-
1
-
-
33845775154
-
Breach delivery: Increased solute uptake points to a defective skin barrier in atopic dermatitis
-
McLean WH, Hull PR: Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis. J Invest Dermatol 2007; 127: 8-10.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 8-10
-
-
McLean, W.H.1
Hull, P.R.2
-
2
-
-
0016545625
-
Drug permeation through human skin-theory and in vitro experimental measurement
-
Michaels AS, Chandrasekaran SK, Shaw JE: Drug permeation through human skin-theory and in vitro experimental measurement. AIChE J 1975; 21: 985-996.
-
(1975)
AIChE J
, vol.21
, pp. 985-996
-
-
Michaels, A.S.1
Chandrasekaran, S.K.2
Shaw, J.E.3
-
3
-
-
0029992312
-
Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis
-
Simon M, Haftek M, Sebbag M, Montezin M, Girbal-Neuhauser E, Schmitt D, Serre G: Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis. Biochem J 1996; 137: 173-177.
-
(1996)
Biochem J
, vol.137
, pp. 173-177
-
-
Simon, M.1
Haftek, M.2
Sebbag, M.3
Montezin, M.4
Girbal-Neuhauser, E.5
Schmitt, D.6
Serre, G.7
-
5
-
-
33745524911
-
Breaking the (un)sound barrier: Filaggrin is a major gene for atopic dermatitis
-
Irvine AD, McLean WH: Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol 2006; 126: 1200-1202.
-
(2006)
J Invest Dermatol
, vol.126
, pp. 1200-1202
-
-
Irvine, A.D.1
McLean, W.H.2
-
6
-
-
33645399288
-
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
-
Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, Di-Giovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38: 441-446.
-
(2006)
Nat Genet
, vol.38
, pp. 441-446
-
-
Palmer, C.N.1
Irvine, A.D.2
Terron-Kwiatkowski, A.3
Zhao, Y.4
Liao, H.5
Lee, S.P.6
Goudie, D.R.7
Sandilands, A.8
Campbell, L.E.9
Smith, F.J.10
O'Regan, G.M.11
Watson, R.M.12
Cecil, J.E.13
Bale, S.J.14
Compton, J.G.15
Di-Giovanna, J.J.16
Fleckman, P.17
Lewis-Jones, S.18
Arseculeratne, G.19
Sergeant, A.20
Munro, C.S.21
El Houate, B.22
McElreavey, K.23
Halkjaer, L.B.24
Bisgaard, H.25
Mukhopadhyay, S.26
McLean, W.H.27
more..
-
7
-
-
33644622891
-
Loss-of-function mutations in the gene encoDing filaggrin cause ichthyosis vulgaris
-
Smith FJ, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, Liao H, Evans AT, Goudie DR, Lewis-Jones S, Arseculeratne G, Munro CS, Sergeant A, O'Regan G, Bale SJ, Compton JG, Digiovanna JJ, Presland RB, Fleckman P, McLean WH: Loss-of-function mutations in the gene encoDing filaggrin cause ichthyosis vulgaris. Nat Genet 2006; 38: 337-342.
-
(2006)
Nat Genet
, vol.38
, pp. 337-342
-
-
Smith, F.J.1
Irvine, A.D.2
Terron-Kwiatkowski, A.3
Sandilands, A.4
Campbell, L.E.5
Zhao, Y.6
Liao, H.7
Evans, A.T.8
Goudie, D.R.9
Lewis-Jones, S.10
Arseculeratne, G.11
Munro, C.S.12
Sergeant, A.13
O'Regan, G.14
Bale, S.J.15
Compton, J.G.16
Digiovanna, J.J.17
Presland, R.B.18
Fleckman, P.19
McLean, W.H.20
more..
-
8
-
-
80053517839
-
Filaggrin mutations associated with skin and allergic diseases
-
Irvine AD, McLean WHI, Leung DYM: Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011; 365: 1315-1327.
-
(2011)
N Engl J Med
, vol.365
, pp. 1315-1327
-
-
Irvine, A.D.1
McLean, W.H.I.2
Leung, D.Y.M.3
-
9
-
-
33745353511
-
Loss-offunction variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
-
WeiDinger S, Illig T, Baurecht H, Irvine AD, Rodriguez E, Diaz-Lacava A, Klopp N, Wagenpfeil S, Zhao Y, Liao H, Lee SP, Palmer CN, Jenneck C, Maintz L, Hagemann T, Behrendt H, Ring J, Nothen MM, McLean WH, Novak N: Loss-offunction variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol 2006; 118: 214-219.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 214-219
-
-
WeiDinger, S.1
Illig, T.2
Baurecht, H.3
Irvine, A.D.4
Rodriguez, E.5
Diaz-Lacava, A.6
Klopp, N.7
Wagenpfeil, S.8
Zhao, Y.9
Liao, H.10
Lee, S.P.11
Palmer, C.N.12
Jenneck, C.13
Maintz, L.14
Hagemann, T.15
Behrendt, H.16
Ring, J.17
Nothen, M.M.18
McLean, W.H.19
Novak, N.20
more..
-
10
-
-
84856283235
-
Meta-analysis of genome-wide association studies identified three new risk loci for atopic dermatitis
-
Paternoster L, Standl M, Chen CM, Ramasamy A, Bonnelykke K, Duijts L, Ferreira MA, Alves AC, Thyssen JP, Albrecht E, Baurecht H, Feenstra B, Sleiman PM, Hysi P, Warrington NM, Curjuric I, Myhre R, Curtin JA, Groen-Blokhuis MM, Kerkhof M, Saaf A, Franke A, Ellinghaus D, Folster-Holst R, Dermitzakis E, Montgomery SB, Prokisch H, Heim K, Hartikainen AL, Pouta A, Pekkanen J, Blakemore AI, Buxton JL, Kaakinen M, Duffy DL, Madden PA, Heath AC, Montgomery GW, Thompson PJ, Matheson MC, Le Souef P, Australian Asthma Genetics Consortium (AAGC), St Pourcain B, Smith GD, Henderson J, Kemp JP, Timpson NJ, Deloukas P, Ring SM, Wichmann HE, Muller-Nurasyid M, Novak N, Klopp N, Rodriguez E, McArdle W, Linneberg A, Menne T, Nohr EA, Hofman A, Uitterlinden AG, van Duijn CM, Rivadeneira F, de Jongste JC, van der Valk RJ, Wjst M, Jogi R, Geller F, Boyd HA, Murray JC, Kim C, Mentch F, March M, Mangino M, Spector TD, Bataille V, Pennell CE, Holt PG, Sly P, Tiesler CM, Thiering E, Illig T, Imboden M, Nystad W, Simpson A, Hottenga JJ, Postma D, Koppelman GH, Smit HA, Soderhall C, Chawes B, Kreiner-Moller E, Bisgaard H, Melen E, Boomsma DI, Custovic A, Jacobsson B, Probst-Hensch NM, Palmer LJ, Glass D, Hakonarson H, Melbye M, Jarvis DL, Jaddoe VW, Gieger C, Genetics of Overweight Young Adults (GOYA) Consortium, Strachan DP, Martin NG, Jarvelin MR, Heinrich J, Evans DM, WeiDinger S, EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium: Meta-analysis of genome-wide association studies identified three new risk loci for atopic dermatitis. Nat Genet 2012; 44: 187-192.
