Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid

Matrix Biology

Volumn 31, Issue 1, 2012, Pages 38-44

  Lin, Lan ^a,b   Betsuyaku, Tomoko ^c   Heimbach, Lisa ^b   Li, Ning ^b   Rubenstein, David ^b   Shapiro, Steven D ^d   An, Lijia ^a   Giudice, George J ^e   Diaz, Luis A ^b   Senior, Robert M ^f   Liu, Zhi ^b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune mouse model; Basement membrane; BP180; Bullous pemphigoid; Chemotaxis; Neutrophil elastase

Indexed keywords

ALPHA 1 ANTITRYPSIN; BULLOUS PEMPHIGOID ANTIGEN 1; CELL MEMBRANE PROTEIN; CHEMOTACTIC PEPTIDE; COLLAGEN TYPE 17; EPITOPE; IMMUNOGLOBULIN G; LEUKOCYTE ELASTASE; PROTEIN BP180; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BULLOUS PEMPHIGOID; COLLAGEN DEGRADATION; CONTROLLED STUDY; EXTRACELLULAR SPACE; HEMIDESMOSOME; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUTROPHIL CHEMOTAXIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALPHA 1-ANTITRYPSIN; ANIMALS; AUTOANTIGENS; BASEMENT MEMBRANE; CHEMOTAXIS; EXTRACELLULAR MATRIX; HEMIDESMOSOMES; HUMANS; IMMUNODOMINANT EPITOPES; LEUKOCYTE ELASTASE; MICE; NEUTROPHILS; NON-FIBRILLAR COLLAGENS; PEMPHIGOID, BULLOUS;

MURINAE; MUS;

EID: 84855599954     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2011.09.003     Document Type: Article

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