Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content

Journal of Biological Chemistry

Volumn 290, Issue 40, 2015, Pages 24534-24546

  Montermini, Laura ^a   Meehan, Brian ^a   Garnier, Delphine ^a   Lee, Wan Jin ^a   Lee, Tae Hoon ^a   Guha, Abhijit ^b   Al Nedawi, Khalid ^c   Rak, Janusz ^a  

^a MONTREAL CHILDREN S HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DIAGNOSIS; DISEASES; ENZYMES; MAMMALS; TUMORS;

ANTI-CANCER AGENTS; CONDITIONED MEDIAS; EMISSION PROFILE; EPIDERMAL GROWTH FACTOR RECEPTORS; KINASE INHIBITORS; MOLECULAR SIGNATURES; RECEPTOR TYROSINE KINASE; SECOND GENERATION;

TARGETED DRUG DELIVERY;

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; CANERTINIB; CASPASE; CETUXIMAB; DACOMITINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; GENOMIC DNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEOME; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CONDITIONED MEDIUM; DNA; EGFR PROTEIN, HUMAN; EGFR PROTEIN, MOUSE; ETOPOSIDE; MORPHOLINE DERIVATIVE; QUINAZOLINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL ACTIVITY; CELL GROWTH; CELL ISOLATION; CELLULAR SECRETION; CONTROLLED STUDY; DNA DETERMINATION; ENZYME PHOSPHORYLATION; EXOSOME; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; ANIMAL; BRAIN TUMOR; CANCER TRANSPLANTATION; CHEMISTRY; CONDITIONED MEDIUM; GENETIC TRANSFECTION; GLIOMA; METABOLISM; NEOPLASM; PHOSPHORYLATION; PROTEOMICS; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOMARKERS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CETUXIMAB; CULTURE MEDIA, CONDITIONED; DNA; ETOPOSIDE; EXOSOMES; EXTRACELLULAR VESICLES; GLIOMA; HUMANS; MICE; MICE, SCID; MORPHOLINES; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEOMICS; QUINAZOLINONES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFECTION;

EID: 84943329388     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.679217     Document Type: Article

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