-
(2012)
Nat Genet
, vol.44
, pp. 187-192
-
-
Paternoster, L.1
Standl, M.2
Chen, C.M.3
Ramasamy, A.4
Bonnelykke, K.5
Duijts, L.6
Ferreira, M.A.7
Alves, A.C.8
Thyssen, J.P.9
Albrecht, E.10
Baurecht, H.11
Feenstra, B.12
Sleiman, P.M.13
Hysi, P.14
Warrington, N.M.15
Curjuric, I.16
Myhre, R.17
Curtin, J.A.18
Groen-Blokhuis, M.M.19
Kerkhof, M.20
Saaf, A.21
Franke, A.22
Ellinghaus, D.23
Folster-Holst, R.24
Dermitzakis, E.25
Montgomery, S.B.26
Prokisch, H.27
Heim, K.28
Hartikainen, A.L.29
Pouta, A.30
Pekkanen, J.31
Blakemore, A.I.32
Buxton, J.L.33
Kaakinen, M.34
Duffy, D.L.35
Madden, P.A.36
Heath, A.C.37
Montgomery, G.W.38
Thompson, P.J.39
Matheson, M.C.40
Le Souef, P.41
more..
-
11
-
-
84856078713
-
Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect
-
Brown SJ, Kroboth K, Sandilands A, Campbell LE, Pohler E, Kezic S, Cordell HJ, McLean WH, Irvine AD: Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol 2012; 132: 98-104.
-
(2012)
J Invest Dermatol
, vol.132
, pp. 98-104
-
-
Brown, S.J.1
Kroboth, K.2
Sandilands, A.3
Campbell, L.E.4
Pohler, E.5
Kezic, S.6
Cordell, H.J.7
McLean, W.H.8
Irvine, A.D.9
-
12
-
-
78651389483
-
Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin lossof-function mutations
-
Jakasa I, Koster ES, Calkoen F, McLean WH, Campbell LE, Bos JD, Verberk MM, Kezic S: Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin lossof-function mutations. J Invest Dermatol 2011; 131: 540-542.
-
(2011)
J Invest Dermatol
, vol.131
, pp. 540-542
-
-
Jakasa, I.1
Koster, E.S.2
Calkoen, F.3
McLean, W.H.4
Campbell, L.E.5
Bos, J.D.6
Verberk, M.M.7
Kezic, S.8
-
13
-
-
77956393023
-
Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes
-
O'Regan GM, Kemperman PM, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Rowland M, Puppels GJ, McLean WH, Caspers PJ, Irvine AD: Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol 2010; 126: 574.e1-580.e1.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 574e1-580e1
-
-
O'Regan, G.M.1
Kemperman, P.M.2
Sandilands, A.3
Chen, H.4
Campbell, L.E.5
Kroboth, K.6
Watson, R.7
Rowland, M.8
Puppels, G.J.9
McLean, W.H.10
Caspers, P.J.11
Irvine, A.D.12
-
14
-
-
78649639291
-
Filaggrin loss-offunction mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age
-
Flohr C, England K, Radulovic S, McLean WH, Campbel LE, Barker J, Perkin M, Lack G: Filaggrin loss-offunction mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 2010; 163: 1333-1336.
-
(2010)
Br J Dermatol
, vol.163
, pp. 1333-1336
-
-
Flohr, C.1
England, K.2
Radulovic, S.3
McLean, W.H.4
Campbel, L.E.5
Barker, J.6
Perkin, M.7
Lack, G.8
-
15
-
-
82555170559
-
Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris
-
Winge MC, Hoppe T, Berne B, Vahlquist A, Nordenskjold M, Bradley M, Torma H: Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris. PLoS One 2011; 6:e28254.
-
(2011)
PLoS One
, vol.6
, pp. e28254
-
-
Winge, M.C.1
Hoppe, T.2
Berne, B.3
Vahlquist, A.4
Nordenskjold, M.5
Bradley, M.6
Torma, H.7
-
16
-
-
84908140008
-
Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis
-
Thyssen JP, Kezic S: Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 2014; 134: 792-799.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 792-799
-
-
Thyssen, J.P.1
Kezic, S.2
-
17
-
-
84888197987
-
Complete filaggrin deficiency in ichthyosis vulgaris is associated with only moderate changes in epidermal permeability barrier function profile
-
Perusquia-Ortiz AM, Oji V, Sauerland MC, Tarinski T, Zaraeva I, Seller N, Metze D, Aufenvenne K, Hausser I, Traupe H: Complete filaggrin deficiency in ichthyosis vulgaris is associated with only moderate changes in epidermal permeability barrier function profile. J Eur Acad Dermatol Venereol 2013; 27: 1552-1558.
-
(2013)
J Eur Acad Dermatol Venereol
, vol.27
, pp. 1552-1558
-
-
Perusquia-Ortiz, A.M.1
Oji, V.2
Sauerland, M.C.3
Tarinski, T.4
Zaraeva, I.5
Seller, N.6
Metze, D.7
Aufenvenne, K.8
Hausser, I.9
Traupe, H.10
-
18
-
-
79959249198
-
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function
-
Gruber R, Elias PM, Crumrine D, Lin TK, Brandner JM, Hachem JP, Presland RB, Fleckman P, Janecke AR, Sandilands A, McLean WH, Fritsch PO, Mildner M, Tschachler E, Schmuth M: Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol 2011; 178: 2252-2263.
