Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

Biomaterials

Volumn 82, Issue , 2016, Pages 221-228

  Uchida, Satoshi ^a   Kinoh, Hiroaki ^b   Ishii, Takehiko ^b   Matsui, Akitsugu ^a   Tockary, Theofilus Agrios ^b   Takeda, Kaori Machitani ^b   Uchida, Hirokuni ^a   Osada, Kensuke ^b   Itaka, Keiji ^a   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anti angiogenic therapy; Cholesterol; Enzymatic degradation; MRNA delivery; Pancreatic cancer; Polyplex nanomicelle

Indexed keywords

BLOCK COPOLYMERS; BLOOD; CARDIOVASCULAR SYSTEM; CHOLESTEROL; DIAGNOSIS; DISEASES; HYDROPHOBICITY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PROTEINS; RNA; TUMORS;

ANTI-ANGIOGENIC THERAPY; ENZYMATIC DEGRADATION; MRNA DELIVERY; NANOMICELLE; PANCREATIC CANCERS;

NUCLEIC ACIDS;

CHOLESTEROL; COPOLYMER; MACROGOL; MESSENGER RNA; NANOCARRIER; POLYCATION; VASCULOTROPIN RECEPTOR 1; MICELLE; NANOCAPSULE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MICELLE; MOLECULAR WEIGHT; MOUSE; NANOFABRICATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; POLYPLEX NANOMICELLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC THERAPY; TAIL VEIN; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; GENE THERAPY; GENETICS; PANCREATIC NEOPLASMS; PARTICLE SIZE; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHOLESTEROL; FEMALE; GENETIC THERAPY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, INBRED BALB C; MICELLES; NANOCAPSULES; PANCREATIC NEOPLASMS; PARTICLE SIZE; RNA, MESSENGER; TREATMENT OUTCOME;

EID: 84957561169     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.12.031     Document Type: Article

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