PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses

Molecular Therapy

Volumn 20, Issue 6, 2012, Pages 1196-1203

  Uchida, Satoshi ^a   Itaka, Keiji ^a   Chen, Qixian ^b   Osada, Kensuke ^b   Ishii, Takehiko ^b   Shibata, Masa Aki ^c   Harada Shiba, Mariko ^d   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c OSAKA HEALTH SCIENCE UNIVERSITY   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; PLASMID DNA; POLY(ETHYLENEGLYCOL)BLOCK [POLY(N' (N(2 AMINOETHYL) 2 AMINOETHYL)ASPARTAMIDE)]; POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG LAVAGE; MOUSE; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; TISSUE DISTRIBUTION;

EID: 84861915335     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.20     Document Type: Article

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