-
(2011)
Am J Pathol
, vol.178
, pp. 2252-2263
-
-
Gruber, R.1
Elias, P.M.2
Crumrine, D.3
Lin, T.K.4
Brandner, J.M.5
Hachem, J.P.6
Presland, R.B.7
Fleckman, P.8
Janecke, A.R.9
Sandilands, A.10
McLean, W.H.11
Fritsch, P.O.12
Mildner, M.13
Tschachler, E.14
Schmuth, M.15
-
19
-
-
0035038540
-
Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography
-
Weerheim A, Ponec M: Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography. Arch Dermatol Res 2001; 293: 191-199.
-
(2001)
Arch Dermatol Res
, vol.293
, pp. 191-199
-
-
Weerheim, A.1
Ponec, M.2
-
20
-
-
84885811767
-
Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes
-
van Smeden J, Boiten WA, Hankemeier T, Rissmann R, Bouwstra JA, Vreeken RJ: Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes. Biochim Biophys Acta 2014; 1841: 70-79.
-
(2014)
Biochim Biophys Acta
, vol.1841
, pp. 70-79
-
-
Van Smeden, J.1
Boiten, W.A.2
Hankemeier, T.3
Rissmann, R.4
Bouwstra, J.A.5
Vreeken, R.J.6
-
21
-
-
0031672087
-
A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction
-
Norlen L, Nicander I, Lundsjo A, Cronholm T, Forslind B: A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction. Arch Dermatol Res 1998; 290: 508-516.
-
(1998)
Arch Dermatol Res
, vol.290
, pp. 508-516
-
-
Norlen, L.1
Nicander, I.2
Lundsjo, A.3
Cronholm, T.4
Forslind, B.5
-
23
-
-
0014861491
-
Fatty acid composition of the living layer and stratum corneum lipids of human sole skin epidermis
-
Ansari MN, Nicolaides N, Fu HC: Fatty acid composition of the living layer and stratum corneum lipids of human sole skin epidermis. Lipids 1970; 5: 838-845.
-
(1970)
Lipids
, vol.5
, pp. 838-845
-
-
Ansari, M.N.1
Nicolaides, N.2
Fu, H.C.3
-
24
-
-
0027323115
-
Ceramide composition of the psoriatic scale
-
Motta S, Monti M, Sesana S, Caputo R, Carelli S, Ghidoni R: Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1993; 1182: 147-151.
-
(1993)
Biochim Biophys Acta
, vol.1182
, pp. 147-151
-
-
Motta, S.1
Monti, M.2
Sesana, S.3
Caputo, R.4
Carelli, S.5
Ghidoni, R.6
-
25
-
-
50949109754
-
Characterization of overall ceramide species in human stratum corneum
-
Masukawa Y, Narita H, Shimizu E, Kondo N, Sugai Y, Oba T, Homma R, Ishikawa J, Takagi Y, Kitahara T, Takema Y, Kita K: Characterization of overall ceramide species in human stratum corneum. J Lipid Res 2008; 49: 1466-1476.
-
(2008)
J Lipid Res
, vol.49
, pp. 1466-1476
-
-
Masukawa, Y.1
Narita, H.2
Shimizu, E.3
Kondo, N.4
Sugai, Y.5
Oba, T.6
Homma, R.7
Ishikawa, J.8
Takagi, Y.9
Kitahara, T.10
Takema, Y.11
Kita, K.12
-
26
-
-
79956041030
-
LC/MS analysis of stratum corneum lipids: Ceramide profiling and discovery
-
van Smeden J, Hoppel L, van der Heij den R, Hankemeier T, Vreeken RJ, Bouwstra JA: LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery. J Lipid Res 2011; 52: 1211-1221.
-
(2011)
J Lipid Res
, vol.52
, pp. 1211-1221
-
-
Van Smeden, J.1
Hoppel, L.2
Van Der Heij Den, R.3
Hankemeier, T.4
Vreeken, R.J.5
Bouwstra, J.A.6
-
27
-
-
84855412135
-
Profiling and characterizing skin ceramides using reversed-phase liquid chromatographyquadrupole time-of-flight mass spectrometry
-
t'Kindt R, Jorge L, Dumont E, Couturon P, David F, Sandra P, Sandra K: Profiling and characterizing skin ceramides using reversed-phase liquid chromatographyquadrupole time-of-flight mass spectrometry. Anal Chem 2012; 84: 403-411.
-
(2012)
Anal Chem
, vol.84
, pp. 403-411
-
-
T'Kindt, R.1
Jorge, L.2
Dumont, E.3
Couturon, P.4
David, F.5
Sandra, P.6
Sandra, K.7
-
28
-
-
84887981330
-
1-O-acylceramides are natural components of human and mouse epidermis
-
Rabionet M, Bayerle A, Marsching C, Jennemann R, Grone HJ, Yildiz Y, Wachten D, Shaw W, Shayman JA, Sandhoff R: 1-O-acylceramides are natural components of human and mouse epidermis. J Lipid Res 2013; 54: 3312-3321.
-
(2013)
J Lipid Res
, vol.54
, pp. 3312-3321
-
-
Rabionet, M.1
Bayerle, A.2
Marsching, C.3
Jennemann, R.4
Grone, H.J.5
Yildiz, Y.6
Wachten, D.7
Shaw, W.8
Shayman, J.A.9
Sandhoff, R.10
-
29
-
-
0018191471
-
Glycosphingolipids and ceramides in human and pig epidermis
-
Gray GM, White RJ: Glycosphingolipids and ceramides in human and pig epidermis. J Invest Dermatol 1978; 70: 336-341.
-
(1978)
J Invest Dermatol
, vol.70
, pp. 336-341
-
-
Gray, G.M.1
White, R.J.2
-
30
-
-
0021878670
-
The composition of the ceramides from human stratum corneum and from comedones
-
Wertz PW, Miethke MC, Long SA, Strauss JS, Downing DT: The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 1985; 84: 410-412.
-
(1985)
J Invest Dermatol
, vol.84
, pp. 410-412
-
-
Wertz, P.W.1
Miethke, M.C.2
Long, S.A.3
Strauss, J.S.4
Downing, D.T.5
-
31
-
-
0028073181
-
6-Hydroxy-4-sphingenine in human epidermal ceramides
-
Robson KJ, Stewart ME, Michelsen S, Lazo ND, Downing DT: 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res 1994; 35: 2060-2068.
