A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates

International Journal of Pharmaceutics

Volumn 501, Issue 1-2, 2016, Pages 102-111

  Bicker, Joana ^a,b   Alves, Gilberto ^b,c   Fortuna, Ana ^a,b   Soares Da Silva, Patrício ^d,e   Falcão, Amílcar ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^d DEPARTMENT OF RESEARCH AND DEVELOPMENT   (Portugal)

^e University of Porto   (Portugal)

Author keywords

Apparent permeability; Bloodbrain barrier; Central nervous system; High throughput screening; PAMPA

Indexed keywords

ATENOLOL; BRAIN EXTRACT; CAFFEINE; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; CIMETIDINE; DOPAMINE; FUROSEMIDE; HYDROCORTISONE; LIPID; LOPERAMIDE; NORFLOXACIN; OXCARBAZEPINE; PHENYTOIN; PIROXICAM; PROPRANOLOL; QUINIDINE; SALAZOSULFAPYRIDINE; TRAZODONE; VERAPAMIL; ARTIFICIAL MEMBRANE; DRUG; PHOSPHOLIPID;

ACTIVE TRANSPORT; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG SCREENING; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INCUBATION TIME; LIPID MEMBRANE; MEMBRANE PERMEABILITY; OCCIPITAL CORTEX; PARALLEL ARTFICIAL MEMBRANE PERMEABILITY ASSAY; PARIETAL CORTEX; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ANIMAL; ARTIFICIAL MEMBRANE; BRAIN; CHEMISTRY; METABOLISM; PERMEABILITY; PIG; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; MEMBRANES, ARTIFICIAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS; SWINE;

EID: 84957593450     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.01.074     Document Type: Article

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