Stem cells: Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

Science

Volumn 351, Issue 6273, 2016, Pages

  Matsumura, Hiroyuki ^a   Mohri, Yasuaki ^a   Thanh Binh, Nguyen ^a,b   Morinaga, Hironobu ^a   Fukuda, Makoto ^a   Ito, Mayumi ^c   Kurata, Sotaro ^d   Hoeijmakers, Jan ^e   Nishimura, Emi K ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Kurata Clinic   (Japan)

^e ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COL17A1 PROTEIN; COLLAGEN TYPE 17; UNCLASSIFIED DRUG; AUTOANTIGEN; NONFIBRILLAR COLLAGEN;

AGING; AMINO ACID; CATALYSIS; COLLAGEN; HAIR; PHENOTYPE; PHYSIOLOGY; RODENT;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; DNA DAMAGE; EPIDERMIS; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HAIR FOLLICLE; HAIR FOLLICLE STEM CELL; HAIR LOSS; HUMAN; HUMAN TISSUE; MIDDLE AGED; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEM CELL; AGING; ALOPECIA; ANIMAL; C57BL MOUSE; DEFICIENCY; DESMOSOME; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

MUS;

AGED; AGING; ALOPECIA; ANIMALS; AUTOANTIGENS; CELL AGING; CELL DIFFERENTIATION; DESMOSOMES; DNA DAMAGE; FEMALE; GENOMIC INSTABILITY; HAIR FOLLICLE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; NON-FIBRILLAR COLLAGENS; PROTEOLYSIS; STEM CELLS;

EID: 84957571698     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad4395     Document Type: Article

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