-
(1994)
J Lipid Res
, vol.35
, pp. 2060-2068
-
-
Robson, K.J.1
Stewart, M.E.2
Michelsen, S.3
Lazo, N.D.4
Downing, D.T.5
-
32
-
-
0032800021
-
A new 6-hydroxy-4-sphingenine-containing ceramide in human skin
-
Stewart ME, Downing DT: A new 6-hydroxy-4-sphingenine-containing ceramide in human skin. J Lipid Res 1999; 40: 1434-1439.
-
(1999)
J Lipid Res
, vol.40
, pp. 1434-1439
-
-
Stewart, M.E.1
Downing, D.T.2
-
33
-
-
69449098731
-
Comprehensive quantification of ceramide species in human stratum corneum
-
Masukawa Y, Narita H, Sato H, Naoe A, Kondo N, Sugai Y, Oba T, Homma R, Ishikawa J, Takagi Y, Kitahara T: Comprehensive quantification of ceramide species in human stratum corneum. J Lipid Res 2009; 50: 1708-1719.
-
(2009)
J Lipid Res
, vol.50
, pp. 1708-1719
-
-
Masukawa, Y.1
Narita, H.2
Sato, H.3
Naoe, A.4
Kondo, N.5
Sugai, Y.6
Oba, T.7
Homma, R.8
Ishikawa, J.9
Takagi, Y.10
Kitahara, T.11
-
34
-
-
84898049711
-
A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains
-
Shin JH, Shon JC, Lee K, Kim S, Park CS, Choi EH, Lee CH, Lee HS, Liu KH: A lipidomic platform establishment for structural identification of skin ceramides with non-hydroxyacyl chains. Anal Bioanal Chem 2014; 406: 1917-1932.
-
(2014)
Anal Bioanal Chem
, vol.406
, pp. 1917-1932
-
-
Shin, J.H.1
Shon, J.C.2
Lee, K.3
Kim, S.4
Park, C.S.5
Choi, E.H.6
Lee, C.H.7
Lee, H.S.8
Liu, K.H.9
-
35
-
-
84930410833
-
Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins
-
Joo KM, Hwang JH, Bae S, Nahm DH, Park HS, Ye YM, Lim KM: Relationship of ceramide-, and free fatty acid-cholesterol ratios in the stratum corneum with skin barrier function of normal, atopic dermatitis lesional and non-lesional skins. J Dermatol Sci 2015; 77: 71-74.
-
(2015)
J Dermatol Sci
, vol.77
, pp. 71-74
-
-
Joo, K.M.1
Hwang, J.H.2
Bae, S.3
Nahm, D.H.4
Park, H.S.5
Ye, Y.M.6
Lim, K.M.7
-
36
-
-
84891370203
-
The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
-
van Smeden J, Janssens M, Kaye EC, Caspers PJ, Lavrijsen AP, Vreeken RJ, Bouwstra JA: The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients. Exp Dermatol 2014; 23: 45-52.
-
(2014)
Exp Dermatol
, vol.23
, pp. 45-52
-
-
Van Smeden, J.1
Janssens, M.2
Kaye, E.C.3
Caspers, P.J.4
Lavrijsen, A.P.5
Vreeken, R.J.6
Bouwstra, J.A.7
-
37
-
-
0023274940
-
Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum
-
Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum. J Invest Dermatol 1987; 88: 714-718.
-
(1987)
J Invest Dermatol
, vol.88
, pp. 714-718
-
-
Madison, K.C.1
Swartzendruber, D.C.2
Wertz, P.W.3
Downing, D.T.4
-
38
-
-
0025955486
-
Structural investigations of human stratum corneum by small-angle X-ray scattering
-
Bouwstra JA, Gooris GS, van der Spek JA, Bras W: Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol 1991; 97: 1005-1012.
-
(1991)
J Invest Dermatol
, vol.97
, pp. 1005-1012
-
-
Bouwstra, J.A.1
Gooris, G.S.2
Van Der Spek, J.A.3
Bras, W.4
-
40
-
-
0008653289
-
Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging
-
Schreiner V, Gooris GS, Pfeiffer S, Lanzendorfer G, Wenck H, Diembeck W, Proksch E, Bouwstra J: Barrier characteristics of different human skin types investigated with X-ray diffraction, lipid analysis, and electron microscopy imaging. J Invest Dermatol 2000; 114: 654-660.
-
(2000)
J Invest Dermatol
, vol.114
, pp. 654-660
-
-
Schreiner, V.1
Gooris, G.S.2
Pfeiffer, S.3
Lanzendorfer, G.4
Wenck, H.5
Diembeck, W.6
Proksch, E.7
Bouwstra, J.8
-
41
-
-
84871910075
-
Nature versus nurture: Does human skin maintain its stratum corneum lipid properties in vitro?
-
Thakoersing VS, Danso MO, Mulder A, Gooris G, El Ghalbzouri A, Bouwstra JA: Nature versus nurture: does human skin maintain its stratum corneum lipid properties in vitro? Exp Dermatol 2012; 21: 865-870.
-
(2012)
Exp Dermatol
, vol.21
, pp. 865-870
-
-
Thakoersing, V.S.1
Danso, M.O.2
Mulder, A.3
Gooris, G.4
El Ghalbzouri, A.5
Bouwstra, J.A.6
-
42
-
-
84872186168
-
Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents
-
Thakoersing VS, van Smeden J, Mulder AA, Vreeken RJ, El Ghalbzouri A, Bouwstra JA: Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents. J Invest Dermatol 2013; 133: 59-67.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 59-67
-
-
Thakoersing, V.S.1
Van Smeden, J.2
Mulder, A.A.3
Vreeken, R.J.4
El Ghalbzouri, A.5
Bouwstra, J.A.6
-
43
-
-
0028040472
-
Characterization of lowtemperature (i
-
Gay CL, Guy RH, Golden GM, Mak VH, Francoeur ML: Characterization of lowtemperature (i.e., <65 degrees C) lipid transitions in human stratum corneum. J Invest Dermatol 1994; 103: 233-239.
-
(1994)
E., <65 Degrees C) Lipid Transitions in Human Stratum Corneum. J Invest Dermatol
, vol.103
, pp. 233-239
-
-
Gay, C.L.1
Guy, R.H.2
Golden, G.M.3
Mak, V.H.4
Francoeur, M.L.5
-
44
-
-
0025047520
-
Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy
-
Mak VH, Potts RO, Guy RH: Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res 1990; 7: 835-841.
