Two generation reproduction and teratogenicity studies of feeding quinocetone fed to Wistar rats

Food and Chemical Toxicology

Volumn 50, Issue 5, 2012, Pages 1600-1609

  Wang, Xu ^a   Zhang, Wei ^a   Wang, Yu Lian ^a   Ihsan, Awais ^a,b   Dai, Meng Hong ^a   Huang, Ling Li ^a   Chen, Dong Mei ^a   Tao, Yan Fei ^a   Peng, Da Peng ^a   Liu, Zhen Li ^a   Yuan, Zong Hui ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b Department of Biosciences   (Pakistan)

Author keywords

Olaquindox; Quinocetone; Quinoxaline 1,4 dioxide derivatives; Reproductive toxicity; Teratogenicity; Wistar rats

Indexed keywords

OLAQUINDOX; QUINOCETONE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FETUS WEIGHT; FOOD INTAKE; FOOD METABOLIC EFFICIENCY; LITTER WEIGHT; MALE; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; TAIL LENGTH; TERATOGENICITY;

ANIMAL FEED; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FEMALE; MALE; QUINOXALINES; RATS; RATS, WISTAR; REPRODUCTION; TERATOGENS; TOXICITY TESTS;

RATTUS; RATTUS NORVEGICUS;

EID: 84862783083     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.12.039     Document Type: Article

References (54)

