The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule

Molecular Medicine Reports

Volumn 8, Issue 1, 2013, Pages 272-276

  Zhang, Long ^a   Wu, Xiaohou ^a   Luo, Chunli ^a   Chen, Xiong ^a   Yang, Lin ^a   Tao, Jia ^a   Shi, Junhui ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Angiogenesis; Exosome; Hepatocyte cell adhesion molecule; Intercellular communication; Renal cancer; Vascular endothelial growth factor

Indexed keywords

CELL ADHESION MOLECULE; MATRIGEL; MESSENGER RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CELL COMMUNICATION; DOWN REGULATION; EXOSOME; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CANCER; LIVER CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUCROSE GRADIENT; TRANSMISSION ELECTRON MICROSCOPY; ULTRAFILTRATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING;

CELL LINE, TUMOR; EXOSOMES; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KIDNEY NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ADENOVIRIDAE;

EID: 84878911644     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1458     Document Type: Article

References (31)

1. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60: 277-300, 2010.
2. Keller S, Sanderson MP, Stoeck A and Altevogt P: Exosomes: from biogenesis and secretion to biological function. Immunol Lett 107: 102-108, 2006. (Pubitemid 44779821)
3. Iero M, Valenti R, Huber V, et al: Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ 15: 80-88, 2008. (Pubitemid 350286175)
4. Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A and Ratajczak MZ: Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20: 1487-1495, 2006. (Pubitemid 44264090)
5. Quesenberry PJ and Aliotta JM: The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches and microvesicles. Stem Cell Rev 4: 137-147, 2008.
6. Cocucci E, Racchetti G and Meldolesi J: Shedding microvesicles: artefacts no more. Trends Cell Biol 19: 43-51, 2009.
7. Théry C: Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep 3: 15, 2011.
8. Mathivanan S, Ji H and Simpson RJ: Exosomes: extracellular organelles important in intercellular communication. J Proteomics 73: 1907-1920, 2010.
9. Fevrier B and Raposo G: Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16: 415-421, 2004. (Pubitemid 38903148)
10. Marleau AM, Chen CS, Joyce JA and Tullis RH: Exosome removal as a therapeutic adjuvant in cancer. J Transl Med 10: 134, 2012.
11. Lin WW and Karin M: A cytokine-mediated link between innate immunity, inflammation and cancer. J Clin Invest 117: 1175-1183, 2007.
12. Goth MI, Hubina E, Raptis S, Nagy GM and Toth BE: Physiological and pathological angiogenesis in the endocrine system. Microsc Res Tech 60: 98-106, 2003. (Pubitemid 36055238)
13. Pircher A, Medinger M and Drevs J: Liver cancer: Targeted future options. World J Hepatol 3: 38-44, 2011.
14. Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
15. Yang R, Zhang H and Zhu L: Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells. Mol Med Rep 4: 981-983, 2011.
16. He Y, Wu X, Luo C, Wang L and Lin J: Functional significance of the hepaCAM gene in bladder cancer. BMC Cancer 10: 83, 2010.
17. Moh MC, Zhang T, Lee LH and Shen S: Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells. Carcinogenesis 29: 2298-2305, 2008.
18. Zhang T, Moh MC, Lee LH and Shen S: The immunoglobulin-like cell adhesion molecule hepaCAM is cleaved in the human breast carcinoma MCF7 cells. Int J Oncol 37: 155-165, 2010.
19. Yang S, Wu X, Luo C, Pan C and Pu J: Expression and clinical significance of hepaCAM and VEGF in urothelial carcinoma. World J Urol 28: 473-478, 2010.
20. Belting M and Wittrup A: Nanotubes, exosomes and nucleic acid-binding peptides provide novel mechanisms of intercellular communication in eukaryotic cells: implications in health and disease. J Cell Biol 183: 1187-1191, 2008.
21. Al-Nedawi K, Meehan B and Rak J: Microvesicles: messengers and mediators of tumor progression. Cell Cycle 8: 2014-2018, 2009.
22. Skog J, Würdinger T, van Rijn S, et al: Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10: 1470-1476, 2008.
23. Al-Nedawi K, Meehan B, Micallef J, et al: Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10: 619-624, 2008. (Pubitemid 351627382)
24. Al-Nedawi K, Meehan B, Kerbel RS, Allison AC and Rak J: Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci USA 106: 3794-3799, 2009.
25. Corrado C, Flugy AM, Taverna S, et al: Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PLoS One 7: e42310, 2012.
26. Grange C, Tapparo M, Collino F, et al: Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res 71: 5346-5356, 2011.
27. Martinez MC and Andriantsitohaina R: Microparticles in angiogenesis: therapeutic potential. Circ Res 109: 110-119, 2011.
28. Song H, Yin D and Liu Z: GDF-15 promotes angiogenesis through modulating p53/HIF-1alpha signaling pathway in hypoxic human umbilical vein endothelial cells. Mol Biol Rep 39: 4017-4022, 2012.
29. Ma J, Xue Y, Cui W, et al: Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions. Cancer 118: 4105-4116, 2012.
30. Ling Y, Chen Y, Chen P, et al: Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest. Exp Biol Med (Maywood) 236: 851-858, 2011.
31. Reinmuth N, Thomas M, Meister M, Schnabel PA and Kreuter M: Current data on predictive markers for anti-angiogenic therapy in thoracic tumours. Eur Respir J 36: 915-924, 2010.