-
(1990)
Pharm Res
, vol.7
, pp. 835-841
-
-
Mak, V.H.1
Potts, R.O.2
Guy, R.H.3
-
45
-
-
0026669010
-
Structure of human stratum-corneum as a function of temperature and hydration-A wide-angle X-ray-diffraction study
-
Bouwstra JA, Gooris GS, Salomonsdevries MA, Vanderspek JA, Bras W: Structure of human stratum-corneum as a function of temperature and hydration-a wide-angle X-ray-diffraction study. Int J Pharm 1992; 84: 205-216.
-
(1992)
Int J Pharm
, vol.84
, pp. 205-216
-
-
Bouwstra, J.A.1
Gooris, G.S.2
Salomonsdevries, M.A.3
Vanderspek, J.A.4
Bras, W.5
-
46
-
-
0032833887
-
Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature
-
Pilgram GS, Engelsma-van Pelt AM, Bouwstra JA, Koerten HK: Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and temperature. J Invest Dermatol 1999; 113: 403-409.
-
(1999)
J Invest Dermatol
, vol.113
, pp. 403-409
-
-
Pilgram, G.S.1
Engelsma-Van Pelt, A.M.2
Bouwstra, J.A.3
Koerten, H.K.4
-
47
-
-
84912116008
-
Micron-scale assessment of molecular lipid organization in human stratum corneum using microprobe X-ray diffraction
-
Doucet J, Potter A, Baltenneck C, Domanov YA: Micron-scale assessment of molecular lipid organization in human stratum corneum using microprobe X-ray diffraction. J Lipid Res 2014; 55: 2380-2388.
-
(2014)
J Lipid Res
, vol.55
, pp. 2380-2388
-
-
Doucet, J.1
Potter, A.2
Baltenneck, C.3
Domanov, Y.A.4
-
48
-
-
84902137300
-
Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing
-
Mojumdar EH, Helder RW, Gooris GS, Bouwstra JA: Monounsaturated fatty acids reduce the barrier of stratum corneum lipid membranes by enhancing the formation of a hexagonal lateral packing. Langmuir 2014; 30: 6534-6543.
-
(2014)
Langmuir
, vol.30
, pp. 6534-6543
-
-
Mojumdar, E.H.1
Helder, R.W.2
Gooris, G.S.3
Bouwstra, J.A.4
-
49
-
-
77956878030
-
Changes in the ceramide profile of atopic dermatitis patients
-
Ishikawa J, Narita H, Kondo N, Hotta M, Takagi Y, Masukawa Y, Kitahara T, Takema Y, Koyano S, Yamazaki S, Hatamochi A: Changes in the ceramide profile of atopic dermatitis patients. J Invest Dermatol 2010; 130: 2511-2514.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 2511-2514
-
-
Ishikawa, J.1
Narita, H.2
Kondo, N.3
Hotta, M.4
Takagi, Y.5
Masukawa, Y.6
Kitahara, T.7
Takema, Y.8
Koyano, S.9
Yamazaki, S.10
Hatamochi, A.11
-
50
-
-
0025819102
-
Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?
-
Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523-526.
-
(1991)
J Invest Dermatol
, vol.96
, pp. 523-526
-
-
Imokawa, G.1
Abe, A.2
Jin, K.3
Higaki, Y.4
Kawashima, M.5
Hidano, A.6
-
52
-
-
18044396524
-
Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin
-
Farwanah H, Raith K, Neubert RH, Wohlrab J: Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin. Arch Dermatol Res 2005; 296: 514-521.
-
(2005)
Arch Dermatol Res
, vol.296
, pp. 514-521
-
-
Farwanah, H.1
Raith, K.2
Neubert, R.H.3
Wohlrab, J.4
-
53
-
-
79952711942
-
Distinct barrier integrity phenotypes in filaggrinrelated atopic eczema following sequential tape stripping and lipid profiling
-
Angelova-Fischer I, Mannheimer AC, Hinder A, Ruether A, Franke A, Neubert RH, Fischer TW, Zillikens D: Distinct barrier integrity phenotypes in filaggrinrelated atopic eczema following sequential tape stripping and lipid profiling. Exp Dermatol 2011; 20: 351-356.
-
(2011)
Exp Dermatol
, vol.20
, pp. 351-356
-
-
Angelova-Fischer, I.1
Mannheimer, A.C.2
Hinder, A.3
Ruether, A.4
Franke, A.5
Neubert, R.H.6
Fischer, T.W.7
Zillikens, D.8
-
54
-
-
0031915569
-
Ceramide and cholesterol composition of the skin of patients with atopic dermatitis
-
Di Nardo A, Wertz P, Giannetti A, Seidenari S: Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 1998; 78: 27-30.
-
(1998)
Acta Derm Venereol
, vol.78
, pp. 27-30
-
-
Di Nardo, A.1
Wertz, P.2
Giannetti, A.3
Seidenari, S.4
-
55
-
-
0033397858
-
Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of nonlesional skin of atopic eczema
-
Bleck O, Abeck D, Ring J, Hoppe U, Vietzke JP, Wolber R, Brandt O, Schreiner V: Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of nonlesional skin of atopic eczema. J Invest Dermatol 1999; 113: 894-900.
-
(1999)
J Invest Dermatol
, vol.113
, pp. 894-900
-
-
Bleck, O.1
Abeck, D.2
Ring, J.3
Hoppe, U.4
Vietzke, J.P.5
Wolber, R.6
Brandt, O.7
Schreiner, V.8
-
56
-
-
77953093849
-
Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
-
Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, Hogh JK, Hellgren LI, Jemec GB, Agner T, WeiDinger S: Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010; 65: 911-918.
-
(2010)
Allergy
, vol.65
, pp. 911-918
-
-
Jungersted, J.M.1
Scheer, H.2
Mempel, M.3
Baurecht, H.4
Cifuentes, L.5
Hogh, J.K.6
Hellgren, L.I.7
Jemec, G.B.8
Agner, T.9
WeiDinger, S.10
-
57
-
-
84869027328
-
Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients
-
Janssens M, van Smeden J, Gooris GS, Bras W, Portale G, Caspers PJ, Vreeken RJ, Hankemeier T, Kezic S, Wolterbeek R, Lavrijsen AP, Bouwstra JA: Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res 2012; 53: 2755-2766.
-
(2012)
J Lipid Res
, vol.53
, pp. 2755-2766
-
-
Janssens, M.1
Van Smeden, J.2
Gooris, G.S.3
Bras, W.4
Portale, G.5
Caspers, P.J.6
Vreeken, R.J.7
Hankemeier, T.8
Kezic, S.9
Wolterbeek, R.10
Lavrijsen, A.P.11
Bouwstra, J.A.12
-
58
-
-
84894030033
-
Interferon-gamma decreases ceramides with long-chain fatty acids: Possible involvement in atopic dermatitis and psoriasis
-
Tawada C, Kanoh H, Nakamura M, Mizutani Y, Fujisawa T, Banno Y, Seishima M: Interferon-gamma decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis. J Invest Dermatol 2014; 134: 712-718.