1. Belhadjali H., Marguerry M.C., Journe F., Giordano-Labadie F., Lefevre H., Bazex J. Allergic and photoallergic contact dermatitis to olaquindox in a pig breeder with prolonged photosensitivity. Photodermatol. Photoimmunol. Photomed. 2002, 18:52-53.
2. Beutin L., Preller E., Kowalski B. Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides. Antimicrob. Agents Chemother. 1981, 20(3):336-343.
3. Byfield G., Budd S., Hartnett M.E. The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model. Invest. Ophthalmol. Vis. Sci. 2009, 50(7):3360-3365.
4. Carta A., Corona P., Loriga M. Quinoxaline 1,4-dioxide: a versatile scaffold endowed with manifold activities. Curr. Med. Chem. 2005, 12(19):2259-2272.
5. Chen Q., Tang S., Jin X., Zou J., Chen K., Zhang T., Xiao X. Investigation of the genotoxicity of quinocetone, carbadox and olaquindox in vitro using Vero cells. Food Chem. Toxicol. 2009, 47:328-334.
6. Dawson A.B. A note on the staining of the skeleton of cleared specimens with Alizarin. Red S. Stain Technol. 1926, 1:123-124.
7. De Vries H., Bojarski J., Donker A.A., Bakri A., Beyersbergen van Henegouwen G.M. Photochemical reactions of quindoxin, olaquindox, carbadox and cyadox with protein, indicating photoallergic properties. Toxicology 1990, 63:85-95.
8. EU, 1998. Commission Regulation No. 2788/98, Off. J. Eur. Commun. L347, 3.
9. Fang G., He Q., Zhou S., Wang D., Zhang Y., Yuan Z. Subchronic oral toxicity study with cyadox in Wistar rats. Food Chem. Toxicol. 2006, 44:36-41.
10. FDA (US Food and Drug Administration). Toxicological Principles for the Safety Assessment of Food Ingredients. IV.C.9b. Guidelines for Developmental Toxicity Studies. 2000a.
11. FDA (US Food and Drug Administration). Toxicological Principles for the Safety Assessment of Food Ingredients. IV.C.9.a. Guidelines for Reproduction Toxicity Studies. 2000b.
12. Hao L., Chen Q., Xiao X. Molecular mechanism of mutagenesis induced by olaquindox using a shuttle vector pSP189/mammalian cell system. Mutat. Res. 2006, 599:21-25.
13. Huang X.J., Wang X., Ihsan A., Liu Q., Xue X.J., Su S.J., Yang C.H., Yuan Z.H. Interactions of NADPH oxidase, renin-angiotensin-aldosterone system and reactive oxigen species in mequindox - mediated aldosterone secretion in Wistar. Toxicol. Lett. 2010, 198(2):112-118.
14. Huang X.J., Zhang H.H., Wang X., Huang L.L., Zhang L.Y., Yan C.X., Liu Y., Yuan Z.H. ROS mediated cytotoxicity of porcine adrenocortical cells induced by QdNOs derivatives in vitro. Chem. Biol. Interact. 2010, 185:227-234.
15. Ihsan A., Wang X., Huang X.J., Liu Y., Liu Q., Zhou W., Yuan Z.H. Acute and subchronic toxicological evaluation of Mequindox in Wistar rats. Regul. Toxicol. Pharmacol. 2010, 57:307-314.
16. Ihsan A., Wang X., Liu Z., Wang Y., Huang X., Liu Y., Yu H., Zhang H., Li T., Yang C., Yuan Z. Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats. Toxicol. Appl. Pharmacol. 2011, 252:281-288.
17. Kruskal W.H., Wallis W.A. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 1952, 47:583-621.
18. Latendresse J.R., Warbrittion A.R., Jonassen H., Creasy D.M. Fixation of testes and eyes using a modified Davidson's fluid: comparison with Bouin's fluid and conventional Davidson's fluid. Toxicol. Pathol. 2002, 30:524-533.
19. Lindamood C., Farnell D.R., Giles H.D., Prejean J.D., Collins J.J., Takahashi K., Maronpot R.R. Subchronic toxicity studies of t-butyl alcohol in rats and mice. Fundam. Appl. Toxicol. 1992, 19:91-100.
20. Liu Z.Y., Huang L.L., Chen D.M., Dai M.H., Tao Y.F., Wang Y.L., Yuan Z.H. Application of electrospray ionization hybrid ion trap/time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro. Anal. Bioanal. Chem. 2010, 396(3):1259-1271.
21. Liu Z.Y., Huang L.L., Chen D.M., Yuan Z.H. Metabolism of mequindox in liver microsomes of rats, chicken and pigs. Rapid Commun. Mass Spectrom. 2010, 24:909-918.
22. Madamanchi N.R., Li S., Patterson C., Runge M.S. Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway. Arterioscler. Thromb. Vasc. Biol. 2001, 21(3):321-326.
23. Marrero M.B., Banes-Berceli A.K., Stern D.M., Eaton D.C. Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am. J. Physiol. Renal Physiol. 2006, 290(4):762-768.
24. Ministry of Agriculture, PR China, 2003. Notice No. 295. http://www.agri.gov.cn/xxgkxzsp/t20080304_1028167.htm.
25. Nishimura K.A. Microdissection method for detecting thoracic visceral malformations in mouse and rat fetuses. Congenit. Anom. 1974, 14:23-40.
26. NRC (National Research Council). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC. 1996.
27. Ohta T., Moriya M., Kaneda Y., Watanabe K., Miyazawa T., Sugiyama F., Shirasu Y. Mutagenicity screening of feed additives in the microbial system. Mutat. Res. 1980, 77:21-30.
