, S.4    Lee, J.M.5    Elias, P.M.6
  • 77
    • 0034664935 scopus 로고    scopus 로고
    • The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide
    • Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G: The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem J 2000; 350: 747-756.
    • (2000) Biochem J , vol.350 , pp. 747-756
    • Higuchi, K.1    Hara, J.2    Okamoto, R.3    Kawashima, M.4    Imokawa, G.5
  • 78
    • 0033828399 scopus 로고    scopus 로고
    • High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leaDing to barrier disruption in atopic dermatitis
    • Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G: High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leaDing to barrier disruption in atopic dermatitis. J Invest Dermatol 2000; 115: 406-413.
    • (2000) J Invest Dermatol , vol.115 , pp. 406-413
    • Hara, J.1    Higuchi, K.2    Okamoto, R.3    Kawashima, M.4    Imokawa, G.5
  • 86
    • 0041621569 scopus 로고    scopus 로고
    • PH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion
    • Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM: pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 2003; 121: 345-353.
    • (2003) J Invest Dermatol , vol.121 , pp. 345-353
    • Hachem, J.P.1    Crumrine, D.2    Fluhr, J.3    Brown, B.E.4    Feingold, K.R.5    Elias, P.M.6
  • 87
    • 0036708473 scopus 로고    scopus 로고
    • Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient
    • Hanson KM, Behne MJ, Barry NP, Mauro TM, Gratton E, Clegg RM: Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys J 2002; 83: 1682-1690.
    • (2002) Biophys J , vol.83 , pp. 1682-1690
    • Hanson, K.M.1    Behne, M.J.2    Barry, N.P.3    Mauro, T.M.4    Gratton, E.5    Clegg, R.M.6
  • 88
    • 84908129722 scopus 로고    scopus 로고
    • Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis
    • Elias PM, Wakefield JS: Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol 2014; 134: 781.e1-791.e1.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 781e1-791e1
    • Elias, P.M.1    Wakefield, J.S.2
  • 89
    • 42149101196 scopus 로고    scopus 로고
    • Outside-to-inside' (and now back to 'outside') pathogenic mechanisms in atopic dermatitis
    • Elias PM, Steinhoff M: 'Outside-to-inside' (and now back to 'outside') pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 2008; 128: 1067-1070.
    • (2008) J Invest Dermatol , vol.128 , pp. 1067-1070
    • Elias, P.M.1    Steinhoff, M.2
  • 90
    • 16844386596 scopus 로고    scopus 로고
    • Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factoralpha and interferon-gamma in human epidermis
    • Hatano Y, Terashi H, Arakawa S, Katagiri K: Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factoralpha and interferon-gamma in human epidermis. J Invest Dermatol 2005; 124: 786-792.
    • (2005) J Invest Dermatol , vol.124 , pp. 786-792
    • Hatano, Y.1    Terashi, H.2    Arakawa, S.3    Katagiri, K.4
  • 91
    • 84902548285 scopus 로고    scopus 로고
    • TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents
    • Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA: TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol 2014; 134: 1941-1950.
    • (2014) J Invest Dermatol , vol.134 , pp. 1941-1950
    • Danso, M.O.1    Van Drongelen, V.2    Mulder, A.3    Van Esch, J.4    Scott, H.5    Van Smeden, J.6    El Ghalbzouri, A.7    Bouwstra, J.A.8
  • 92
    • 84903446483 scopus 로고    scopus 로고
    • Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis
    • Lee HJ, Lee SH: Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis. Allergy Asthma Immunol Res 2014; 6: 276-287.
    • (2014) Allergy Asthma Immunol Res , vol.6 , pp. 276-287
    • Lee, H.J.1    Lee, S.H.2
  • 93
    • 55349122914 scopus 로고    scopus 로고
    • Barrier-repair therapy for atopic dermatitis: Corrective lipid biochemical therapy
    • Elias PM: Barrier-repair therapy for atopic dermatitis: corrective lipid biochemical therapy. Expert Rev Dermatol 2008; 3: 441-452.
    • (2008) Expert Rev Dermatol , vol.3 , pp. 441-452
    • Elias, P.M.1
  • 95
    • 84891415326 scopus 로고    scopus 로고
    • Netherton syndrome: Skin inflammation and allergy by loss of protease inhibition
    • Hovnanian A: Netherton syndrome: skin inflammation and allergy by loss of protease inhibition. Cell Tissue Res 2013; 351: 289-300.
    • (2013) Cell Tissue Res , vol.351 , pp. 289-300
    • Hovnanian, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.