-
(2014)
J Invest Dermatol
, vol.134
, pp. 712-718
-
-
Tawada, C.1
Kanoh, H.2
Nakamura, M.3
Mizutani, Y.4
Fujisawa, T.5
Banno, Y.6
Seishima, M.7
-
59
-
-
0036426720
-
Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis
-
Macheleidt O, Kaiser HW, Sandhoff K: Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. J Invest Dermatol 2002; 119: 166-173.
-
(2002)
J Invest Dermatol
, vol.119
, pp. 166-173
-
-
MacHeleidt, O.1
Kaiser, H.W.2
Sandhoff, K.3
-
60
-
-
0026804703
-
Disturbed extruDing mechanism of lamellar bodies in dry non-eczematous skin of atopics
-
Fartasch M, Bassukas ID, Diepgen TL: Disturbed extruDing mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol 1992; 127: 221-227.
-
(1992)
Br J Dermatol
, vol.127
, pp. 221-227
-
-
Fartasch, M.1
Bassukas, I.D.2
Diepgen, T.L.3
-
61
-
-
69749125763
-
Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
-
Elias PM, Schmuth M: Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2009; 9: 437-446.
-
(2009)
Curr Opin Allergy Clin Immunol
, vol.9
, pp. 437-446
-
-
Elias, P.M.1
Schmuth, M.2
-
62
-
-
84903161266
-
Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema
-
Janssens M, van Smeden J, Puppels GJ, Lavrijsen AP, Caspers PJ, Bouwstra JA: Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema. Br J Dermatol 2014; 170: 1248-1255.
-
(2014)
Br J Dermatol
, vol.170
, pp. 1248-1255
-
-
Janssens, M.1
Van Smeden, J.2
Puppels, G.J.3
Lavrijsen, A.P.4
Caspers, P.J.5
Bouwstra, J.A.6
-
63
-
-
84873469301
-
Treating atopic dermatitis at the source: Corrective barrier repair therapy based upon new pathogenic insights
-
Elias PM, Sun R, Eder AR, Wakefield JS, Man M-Q: Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights. Exp Rev Dermatol 2013; 8: 27-36.
-
(2013)
Exp Rev Dermatol
, vol.8
, pp. 27-36
-
-
Elias, P.M.1
Sun, R.2
Eder, A.R.3
Wakefield, J.S.4
Man, M.-Q.5
-
64
-
-
0034787028
-
Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis
-
Pilgram GS, Vissers DC, van der Meulen H, Pavel S, Lavrijsen SP, Bouwstra JA, Koerten HK: Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 2001; 117: 710-717.
-
(2001)
J Invest Dermatol
, vol.117
, pp. 710-717
-
-
Pilgram, G.S.1
Vissers, D.C.2
Van Der Meulen, H.3
Pavel, S.4
Lavrijsen, S.P.5
Bouwstra, J.A.6
Koerten, H.K.7
-
65
-
-
84903401672
-
The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
-
Mojumdar EH, Kariman Z, van Kerckhove L, Gooris GS, Bouwstra JA: The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes. Biochim Biophys Acta 2014; 1838: 2473-2483.
-
(2014)
Biochim Biophys Acta
, vol.1838
, pp. 2473-2483
-
-
Mojumdar, E.H.1
Kariman, Z.2
Van Kerckhove, L.3
Gooris, G.S.4
Bouwstra, J.A.5
-
66
-
-
33646878529
-
A novel in vitro percutaneous penetration model: Evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives
-
de Jager M, Groenink W, Bielsa i Guivernau R, Andersson E, Angelova N, Ponec M, Bouwstra J: A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives. Pharm Res 2006; 23: 951-960.
-
(2006)
Pharm Res
, vol.23
, pp. 951-960
-
-
De Jager, M.1
Groenink, W.2
Bielsa Guivernau, R.3
Andersson, E.4
Angelova, N.5
Ponec, M.6
Bouwstra, J.7
-
67
-
-
84855950624
-
Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model
-
Park YH, Jang WH, Seo JA, Park M, Lee TR, Kim DK, Lim KM: Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model. J Invest Dermatol 2012; 132: 476-479.
-
(2012)
J Invest Dermatol
, vol.132
, pp. 476-479
-
-
Park, Y.H.1
Jang, W.H.2
Seo, J.A.3
Park, M.4
Lee, T.R.5
Kim, D.K.6
Lim, K.M.7
-
68
-
-
84885956811
-
Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model
-
Nakajima K, Terao M, Takaishi M, Kataoka S, Goto-Inoue N, Setou M, Horie K, Sakamoto F, Ito M, Azukizawa H, Kitaba S, Murota H, Itami S, Katayama I, Takeda J, Sano S: Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model. J Invest Dermatol 2013; 133: 2555-2565.
-
(2013)
J Invest Dermatol
, vol.133
, pp. 2555-2565
-
-
Nakajima, K.1
Terao, M.2
Takaishi, M.3
Kataoka, S.4
Goto-Inoue, N.5
Setou, M.6
Horie, K.7
Sakamoto, F.8
Ito, M.9
Azukizawa, H.10
Kitaba, S.11
Murota, H.12
Itami, S.13
Katayama, I.14
Takeda, J.15
Sano, S.16
-
69
-
-
84855916623
-
Loss of ceramide synthase 3 causes lethal skin barrier disruption
-
Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Grone HJ, Sandhoff R: Loss of ceramide synthase 3 causes lethal skin barrier disruption. Hum Mol Genet 2012; 21: 586-608.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 586-608
-
-
Jennemann, R.1
Rabionet, M.2
Gorgas, K.3
Epstein, S.4
Dalpke, A.5
Rothermel, U.6
Bayerle, A.7
Van Der Hoeven, F.8
Imgrund, S.9
Kirsch, J.10
Nickel, W.11
Willecke, K.12
Riezman, H.13
Grone, H.J.14
Sandhoff, R.15
-
70
-
-
84884417429
-
Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length
-
Eckl KM, Tidhar R, Thiele H, Oji V, Hausser I, Brodesser S, Preil ML, Onal-Akan A, Stock F, Muller D, Becker K, Casper R, Nurnberg G, Altmuller J, Nurnberg P, Traupe H, Futerman AH, Hennies HC: Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. J Invest Dermat 2013; 133: 2202-2211.