28. SCAN (Standing Committee for Animal Nutrition). Short report of the meeting of the standing committee for animal nutrition. 1998.
29. Scheutwinkel-Reich M., vd Hude W. Sister-chromatid exchange in Chinese hamster V79 cells exposed to quindoxin, carbadox and olaquindox. Mutat. Res. 1984, 139:199-202.
30. Seed J., Chapin R.E., Clegg E.D., Darney S.P., Dostal L., Foote R.H., Hurtt M.E., Klinefilter G.R., Makris S., Schrader S., Seyler D., Sprando R.L., Treinen K.A., Veeranachaneni R. Consensus report: methods for assessing sperm motility, morphology, and counts in the rat, rabbit and dog. Repro. Toxicol. 1996, 10:237-244.
31. Shapiro B.H., Agrawal A.K., Pampori N.A. Gender differences in drug metabolism regulated by growth hormone. Int. J. Biochem. Cell Biol. 1995, 27:9-20.
32. Shumate M.L., Yumet G., Ahmed T.A., Cooney R.N. Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 2005, 289(2):227-239.
33. Sokol R.J., Devereaux M., Khandwala R.A. Effect of dietary lipid and vitamin E on mitochondrial lipid peroxidation and hepatic injury in the bile duct-ligated rat. J Lipid Res. 1991, 32(8):1349-1357.
34. Tucker M.J. Carcinogenic action of quinoxaline 1,4-dioxide in rats. J. Natl. Cancer Inst. 1975, 55:137-146.
35. US Food and Drug Administration, 1978. Good Laboratory Practice Regulations 21 CFR Part 58. Federal Register 22 December 1978 and subsequent amendments.
36. Vicente E., Perez-Silanes S., Lima L.M., Ancizu S., Burguete A., Solano B., Villar R., Aldana I., Monge A. Selective activity against Mycobacterium tuberculosis of new quinoxaline 1,4-di-N-oxides. Bioorg. Med. Chem. 2009, 17:385-389.
37. Wang, F.L., Y.C. Wang, R.C. Zhao, X.L. Yang, S.J. Li, Z.Z. Xu, Q.F. Xue, P.J. Liang, L.Y. Yao, 1995. Effect of quinocetone on the growth performance of weaned piglets. J.T.C.V.M. 3, 16-19.
38. Wang S.H., Xu S.X., Xiang D.L., Shun Y.M., Huang Q.J., Xu Y.B., Wang M.Z. The subchronic oral toxicity study with olaquindox in rats. Chin. J. Vet. Drug. 1991, 25(4):13-14.
39. Wang X., Fang G.J., Wang Y.L., Ihsan A., Huang L.L., Zhou W., Liu Z.L., Yuan Z.H. Two generation reproduction and teratogenicity studies of feeding cyadox in Wistar rats. Food Chem. Toxicol. 2011, 49:1068-1079.
40. Wang X., He Q.H., Wang Y.L., Ihsan A., Huang L.L., Zhou W., Su S.J., Liu Z.L., Yuan Z.H. A chronic toxicity study of cyadox in Wistar rats. Regul. Toxicol. Pharmacol. 2011, 59(2):324-333.
41. Wang X., Huang X.J., Ihsan A., Liu Z.Y., Huang L.L., Zhang H.H., Zhang H.F., Zhou W., Liu Q., Xue X.J., Yuan Z.H. Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox. Toxicology 2011, 280(3):126-134.
42. Wang X., Zhang W., Wang Y., Peng D., Ihsan A., Huang X., Huang L., Liu Z., Dai M., Zhou W., Yuan Z. Acute and subchronic oral toxicological evaluations of quinocetone in Wistar rats. Regul. Toxicol. Pharmacol. 2010, 58:421-427.
43. Wang Y.C., Zh R.C., Yan X.L., Li J.S., Du X.L., Xue F.Q., Xu Z.Z., Liang J.P., Zhang J.Y., Zhu Y.P. The subchronic oral toxicity study with olaquindox in rats. Chin. J. Vet. Sci. Tech. 1993, 28(4):25-26.
44. WHO (World Health Organization), 1991a. Toxicological evaluation of certain veterinary drug residues in food. Carbadox. WHO Food Additives Series, No. 27, no. 700 on INCHEM.
45. WHO (World Health Organization), 1991b. Toxicological evaluation of certain veterinary drug residues in food. Olaquindox. WHO Food Additives Series, No. 27, no. 701 on INCHEM.
46. WHO (World Health Organization), 1994. Toxicological evaluation of certain veterinary drug residues in food. WHO Food Additives Series, No. 33, nos 804-817 on INCHEM.
47. Wilson J.G. Methods for administering agents and detecting malformations in experimental animals. Teratology. Principles and Techniques 1965, 262-277. University of Chicago Press, Chicago and London. J.G. Wilson, J. Warkany (Eds.).
48. Wu Y., Yu H., Wang Y., Huang L., Tao Y., Chen D., Peng D., Liu Z., Yuan Z. Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues. J. Chromatogr. A 2007, 1146:1-7.
49. Xu J.N., Wang Q.K., Cui T., Huang Q.Y., Wang J.G. Studies on the subchronic oral toxicity of quinocetone. Chin. J. Vet. Drug 2005, 39(3):10-15.
50. Xu S.X., Zheng D. The accumulative toxicity study with olaquindox in mice. Chin. J. Vet. Drug 1992, 26(2):22-24.
51. Xu Z., Li J., Zhao R., Wang Y., Xue F., Liang J., Yan X., Du X., Zhang J., He Z. The effects of quinocetone on liveweight gain of piglets. Vet. Sci. China 1995, 25(6):37-39.
52. Yoshimura H. Teratogenic assessment of carbadox in rats. Toxicol. Lett. 2002, 129:115-118.
53. Yoshimura H., Nakamura M., Koeda T., Yoshikawa K. Mutagenicities of carbadox and olaquindox-growth promoters for pigs. Mutat. Res. 1981, 90:49-55.
54. Zou J., Chen Q., Tang S., Jin X., Chen K., Zhang T., Xiao X. Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat. Res. 2009, 676:27-33.