-
(2013)
J Invest Dermat
, vol.133
, pp. 2202-2211
-
-
Eckl, K.M.1
Tidhar, R.2
Thiele, H.3
Oji, V.4
Hausser, I.5
Brodesser, S.6
Preil, M.L.7
Onal-Akan, A.8
Stock, F.9
Muller, D.10
Becker, K.11
Casper, R.12
Nurnberg, G.13
Altmuller, J.14
Nurnberg, P.15
Traupe, H.16
Futerman, A.H.17
Hennies, H.C.18
-
72
-
-
26444570089
-
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity
-
Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM: Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 2005; 125: 510-520.
-
(2005)
J Invest Dermatol
, vol.125
, pp. 510-520
-
-
Hachem, J.P.1
Man, M.Q.2
Crumrine, D.3
Uchida, Y.4
Brown, B.E.5
Rogiers, V.6
Roseeuw, D.7
Feingold, K.R.8
Elias, P.M.9
-
73
-
-
0026670198
-
Â-Glucocerebrosidase activity in murine epidermis: Characterization and localization in relation to differentiation
-
Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elias PM: â-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation. J Lipid Res 1992; 33: 1201-1209.
-
(1992)
J Lipid Res
, vol.33
, pp. 1201-1209
-
-
Holleran, W.M.1
Takagi, Y.2
Imokawa, G.3
Jackson, S.4
Lee, J.M.5
Elias, P.M.6
-
74
-
-
0031744403
-
Barrier recovery is impeded at neutral pH, independent of ionic effects: Implications for extracellular lipid processing
-
Mauro T, Holleran WM, Grayson S, Gao WN, Man MQ, Kriehuber E, Behne M, Feingold KR, Elias PM: Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res 1998; 290: 215-222.
-
(1998)
Arch Dermatol Res
, vol.290
, pp. 215-222
-
-
Mauro, T.1
Holleran, W.M.2
Grayson, S.3
Gao, W.N.4
Man, M.Q.5
Kriehuber, E.6
Behne, M.7
Feingold, K.R.8
Elias, P.M.9
-
75
-
-
2942620512
-
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis
-
Jensen JM, Folster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schutze S, Proksch E: Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol 2004; 122: 1423-1431.
-
(2004)
J Invest Dermatol
, vol.122
, pp. 1423-1431
-
-
Jensen, J.M.1
Folster-Holst, R.2
Baranowsky, A.3
Schunck, M.4
Winoto-Morbach, S.5
Neumann, C.6
Schutze, S.7
Proksch, E.8
-
76
-
-
84896077471
-
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate
-
Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K: Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. PLoS One 2014; 9:e89402.
-
(2014)
PLoS One
, vol.9
, pp. e89402
-
-
Oizumi, A.1
Nakayama, H.2
Okino, N.3
Iwahara, C.4
Kina, K.5
Matsumoto, R.6
Ogawa, H.7
Takamori, K.8
Ito, M.9
Suga, Y.10
Iwabuchi, K.11
-
77
-
-
0034664935
-
The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide
-
Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G: The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem J 2000; 350: 747-756.
-
(2000)
Biochem J
, vol.350
, pp. 747-756
-
-
Higuchi, K.1
Hara, J.2
Okamoto, R.3
Kawashima, M.4
Imokawa, G.5
-
78
-
-
0033828399
-
High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leaDing to barrier disruption in atopic dermatitis
-
Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G: High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leaDing to barrier disruption in atopic dermatitis. J Invest Dermatol 2000; 115: 406-413.
-
(2000)
J Invest Dermatol
, vol.115
, pp. 406-413
-
-
Hara, J.1
Higuchi, K.2
Okamoto, R.3
Kawashima, M.4
Imokawa, G.5
-
79
-
-
84888347909
-
Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents
-
van Drongelen V, Alloul-Ramdhani M, Danso MO, Mieremet A, Mulder A, van Smeden J, Bouwstra JA, El Ghalbzouri A: Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents. Exp Dermatol 2013; 22: 807-812.
-
(2013)
Exp Dermatol
, vol.22
, pp. 807-812
-
-
Van Drongelen, V.1
Alloul-Ramdhani, M.2
Danso, M.O.3
Mieremet, A.4
Mulder, A.5
Van Smeden, J.6
Bouwstra, J.A.7
El Ghalbzouri, A.8
-
80
-
-
77955716350
-
Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model
-
Mildner M, Jin J, Eckhart L, Kezic S, Gruber F, Barresi C, Stremnitzer C, Buchberger M, Mlitz V, Ballaun C, Sterniczky B, FoDinger D, Tschachler E: Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model. J Invest Dermatol 2010; 130: 2286-2294.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 2286-2294
-
-
Mildner, M.1
Jin, J.2
Eckhart, L.3
Kezic, S.4
Gruber, F.5
Barresi, C.6
Stremnitzer, C.7
Buchberger, M.8
Mlitz, V.9
Ballaun, C.10
Sterniczky, B.11
FoDinger, D.12
Tschachler, E.13
-
81
-
-
84894028423
-
Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct
-
Vavrova K, Henkes D, Struver K, Sochorova M, Skolova B, Witting MY, Friess W, Schreml S, Meier RJ, Schafer-Korting M, Fluhr JW, Kuchler S: Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct. J Invest Dermatol 2014; 134: 746-753.
-
(2014)
J Invest Dermatol
, vol.134
, pp. 746-753
-
-
Vavrova, K.1
Henkes, D.2
Struver, K.3
Sochorova, M.4
Skolova, B.5
Witting, M.Y.6
Friess, W.7
Schreml, S.8
Meier, R.J.9
Schafer-Korting, M.10
Fluhr, J.W.11
Kuchler, S.12
-
82
-
-
84903731426
-
Filaggrinstratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis
-
Cole C, Kroboth K, Schurch NJ, Sandilands A, Sherstnev A, O'Regan GM, Watson RM, McLean WH, Barton GJ, Irvine AD, Brown SJ: Filaggrinstratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. J Allergy Clin Immunol 2014; 134: 82-91.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 82-91
-
-
Cole, C.1
Kroboth, K.2
Schurch, N.J.3
Sandilands, A.4
Sherstnev, A.5
O'Regan, G.M.6
Watson, R.M.7
McLean, W.H.8
Barton, G.J.9
Irvine, A.D.10
Brown, S.J.11
-
83
-
-
33745427100
-
New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions
-
quiz 22-23
-
Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R: New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol 2006; 118: 3-21; quiz 22-23.
-
(2006)
J Allergy Clin Immunol
, vol.118
, pp. 3-21
-
-
Cork, M.J.1
Robinson, D.A.2
Vasilopoulos, Y.3
Ferguson, A.4
Moustafa, M.5
MacGowan, A.6
Duff, G.W.7
Ward, S.J.8
Tazi-Ahnini, R.9
-
84
-
-
46649119445
-
Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum
-
Kezic S, Kemperman PM, Koster ES, de Jongh CM, Thio HB, Campbell LE, Irvine AD, McLean WH, Puppels GJ, Caspers PJ: Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 2008; 128: 2117-2119.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 2117-2119
-
-
Kezic, S.1
Kemperman, P.M.2
Koster, E.S.3
De Jongh, C.M.4
Thio, H.B.5
Campbell, L.E.6
Irvine, A.D.7
McLean, W.H.8
Puppels, G.J.9
Caspers, P.J.10
-
85
-
-
84862793140
-
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
-
Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD: Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol 2012; 129: 1031.e1-1039.e1.
-
(2012)
J Allergy Clin Immunol
, vol.129
, pp. 1031e1-1039e1
-
-
Kezic, S.1
O'Regan, G.M.2
Lutter, R.3
Jakasa, I.4
Koster, E.S.5
Saunders, S.6
Caspers, P.7
Kemperman, P.M.8
Puppels, G.J.9
Sandilands, A.10
Chen, H.11
Campbell, L.E.12
Kroboth, K.13
Watson, R.14
Fallon, P.G.15
McLean, W.H.16
Irvine, A.D.17
-
86
-
-
0041621569
-
PH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion
-
Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM: pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 2003; 121: 345-353.
-
(2003)
J Invest Dermatol
, vol.121
, pp. 345-353
-
-
Hachem, J.P.1
Crumrine, D.2
Fluhr, J.3
Brown, B.E.4
Feingold, K.R.5
Elias, P.M.6
-
87
-
-
0036708473
-
Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient
-
Hanson KM, Behne MJ, Barry NP, Mauro TM, Gratton E, Clegg RM: Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys J 2002; 83: 1682-1690.
-
(2002)
Biophys J
, vol.83
, pp. 1682-1690
-
-
Hanson, K.M.1
Behne, M.J.2
Barry, N.P.3
Mauro, T.M.4
Gratton, E.5
Clegg, R.M.6
-
88
-
-
84908129722
-
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis
-
Elias PM, Wakefield JS: Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol 2014; 134: 781.e1-791.e1.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 781e1-791e1
-
-
Elias, P.M.1
Wakefield, J.S.2
-
89
-
-
42149101196
-
Outside-to-inside' (and now back to 'outside') pathogenic mechanisms in atopic dermatitis
-
Elias PM, Steinhoff M: 'Outside-to-inside' (and now back to 'outside') pathogenic mechanisms in atopic dermatitis. J Invest Dermatol 2008; 128: 1067-1070.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1067-1070
-
-
Elias, P.M.1
Steinhoff, M.2
-
90
-
-
16844386596
-
Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factoralpha and interferon-gamma in human epidermis
-
Hatano Y, Terashi H, Arakawa S, Katagiri K: Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factoralpha and interferon-gamma in human epidermis. J Invest Dermatol 2005; 124: 786-792.
-
(2005)
J Invest Dermatol
, vol.124
, pp. 786-792
-
-
Hatano, Y.1
Terashi, H.2
Arakawa, S.3
Katagiri, K.4
-
91
-
-
84902548285
-
TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents
-
Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra JA: TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol 2014; 134: 1941-1950.
-
(2014)
J Invest Dermatol
, vol.134
, pp. 1941-1950
-
-
Danso, M.O.1
Van Drongelen, V.2
Mulder, A.3
Van Esch, J.4
Scott, H.5
Van Smeden, J.6
El Ghalbzouri, A.7
Bouwstra, J.A.8
-
92
-
-
84903446483
-
Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis
-
Lee HJ, Lee SH: Epidermal permeability barrier defects and barrier repair therapy in atopic dermatitis. Allergy Asthma Immunol Res 2014; 6: 276-287.
-
(2014)
Allergy Asthma Immunol Res
, vol.6
, pp. 276-287
-
-
Lee, H.J.1
Lee, S.H.2
-
93
-
-
55349122914
-
Barrier-repair therapy for atopic dermatitis: Corrective lipid biochemical therapy
-
Elias PM: Barrier-repair therapy for atopic dermatitis: corrective lipid biochemical therapy. Expert Rev Dermatol 2008; 3: 441-452.
-
(2008)
Expert Rev Dermatol
, vol.3
, pp. 441-452
-
-
Elias, P.M.1
-
94
-
-
84900874438
-
Intercellular skin barrier lipid composition and organization in Netherton syndrome patients
-
van Smeden J, Janssens M, Boiten WA, van Drongelen V, Furio L, Vreeken RJ, Hovnanian A, Bouwstra JA: Intercellular skin barrier lipid composition and organization in Netherton syndrome patients. J Invest Dermatol 2014; 134: 1238-1245.
-
(2014)
J Invest Dermatol
, vol.134
, pp. 1238-1245
-
-
Van Smeden, J.1
Janssens, M.2
Boiten, W.A.3
Van Drongelen, V.4
Furio, L.5
Vreeken, R.J.6
Hovnanian, A.7
Bouwstra, J.A.8
-
95
-
-
84891415326
-
Netherton syndrome: Skin inflammation and allergy by loss of protease inhibition
-
Hovnanian A: Netherton syndrome: skin inflammation and allergy by loss of protease inhibition. Cell Tissue Res 2013; 351: 289-300.
-
(2013)
Cell Tissue Res
, vol.351
, pp. 289-300
-
-
Hovnanian, A.1
-
96
-
-
77949752021
-
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing
-
Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A: Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest 2010; 120: 871-882.
-
(2010)
J Clin Invest
, vol.120
, pp. 871-882
-
-
Bonnart, C.1
Deraison, C.2
Lacroix, M.3
Uchida, Y.4
Besson, C.5
Robin, A.6
Briot, A.7
Gonthier, M.8
Lamant, L.9
Dubus, P.10
Monsarrat, B.11
Hovnanian, A.12
|